8696

Species: Tetrahymena
Alias: PreTt08696, 15.m00407, 559, 3697.m00119, TTHERM_00189460, 8696
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
8696.AA Protein None 605 None Fasta, JSON
8696.NA RNA None 1818 None Fasta, JSON
8696.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of 8696.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 8696.AA ULK 18-275 40 4e-142 478.45 In-house 1-324 (324) Show / Hide
Range on Protein: 18-275
Range on HMM: 1-324/324
Sequence Identity: 40% (133 aa)

VVVNNVLGKGAFG-KVYRGFCVEDE--NKLVAAKAIPIKSISDSGKM------LELIKREIAILQKVS---SPF--IVSLYDVARTS--NNLYMFLEYCH
 ..|..||||.|| |||.|......  |..||.| |..|..... ..      ..|.|.|| |..|     .|.  || |||. .||  ||.|...||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

DGDLKEYLKKK-------EGKRLSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLSNGI-------------AKISDFGFSRVVEKDD---PALLS
.|||..|.||.       |.|||||.||..||..|..|||||.||.||||||||.||...||.             .||.||||...|....     . .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

RL------GSPLYMTPQILD----GVPFN-FKCDVWSVGVVFFEMLYGTTP---WIGDSQV----KLLQN-------IKSIPLKFP---ENPIRSKEVKD
 .      |.|||| ||||     . |.. .|||.||.|..|.||||| .|   |   .|.    ||..|       ||  |..||   ..|..|.|.||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LLRGMLKVKEEERMSWEEIFNHPLI
|.|.||...|..|.|||||||||..
LIRRMLQYDEKDRISWEEIFNHPWF

Kinase 8696.AA ULK 18-275 40 5.8e-141 474.59 In-house 1-329 (329) Show / Hide
Range on Protein: 18-275
Range on HMM: 1-329/329
Sequence Identity: 40% (132 aa)

VVVNNVLGKGAFGKVYRGFCVEDE---NKLVAAKAIPIKSISDSGKM------LELIKREIAILQKVS----SPF----IVSLYDVARTS--NNLYMFLE
 ..|..||||.|||||.|......   |..||.| |...... . ..      ..|.|.|| |..|      ...    || |||. .||  ||.|...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCHDGDLKEYLKKK--------EGKRLSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLSNGI-------------AKISDFGFSRVVEKD---DP
|| .|||..|.||.        |.|||||.||..||..|..|||||.||.||||||||.||...||.             .||.||||...|..|   . 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

ALLSRL------GSPLYMTPQILD----GVPFN-FKCDVWSVGVVFFEMLYGTTP---WIGDSQV-----KLLQN-------IKSIPLKFP---ENPIRS
 ... .      |.|||| ||||     . |.. .|||.||.|..|.||||| .|   |   .|.     ||..|       ||..||.||   ..|..|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

KEVKDLLRGMLKVKEEERMSWEEIFNHPLI
.|.|||.|.||...|..|.||||.||||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF

Kinase 8696.AA CAMK 23-275 22 2.6e-85 274.75 In-house 1-425 (425) Show / Hide
Range on Protein: 23-275
Range on HMM: 1-425/425
Sequence Identity: 22% (97 aa)

VLGKGAFGKVYRGFCVEDEN-----------KLVAAKAIPIKSISD------------------------SGKMLELIKREIAILQK-------VSSPFI
.||.|.||||....  .. .           . ||.| |. | ..|                        ..|... ..|||.|..|       .. | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSLYDVAR------------TSNN--------LYMFL---EYCHDG----DLKEYLKKKEG-------------KRLSEPEALIFFRHIVEGFKELQKHK
..||.|              | ..        .||..   |||  |    || .|......             .|..| ||  .|| |... . . .|.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPANIML-SN-----------------GIAKISDFGFSRVVEK-----------------------DDPALLSRLGSPLYMT-PQILDG-----
|.|||.|| ||.| .|                 .  ||.||||......                       ... .  . |.| ||  | .| |     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------VPFNFKCDVWSVGVVFFEMLYGTTPWIGD-------------SQVKLLQNIKSIPLKFPENPIRS----------------------KEVK
          . ..|||.||.||. . || |. |. ||             .. .|...|..    ||. ..                        .|.|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLLRGMLKVKEEERMSWEEIFNHPLI
||.|.||.|  |.||. |.. ||| .
DLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 8696.AA S_TKc 18-275 32 2.7e-84 287.29 SMART 1-231 (231) Show / Hide
Range on Protein: 18-275
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

VVVNNVLGKGAFGKVYRGFCVEDENKLVAAKAIPIKSISDSGKMLELIKREIAILQKVSSPFIVSLYDVARTSNNLYMFLEYCHD--GDLKEYLKKKEGK
  . ...|||||||||..  ..  ...|| | |.           | |.|||.||.|   |.|| |||| .. ..|||..|||    |||..|.||. ..
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

R----LSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLSNGIAKISDFGFSRVVEKDDPALLSRLGSPLYMTPQILDGVPFNF-KCDVWSVGVVFF
.    ..| .|  ... |... . . .|.|||||.||.||.|..   ||.|||..|..        .  |.| || | .|   .... |||.||.|....
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLYGTTPWIGDSQVKLLQNIKSIPLKFPENPIRSKEVKDLLRGMLKVKEEERMSWEEIFN-------HPLI
|||.| .|.    . .....|.            |.|.||..|..|..  |.|..  |...       || .
EMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 8696.AA Ciliate-E2c 21-275 33 4.9e-82 278.85 In-house 4-310 (310) Show / Hide
Range on Protein: 21-275
Range on HMM: 4-310/310
Sequence Identity: 33% (102 aa)

NNVLGKGAFGKVYRGFCVEDENKLVAA---------KAIPIKSI----SDSGKMLELIKREIAILQKVSSPFIVSLYDVARTSNNLYMFLEYCHDGDLKE
|| ||.| .||||..  .||..   .          | .. |..     .  . .| |.||| .. .  .| |.  ||   |....| ..||| .|.|. 
NNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGTLEQ

YLKKKEGKRLSEPEALIFFRHIVEGFKELQKH-KIIHRDIKPANIMLSNGIAKISDFGFSRVVEKDDPALLS----RLGSPLYMTPQILDGVPFNF-KCD
|...|   ...| . |  |  |. .||.| |  .|.||||||.|| . ||. || |||||. .  |     .      |.|.|| |||| |   .  | |
YIYHKP--KPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKSD

VWSVGVVFFEMLYGTTPWI------------------GDSQVKLLQNIK---------------SIPLKFPEN--PIRSKEVKDLLRGMLKVKEEERMSW
.|| ||. ..||.   ||                   ......| |.|.                 ...||||    .|.|||.|.. || | || | .|
IWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRIDW

EEIFNHPLI
.|||||..|
DEIFNHECI

Kinase 8696.AA AGC 18-275 23 5.3e-80 205.72 In-house 1-395 (395) Show / Hide
Range on Protein: 18-275
Range on HMM: 1-395/395
Sequence Identity: 23% (93 aa)

VVVNNVLGKGAFGKVYRGFCVE-----DENKLVAAKAIPIKS-ISDSGK-MLELIKRE------------IAILQKVS----------SPFIVS-LYDVA
  .  |.|||.|||||    ..     | .|. | | .  |  | .  | |.| ...|              ||.|..          .||||. |.   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

RTSNN--LYMFLEYCH----------DGDLKEYLKKK-EGKRLSEPEALIFFR-------HIVEGFKELQK-HKIIHRD-IKPANIMLSN-GIAKISDFG
 . ..  ||. .||.           ...|  .|...   .|..|..| ...        .|| ..  | . ..||||| .|| ||.| . |  |..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FSRVVEKDD--------------------------------------------------PALLSRLG--SPLYMTPQILDGVPFNFKCDVWS--VGVVFF
.. .. .|.                                                      .  |  .| || | ||     .. || ||  .|....
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLYGTTPWIGDSQV----------KLLQNIK------SIPLKFPEN--------PIRSKEVKDLLRGMLKVKEEERMS----------WEEIFNHPLI
|||.| .|  ||. .          .. |.|.      . ..||| .        .  |.| |||....|..  |.|             ||| |||  
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF

Kinase 8696.AA Ciliate-E2 18-275 22 2.5e-77 263.24 In-house 1-365 (365) Show / Hide
Range on Protein: 18-275
Range on HMM: 1-365/365
Sequence Identity: 22% (87 aa)

VVVNNVLGKGAFGKVYRGFCVEDENKL-----------------VAAKAIPIKSISDSG-KMLELIKREI-------------AILQKVSSPFIVSLYDV
  .....|.|.||.||..   .. ..                  |..| . .|... .. .... .....              ||.....|.|. .|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

AR--TSNNLYMFLEYCHDGDLKEYLKKK----------EGKRLSEPEALIFFRHIVE---------------GFKELQKHK-IIHRDIKPANIMLSNGIA
    . ||.|. .|||  |||..|.|..          . |...| |.. ....|..               ....| . . |||||||| ||..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I

KISDFGFSRVVEKD----------DPALLSR----------------------LGSPLYMTPQILDGVP---------FNFKCDVWSVGVVFFEMLYGTT
||.|||.|. . .|             .  .                      .|.| || |.|| | .          ..|||.||.||...|||.| .
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PWIGDSQVKLLQNIKSIPLKFP----------------ENPIRSKEVKDLLRG----MLKVKEEERMS-WEEIFNHPLI
|.        .|.||  ...||                ..   |.|.|||..     ||....|.|.. ||.|.||| .
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 8696.AA CAMKL 17-275 32 8.7e-74 234.81 In-house 1-297 (297) Show / Hide
Range on Protein: 17-275
Range on HMM: 1-297/297
Sequence Identity: 32% (97 aa)

FVVVNNVLGKGAFGKVYRGFCVEDENKLVAAKAIPIKSISDSGKMLEL-----------IKREIAILQKVS---SPFIVSLYDVARTSNN------LYMF
. ..  .||||.||||  .  .   .. || | | .| |..  .|.             |.|||.|.....    | |..||.|  |...      .|..
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEYCHDGD--LKEYLKKKEGKR--LSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLS-NG--IAKISDFGFSRVVEK----DDPALLSRLGSPLY
.|||  |.  | .|..|....|  ..|.||  .|| ||.. . . .|.|.|||||| ||.|. ||   .||.|||||   ..    ..  |  . ||| |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

MTPQILDG--VPFN-FKCDVWSVGVVFFEMLYGTTPWIGDS-------QVKLLQNIKSIPLKFPENP-IRSKEVKDLLRGMLKVKEEERMSWEEIFNHPL
| | |. |   |.. .| |.|| ||. . |..|. |. .|.        . .| ... .  ..|  .   | ...||.|.||.|. |.|.. ..| ||| 
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

I
 
M

Kinase 8696.AA Pkinase 18-275 27 2e-73 255.05 Pfam 1-293 (293) Show / Hide
Range on Protein: 18-275
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

VVVNNVLGKGAFGKVYRGFCVEDENKLVAAKAIPIKSISDSGKMLEL-IKREIAILQKVSSPFIVSLYDVARTSNNLYMFLEYCHDG----DLKEYLKKK
 ..  ..|.|.||.||..  . ..  .|| | |. ...... ..  . . .||.|......|.|| |||. ......|| .|||  |    ||..|.. .
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

EGKRL--SEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLS-NGIA----KISDFGFSRVV-EKDDPALLSRLGSPLYMTPQILD-GVPFNFKCDVW
.....  || |.  ... |..| . . ...|||||.||.||... ||      ||.|||..... .  .. . .. |.| || | ..  | .   |.|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SVGVVFFEMLYGTTPWIGD------SQVKLLQNIKSIPLKFPENPIRS-------------------KEVKDLLRGMLKVKEEERMSWEEIFNHPLI
|.|....||| | .|. |.      .| .....|.. ||.|..   .|                   .| ||.....|... ..| ..|.|..|| .
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 8696.AA Ciliate-E2-Unclassified 19-275 26 4.4e-70 239.14 In-house 2-352 (352) Show / Hide
Range on Protein: 19-275
Range on HMM: 2-352/352
Sequence Identity: 26% (93 aa)

VVNNVLGKGAFGKVYRGFCVEDENKLVAAKAIPIKSISDSGKML----ELIKREIAILQK------------------VSSPFIVSLYDVARTSNNLYMF
 .. ..|.|.|||||.  |.....|...|. . .|..... |      |..  .... .|                    .|||| .... .. .|.|. 
KIIKQIGQGGFGKVYK--CQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYCHDGDLKEYLKKKEG---------------KRLSEPEAL-----IFFRHIVEGF-KELQKHKIIHRDIKPANIMLSNG----IAKISDFGFSRVVEK
.||| .|||..|.||...               |...| .|.      .|..|..|. .  .|..|||||||| ||...|.      ||.|||.|.  ..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

D---------------DPALLSRLGSPLYM----TPQILDGVPFN----FKCDVWSVGVVFFEMLYGTTPWIGDSQVK----------------LLQNIK
.               .  . .. |.| ||     | .|.|   .    .|||.||.||...|||.|. |  . .. .                |.||||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

SIPLKFPENP------IRSKEVKDLLR----GMLKVKEEERMSWEEIFNHPLI
  ...||. |      . |.|.||...     |||.. ..|...|.|.|||..
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 8696.AA MARK 19-275 33 2.6e-56 182.63 In-house 2-262 (262) Show / Hide
Range on Protein: 19-275
Range on HMM: 2-262/262
Sequence Identity: 33% (90 aa)

VVNNVLGKGAFGKVYRGFCVEDENKLVAAKAIPIKSISDSGKMLELIKREIAILQKVSSPFIVSLYDVAR--TSNN-LYMFLEYCHDGDLKEYLKKKEGK
 .  ..|.|...||. .  .  . . || | .. ....|  .| . ..|||.|..|.. | |..|..|    |... .|. .||.  |.| .|.|.... 
KMLKTIGHGSYAKVKLACHKHTG-RKVAIKIYEKFKLNDPQWM-KNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNG

RLSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIML-SNG--IAKISDFGFSRVVEKDDPALLSRL-GSPLYMTPQILDGVPFN-FKCDVWSVGVVFF
||.|.||  .|| ||.. . . .. |.|||||| ||.. .||   .||.|||||. .. .   .|..  |.| || |.|. . | . .| |.|| ||| .
RLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPG--QKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLY

EMLYGTTPWIGDS--QVKLLQNIKSIPLKFPENPIRSKEVKDLLRGMLKVKEEERMSWEEIFNHPLI
 |. |. |. ||.  ...| ..| .   ..| .   ||| ..|.. .|.|  |||.. ||| .|| .
FMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM

Kinase 8696.AA RSK 21-275 30 8.8e-53 181.67 In-house 1-278 (278) Show / Hide
Range on Protein: 21-275
Range on HMM: 1-278/278
Sequence Identity: 30% (86 aa)

NNVLGKGAFGKVY--RGFCVEDENKLVAAKAIPIKSISDSGKMLELIKREIAILQKVS-SPFIVSLYDVARTSNNLYMFLEYCHDGDLKEYLKKKEGK-R
  |||.|..|||.  |    .| ... | | .  . |  . | ..  ..|. ||. .  .||||.|... .|   ||. .|||. |.| . |.|.. .  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLSN----GIAKISDFGFSRV-VEKDDPALLSRLGSPLYMTPQILD----GVPFNFKCDVWSVGV
.|| || . .. ||   . | ...|||||.|| ||.. .    |  |..||||..  . ..   . .  ..  || | .|     ..  .  ||.|| ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VFFEMLYGTTPWIG---DSQVKLLQNIKSIP--LKFPENPIRSKEVKDLLRGMLKVKEEERMS-----WEEIFNHPLI
. .||| | .|  |   ... .....|..    |..|...  |.| |||.|.||.. .. | .      ||| .|| .
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase 8696.AA Pkinase_Tyr 18-173 29 1.7e-29 100.48 Pfam 1-165 (270) Show / Hide
Range on Protein: 18-173
Range on HMM: 1-165/270
Sequence Identity: 29% (49 aa)

VVVNNVLGKGAFGKVYRGFCV---EDENKLVAAKAIPIKSISDSGK--MLELIKREIAILQKV-SSPFIVSLYDVAR-TSNN--LYMFLEYCHDGDLKEY
.. . .||.||||.||.| .    ....  || | .  |  ...    . .... |..|. .  . | ||.|| |    .    .|. .||.  |||..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LKKK--EGKRLSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLS-NGIAKISDFGFSRVVEKDD
|.|.  ....|. .. | . . | .|   |  ...||||.   |.... |...||.||| .| ...||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDD

Kinase 8696.AA TyrKc 18-275 27 1.7e-21 78.63 SMART 1-280 (280) Show / Hide
Range on Protein: 18-275
Range on HMM: 1-280/280
Sequence Identity: 27% (81 aa)

VVVNNVLGKGAFGKVYRGFCVEDENKLVAAKAIPIKSISDSGKMLELIKREIAILQKV--SSPFIVSLYDVARTS-------NNLYMFLEYCHDGDLKEY
.. . .|| ||||.||.|         || | .   .       .| . ||. |. |.  . | || || |....         |.. .||.  ||||.|
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKKKEGKRLSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLSNG-IAKISDFGFSRVVEKDDPALLSRLGSPLYMTPQ---ILDG-VP--------
|.|...| |. .. | |   | .|   | ....||||.   |...... ..|||||| || .. || .      |  | ...     .. .|        
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRWMAPEC

-----FNFKCDVWSVGVVFFEML-YGTTPWIG-----DSQVKLLQNIKSI-PLKFPEN------PIRSKEVKDLLRGMLKVKEEERMSWEEIFNHPLI
     |..| |||| ||. .|.. || .|. |      |   .....|.   .. |.|      .. ..|. .. .   . . |.| . .||  | ..
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase 8696.AA Pkinase_Tyr 190-221 41 1.398901 2.59 Pfam 186-218 (270) Show / Hide
Range on Protein: 190-221
Range on HMM: 186-218/270
Sequence Identity: 41% (14 aa)

ILDGVPFNFKCDVWSVGVVFFEMLY-GTTP-WIG
| .|. |. | |||| ||. .|..  | .| . |
INYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPG