Gene 15705 (Tetrahymena)

15705

Species: Tetrahymena
Alias: TTHERM_00295950, 582, 3692.m00168, 15705, PreTt15705, 27.m00365
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
15705.AA Protein None 1085 None Fasta, JSON
15705.kin_dom Protein Kinase Domain None 266 None Fasta, JSON
15705.NA RNA None 3258 None Fasta, JSON

Protein domain

Protein domains of 15705.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15705.AA ULK 75-340 38 1.8e-128 433.08 In-house 1-324 (324) Show / Hide 
Range on Protein: 75-340
Range on HMM: 1-324/324
Sequence Identity: 38% (126 aa)

IVFNEKLGGGQFS-QVYKAMDKNDKTHEQYFAVKIIPMSSTQYQKFANY----NQLLQKEIEILLKAR---HQN--LICMHDLKQTP--NNLYLFLDYCN
.. |..|| |.|  .|||. .|...|  ||.|.|.|.... . .|  ..     |||..||.|. |     |.|   ....| ..|.  ||.|....|||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLRQYIVKKKN--------RLAEEEAVEFFKQMCAGYQALNEKKIIHRDLKPENILLHDNK-------------IKIGDFGFARIVND--LDQAVRMT
||||.||| |.|.        || |.||..|||| |.|...|....|||||.||.|||.|...             .||.|||||..|..  ..| ...|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

QK------CSPLYAPPQILL----NEKYS-SKCDVWSMGCIFFEMLYGKPPFTAHSIISLTENIKKMVGS----------GPYQLP---AYPPIAQEAKD
..      ..|||  ||||     ...|. .|||.||.||||.||||||.|| .  . .. ..|.|..             | | |   . |.| .| ||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

ILVKMLMYNEKDRISWDEIFNHPIL
.. .|| |.|||||||.||||||..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 15705.AA ULK 75-340 37 5.4e-126 424.88 In-house 1-329 (329) Show / Hide 
Range on Protein: 75-340
Range on HMM: 1-329/329
Sequence Identity: 37% (123 aa)

IVFNEKLGGGQFSQVYKA--MDKNDKTHEQYFAVKIIPMSSTQYQKFANY----NQLLQKEIEILLKAR--------HQNLICMHDLKQTP--NNLYLFL
.. |..|| |.| .|||.  ....|  . ...|.|.|. .. . ..  ..     |||..||.|. |          |.| ....| ..|.  ||.|...
YCLNHCLGKGSFGKVYKGRNKKTKD-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

DYCNGGDLRQYIVKKKN---------RLAEEEAVEFFKQMCAGYQALNEKKIIHRDLKPENILLHDNK-------------IKIGDFGFARIVN-D-LDQ
.|||||||.||| |.|.         || |.||..|||| ..|...|....|||||.||.|||.|...             .||.|||||. |. | ..|
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ

AVRMTQK------CSPLYAPPQILL----NEKYS-SKCDVWSMGCIFFEMLYGKPPFTAHSIISLT-----ENIKK------MVGSGPYQLP---AYPPI
.. ||..      ..|||  ||||     ...|. .|||.||.||||.||||||||| |  . ..      ..|..      .. . | | |   . |.|
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

AQEAKDILVKMLMYNEKDRISWDEIFNHPIL
 .| ||.. .|| |.|||||||.|.||||..
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 15705.AA S_TKc 75-340 31 5.8e-85 289.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 75-340
Range on HMM: 1-231/231
Sequence Identity: 31% (89 aa)

IVFNEKLGGGQFSQVYKAMDKNDKTHEQYFAVKIIPMSSTQYQKFANYNQLLQKEIEILLKARHQNLICMHDLKQTPNNLYLFLDYCNG--GDLRQYIVK
  . .|.| | |..|||. .|.     ...|.|||.             . ...||.|| | .| |.. ..|  |. ..||....||.|  |||..||.|
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

KKNR-----LAEEEAVEFFKQMCAGYQALNEKKIIHRDLKPENILLHDNKIKIGDFGFARIVNDLDQAVRMTQKCSPLYAPPQILLNEKYSS-KCDVWSM
.. .     . | .|  ...|.| . . . ...||||||||||||| .  |||.|||.||..        .|.  .| | .| .|   .|.  |||.|| 
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GCIFFEMLYGKPPFTAHSIISLTENIKKMVGSGPYQLPAYPPIAQEAKDILVKMLMYNEKDRISWDEIFN-------HPIL
|||..|||.|.|||    .  . ..|.                 .||||.. |.| .. ..|..  |...       || .
GCILYEMLCGYPPFP--QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15705.AA Ciliate-E2 75-340 25 2.6e-78 266.48 In-house 1-365 (365) Show / Hide 
Range on Protein: 75-340
Range on HMM: 1-365/365
Sequence Identity: 25% (99 aa)

IVFNEKLGGGQFSQVYKAMDKNDKTHEQ---------------YFAVKIIPMSSTQYQKFANYNQLLQ--KEIE----------ILLKARHQNLICMHDL
. |..|.| |.|..|||. .....  ..               ....||. | . . ..  . .| ..  .||.          || .  | |.| |.. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

KQ--TPNNLYLFLDYCNGGDLRQYIVKKK----------NRLAEEEAVEFFKQMCAGY---------------QALNEKK-IIHRDLKPENILLHDNKIK
 |  . ||.|| ..||.||||..|| ..|          ... |.|. ...|| . |.               . | .|. |||||.||||||.    ||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IGDFGFARIVNDLDQAVRMTQKC------------------------------SPLYAPPQILLNEK---------YSSKCDVWSMGCIFFEMLYGKPPF
| |||......|  |  .. | |                              .| | .|.|| ..|         |. |||.||.|.|..|||.|||||
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

TAHSIISLTENIKKMVGSGPYQLP----------------AYPPIAQEAKDILVK----MLMYNEKDRIS-WDEIFNHPIL
             .    .....|                 .  . ||.||.. |    || .... ||. |..|.|||..
------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 15705.AA CAMK 80-340 23 1.6e-76 245.94 In-house 1-425 (425) Show / Hide 
Range on Protein: 80-340
Range on HMM: 1-425/425
Sequence Identity: 23% (98 aa)

KLGGGQFSQVYKAMDKNDKTHE---------QYFAVKIIPMSSTQ------------YQKF----------ANYNQLLQKEIEILLK-------ARHQNL
.|| |.|..|.....||..  |         | .|.|||. .  .             .|           ..  . ...||||. |        .| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ICMHDLKQ------------TPNN--------LYLFL---DYCNGG----DLRQYIVKKKN--------------RLAEEEAVEFFKQMCAGYQALNEKK
| ...  .            | ..        .|...   .|| ||    || .|||....              |. |.||  .|.|.| . . . ...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDLKPENILLHDN------------------KIKIGDFGFARIVNDLD----------------------QAVRMTQKCSPLYAP-PQILLN-----
|.||||||||||| ||                  .||| |||||..... .                           |.  .| |.. | .|.      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EKYSSKCDVWSMGCIFFEMLYGKPPFTAH---SIIS------LTENIKKMVGSGPYQLPAYP--PIA--------------------QEAK
         . |. |||.||.|.| . || |.||| .    .|..        ....... .| |. | ..  ||                     ||.|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DILVKMLMYNEKDRISWDEIFNHPIL
| . ||| .. ..|.. ... ||| .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 15705.AA AGC 77-340 20 5.5e-76 195.09 In-house 1-395 (395) Show / Hide 
Range on Protein: 77-340
Range on HMM: 1-395/395
Sequence Identity: 20% (82 aa)

FNEK--LGGGQFSQVYKAMDKNDK---THEQYFAVKIIPMSS---TQY--QKFANYNQL-------LQKEIEILLKAR----------HQNLIC-MHDLK
|. .  .| | |..|| . .|...   . ..|.|.|..  .         .   ...         ...| .|| |..          |....  .|   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPNN--LYLFLDYCN---------GG-DLRQYIVK--KKNRLAEEEAVEFFKQ-------MCAGYQALNE-KKIIHRD-LKPENILLHD-NKIKIGDFG
|....  ||. ..|..         || .| ... .  |. |. ||.|  .. .       .. . . | . ..||||| |||||||| .   ||. |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FARIVNDLD------------------------------------------------QAVRMTQKC---SPLYAPPQILLNEKYSSKCDVWS--MGCIFF
.. .... .                                                . .| .  |   .| | .| ||    |.  || ||  .||...
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLYGKPPFTAHS----------IISLTENIK--KMVGSGPYQLPAY--------PPIAQEAKDILVKMLMYNEKDRIS----------WDEIFNHPIL
|||.|.|||....             . ..|.  ... . . ..| .        . . .||||.. |.|  . ..|.            .|| |||  
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 15705.AA Pkinase 75-340 27 2.3e-72 251.49 Pfam 1-293 (293) Show / Hide 
Range on Protein: 75-340
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

IVFNEKLGGGQFSQVYKAMDKNDKTHEQYFAVKIIPMSSTQYQKFANYNQLLQKEIEILLKARHQNLICMHDLKQTPNNLYLFLDYCNGG----DLRQYI
... .|.| | |..|||...|..      .|||||. ...  .|  .   |   ||.|... .| | . ..|  ......|. ..||.||    ||  ||
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

V-KKKNRL--AEEEAVEFFKQMCAGYQALNEKKIIHRDLKPENILLH-DNKI----KIGDFGFARIVNDLDQAVRMTQKCSPLYAPPQILL-NEKYSSKC
  ......   |.|.  ...|.. | . . ...||||||||||||.. .. |    ||.|||.|. ..   .   .|  ..| |..| ... ...|..|.
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSMGCIFFEMLYGKPPFTAH------SIISLTENIKKMVGSGPYQLPAYPP---------------IAQEAKDILVKMLMYNEKDRISWDEIFNHPIL
|.||.|||..||| |.|||  |      . . . ..|..   . ... .  ..               . .|.||.. ..| .. |.|.....|..|| .
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 15705.AA Ciliate-E2-Unclassified 75-340 26 3.2e-69 236.29 In-house 1-352 (352) Show / Hide 
Range on Protein: 75-340
Range on HMM: 1-352/352
Sequence Identity: 26% (92 aa)

IVFNEKLGGGQFSQVYKAMDKNDK--THEQYFAVKIIPMSSTQYQKFANYNQLLQKEIE---------------ILLKARHQNLICMHDLKQTPNNLYLF
  .....| |.|..|||. .|..|   . .|  ...| ..  . .|  .... .. . .               |||   | ... |.. .|. .|.|. 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LDYCNGGDLRQYIVKKKN----------------RLAEEEAV-----EFFKQMCAGYQALNEKK-IIHRDLKPENILLHDN----KIKIGDFGFARIVND
..||.||||.||| |.|.                .. |..|.      .|.| . | . | .|. |||||.||||||...|    .||| |||...  ..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

L--------------DQAVRMTQKCSPLYA----PPQILLNEKYS----SKCDVWSMGCIFFEMLYGKPPFTAHSIIS------------LTENIKKMVG
               .|    |. ..| |     .| .| ...|.     |||.||.|.|..|||.|..|| . . ..              .....   
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

SGPYQLPAYPP------IAQEAKDILV----KMLMYNEKDRISWDEIFNHPIL
 ...| | .|.      . .||||..     ||| .| . ||....|.|||..
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 15705.AA Ciliate-E2c 75-340 30 5.7e-69 235.45 In-house 1-310 (310) Show / Hide 
Range on Protein: 75-340
Range on HMM: 1-310/310
Sequence Identity: 30% (96 aa)

IVFNEKLGGGQFSQVYKA---MDKNDKTHE----QYFAVKIIPMSST--QYQKFANYNQLLQKEIEILLKARHQNLICMHDLKQTPNNLYLFLDYCNGGD
|  |. || |.. .||||    |..    .    | ||.|... ..      .. .    . .||... .  | . | . | ||| ...||.. |||||.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LRQYIVKKKN-RLAEEEAVEFFKQMCAGYQALNEK-KIIHRDLKPENILLHDNKIKIGDFGFARIVNDLDQAVRMTQ-----KCSPLYAPPQILLN-EKY
| |||  ... .. |.. .  |.|  .. . | .. .|.|||.||||||.|.  ||| ||||..|..  |. .  ||       .|.|  ||||    .|
LEQYI--YHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQ--DDNIQNTQGFNTCCGTPMYMAPQILEGKNYY

SSKCDVWSMGCIFFEMLYGKPPFT------------------AHSIISLTENIKK-------MVGSGPYQLPAYPPIA------QEAKDILVKMLMYNEK
 .| |.|| |.  ..||. |.|.                   . .   | ..|..         |  | . .   | .      || |... ||| . |.
TEKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEE

DRISWDEIFNHPIL
.||.|||||||...
KRIDWDEIFNHECI
Kinase 15705.AA CAMKL 74-340 28 1.1e-60 192.31 In-house 1-297 (297) Show / Hide 
Range on Protein: 74-340
Range on HMM: 1-297/297
Sequence Identity: 28% (86 aa)

YIVFNEKLGGGQFSQVYKAMD-KNDKTHEQYFAVKIIPMSSTQYQKFANYNQL---------LQKEIEILLKAR---HQNLICMHDLKQTPNN------L
|..    || | |..|  |.. ..    ..  |.|||  . ..   ... | .         ...||.|. . .   |.| | ...  .||..      .
YRIGK-TLGKGSFGKVKLATHIRTT---GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKI

YLFLDYCNGGD--LRQYIVKKKN---RLAEEEAVEFFKQMCAGYQALNEKKIIHRDLKPENILLHDNK---IKIGDFGFARIVND--LDQAVRMTQKC-S
||.. || ||.  | .||||...   |. |.||  .|.|.... . . ...|.|||.||||||| .|.   ||| ||||. .  .        ..  | |
YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGS

PLYAPPQILLN--EKYS-SKCDVWSMGCIFFEMLYGKPPFTAHSII----SLTENIKKMVGSGPYQLPAYPPIAQEAKDILVKMLMYNEKDRISWDEIFN
| |..| |..   ..|   | |.||.| | . |..|. || . ..     . . . .... .| |. | .. .  ...|.. |||. | ..|.. ..| |
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN

HPIL
|| .
HPWM
Kinase 15705.AA MARK 74-340 29 1.4e-52 170.32 In-house 1-262 (262) Show / Hide 
Range on Protein: 74-340
Range on HMM: 1-262/262
Sequence Identity: 29% (83 aa)

YIVFNEKLGGGQFSQVYKAMDKNDKTHEQYFAVKIIPMSSTQYQKFA-NYNQLLQKEIEILLKARHQNLICMHDLKQ--TPNN-LYLFLDYCNGGDLRQY
| .  . .| | ...|..| .|  .|. . .|.||..     ....  .  . .. ||||. |  | | |....  .  |... .|| ..|. ||.|..|
YKMLKT-IGHGSYAKVKLACHK--HTG-RKVAIKIYE----KFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDY

IVKK-KNRLAEEEAVEFFKQMCAGYQALNEKKIIHRDLKPENILLHDN---KIKIGDFGFARIVNDLDQAVRMTQKC-SPLYAPPQILLNEKYS-SKCDV
|... . || ||||  .|.|.. . . . .| |.|||.||||||. .|   .||| ||||.....      . .  | .| |..|.|.| ..|   | |.
IKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIP---PGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDI

WSMGCIFFEMLYGKPPFTAHS--IISLTENIKKMVGSGPYQLPAYPPIAQEAKDILVKMLMYNEKDRISWDEIFNHPIL
||.| . . |. |. || . .  .  | ..| .    | |. | .  .  |..... ..|. | ..|.. .|| .|| .
WSLGVVLYFMVCGYFPFDGDTQDYKELYKKILR----GKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 15705.AA STE 75-340 21 1.3e-46 161.13 In-house 1-359 (359) Show / Hide 
Range on Protein: 75-340
Range on HMM: 1-359/359
Sequence Identity: 21% (80 aa)

IVFNEKLGGGQFSQVYKAMDKND----KTHEQ--------YFAVKIIPMSSTQ-----------YQKFANYNQLLQKEIEILLKAR--HQNLICMHDLKQ
  . ||.| | | .|||||....    || |.        ..|.|...... .            .|. .  | ..|||.|. | .  |.| .  ..   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TP-------NNLYLFLDYCNGGDLRQYIV---KKKNRLA----------EEEAVEFFKQMCAG-YQALNEKKIIHRDLKPENILLHDNKIKIGDFGFARI
         ..|.... |..|| |.. |    .....|           |..   . .| . |  . | ...|||||.|| ||||    .|. |||.. .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

VND--------------LDQA-VRMTQKCSPLYAPPQILLN------EKYSSKCDVWSMGCIFFEMLYGKPPFTAHSIISLTENIKKMVGSGP-------
..|              ....  | |   .| .  | ....       .|. |||.|| ||   ||. ||||.   .  .   .| .. ....       
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--YQLPAYPP--------------------IAQEAKDILVKMLMYNEKDRISWDEIFN--HPIL
   . |  |.                      .| || . | | .. ..| . ..  .  || .
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 15705.AA TyrKc 75-340 24 3.4e-21 77.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 75-340
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

IVFNEKLGGGQFSQVYKAMDKNDKTHEQYFAVKIIPMSSTQYQKFANYNQLLQKEIEILLKA--RHQNLICMHDLKQTP-------NNLYLFLDYCNGGD
|....||| |.| .|||.. |      .  ||| .  ..          . . .|..|. |   .|.|.....    ..         |.. . |. .||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

LRQYIVKKKNRLAEEEAVEFFKQMCAGYQALNEKKIIHRDLKPENILLHDNK-IKIGDFGFARIVNDL------DQAVRMTQ-KCSP--L---YAPPQIL
|..|. |....|  .. ..|  | ..| . | .|..|||||   |.|...|. .||.||| .| . |       ..  |... |..   |     .|  .
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

LNEKYSSKCDVWSMGCIFFEML-YGKPPFTA-----HSIISLTENIKKMVGSGPYQLPAYPP--------IAQEAKDILVKMLMYNEKDRISWDEIFNHP
   |...| |||| |   .|.. ||..|         | . . |..|.      | .|  |           .|  .|  .  ... .|| .  ||  | 
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG-----YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HE

IL
..
CF
Kinase 15705.AA Pkinase_Tyr 75-280 28 7.1e-21 71.33 Pfam 1-216 (270) Show / Hide 
Range on Protein: 75-280
Range on HMM: 1-216/270
Sequence Identity: 28% (62 aa)

IVFNEKLGGGQFSQVYKAMDK-NDKTHEQYFAVKIIPMSSTQYQKFANYNQLLQKEIEILLKA-RHQNLICMHDLKQ-TPNN--LYLFLDYCNGGDLRQY
|.|..||| |.| .|||.  |  .. ...  |||... .... |    . . . .|..|. .  .|.|.....           .|. . |. .|||. |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IVKK---KNRLAEEEAVEFFKQMCAGYQALNEKKIIHRDLKPENILLH-DNKIKIGDFGFARIV-NDLDQAVRMTQ--KCSPLYAPPQILLNEKYSSKCD
  |.   |..|  .. ...  | ..| . | .|..|||||   |.|.. .|..||.||| || . ||    .|...  |.     .|  . . |...| |
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSD

VWSMGCIFFEMLY-GKPP-F
||| |   .|..  |. | .
VWSFGVLMWEIFTYGEQPTY