Gene 22048 (Tetrahymena)

22048

Species: Tetrahymena
Alias: 83.m00117, 639, PreTt22048, TTHERM_00599810, 3685.m00009, 22048
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
22048.AA Protein None 534 None Fasta, JSON
22048.kin_dom Protein Kinase Domain None 263 None Fasta, JSON
22048.NA RNA None 1605 None Fasta, JSON

Protein domain

Protein domains of 22048.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22048.AA ULK 17-279 28 3.1e-80 272.89 In-house 1-324 (324) Show / Hide 
Range on Protein: 17-279
Range on HMM: 1-324/324
Sequence Identity: 28% (94 aa)

IEMNNQIGSGQHG-SVYMAHRKDFG--VKKLACKIQQ--------SNRN------QIKEEISIIKEVN---GIY--IAEVLDVYKTS--SYIYIFMRHYQ
...|...|.|. |  || .  |. .   .. |||. .        ....      ..| ||.|.|. .   . .  | . .|...||   .|||.|   .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

KGDLDHYLQENRL--------KLSEKDILTIFYKIIYGYFQNIYNRQIIHRDIKASNILMDELDPY-------------ITDFGLSIKFQD--LQKEVNP
 |||..|...|.         .|||. .. .| | |  .|. .....||||||| .|||. . .|.             |.|||.. ....  ... .. 
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFF-KQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

YFK------GTLFYSSPQIQGLE--GSIYS-YKTDIYSLGILLYYMLYSQYP-ENSKQLRDYEKFMQKLKNEGNLHA----IKFPKTKEN-----STISL
...      ||  | .|||.  .  .  |. ||.||.|||...|.||| .|| ...    .|.. .|||.| | . .    ||  . . .       || 
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNG-K-EQQIYIKNQPIQFPKPPKDPKISP

ETKNLILQMITYKEEDRIEITELLNHKVF
|.|.|| .|..|.|.|||...|..||..|
ECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 22048.AA ULK 17-279 29 9.9e-80 271.19 In-house 1-329 (329) Show / Hide 
Range on Protein: 17-279
Range on HMM: 1-329/329
Sequence Identity: 29% (97 aa)

IEMNNQIGSGQHGSVYMAHRKDFG---VKKLACKI------QQSNRN--------QIKEEISIIKEVN----GIY----IAEVLDVYKTS--SYIYIFMR
...|...|.|. | || .  |. .   ..| |||.      .|.| .        ..| || |.|. .    ...    | . .|...||   .|||.| 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

HYQKGDLDHYLQENRL---------KLSEKDILTIFYKIIYGYFQNIYNRQIIHRDIKASNILMDELDPY-------------ITDFGLSIKFQ-D-LQK
  . |||..|...|.          .|||. .. .| | |  .|. .. ..||||||| .|||... .|.             |.|||.. ... | ...
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFF-KQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ

EVNPYFK------GTLFYSSPQIQGLE--GSIYS-YKTDIYSLGILLYYMLYSQYP-ENSKQLRDYEKFMQKLKNEGNLHA--IKFPKTK-----ENSTI
... ...      ||  | .|||   .  .  |. ||.||.|||...|.||| ..| ...    .|....|||.| .. ..  ||  ...     .. .|
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

SLETKNLILQMITYKEEDRIEITELLNHKVF
| |.|.|| .|..|.|.|||...||.||..|
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 22048.AA Ciliate-E2 17-279 23 4.8e-52 176.94 In-house 1-365 (365) Show / Hide 
Range on Protein: 17-279
Range on HMM: 1-365/365
Sequence Identity: 23% (91 aa)

IEMNNQIGSGQHGSVYMA-HRKD---------------------FGVKKLACKIQ-QSNRNQIKEEISIIKEVN----------------GIYIAEVLDV
.. ...||.|..|||| . ..|.                     . .|. | ||. ... .||| ||.|..|.|                  .| .  ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YK--TSSYIYIFMRHYQKGDLDHYLQENRLK----------LSEKDILTIFYKIIYGY--------------FQNIYNRQ-IIHRDIKASNILMDELDPY
..  . ..||. |  .| ||| .|...|..|          ..|| |..|...|..|.              .. . ..  ||||||| .|||.    . 
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

ITDFGLSIKFQDL---------QKEVNPYF----------------------KGTLFYSSPQIQGLEG-------SIYSYKTDIYSLGILLYYMLYSQYP
|.||||| |..|          .|.    .                       ||. | .|.| . ..         |.|| ||.|||..||.||. ..|
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

ENSKQLRDYEKFMQKLKNEGNLHAIKFPKTK-------------ENSTISLETKNLILQ----MITYKEEDRIE-ITELLNHKVF
             |. . ...   |.||. .             ..  .|.|.|.|| .    |. ...| ||  . ..|||. |
F------------QQQIKQCK---IDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 22048.AA S_TKc 17-279 25 5.2e-44 153.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-279
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)

IEMNNQIGSGQHGSVYMAHRKDFGVKKLACKIQQSNRNQIKEEISIIKEVNGIYIAEVLDVYKTSSYIYIFMRHYQK--GDLDHYLQENRLK-----LSE
 |. ..||.|  |.|| .. |.   .. |.||     ..|. ||.| |. .  .|   .||. . ...|..| .     ||| .|..... .     ..|
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

KDILTIFYKIIYGYFQNIYNRQIIHRDIKASNILMDELDPYITDFGLSIKFQDLQKEVNPYFKGTLFYSSPQIQGLEGSIYSY-KTDIYSLGILLYYMLY
 ..  ..| |. .  . . ...|||||.| .|||.||    |.||||. ..          | ||..| .| .       |.. | |..|.|..|| ||.
-HARFYMYQICCA-LEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLC

SQYPENSKQLRDYEKFMQKLKNEGNLHAIKFPKTKENSTISLETKNLILQMITYKEEDRIEITELLN-------HKVF
 . |       .... ..|..                   | | |..| .. ..  |.|. . |.|.       |  |
GYPPFP-----QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22048.AA CAMK 22-279 17 1.5e-36 114.75 In-house 1-425 (425) Show / Hide 
Range on Protein: 22-279
Range on HMM: 1-425/425
Sequence Identity: 17% (76 aa)

QIGSGQHGSVYMAHRKDFGV-----------KKLACKI--------------------------------QQSNRNQIKEEISIIKE-------VNGIYI
..|.|. | |. . .|  .            .| |.||                                ....| ... ||.| |        ..   |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

AEVLDVYK------------TSSY--------IYIFM---RHYQKG----DLDHYLQENRL--------------KLSEKDILTIFYKIIYGYFQNIYNR
   ..||             | |.        .|..|    . . |    ||  |..|..               ...|..  ..|  |. .  . . ..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSA-VHYCHSH

QIIHRDIKASNILMDE------------------LDPYITDFGLSIKFQDL--------QKEVNPY---------------FKGTLFYSS-PQIQGLEGS
 |.|||.|  |||.|.                   .  |.|||...||..         .|. .                 | ||. | . | .  |.|.
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-MHNQWTTPTEGQKMKTFCGTPEYMAAPEV--LNGK

I--------------YSYKTDIYSLGILLYYMLYSQYPENSK-QLRDYE--------KFMQKLKNEGNLHAIKFPKTK-----------------ENSTI
               |..|.|. |.|..|| ||   .| ... . ...|        . . .   .|. . . .. ..                 .. ..
GHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FV

SLETKNLILQMITYKEEDRIEITELLNHKVF
| | |.|| .| ..  |.|. |.. |||. .
SQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 22048.AA Pkinase 17-279 24 2e-35 126.31 Pfam 1-293 (293) Show / Hide 
Range on Protein: 17-279
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

IEMNNQIGSGQHGSVYMAHRKDFGVKKLACKIQQSNRNQIKE--------EISIIKEVNGIYIAEVLDVYKTSSYIYIFMRHYQKG----DLDHYLQ-EN
..   .||||  |.|| .|.|. |  . |.||    ..  ..        ||.| |..|  .| . .|.. ....||. | . ..|    || .|.. ..
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RLKL--SEKDILTIFYKIIYGYFQNIYNRQIIHRDIKASNILMD-ELDP----YITDFGLSIKFQDLQKEVNPYFKGTLFYSSPQIQGLE-GSIYSYKTD
. ..  ||...  ..| |. |  . .... |||||.| .|||.| . ..     |.||||. .|.   .. .  | ||..| .| .  .  |. |..| |
HGCFYFSEWECKFYMYQILRG-LEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV--IRGGQYYGPKVD

IYSLGILLYYMLYS-QYPENS----KQLRDYEKFMQKLK-----NEGNLHAIK--------FPKTKENSTISLETKNLILQMITYKEEDRIEITELLNHK
..|.|..||.||       ..    . ....... ....     .. ... |         |  ..    .| | | .|  ..... ..|. ....|.|.
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

VF
 |
WF
Kinase 22048.AA Ciliate-E2-Unclassified 17-279 24 9.7e-35 117.94 In-house 1-352 (352) Show / Hide 
Range on Protein: 17-279
Range on HMM: 1-352/352
Sequence Identity: 24% (86 aa)

IEMNNQIGSGQHGSVYMAHRKDFG---VKKLACKIQQSNRNQIKE---------EISIIK----------------EVNGIYIAEVLDVYKTSSYIYIFM
 ... |||.|..|.||.. .|. .   ..| ..|||. ...||..         |. ..|                  . ..|   ... ..  .||| |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

RHYQKGDLDHYLQ-------------ENRLK---LSEKDIL-----TIFYKIIYGYFQNIYNRQIIHRDIKASNILMDEL----DPYITDFGLSIKFQDL
   . |||  |..             .|...   ..|. ..     ..|. |. |  . ...  ||||||| .|||.|.      . |.|||.|.| |. 
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------QKEVNPYFKGTLFYS----SPQIQGLEGSIYS----YKTDIYSLGILLYYMLYSQYPENSKQLRD------------YEKFMQKLK
              ...    | ||. |     .| .  |.|  |.    || ||.|||..||.||. .|| ....  .            |.| ... .
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEV--LQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

NEGNLHAIKFPKTKENSTISLETKNLIL----QMITYKEEDRIEITELLNHKVF
...|.   |||. .   ..| | |..|     .|. .. . || . ..|||  |
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 22048.AA Ciliate-E2c 17-279 29 4.7e-32 109.67 In-house 1-310 (310) Show / Hide 
Range on Protein: 17-279
Range on HMM: 1-310/310
Sequence Identity: 29% (92 aa)

IEMNNQIGSGQHGSVYMAHRKD--------------FGVKKLACKI------QQSNRN-QIKEEISIIKEVNGIYIAEVLDVYKTSSYIYIFMRHYQKGD
|. ||  |||. |.|| | .                | .| .. |.       ...    |. || . |. |  .| .  |  .|.. ||..|     |.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LDHYLQEN-RLKLSEKDILTIFYKIIYGYFQNIYNR-QIIHRDIKASNILMDELDPYITDFGLSIKFQDLQKEVNP---YFKGTLFYSSPQIQGLEG-SI
|  |. .. ...  || .|. |  ||.. |. ..    |.||||| .|||  .  . | |||.| ..||. .  .       || .|..|||  |||   
LEQYIYHKPKPN--EKQCLYYFSQIISA-FKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQI--LEGKNY

YSYKTDIYSLGILLYYMLYSQYPEN---------------SKQLRDYEKFMQKLKNEGN-----------LHAIKFPKTKENSTISLETKNLILQMITYK
| .| || |||..|||||.  .|                 . .    ..  |  .. .|              |.||.  |.. ||.|.| ||  |. . 
YTEKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQN-ISQEVKQLIHKMLQVD

EEDRIEITELLNHKVF
||.||.  |. ||  .
EEKRIDWDEIFNHECI
Kinase 22048.AA CAMK-Unique 17-279 19 4.7e-26 82.83 In-house 1-363 (363) Show / Hide 
Range on Protein: 17-279
Range on HMM: 1-363/363
Sequence Identity: 19% (70 aa)

IEMNNQIGSGQHGSVYMAHR----KDFGVKKLACKIQQSNRNQI-------------------KEEISIIKEVNGIYIAEVLDV----YKTSS-------
..|.. ||.|  | || ..     | . .|..  . ...... .                   |.|..| | |.   | ...|.    . ..        
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------YIYIFMRHYQKGDLDHYLQEN-------------------RLKLSE--KDILTIFYKIIYGYFQNIYNRQIIHRDIKASNILMDELDP----
        |.||.| . |.|||  ..|..                   . ..||   |...|. ..         . .|.|||.|. ||.  .  .    
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSA-VAYMHSQDIVHRDLKLENIMVCYSFKDNNH

-------------YITDFGLSIKFQDLQKE-VNPYFKGTLFYSSP--------------QIQGLEGSIYSYKT----DIYSLGILLYYMLYSQYP-ENSK
              ..||||. ...  ... .   . ||. | .|              ..  .... |...     || ||| ..||||    | . . 
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEV--INMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCEC

QLRDYEKFMQKLKNEGNLHAI-KFPKTKENST--ISLETKNLILQMITYKEEDRIEITELLNHKVF
  ||||    ..      . . .|.. .....  || | |... .  |..   |. . ||| |  .
EDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 22048.AA STE 17-279 18 6.9e-26 88.45 In-house 1-359 (359) Show / Hide 
Range on Protein: 17-279
Range on HMM: 1-359/359
Sequence Identity: 18% (68 aa)

IEMNNQIGSGQHGSVYMAHRKD-------------------FGVKKLACKIQQ----------------SNRNQIKEEISIIKEVN--GIYIAEVLDVYK
 |   .||.|  |.|| | ...                   . .|..  . ..                ....||..||.| |. |    .| . .. | 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TS-------SYIYIFMRHYQKGDLDHYLQENRLKLS-------------EKDILTIFYKIIYG--YFQNIYNRQIIHRDIKASNILMDELDPYITDFGLS
         ....|.| .   | ||  ....  ..              |. | .| . |. |  |.    .  |||||||..|||.      ..|||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL----VKLCDFGVC

IKFQD---------------LQKEVNPYFKGTLFYSSPQIQGLEGSI----YSYKTDIYSLGILLYYMLYSQYPENS-KQLRDYEKFMQKLKNEG-----
 ...|                ... .  | ||  . .| .   .|.     |..| ||.|||...  |.  ..|    . .| .  .... . .      
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

---NLHAIKFPKTKE--------------NSTISLETKNLILQMITYKEEDRIEITELLN--HKVF
   | .  ..| . .               .  | | |. | .  ..  ..|   ..||.  |. .
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 22048.AA MARK 18-207 31 5.1e-19 58.97 In-house 2-200 (262) Show / Hide 
Range on Protein: 18-207
Range on HMM: 2-200/262
Sequence Identity: 31% (65 aa)

EMNNQIGSGQHGSVYMAHRKDFGVKKLACKIQQ-------SNRNQIKEEISIIKEVNGIYIAEVLDVYK--TSSY-IYIFMRHYQKGDLDHYLQEN--RL
.|  .|| | .. |. |. |  | .| | || .        ... .. ||.| | ..  .| . ..|    |..  ||. | .. .|.| .|...   . 
KMLKTIGHGSYAKVKLACHKHTG-RKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNG-

KLSEKDILTIFYKIIYGYFQNIYNRQIIHRDIKASNILMDEL---DPYITDFGLSIKFQDLQKEVNPYFKGTLFYSSPQIQGLEGSIYS-YKTDIYSLGI
.|.|..  .||  |...  .   .. |.|||||. |||.||    .  |.|||.||...  ||     | ||. | .|.|  ...  |  .|.||.|||.
RLHEEEARRIFRQIVSA-VNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLN--TFCGTPPYMAPEI--FLKKPYDGPKVDIWSLGV

LLYYML
.||.|.
VLYFMV
Kinase 22048.AA CAMKL 129-279 26 9.8e-18 53.03 In-house 145-297 (297) Show / Hide 
Range on Protein: 129-279
Range on HMM: 145-297/297
Sequence Identity: 26% (44 aa)

NRQIIHRDIKASNILMDELD---PYITDFGLSIKFQD--LQKE-VNPYFKGTLFYSSPQIQGLEG-SI-YS-YKTDIYSLGILLYYMLYSQYP--ENSKQ
.. |.|||||. ||| || .     |.|||.|.....   ...     | |.. | .| |  ..|    |  .|.|| |.|..|| |.. ..|  . . .
SHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEI--FQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN

LRDYEKFMQKLKNEGNLHAIKFPKTKENS---TISLETKNLILQMITYKEEDRIEITELLNHKVF
 .      |. .|  .|. ..    ..      .| . ..|| .| . . |.|. | ...||. .
-K------QGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 22048.AA TyrKc 17-279 20 7.6e-11 -47.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-279
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

IEMNNQIGSGQHGSVYMAHRKDFGVKKLACKIQQ--SNRNQIKEEISIIKEV--NGIYIAEVLDVYKTS-------SYIYIFMRHYQKGDLDHYLQENRL
|... ..|.|. | || .. |     . | |  .  . |  . .|..| ...  .   |   . |  ..         ..| | .  .|||..||...| 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KLSEKDILTIFYKIIYGYFQNIYNRQIIHRDIKASNILMDELD-PYITDFGLSIKFQDL--------QKEV----NPYFKGTLFYSSPQIQGLEGSIYSY
||. || | . . |  |  . .  ...||||. | |.| .|     |.||||| .  |          . .    .  .   .   .|       .... 
KLCMKDLLSFCWQIACG-MEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTT

KTDIYSLGILLYYML---YSQYPE------NSKQLRDY---EKFMQKLKN----EGNLHAIKFPKTKENSTISLETKNLILQMITYKEEDRIEITELLNH
|.|..| |.... ..    . ||.      . .... |    . | . .|            |       . . |  ....|   .. |||   .|.  |
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------F------VCCPDEMYQIMKQCWHEDPEDRPTFSEI--H

KVF
. |
ECF
Kinase 22048.AA Pkinase_Tyr 17-113 25 6e-06 20.77 Pfam 1-114 (270) Show / Hide 
Range on Protein: 17-113
Range on HMM: 1-114/270
Sequence Identity: 25% (29 aa)

IEMNNQIGSGQHGSVYMAHRK--DFG------VKKLACKIQQSN--RNQIKEEISIIKEV-NGIYIAEVLDVYK-TSSY--IYIFMRHYQKGDLDHYLQE
|... ..|.|. |.||... |  . .      ||.|  .  ...  |    .|..| |.  .   |   . |    .    ||| | . ..|||..||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---RLKLSEKDIL
.   . .|. ||.|
HREDKQPLTMKDLL
Kinase 22048.AA CAMKL 15-116 20 0.000443 8.75 In-house 1-133 (297) Show / Hide 
Range on Protein: 15-116
Range on HMM: 1-133/297
Sequence Identity: 20% (28 aa)

YVIEMNNQIGSGQHGSVYMAHRKDFGVKKLACKIQQSNRNQ-------------------IKEEISIIKEVN---GIYIAEVLDVYKTSSY------IYI
| |.   ..| |  | | .|. . .  .| | ||   .. .                   |. ||.| | .|      |   ..|. |...      ||.
YRIGK--TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

FMRHYQKGD--LDHYLQENRL---KLSEKDILTIF
.| . . |.  | .|.....    ...|..   .|
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYF
Kinase 22048.AA MARK 248-279 34 0.002933 6.7 In-house 231-262 (262) Show / Hide 
Range on Protein: 248-279
Range on HMM: 231-262/262
Sequence Identity: 34% (11 aa)

ISLETKNLILQMITYKEEDRIEITELLNHKVF
.| | .||| ...|   |.|. |.|...|. .
VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 22048.AA Pkinase_Tyr 185-204 25 1.798989 2.22 Pfam 186-205 (270) Show / Hide 
Range on Protein: 185-204
Range on HMM: 186-205/270
Sequence Identity: 25% (5 aa)

LEGSIYSYKTDIYSLGILLY
.  .... |.|..| |.|..
INYGKFTTKSDVWSFGVLMW