Gene 3125 (Tetrahymena)
3125
Sequence
Protein domains of 3125.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 3125.AA | SCY1 | 25-285 | 27 | 5.4e-112 | 378.37 | In-house | 1-337 (337) | Show / Hide |
Range on Protein: 25-285
Range on HMM: 1-337/337
Sequence Identity: 27% (94 aa)
WKIYNAVKQDSTKRKVSIWSFDKKNITDKAAKAAKEEIAAFLKKEATSMMKIRHPNIVNLVEPVIEDKYSMAFVTERVDDNLYNLMKKGDYKAICQS---
|||.|..|. .|....|...||||||.........|||..||||.|......|||||.....|..|.|..|...||.....|.|..||.|.|..||.
WKIHNGTKK-YTGQECSVFVFDKKNIEKWHKDSWWEEICEFLKKQAKRLKRLRHPNILQYIHPLEESKDCMMYATEEIFQPLENVLKKWDNKKSCQTQKT
-----------------------ELELKLQVENILKVLQFLHNDVKTAHLGIAPENIFIVN-GQWKIAG---------FTFSTPIQNQTSTDVQNADFTK
|||.......||..|.|||||....|..|.||.||... |.|||.| ..| ..|||.............
QDVDFGQNTQPQRPYHKKDWKLDELEVCWGIFQILDALSFLHNDCHMVHNNICPESIFVNKNGDWKIGGDDDDAGGWGMDFVCDIQNGNPQMPWFPCQEW
R------------PFDHFAQFYPNLSFSAPEVAEIP------------PKCTFASDIFSLSLLILLMYQIKYMQTTNVTPM-----------------LS
| .........||....|||..... .|||.|||.|||..|| .|..|..|.|..... ..
REMDYISVSSTKPDNKYPPPCQPNPDWLAPEYIHEDQHTPASYNWGQEQKCTWASDMFSLGCLIWWVYNGKKPQITCNSNPYSTFHRYMEQWNAMSHCWW
SKTVGEYSSQLGQIQNHFKSQNYIQRDMNEDFKKLVSR
.....|....||....|...|....|.....|....
DHIPKELQEHLGHCYCHLLHQDPTCRPDPQQFLQHCYF
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| Kinase | 3125.AA | Ciliate-E2 | 26-330 | 17 | 3.1e-11 | 34.79 | In-house | 25-365 (365) | Show / Hide |
Range on Protein: 26-330
Range on HMM: 25-365/365
Sequence Identity: 17% (70 aa)
KIYNAVKQDSTK-------RKVSIWSFDKKNITDKAAKAAKEEIAAF---------LKKEATSMMKIRHPNIVNLVEPVIE-DKYSMAFVTERVDD-NLY
| .. ...| .| || | . .|.. . .. | || . . .| . .. ||||....| .| |. .. .|.| .. .|.
KQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLF
NLMKKGDYKAICQ-------SELELKLQVENILK---------------VLQFLHNDVKTAHLGIAPENIFIVNGQWKIAGFTFST----PIQNQTSTDV
..|. . | .. .| | | . ||. |..||. . | | ||||.. ||. | .|. . ||.| .
DYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTH-KQ
QNADFTKRP---------------FDHFAQFYPNLSFSAPEVAEIPPK--------CTFASDIFSL--SLLILLMYQIKYMQTTNVTPMLSSKTVGEYSS
|. .. .. | ... .. . |||. . . ....||.|| | ..|. . .
QCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------------
QLGQIQNHFKSQNYIQRDMNE-------------DF-------KKLVSR----MLAKNPSTSLFMYECMLITDKQNFKFLNKIKNRPT-IEQIKESSWM
. |. |. . .| .. | | .. || |.| ..|.| .|||.. |.
------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDP------------------------EKRITGWEQILNHPWF
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| S_TKc | 3125.AA | S_TKc | 13-312 | 16 | 1.7e-10 | -22.89 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 13-312 Range on HMM: 1-231/231 Sequence Identity: 16% (50 aa) KEPQCVGGQNGIWKIYNAVKQDSTKRKVSIWSFDKKNITDKAAKAAKEEIAAFLKKEATSMMKIRHPNIVNLVEPVIEDKYSMAFVTERVDD---NLYNL | . |. . | | ... . |.|.| | . ...| ..| .|||||.| . . .. .|.| .| .|. . YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDY MKKGDYKAIC--QSELELKLQVENILKVLQFLHNDVKTAHLGIAPENIFIVNGQWKIAGFTFSTPIQNQTSTDVQNADFTKRPFDHFAQFYPNLSFSAPE .|| .. . .| . . . |.. |...|. . | . ||||.. . . ||. | ... . | . . ||| IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL---------------------TTFCGTPWYMAPE VAEIPPKCTF-ASDIFSLSLLILLMYQIKYMQTTNVTPMLSSKTVGEYSSQLGQIQNHFKSQNYIQRDMNEDFKKLVSRMLAKNPSTSLFMYECML-ITD | . .. ..|. |. .. |. . .... | .| ...| .....| |.|. . |.. | VL----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD KQNFKFL . .. IKCHPWF |
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| Kinase | 3125.AA | RCK | 68-116 | 35 | 7.6e-09 | 23.9 | In-house | 46-99 (298) | Show / Hide |
Range on Protein: 68-116 Range on HMM: 46-99/298 Sequence Identity: 35% (19 aa) KEATSMMKIR-HPNIVNLVEPVIEDK-YSMAFVTERVDDNLYNLMKK---GDYK .| .|..|. ||||..| | ..... |. .|| | .| ||| .|| .. . REIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKY |
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| Kinase | 3125.AA | MAK | 72-111 | 44 | 3e-06 | 15.57 | In-house | 80-121 (352) | Show / Hide |
Range on Protein: 72-111 Range on HMM: 80-121/352 Sequence Identity: 44% (19 aa) SMMKIR-HPNIVNLVEPVIE--DKYSMAFVTERVDDNLYNLMK |. |. ||||| | | || . || | .||| .|| SLKKLNAHPNIVKLKE-VIRDSENDHLYFVFEYMKENLYQMMK |
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| Kinase | 3125.AA | TSSK | 315-330 | 43 | 1.3e-05 | 14.36 | In-house | 274-289 (289) | Show / Hide |
Range on Protein: 315-330 Range on HMM: 274-289/289 Sequence Identity: 43% (7 aa) IKNRPTIEQIKESSWM ..|||.|..|....|| PCNRPHINEICHHCWM |
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| Kinase | 3125.AA | CAMKL | 316-330 | 53 | 3e-05 | 12.55 | In-house | 283-297 (297) | Show / Hide |
Range on Protein: 316-330 Range on HMM: 283-297/297 Sequence Identity: 53% (8 aa) KNRPTIEQIKESSWM . ||||.||.. || EKRPTIHQIMNHPWM |
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| Kinase | 3125.AA | Ciliate-E2c | 132-177 | 41 | 5.8e-05 | 13.43 | In-house | 123-168 (310) | Show / Hide |
Range on Protein: 132-177 Range on HMM: 123-168/310 Sequence Identity: 41% (19 aa) ILKVLQFLHNDVKTAHLGIAPENIFIVNGQWKIAGFTFSTPIQNQT |. .. || .. .| | ||||.| ||. ||| | || .|... IISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDN |
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| Kinase | 3125.AA | Pkinase_Tyr | 56-85 | 36 | 0.000111 | 16.48 | Pfam | 39-70 (270) | Show / Hide |
Range on Protein: 56-85 Range on HMM: 39-70/270 Sequence Identity: 36% (12 aa) KAAKEE--IAAFLKKEATSMMKI-RHPNIVNLV .| .|. ...|.. || |... .|||||.|. GAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLY |
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| Kinase | 3125.AA | Ciliate-E2-Unclassified | 31-224 | 19 | 0.000114 | 12.15 | In-house | 18-256 (352) | Show / Hide |
Range on Protein: 31-224 Range on HMM: 18-256/352 Sequence Identity: 19% (48 aa) VKQDSTKRKV-------SIWSFDKKNITDKAAKAAKEEIAAFLKK---------EAT-SMMKIRHPNIVNLVEPVIEDKYSMAFVTERVD-----DNLYN ......| .. .| ....|.| | |... . || .. .. . ||.||.... . .|| . .|.| .. . . . CQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFY-CFQDKQNIYIVMEYCEGGDLWQYIKK LMK----KGD-----YKAICQSELELK-----LQVENILKVLQFLHNDVKTAHLGIAPENIFIVNG----QWKIAGFTFSTPIQNQTSTDVQN--ADFTK .| ..| .. . .| . | ||. |..|| . | | ||||.. |. . ||..| .| .|.. | | . . RKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQI RPFDHFAQFYPNLSFS----APEVAEI-PPKCT--FASDIFSL ..... .| .... |||| . . . ...||.|| WKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSL |
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| Kinase | 3125.AA | CAMK | 316-330 | 46 | 0.000168 | 9.63 | In-house | 411-425 (425) | Show / Hide |
Range on Protein: 316-330 Range on HMM: 411-425/425 Sequence Identity: 46% (7 aa) KNRPTIEQIKESSWM ..|.||||... || EKRMTIEQCLNHPWM |
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| Kinase | 3125.AA | Ciliate-C1 | 66-93 | 34 | 0.000201 | 6.78 | In-house | 64-92 (328) | Show / Hide |
Range on Protein: 66-93 Range on HMM: 64-92/328 Sequence Identity: 34% (10 aa) LKKEATSMMKIR-HPNIVNLVEPVIEDKY .. |.... . ||||||.|. . | .| HNNEIKHLQELKNHPNIVNMVQIIREIQY |
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| Kinase | 3125.AA | CAMKL | 50-86 | 21 | 0.002037 | 6.6 | In-house | 32-82 (297) | Show / Hide |
Range on Protein: 50-86 Range on HMM: 32-82/297 Sequence Identity: 21% (11 aa) ITDKAAKAAKEEIAAF-----------LKKEATSMMKIR---HPNIVNLVE | || . .. . . ...|. |.... ||||. | | IIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYE |
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| Kinase | 3125.AA | CAMK | 65-103 | 17 | 0.003987 | 5.12 | In-house | 77-143 (425) | Show / Hide |
Range on Protein: 65-103 Range on HMM: 77-143/425 Sequence Identity: 17% (12 aa) FLKKEATSMMK-------IRHPNIVNLVE-------------------PVIEDKYSMAFVT---ERVD ....| |.| ..||||..| | . ... | .|. | .. NVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCS |
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| Kinase | 3125.AA | Ciliate-C1 | 317-330 | 35 | 0.00719 | 2.66 | In-house | 315-328 (328) | Show / Hide |
Range on Protein: 317-330 Range on HMM: 315-328/328 Sequence Identity: 35% (5 aa) NRPTIEQIKESSWM .|.|...|| |. KRITLQEIKCHPWY |
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| Kinase | 3125.AA | Ciliate-E2-Unclassified | 313-330 | 33 | 0.022083 | 4.1 | In-house | 335-352 (352) | Show / Hide |
Range on Protein: 313-330 Range on HMM: 335-352/352 Sequence Identity: 33% (6 aa) NKIKNRPTIEQIKESSWM .....|.|.|||.. |. KNPNKRITFEQILNHPWF |
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