Gene 1348 (Tetrahymena)

1348

Species: Tetrahymena
Alias: 1348, 906, PreTt01348, 133.m00073, TTHERM_00790580
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
1348.AA Protein None 915 None Fasta, JSON
1348.kin_dom Protein Kinase Domain None 273 None Fasta, JSON
1348.NA RNA None 2748 None Fasta, JSON

Protein domain

Protein domains of 1348.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 1348.AA ULK 262-534 33 6.2e-120 404.75 In-house 1-324 (324) Show / Hide 
Range on Protein: 262-534
Range on HMM: 1-324/324
Sequence Identity: 33% (112 aa)

RVKDRILGEGSFANTYIAQLQNDNS--KKIYACKIIQKQQLIQKLLQANNPHEKQEFFLKALYNEVEVWKTLD---HSN--IVRFYDYSETA--NNYYFI
 .....||.|||....     ...   ....|||.|.|.....| ....   .  ..... | ||....|.|.   | |  ||..||..||.  ||.|.|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE---G--QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYII

MEYCEGGDLE-LLKKKIN--------RVDEKQAVILFHQLIEGCKYLYDKSVFHRDLKPANVLISDG-------------VAKIADFGFCKLVEEN-KEK
||||.||||| ..||. .        |  |..|.. |.|...|.|.|... . |||.||.| ||..|             |.|||||||.| |..| .|.
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

AMFRTTV------GTPYYMSPQILS----SAEYS-IKCDVWSLGVMFYEILTGSLPWLVPAKSSTQ----ELLDK-------IIKEQLEFP---KSLALS
 |. |.|      |||.||.||||.      .|. .|||.||||..|||.|.|. |.  . .....    .|...       | .....||   |.  .|
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS

NEIKNLISCMLQINEDERISMPEALQQIQI
.|.|.||..|||..|..||| .| ..   .
PECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 1348.AA ULK 262-534 33 3.2e-119 402.39 In-house 1-329 (329) Show / Hide 
Range on Protein: 262-534
Range on HMM: 1-329/329
Sequence Identity: 33% (114 aa)

RVKDRILGEGSFANTYIAQLQNDNS---KKIYACKIIQKQQLIQKLLQANNPHEKQEFFLKALYNEVEVWKTLD--------HSNIVRFYDYSETA--NN
 .....||.|||. ..     ...    ....|||.|.||...||. ...   .  ..... | ||....|.|.        | |||..||..||.  ||
YCLNHCLGKGSFG-KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQE---G--QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNN

YYFIMEYCEGGDLE-LLKKKIN---------RVDEKQAVILFHQLIEGCKYLYDKSVFHRDLKPANVLISDG-------------VAKIADFGFCKLVEE
.|.|||||.||||| ..||. .         |  |..|.. |.|...|.|.|... . |||.||.|.||..|             |.|||||||.| |..
IYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDN

N-KEKAMFRTTV------GTPYYMSPQILS----SAEYS-IKCDVWSLGVMFYEILTGSLPWLVPAKSSTQ-----ELLDK-------IIKEQLEFP---
. .|..|. |.|      |||.||.||||.      .|.  |||.||||..|||.|.|  |.  . .....     .|...       | |..|.||   
DNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG

KSLALSNEIKNLISCMLQINEDERISMPEALQQIQI
..  .|.|.|.||..|||..|..||| .| ..   .
NDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 1348.AA CAMK 267-530 21 2.4e-80 258.46 In-house 1-421 (425) Show / Hide 
Range on Protein: 267-530
Range on HMM: 1-421/425
Sequence Identity: 21% (92 aa)

ILGEGSFANTYIAQLQNDNS----------KKIYACKIIQKQQL-------------IQKLLQANNPHEKQEFFLKALYNEVEVWKT-------LDHSNI
.||.|||.  . ..  |..           .. .|.||| |..|             |.|  . ..  . ... .| ...|.|. |.       ||| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRFYDYSE------------TANN--------YYFIM---EYCEGGDL--ELLKKKINR-----------------VDEKQAVILFHQLIEGCKYLYDKS
...|.. |            | ..        .|..|   |||.||.|  .|. . . .                 ..|..|  .|.|.... .|. .. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VFHRDLKPANVLISD------------------GVAKIADFGFCKLVEENKEKA---------------------MFRTTVGTPYYMS-PQILSS-----
. |||||| |.|..|                  .  ||.|||| . ......                       ...| .|||.||. | .|..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------AEYSIKCDVWSLGVMFYEILTGSLPWLVPAKS----------STQELLDKIIKEQLEFP-----------------------KSLALSNEI
           |. |||.||.||. |  |.| .|.  .  .          . .||. ||.| . .||                       ..  .| | 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQEC

KNLISCMLQINEDERISMPEALQ
|.||..||| . ..|..  ..|.
KDLIRKMLQVDPEKRMTIEQCLN
Kinase 1348.AA S_TKc 262-534 28 1.1e-78 268.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 262-534
Range on HMM: 1-231/231
Sequence Identity: 28% (81 aa)

RVKDRILGEGSFANTYIAQLQNDNSKKIYACKIIQKQQLIQKLLQANNPHEKQEFFLKALYNEVEVWKTLDHSNIVRFYDYSETANNYYFIMEYCEG--G
  . |..|.|.|.  | ..  .  ...|.|.|||                       . ...|... |  .| |||..||. .. ...|..||||.|  |
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK----------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLG

DLELLKKKINR------VDEKQAVILFHQLIEGCKYLYDKSVFHRDLKPANVLISDGVAKIADFGFCKLVEENKEKAMFRTTVGTPYYMSPQILSSAEYS
||  . || .|       .| .|  ...|.... .|. .. . ||||||.|.|... . ||.|||.....         .| .|||.||.| .|    |.
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYG

I-KCDVWSLGVMFYEILTGSLPWLVPAKSSTQELLDKIIKEQLEFPKSLALSNEIKNLISCMLQINEDERISMPEALQ-------QIQI
  |||.||.|...|| |.|  |.        |....||             | | |..|. .|| . ..|..  ||||          .
KCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 1348.AA Ciliate-E2 262-534 23 3.5e-73 249.42 In-house 1-365 (365) Show / Hide 
Range on Protein: 262-534
Range on HMM: 1-365/365
Sequence Identity: 23% (91 aa)

RVKDRILGEGSFANTYIAQL-QNDN--------------------SKKIYACKIIQKQQLIQKL--LQANN--PHEKQEFFLKALYNEVEVWKTLDHSNI
  . ...|.|.|.  | ..  ....                     .|||| ||..|.|..|..  .. ..   . ..    | . || .. ..|.| ||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FY----KKI-NEKNILEQLNHPNI

VRFYDYSE--TANNYYFIMEYCEGGDLE-------LLKKKI----NRVDEKQAVILFHQLIE---------------GCKYLYDKS-VFHRDLKPANVLI
...|.. .  . ||.|..||||.||||.       . ....    .. .||..  .. |...               . .||  |  ..|||.|| |.|.
IKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF

SDGVAKIADFGFCKLV-EENKEKA----------------------------MFRTTVGTPYYMSPQILSSAE---------YSIKCDVWSLGVMFYEIL
     ||.|||..| . ..|...                             ||.|..|||.||.|.||.. .         |. |||.|||||..|| |
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

TGSLPWLVPAKSSTQELLDKIIKEQLEFP----------------KSLALSNEIKNLISC----MLQINEDERIS-MPEALQQIQI
.| .|.           ...|.. ...||                . . .|.| |.||.     ||| ....||. . ..|.   .
FGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 1348.AA Pkinase 262-534 26 1.3e-72 252.3 Pfam 1-293 (293) Show / Hide 
Range on Protein: 262-534
Range on HMM: 1-293/293
Sequence Identity: 26% (83 aa)

RVKDRILGEGSFANTYIAQLQNDNSKKIYACKIIQKQQLIQKLLQ----ANNPHEKQEFFLKALYNEVEVWKTLDHSNIVRFYDYSETANNYYFIMEYCE
 .. |..|.|||.  |... ....   |.|.||| |.    . .|    .               .|... | |.| ||||.||. |. ...|..|||||
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRL---------------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCE

GG----DLE-LLK-KKINRV--DEKQAVILFHQLIEGCKYLYDKSVFHRDLKPANVLIS-DGVA----KIADFGFCKLVEENKEKAMFRTTVGTPYYMSP
||    ||  ... .. ...  .|...   . |...| .|...... ||||||.|.||. .|.     ||.|||..|... .  .  . | .|||.||.|
GGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAP

QILS-SAEYSIKCDVWSLGVMFYEILTGSLPWLVP----AKSSTQELLDKIIKEQLEFPKSLALS-------------------NEIKNLISCMLQINED
 ..  . .|. |.|.||.|...|| |.| .|.          . ......| . .|.|. .   |                    | | .|...|. .  
EVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

ERISMPEALQQIQI
.|.. ...||   .
KRPTAEQILQHPWF
Kinase 1348.AA AGC 262-533 20 1.8e-68 175.2 In-house 1-390 (395) Show / Hide 
Range on Protein: 262-533
Range on HMM: 1-390/395
Sequence Identity: 20% (82 aa)

RVKDRILGEGSFANTYIAQLQND----NSKKIYACKIIQKQQ---LIQ--KLLQANNPHEKQEFFLKALYN------EVEVWKTLD----------HSNI
    ...|.|||   | ..  ..     ..|.||.|...|.    ...  .. .... |. ..       .      | .. ....          | .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHW-KQ-------DQGYVWEERNILEKCNHTHNHPIKSHHPFI

VR-FYDYSETANN--YYFIMEYCE--------GGDLELLKKKIN-----RVDEKQAVILFHQ-------LIEGCKYLYD-KSVFHRD-LKPANVLISD-G
|.  .   .. ..   ||.|||..        ||..||.  . .     | ||..| . . .       .. .  || . . . ||| ||| |.|. . |
VKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDG

VAKIADFGFCKLVEENKEK------------------------------------------------AMFRTTVG--TPYYMSPQILSSAEYSIKCDVWS
  |..|||.|| .  ..||                                                ..  | .|  || ||.| ||    |.  || ||
HIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWS

--LGVMFYEILTGSLPWLVP-------AKSSTQELLDKII------KEQLEFPKS--------LALSNEIKNLISCMLQINEDERISMPEA------LQQ
  ||...|| |||  |              .  |. .||.      .....||            .|.| |.||. .|. . ..|.   .        ..
FGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEE

IQ
|.
IK
Kinase 1348.AA Ciliate-E2c 264-534 32 4.5e-65 222.5 In-house 3-310 (310) Show / Hide 
Range on Protein: 264-534
Range on HMM: 3-310/310
Sequence Identity: 32% (103 aa)

KDRILGEGSFANTYIAQLQN--DNSKK------IYACKIIQKQQLIQKLLQANNPHEKQEFFLK-ALYNEVEVWKTLDHSNIVRFYDYSETANNYYFIME
.. ||| ||... | | .     |...      ..| |..        .|. .. |   |.  | .. .|..  |...| .|..|||   | .. |.|||
RNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMT--------CLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIME

YCEGGDLELLKKKINRVDEKQAVILFHQLIEGCKYLYDK-SVFHRDLKPANVLISDGVAKIADFGFCKLVEENKEK--AMFRTTVGTPYYMSPQILSS-A
||.||.|| . ..  .  ||| . .| |.| . |||...  .||||.||.| || .|. ||||||| | . .   .    | | .|||.||.||||..  
YCNGGTLEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKN

EYSIKCDVWSLGVMFYEILTGSLPWL--------------VPAKSSTQELLDKIIKE----------------QLEFPKS--LALSNEIKNLISCMLQIN
.|  | |.|||||. |. |   |||                | . .|.. | ..|.|                .. ||..    .| |.| ||  |||  
YYTEKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVD

EDERISMPEALQQIQI
|  ||.  |     .|
EEKRIDWDEIFNHECI
Kinase 1348.AA CAMKL 261-530 28 8.1e-65 205.73 In-house 1-293 (297) Show / Hide 
Range on Protein: 261-530
Range on HMM: 1-293/297
Sequence Identity: 28% (84 aa)

YRVKDRILGEGSFANTYIAQL-QNDNSKKIYACKIIQKQQLI-QKLLQANNPHEKQEFFLKALYNEVEVWKTLD---HSNIVRFYDYSETANN------Y
||. .  ||.|||.    |.  ..   .. .| ||| |. .      ..| . .|.|  .  .. |..  | |.   | ||...|.  || ..      .
YRIGK-TLGKGSFGKVKLATHIRTT--GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKI

YFIMEYCEGGD---LELLKKKIN---RVDEKQAVILFHQLIEGCKYLYDKSVFHRDLKPANVLIS-DG--VAKIADFGFCKLVEE--NKEKAMFRTTVGT
| .||||.||.   .. ..|. .   | .|..|  .| |.... .|. .. . |||.|| |.|.. .|  ..||.||||. . ..  ...  ...|  |.
YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGS

PYYMSPQILSS--AEYS-IKCDVWSLGVMFYEILTGSLPWLVP-----AKSSTQELLDKIIKEQLEFPKSLALSNEIKNLISCMLQINEDERISMPEALQ
| ||.| |...   .|   | |.||.||. | ...| ||.  .      |. . .|. ||..   ..|. . .| . ..||. ||| | ..|... . ..
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN
Kinase 1348.AA Ciliate-E2-Unclassified 263-534 25 1.6e-61 210.66 In-house 2-352 (352) Show / Hide 
Range on Protein: 263-534
Range on HMM: 2-352/352
Sequence Identity: 25% (89 aa)

VKDRILGEGSFANTYIAQLQNDNSKK---IYACKIIQKQQLIQKLLQANNPHEKQEFFLKALYNEVE--------VWKTLDHSNIVRFYDYSETANNYYF
 . ...|.|.|.  | .|  ... ..    |..||... |....  . .   |..| . |   . ..          . ..| .||..... .. .| |.
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IMEYCEGGDLEL-LKKKIN----------------RVDEKQAV-----ILFHQLIEGCKYLYDKS-VFHRDLKPANVLISDG----VAKIADFGFCKLVE
.|||||||||.  .||. .                ...|.||.      .| |...| .||  |  . |||.|| |.|....      ||.|||..|  .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

ENKE-------------KAMFRTTVGTPYYM----SPQILSSAEYS----IKCDVWSLGVMFYEILTGSLPWLVPAKSS-------------TQELLDKI
.| .             . |. |..|||.||    .| .| . .|.    .|||.||||| .||.|.| .|   . . .              ..|...|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

IKEQLEFPKSLA------LSNEIKNLIS----CMLQINEDERISMPEALQQIQI
.. ...|||.        .|.| |..|.    .||. | ..||.....|.   .
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 1348.AA CAMK-Unique 264-534 22 4.3e-57 186.94 In-house 3-363 (363) Show / Hide 
Range on Protein: 264-534
Range on HMM: 3-363/363
Sequence Identity: 22% (81 aa)

KDRILGEGSFANTYIAQLQNDNSKKIYACKIIQK---QQLIQKL-----LQANNPHEKQEFFLKALYNEVEVWKTLDHSNIVRFYDY----SETAN----
. ||.|.|.|    .  ...   .|..|||...|   .  .||.     |         .     | .|...||..|| ||...||.     ....    
MHRIIGHGNFG--HVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRD---MKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLC

-----------NYYFIMEYCEGGDL-ELLKK------------------KINRVDEK---QAVILFHQLIEGCKYLYDKSVFHRDLKPANVLISDGVA--
           ..| .||||.|||| ... |                  .......    ..  .. .| .  .|. .... |||||. |....  .   
DLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDN

---------------KIADFGFCKLVEENKEKAMFRTTVGTPYYMSP--------------QILSSAEYSIKC----DVWSLGVMFYEILTGSLPWLVPA
               |..||| |.....||. .|  |..|||.||.|              ...    |. .|    | |||||. |. |.|..|   . 
NHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCEC

KSS-----TQELLDKIIKEQL-EFPKSLALS-----NEIKNLISCMLQINEDERISMPEALQQIQI
. .       |....| | .. .|...   .     .| |... | ...  | |.|  |.|. . |
EDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 1348.AA STE 263-534 21 9.9e-51 174.86 In-house 1-359 (359) Show / Hide 
Range on Protein: 263-534
Range on HMM: 1-359/359
Sequence Identity: 21% (80 aa)

VKD-RILGEGSFANTYIAQLQN-----DNSKK--------IYACKIIQ---KQQLIQKLLQANNPHE---KQEFFLKALYNEVEVWKTLD--HSNIVRFY
 .. ...|.|.|  .| |   .     .. ..        |.| |..    ... . .. | .|  |   |..  .. . .|... | ..  | |||..|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-EN-Q-EN-QELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYY

DYSETA-------NNYYFIMEYCEGGDLELLKK---KINR-----------VDEKQAVILFHQLIEG-CKYLYDKSVFHRDLKPANVLISDGVAKIADFG
.. .         .. . .|||..|| |. . |   ....           ..|.|  .  .|...|  .|| .. . |||.||||.|.    .|..|||
GCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFG

FCK-LVEENKEK------------A-MFRTTVGTPYYMSPQILSS------AEYSIKCDVWSLGVMFYEILTGSLPW---LVP-AKSSTQ---------E
.|. |.... ..            . .  | |||| .|.| ...        .|..|||.|||| .  | .||  ||     . |   ..         |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

LLDKIIKEQL-EFPK-----------------SLALSNEIKNLISCMLQINEDERISMPEALQ--QIQI
.| .|....   .|                  .  .| | |. |.  ||.. ..| .  . |.     |
QL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 1348.AA TyrKc 262-532 21 1.4e-19 72.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 262-532
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

RVKDRILGEGSFANTYIAQLQNDNSKKIYACKIIQKQQLIQKLLQANNPHEKQEFFLKALYNEVEVWKTL--DHSNIVRFYDYSETA-------NNYYFI
 .....|||| |   | ...         | | ...                    ......| .. . |  .| ||||.| .  .          .. .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV

MEYCEGGDL-ELLKKKINRVDEKQAVILFHQLIEGCKYLYDKSVFHRDLKPANVLISDGV-AKIADFGFCKLVEEN----KEKAMFRTTV--GTP-----
|||...||| . |.|. ...  |. .   .|  .|. || .| . ||||   |.|....  .||.||| .. ...      .| . |..   |.      
MEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

YYMSPQILSSAEYSIKCDVWSLGVMFYEILT-GSLPWLVPAK--SSTQELLDKIIKE-QLEFPKSLA------LSNEIKNLISCMLQINEDERISMPEAL
  |.|  .   ....| |||| ||. .||.| |  |.  ...   | ||.. .. .   .. |..         . |. .....  . . ..| .. |  
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

QQI
...
ECF
Kinase 1348.AA Pkinase_Tyr 317-475 30 2.2e-18 62.89 Pfam 46-216 (270) Show / Hide 
Range on Protein: 317-475
Range on HMM: 46-216/270
Sequence Identity: 30% (53 aa)

FLKALYNEVEVWKTL-DHSNIVRFYDYSE-TANN--YYFIMEYCEGGDL-ELLKKK---INRVDEKQAVILFHQLIEGCKYLYDKSVFHRDLKPANVLIS
..... .|... |.| .| ||||.|           .| .|||...||| . |.|.    .... |. .   .|  .|. || .|   ||||   |.|..
CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT

-DGVAKIADFGFCKLVEENKEKAMFRTTVGTPY---YMSPQILSSAEYSIKCDVWSLGVMFYEILT-GSLP-W
 ..|.||.||| .... .|..   .|.. |..     |.|  ..  ....| |||| ||  .||.| |  | .
ENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY