Gene 14572 (Tetrahymena)

14572

Species: Tetrahymena
Alias: PreTt14572, 159, 14572, 3825.m02937, 2.m02196, TTHERM_00040360
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
14572.AA Protein None 803 None Fasta, JSON
14572.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
14572.NA RNA None 2412 None Fasta, JSON

Protein domain

Protein domains of 14572.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 14572.AA ULK 17-274 39 4.2e-132 445.17 In-house 1-324 (324) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-324/324
Sequence Identity: 39% (127 aa)

YNTRHCIGEGSYG-KVFEGIDVKT---QEKIAIKTID---QNIFKND---QYLQCAIMAEIEILKRFD---HKN--IVKFKDIVYED--DTIYIITEFCQ
|. .||.|.||.| ||..|...||   ....|.| ||   .|..||.   ||. . .. ||.|.| ..   |.|  |||..|. ...  . ||||.|.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

DGDLRQFMKSN---------KNLSEDVITQIFKQILEGIRELHKVGVIHRDLKPANILIHNNE-------------FKIADFGFARDVDF--QSEKLLVS
.|||.|..| |         |.|||. . |.||||..| .|||| ..||||.||.||||||.              .||||||||. ||   ... .. .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

CV------GSPMYMDPLILS----RKPYG-TKCDIWSLGVILYEMIMGETPYHKS-RTEQ----ELLIN-------IYTKPLKFELPG--RKCSPKMQNL
||      |.|.|| | ||.    .|||.  ||||||||.|.|||. |..|. .. ....    .|. |       |...|..| .|.   |.||....|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL

IKQMLQVQEVDRISWDDLFNQFGL
|..|||..| |||||...|| . .
IRRMLQYDEKDRISWEEIFNHPWF
Kinase 14572.AA ULK 17-274 39 2.1e-129 436.21 In-house 1-329 (329) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-329/329
Sequence Identity: 39% (130 aa)

YNTRHCIGEGSYGKVFEGIDVKT----QEKIAIKTID---QNIFKND---QYLQCAIMAEIEILKRFD----HKN----IVKFKDIVYED--DTIYIITE
|. .||.|.||.|||..|...||    .||.|.| ||   .|...|.   ||. . .. ||.|.|. .    |||    |||..|. ...  . ||||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCQDGDLRQFMKSNKNLSEDV----------ITQIFKQILEGIRELHKVGVIHRDLKPANILIHNNE-------------FKIADFGFARDVDFQ--SEK
.|..|||.|..| ||.|.||.          . |.|||||.| .|||| ..||||.||.||||||.              .||||||||. ||    ...
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LLVSCV------GSPMYMDPLILS----RKPYG-TKCDIWSLGVILYEMIMGETPYHKS-RTEQ-----ELLIN-------IYTKPLKFEL--PGRKCSP
....||      |.|.|| | ||.    .|||.  ||||||||.|.|||. |..|. .. ....     .|. |       | ..||.|.   .. ..||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

KMQNLIKQMLQVQEVDRISWDDLFNQFGL
....||..|||..| |||||..||| . .
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 14572.AA S_TKc 17-274 29 1.4e-81 278.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-231/231
Sequence Identity: 29% (82 aa)

YNTRHCIGEGSYGKVFEGIDVKTQEKIAIKTIDQNIFKNDQYLQCAIMAEIEILKRFDHKNIVKFKDIVYEDDTIYIITEFCQD--GDLRQFMKSNKN--
|     ||.|..|||. ....||... ||| |.           . |. ||.|||. .|.||||..|. .. | .|...|.|    |||....|...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LSEDVITQIFKQILEGIRELHKVGVIHRDLKPANILIHNNEFKIADFGFARDVDFQSEKLLVSCVGSPMYMDPLILSRKPYGT-KCDIWSLGVILY
    ..| ..  ...||....  .|. |.|||||||.|||. . . ||.|||.|| .         ...|.| || | .|   .||. |||.||.|.|||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMIMGETPYHKSRTEQELLINIYTKPLKFELPGRKCSPKMQNLIKQMLQVQEVDRISWDDLFN-------QFGL
||. |..|..    ........              || . ..|...||.   .|..  ....          .
EMLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 14572.AA Ciliate-E2 17-270 27 1e-80 274.48 In-house 1-361 (365) Show / Hide 
Range on Protein: 17-270
Range on HMM: 1-361/365
Sequence Identity: 27% (101 aa)

YNTRHCIGEGSYGKVFEGIDVKTQE------------------KIAIKTIDQNIFKNDQYLQCA----IMAEIE----------ILKRFDHKNIVKFKDI
|.   .||.|..|.|... . |.|.                  | .|| .  .|.|..|  |      || ||.          ||.. .|.||.|... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VY--EDDTIYIITEFCQDGDLRQFMKSN-----------KNLSEDVITQIFKQILE---------------GIRELHKVG-VIHRDLKPANILIHNNEFK
 .   |..||...|.|| |||....|.|           |...|  | .|.||||.               ....||. . .||||.|| |||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADFGFARDVDFQ------------------------------SEKLLVSCVGSPMYMDPLILSRKP---------YGTKCDIWSLGVILYEMIMGETPY
|.|||.....| .                              .. .  ...|.|.|| | ||..|.         |..||||||||||||||..|..|.
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

HKSRTEQELLINIYTKPLKFELP---------------GRKCSPKMQNLIKQ----MLQVQEVDRIS-WDDLFN
         ...|  ....|  |                 |.|.....|||.    |||...  ||. |....|
---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 14572.AA Pkinase 17-272 29 2.9e-75 261.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 17-272
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

YNTRHCIGEGSYGKVFEGIDVKTQEKIAIKTIDQNIFKNDQYLQCAIM-AEIEILKRFDHKNIVKFKDIVYEDDTIYIITEFCQDG----DLRQFMK--S
| .  .||.||.|.|.......|... |.|.|.    .... .| ..  .||.|.||..|.|||...|.....| ||...|.|. |    ||  ...  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NKNL--SEDVITQIFKQILEGIRELHKVGVIHRDLKPANILIH-NNEF----KIADFGFARDVDFQSEKLLVSCVGSPMYMDPLILS-RKPYGTKCDIWS
....  ||...  ...|||.|.  .|. |.|||||||.||||. |..     ||.|||.|. .|  .   . . .|.| || | ..  ...||.|.|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVILYEMIMGETPYHKS-----RTEQELLINIYTKPLKFELPGRKC------------------SPKMQNLIKQMLQVQEVDRISWDDLFNQ--F
.|.|||||. |..|.  .     ....... .|  .||.|. |   .                  |. .. .|| .|..   .|........   |
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 14572.AA CAMK 22-264 21 2.3e-74 238.83 In-house 1-415 (425) Show / Hide 
Range on Protein: 22-264
Range on HMM: 1-415/425
Sequence Identity: 21% (90 aa)

CIGEGSYGKVFEGIDVKTQ------------EKIAIKTIDQN---------------IFKN---------DQYLQCAIMAEIEILKR-------FDHKNI
 .|.||.|||...|. .|.            .| ||| || .               |.|          ... .  .. ||||.|.        ||.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFKDIVYE-------------------DDTIYIIT---EFCQDG----DLRQFMKSNKN---------------LSEDVITQIFKQILEGIRELHKVGV
.|. ..                      |. .|...   |.|. |    || .. .....               ..|.   ..|.||..... .|. ..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPANILIHNNE------------------FKIADFGFARDVDFQS----------------------EKLLVSCVGSPMYMD-PLILSR------
.|||||| |||. .|.                   ||.|||||. .|  .                       ...  ..|.| ||  | .|..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KPYGTKCDIWSLGVILYEMIMGETPYHKSR------------TEQELLINIYTKPLKFELPGRK---------------------CSPKMQN
        ..|| |||.||.||||| |  |. |.  .             ...||. .| .    |. |  .                     .|.  ..
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIKQMLQVQEVDRIS
||..||||   .|..
LIRKMLQVDPEKRMT
Kinase 14572.AA Ciliate-E2-Unclassified 17-274 24 1.2e-72 247.72 In-house 1-352 (352) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-352/352
Sequence Identity: 24% (88 aa)

YNTRHCIGEGSYGKVFEGIDVKTQEKIAIKTIDQNIFKNDQYL---QCAIMAEIEILKRFD-----------------HKNIVKFKDIVYE--DDTIYII
|.  ..||.|..|||.. .. |.... |.|.. ... .....    .  || |......                   |..... |.. ..  ...|||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TEFCQDGDLRQFMKSNKN-----------------LSEDVIT-----QIFKQILEGIRELHKVG-VIHRDLKPANILIHNN----EFKIADFGFAR----
.|.|..|||.|..|..|.                 ..|  .      ..|.|||.|.  ||. . .||||.|| |||..||    . ||.|||...    
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----DVDFQ-------SEKLLVSCVGSPMYM----DPLILSRKPYG----TKCDIWSLGVILYEMIMGETPY-HKSRTE--------------QELLINI
    | ..|       ..... ...|.|.||     | .| .. |.     ||||||||||||||..|. |.  .....              ..|. ||
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

YTKPLKFELPG-----RKCSPKMQNLIK----QMLQVQEVDRISWDDLFNQFGL
. |...|          . ||. ...|.    .||...   ||......|   .
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 14572.AA Ciliate-E2c 17-274 30 6e-69 235.37 In-house 1-310 (310) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-310/310
Sequence Identity: 30% (96 aa)

YNTRHCIGEGSYGKVFEG---IDVKTQEKI-------AIKTIDQNIF----KNDQYLQCAIMAEIEILKRFDHKNIVKFKDIVYEDDTIYIITEFCQDGD
...    | ||||||. .    |.... .        ||| .  ...     |.     .|. ||...|  .|..|.|| | .  |  ||.|.|.| .|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LRQFMKSNKNLSEDVITQIFKQILEGIRELHKV-GVIHRDLKPANILIHNNEFKIADFGFARDVDFQSEKLLV---SCVGSPMYMDPLILSR-KPYGTKC
| |. ... ...|. .   |.||. .  .|||  ...|||.||.|||||| . |||||||.. .. .  .       |.|.|||| | ||.. . | .| 
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKS

DIWSLGVILYEMIMGETPYH-----------------KSRTEQELLINIY---------------TKPLKFELP-GRKCSPKMQNLIKQMLQVQEVDRIS
||||||| ||.|.  . |                   .  | ..| ..|                |....|      . |.. . ||. |||| | .||.
DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRID

WDDLFNQFGL
||..||   .
WDEIFNHECI
Kinase 14572.AA CAMKL 17-264 30 6.1e-66 209.37 In-house 1-287 (297) Show / Hide 
Range on Protein: 17-264
Range on HMM: 1-287/297
Sequence Identity: 30% (87 aa)

YNTRHCIGEGSYGKVFEGID-VKTQEKIAIKTIDQNIFKNDQYLQCA-----------IMAEIEILKRFD---HKNIVKFKDIVYEDDT------IYIIT
|.    .|.||.|||  ...   |.|| ||| || .  .||.. ..            |  ||.|.|...   |.||.|. .... ...      ||...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFCQDGD--LRQFMKSNKN----LSEDVITQIFKQILEGIRELHKVGVIHRDLKPANILIHNNE---FKIADFGFARDVD---FQSEKLLVSCVGSPMYM
| |. |.  | .. .....    ..|.   ..|.||....  .|. |..|||.|| |||. .|     ||.||||.   .   |.....|  . ||| ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

DPLILSR--KPYG-TKCDIWSLGVILYEMIMGETPYHKSRT------EQELLINIYTKPLKFELPGRKCSPKMQNLIKQMLQVQEVDRIS
 | |...  |||   | ||||.||||| |. |. |             . .| ..  .  ... .  . |   ..||..||||   .|..
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPT
Kinase 14572.AA STE 17-273 23 5.8e-63 215.49 In-house 1-359 (359) Show / Hide 
Range on Protein: 17-273
Range on HMM: 1-359/359
Sequence Identity: 23% (84 aa)

YNTRHCIGEGSYGKVFEGIDV------KTQEK---------IAIKTID-----QNIFK---------NDQYLQCAIMAEIEILKRFD--HKNIVKFKDIV
.    .||.|..|.|. ....      ||.|.         .||| ..     ... .          ..  .  |. ||.|.|...  |.||||. .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

YED-------DTIYIITEFCQDGDLRQFMKSN----KNLS----------EDVITQIFKQILEG-IRELHKVGVIHRDLKPANILIHNNEFKIADFGFAR
. .       |...|. |..  | |....|..    |.|.          |..|  | .|||.|    ||. ..||||.||||||.     |..|||.. 
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCG

DVDF---------------QSEKLLVSCVGSPMYMDPLILSR------KPYGTKCDIWSLGVILYEMIMGETPYHK-SRTEQELLINIY-----------
 ..                 . .   ..||.| .| | ....      |.|.|||||||||  . ||. |. |.|. . ..  ..|..            
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---TKPLKFELP----------------GRKCSPKMQNLIKQMLQVQEVDRISWDDLFN---QFG
    .| ... .                 .|.||.... |.. ||    .| . ..| .    | 
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 14572.AA MARK 17-268 33 3.6e-58 188.81 In-house 1-256 (262) Show / Hide 
Range on Protein: 17-268
Range on HMM: 1-256/262
Sequence Identity: 33% (90 aa)

YNTRHCIGEGSYGKVFEGIDVKTQEKIAIKTID---QNIFKNDQYLQCAIMAEIEILKRFDHKNIVKFKDIVY--EDDT-IYIITEFCQDGDLRQFMKSN
|    .||.|||.||  .....|..| |||...    | ... .     .| ||||.|. ||.||.|. ...   .  . ||.| | .  |.|....|. 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMK----NVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAH

--KNLSEDVITQIFKQILEGIRELHKVGVIHRDLKPANILIHNN---EFKIADFGFARDVDFQSEKLLVSCVGSPMYMDPLILSRKPYG-TKCDIWSLGV
    |.|.   .||.||....  .|. ...|||.|| ||||  |     ||.||||.  . ......| .. |.| || | |...|||  .| |||||||
PNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFS--ICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGV

ILYEMIMGETPYH-KSRTEQELLINIYTKPLKFELPGRKCSPKMQNLIKQMLQVQEVDRISWDDL
.|| |. |  |.  .. .. ||  .|..   |.. | .  |.. .|||...|.|   .|.. ...
VLYFMVCGYFPFDGDTQDYKELYKKILRG--KYDIPCH-VSKECRNLIQRLLTVNPEERPTIEEI
Kinase 14572.AA STE20 17-257 30 1.3e-54 187.7 In-house 1-271 (288) Show / Hide 
Range on Protein: 17-257
Range on HMM: 1-271/288
Sequence Identity: 30% (83 aa)

YNTRHCIGEGSYGKVFEGIDVKTQEK----IAIKTIDQNIFKNDQ---YLQCAIMAEIEILKRFDHKNIVKFKDIVYED----DTIYIITEFCQDGDLRQ
|.  ..||.||||||. .....|.|.    .||| ..    ....     .  |. || |.|...|.||||. .  . |    | ..|. |.|. | |..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMN---LEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTD

FMK---SNKN------LSEDVITQIFKQILEGIRELHKVGVIHRDLKPANILIHNN-EFKIADFGFARDVDF----QSEKLLVSCVGSPMYMDPLILSR-
 ||   . ..      ..|. |  | ...|.|   ||. ..||||.| .|||.  . | |.||||.. ...        .   . ||.| .| | .... 
IMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCM

----KPYGTKCDIWSLGVILYEMIMGETPYHK-SRTEQELLINIYTK-PLKFEL--PGRKCSPKMQNLIKQMLQV
    |.|..||||||||  . ||. || ||.. ...   ..|   .. |....   | .|.||. .......||.
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKP-HKWSPEFHDFVDKCLQK
Kinase 14572.AA Pkinase_Tyr 17-165 29 1.2e-30 104.44 Pfam 1-161 (270) Show / Hide 
Range on Protein: 17-165
Range on HMM: 1-161/270
Sequence Identity: 29% (48 aa)

YNTRHCIGEGSYGKVFEGIDV----KTQEKIAIKTIDQNIFKNDQYLQCAIMAEIEILKRF-DHKNIVKFKDIVY-EDDT--IYIITEFCQDGDLRQFMK
    . .|||..|.|..|.      .|. . |.|..  .    .| .. . |.|..|.| . .|.|||..  ... ...   |||..|... |||. . .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

S----NKNLSEDVITQIFKQILEGIRELHKVGVIHRDLKPANILIH-NNEFKIADFGFARDV
.    ...|.   . |.  || .|   |.  . |||||   |.|.. ||  ||.||| |||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase 14572.AA TyrKc 17-272 22 5e-21 77.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-272
Range on HMM: 1-280/280
Sequence Identity: 22% (64 aa)

YNTRHCIGEGSYGKVFEGIDVKTQEKIAIKTIDQNIFKNDQYLQCAIMAEIEILKRF--DHKNIVKFKDIVYED-------DTIYIITEFCQDGDLRQFM
    . .||| .|.|..|.     .. |.|..  .        . ..| |..|....  .|.|||..  .. ..       . ..|..|..  |||... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KSNKN-LSEDVITQIFKQILEGIRELHKVGVIHRDLKPANILIHNNE-FKIADFGFARDVDFQ-----SEKLLVSCV-GSPMYMDPL------ILSRKPY
..... |. .   ..  || .| . ||. ..|||||   |.|...|   ||.||| .||..       |..  ..   ..  .| |.       .  . .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GTKCDIWSLGVILYEMI-MGETPYHK-SR--TEQELLINIYTKPLKFELPGR-------KCSPKMQNLIKQMLQVQEVDRISWDDLFNQF
 || |.|| || ..|.   |..||        . . .|.   .    . |          |...| ...||  . .  || .  ..  .|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 14572.AA Pkinase_Tyr 193-216 46 0.002762 11.75 Pfam 191-216 (270) Show / Hide 
Range on Protein: 193-216
Range on HMM: 191-216/270
Sequence Identity: 46% (12 aa)

YGTKCDIWSLGVILYEMIM-GETP-Y
. || |.|| || ..|..  ||.| |
FTTKSDVWSFGVLMWEIFTYGEQPTY