Gene 29387 (Tetrahymena)
29387
Sequence
Protein domains of 29387.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 29387.AA | ULK | 1-229 | 25 | 2.2e-63 | 216.9 | In-house | 35-324 (324) | Show / Hide |
Range on Protein: 1-229 Range on HMM: 35-324/324 Sequence Identity: 25% (76 aa) MIA---INNQEDV----------LKELQVAQEIR---GEF--ICELKYAGASA--NFLYLISEYCPEGTLKDYFKKEISPSIND----------IMRIFL || .|... .| |. ... ... |..|. .. |..|.| |||. |.|..| || . . .| MIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFK QIVKGYRQSIYSKGCIHRDIKLDNILMKDGKPK-------------ICDFGFGKFLDD--VNAQINQSYK------CTPLYGSPQITHVQG-VIKYS-YK ||. |. . ......||||||..|||...|.|| |.||||.|..|. ..|..|... .|||| .||| . || ..|. || QICNGF-KELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYK ADIYSLGVLLYQMTNKLNNPNLMKNTNDLKKFHESNQKLG------IRN-TLQFY-----EFVDPNIKEIIYKMMEYTEEARISIDDLEKRVEQ .||.|||...|.| .. . .... .. ... .. | |.| .||. . |..|..|..|..| |. |||.... . CDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
|||||||||
| Kinase | 29387.AA | ULK | 4-229 | 24 | 7.3e-63 | 215.15 | In-house | 43-329 (329) | Show / Hide |
Range on Protein: 4-229 Range on HMM: 43-329/329 Sequence Identity: 24% (71 aa) INNQED--------VLKELQVAQEIR----GEF----ICELKYAGASA--NFLYLISEYCPEGTLKDYFKKEISPSIND----------IMRIFLQIVKG ..|.|. . .| .. ... ... |..|. .. | .|.| |||. |.|..| || . . . .| ||. | QKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNG YRQSIYSKGCIHRDIKLDNILMKDGKPK-------------ICDFGFGKFLD-D-VNAQINQSYK------CTPLYGSPQITHVQG-VIKYS-YKADIYS . . ......||||||..|||...|.|| |.||||.|..| | ...|...... .|||| .||| . || ..|. ||.||.| F-KELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWS LGVLLYQMTNKLNNPNLMKNTNDLKKFHESNQKLG------IRNTLQFYE------FVDPNIKEIIYKMMEYTEEARISIDDLEKRVEQ ||...|.| .. . .. . ....... ... |... .. . |..|..|..|..| |. |||...| . LGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
|||||||||
| Kinase | 29387.AA | Ciliate-E2 | 2-160 | 24 | 8.5e-36 | 120.34 | In-house | 61-289 (365) | Show / Hide |
Range on Protein: 2-160
Range on HMM: 61-289/365
Sequence Identity: 24% (56 aa)
IAINNQEDVL----------KELQVAQEIRGEFICELKYAGA--SANFLYLISEYCPEGTLKD-------YFKKEIS----PSINDIMRIFLQIVKGYR-
..|.. .... .|... ... .|...... . | .||. ||| |.|.| ...||. .... | .|. ||..|..
EQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKT
-------------QSIYSKG-CIHRDIKLDNILMKDGKPKICDFGFGKFLDDVNA------------------------------QINQSYKCTPLYGSP
... ||. .||||||..|||. .||.|||. |..|| | .. ... .|| | .|
KAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAP
QITHVQG------VIKYSYKADIYSLGVLLYQM
.| .. |.||.||.||||.||.|
EILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
|
|||||||||
| Kinase | 29387.AA | Pkinase | 6-227 | 21 | 4.4e-32 | 114.51 | Pfam | 42-293 (293) | Show / Hide |
Range on Protein: 6-227 Range on HMM: 42-293/293 Sequence Identity: 21% (56 aa) NQEDVL-KELQVAQEIRGEFICELKYAGASANFLYLISEYCPEG----TLKDYFK--KEISP--SINDIMRIFLQIVKG--YRQSIYSKGCIHRDIKLDN .|.... |.|. .... ..|..|... . . .|.. |||. | |.|| . .. . | ... ....||..| | ..|.|.||||.|..| DQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEY---CHSMGIIHRDLKPEN ILMK-DGKP----KICDFGFGKFLDDVNAQINQSYKCTPLYGSPQITHVQGVIKYSYKADIYSLGVLLYQMTNKLNNPNLMKNT----NDLKKFHESNQK ||.. .| . ||||||. |..| | . .... .|| | .| . ..| .|..|.|..|.|..||.| .. . .. | . . . ... ILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV--IRGGQYYGPKVDMWSCGCILYEMLCGR---PPFPGHCWHDN-HDQMQMICRI LGIRNTLQFYEFVD-------------------PNIKEIIYKMMEYTEEARISIDDLEKR--V .| .. .... . .. |..|... .. . |...... . . MGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | 29387.AA | Ciliate-E2c | 38-160 | 40 | 2.1e-31 | 107.38 | In-house | 89-212 (310) | Show / Hide |
Range on Protein: 38-160 Range on HMM: 89-212/310 Sequence Identity: 40% (51 aa) LYLISEYCPEGTLKDYFKKEISPSINDIMRIFLQIVKGYRQSIYSK-GCIHRDIKLDNILMKDGKPKICDFGFGKFLDDVNAQINQ---SYKCTPLYGSP .|||.|||..|||..| .. |. . | ||. . . .... . .||||| ||| ..| .||.|||| |. .| | |..| . ||.| .| IYLIMEYCNGGTLEQYIYHKPKPNEKQCLYYFSQIISAF-KYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAP QITHVQGVIKYSYKADIYSLGVLLYQM || . .| .|.|| ||||.||.| QILEG--KNYYTEKSDIWSLGVTLYYM |
|||||||||
| Kinase | 29387.AA | Ciliate-E2-Unclassified | 4-223 | 21 | 1.8e-25 | 85.33 | In-house | 49-346 (352) | Show / Hide |
Range on Protein: 4-223 Range on HMM: 49-346/352 Sequence Identity: 21% (63 aa) INNQEDVLKELQ---------VAQE----IRGEFICELKYAGASANFLYLISEYCPEGTLKDYFKKEIS-----------------PSINDIM-----RI |.|... ..... .|. . .|| . |. . . .|.. |||. |.|..| || . . . . .. IMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFY FLQIVKGYRQSIYSKGCIHRDIKLDNILMKDG----KPKICDFGFGKFLDD---------VNAQINQSYKCTPLYGSPQIT-------HVQG-VIKYS-- | ||..| . ......||||||..|||.... ..||.|||. |.... .. ||... ... |.|. || | FAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA YKADIYSLGVLLYQMTNKLNNPNLMKNTNDLKKFHESNQKL------GIRNTLQF------YEF------VDPNIKEIIY----KMMEYTEEARISIDDL ||.||.||||.||.| | .| .. .. . .. . ..| .| ... ..|. |..| ||... . ||..... YKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI |
|||||||||
| Kinase | 29387.AA | TKL | 38-160 | 23 | 2.1e-17 | 59.21 | In-house | 113-282 (364) | Show / Hide |
Range on Protein: 38-160 Range on HMM: 113-282/364 Sequence Identity: 23% (42 aa) LYLISEYCPEGTLKDYFKKEISPSINDIMRIFLQIVKG--YRQSIYS-----KGCIHRDIKLDNILMK-DGK--------------PKICDFGFGKFLDD |... |||| |.| .|. .. ..|. |.| .| | | .. ||||.| .||| . ... .||||||. .|.. LCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQ VNAQINQSY-----------------KC-TPLYGSPQITHVQ-------------GVIKYSYKADIYSLGVLLYQM . . ... .| || . .| . | . .|| |.|.|| |..|. . SGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI |
|||||||||
| Kinase | 29387.AA | Ciliate-A1 | 39-163 | 30 | 5.8e-17 | 54.24 | In-house | 77-224 (301) | Show / Hide |
Range on Protein: 39-163
Range on HMM: 77-224/301
Sequence Identity: 30% (46 aa)
YLISEYCPEGTLKDYFKKEISPSINDIMRIFLQIVKGYRQSIYSKGCIHRDIKLDNILMK-DGKPKICDFGFGKFLDDVN------------AQINQSYK
..|.||| | | .|.. . .|. | .||..|| .| .. .|||.| .|||. | | ||||.| | | . |.|. |.
FIIMEYCQYGNLFNYCYQNDYMKKEEIYEICYQIIEGY-ADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYH
C-----TPLYGSPQI--THV--QGVI--KYSYKADIYSLGVLLYQMTNK
. .| || | | | | . . |.||||. .. ..|
TCKKGGNLYYMSPEQYQMHYRDQMFIENKIYKQSDMYSLGCIICFLCYK
|
|||||||||
| Kinase | 29387.AA | S_TKc | 1-234 | 21 | 4.4e-16 | 58.96 | SMART | 16-231 (231) | Show / Hide |
Range on Protein: 1-234
Range on HMM: 16-231/231
Sequence Identity: 21% (55 aa)
MIAINNQ-----------EDVLKELQVAQEIRGEFICELKYAGASANFLYLISEYCPE--GTLKDYFKKEISP------SINDIMRIFLQIVKGYRQSIY
. .... |....|.|. .. . ..|. |... . ..||.. |||. |.|.|| || .. . .. ... ||... . .
YKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCA-LEYCH
SKGCIHRDIKLDNILMKDGKPKICDFGFGKFLDDVNAQINQSYKCTPLYGSPQITHVQGVIKYSY-KADIYSLGVLLYQMTNKLNNPNLMKNTNDLKKFH
|.| ||||.| .|||. . ||||||. ..| .. || | .| . .|.. |.|..|.|..|| | | . . . |
SHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKI
ESNQKLGIRNTLQFYEFVDPNIKEIIYKMMEYTEEARISIDDLEK--RVEQICRYL
.| |..| |.... | |... .. . .. . ..
G-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | 29387.AA | STE | 36-160 | 29 | 8.3e-16 | 52.39 | In-house | 110-261 (359) | Show / Hide |
Range on Protein: 36-160
Range on HMM: 110-261/359
Sequence Identity: 29% (46 aa)
NFLYLISEYCPEGTLKDYFKKEISPSI-------------NDIM-RIFLQIVKGYRQSIYSKGCIHRDIKLDNILMKDGKPKICDFGFGKFLDDVNAQI-
. |... ||.. |.| | |. .. .. .| ||.|| . . |.. |||||| .|||. |.||||. . |.| .| |
DELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQLTDSMANIQ
---------NQSYKC-----TPLYGSP-QITH-VQG-VIKYSYKADIYSLGVLLYQM
... |. || . .| |. || . .|..|.||.||| .. |
SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
|
|||||||||
| Kinase | 29387.AA | TKL-Unique | 28-158 | 24 | 1.4e-15 | 51.6 | In-house | 59-219 (290) | Show / Hide |
Range on Protein: 28-158 Range on HMM: 59-219/290 Sequence Identity: 24% (39 aa) LKYAGASA------NFLYLISEYCPEGTLKDYFK----------KEISPSINDIMRIFLQIVKG-YRQSIYSKGCIHRDIKLDNILMKDG------KPKI ..| |... . .....||||.|.| |. ... .. . .......|..| |. . ... ||||.| |.| . . || VHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKI CDFGFGKFLDDVNAQINQ-------SYKC-TPLYGSPQITHVQGVIKYSYKADIYSLGVLLY ||||. ||.. |. .| . .| .... .|... .|| |.|.|| |. |. CDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF-CQYSEKSDVYSFGIVLW |
|||||||||
| Kinase | 29387.AA | MARK | 82-110 | 53 | 1e-11 | 34.72 | In-house | 122-153 (262) | Show / Hide |
Range on Protein: 82-110 Range on HMM: 122-153/262 Sequence Identity: 53% (17 aa) SKGCIHRDIKLDNILM-KDG--KPKICDFGFG ||...|||||..|||. ..| . ||.||||. SKNIVHRDIKPENILIDENGNHNIKIIDFGFS |
|||||||||
| Kinase | 29387.AA | TyrKc | 2-227 | 16 | 8.8e-08 | -96.86 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 2-227 Range on HMM: 1-280/280 Sequence Identity: 16% (49 aa) IAINN----------------------------QEDVLKELQVAQEI--RGEFICELKYAGASA-------NFLYLISEYCPEGTLKDYFKKEIS-PSIN | . .|| ..|... .. . . | | . . |... ||.| | |||| .| . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK DIMRIFLQIVKG--YRQSIYSKGCIHRDIKLDNILMKDGK-PKICDFGFGKFLDDV------NAQINQSY-KCTP-------------LYGSPQITHVQG | . .|| .| | . ||.|||||. |.| .... ||.||| ....| . .. |.. || DLLSFCWQIACGMEY---LHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG--------- VIKYSYKADIYSLGVLLYQMTNKLNNPNLM-----KNTNDLKKFHESNQKLGIRNTLQFYEF----VDPNIKEIIYKMMEYTEEARISIDDLEKRV |.. | |..| ||... . | .. .. .. .. . . . . . .|. . .. | | . .. .. --KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | 29387.AA | MARK | 127-161 | 44 | 8e-05 | 11.88 | In-house | 168-200 (262) | Show / Hide |
Range on Protein: 127-161 Range on HMM: 168-200/262 Sequence Identity: 44% (16 aa) TPLYGSPQITHVQGVIKYS-YKADIYSLGVLLYQMT || | .|.|. . .| .|.||.||||.|| |. TPPYMAPEIFLKK---PYDGPKVDIWSLGVVLYFMV |
|||||||||
| Kinase | 29387.AA | Ciliate-E2c | 198-230 | 33 | 0.004439 | 6.74 | In-house | 279-310 (310) | Show / Hide |
Range on Protein: 198-230 Range on HMM: 279-310/310 Sequence Identity: 33% (11 aa) VDPNIKEIIYKMMEYTEEARISIDDLEKRVEQI ... .|..| || .. || ||. |.. |.| ISQEVKQLIHKMLQVDEEKRIDWDEIFNH-ECI |
|||||||||
| Kinase | 29387.AA | Ciliate-A1 | 202-230 | 24 | 0.006619 | 5.65 | In-house | 273-301 (301) | Show / Hide |
Range on Protein: 202-230 Range on HMM: 273-301/301 Sequence Identity: 24% (7 aa) IKEIIYKMMEYTEEARISIDDLEKRVEQI . .| ||| | . |.| ... .. LQNLIFKMMQYEPNNRCSLQQCIDCLYIF |
|||||||||
| Kinase | 29387.AA | MARK | 38-56 | 52 | 0.048807 | 2.65 | In-house | 77-95 (262) | Show / Hide |
Range on Protein: 38-56 Range on HMM: 77-95/262 Sequence Identity: 52% (10 aa) LYLISEYCPEGTLKDYFKK .||| ||...| | || |. IYLIMEYASGGELYDYIKA |
|||||||||