Gene 23105 (Tetrahymena)

23105

Species: Tetrahymena
Alias: PreTt23105, 31, 7.m00554, 23105, TTHERM_00107120
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: STE11-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
23105.AA Protein None 1235 None Fasta, JSON
23105.kin_dom Protein Kinase Domain None 274 None Fasta, JSON
23105.NA RNA None 3708 None Fasta, JSON

Protein domain

Protein domains of 23105.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23105.AA STE11-Unclassified 959-1232 44 1.8e-178 599.19 In-house 1-308 (308) Show / Hide 
Range on Protein: 959-1232
Range on HMM: 1-308/308
Sequence Identity: 44% (141 aa)

VELRELLGEGAYGKVYKGFIKKTGKFIAVKQLKLGLKD--NNKLQEK-LEQYLQEIALLNHLEHPNIVKYYDCK--HEEDNILIYMEQMPGGSLSSMLEK
.. .|..|.|..|.|||.....||.|.||||.. . ..  ....|.. .... .|...|..|.|.|||.||.|.  ..||.| |.||.|||||..|||.|
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

FGRFEEALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGANILTDGNGTVKLADFGAARYRD------------------TICLPTADGSEFCNS
.|.|.|..|||..|||..|||||||.||.|||||         |||||.|..|..||.|||.|....                  .||.........|.|
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIK---------GANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKS

IKGSLY---WMAPELLN---QESHGRKSDIWSLGCTMIEMATGKHPWPDCRT--FPQLAL-IVKTNQCPPIPEHLS-----------DECKDFIRQCCTF
..|..|   |||||...   |..|.|||||||||||.||||||||||..|..  |..... ||..||.|.||||||           .|||||.|.|...
MQGTPYQPFWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQI

DKKERPTADVLLKHPFL
|.|.||||..||.|||.
DPKKRPTANQLLQHPFI
Kinase 23105.AA STE11 959-1232 42 2e-159 535.94 In-house 1-303 (303) Show / Hide 
Range on Protein: 959-1232
Range on HMM: 1-303/303
Sequence Identity: 42% (134 aa)

VELRELLGEGAYGKVYKGFIKKTGKFIAVKQLKLGLKDN--NKLQEKLEQ------YLQEIALLNHLEHPNIVKYYDCKH---EEDNILIYMEQMPGGSL
  ..|..|.||.|.|||.. ..||...|||| ...  ..  .........      . .||.|. || |.|||.||.|..   ..|.. |.||..|||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

SSMLE-KFGR--FEEALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGANILTDGNGT-VKLADFGAARYRDTICLPTADGSE---FCNSIKGSL
||||. |.|.  |.|..|.|..||| .||.||||.||.|||||         ||||| | .|. .||||||.|..  .||. |.  ..   .|.|..|..
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIK---------GANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTP

Y--------WMAPELLNQES---HGRKSDIWSLGCTMIEMATGKHPWPDCR--TFPQLALIVKT-NQCPPIPEHLS------DECKDFIRQCCTFDKKER
|        ||||| ..||    .|||.||||||||.|||||||.||...   .. ... |... ...||||||.|      .||.||.|.|...|.|.|
YNSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKR

PTADVLLKHPFL
|||. ||.|||.
PTANQLLQHPFI
Kinase 23105.AA STE 959-1232 31 8e-111 374.48 In-house 1-359 (359) Show / Hide 
Range on Protein: 959-1232
Range on HMM: 1-359/359
Sequence Identity: 31% (119 aa)

VELRELLGEGAYGKVYKGFIKK---------------TGKFIAVKQLKLGLKDNNKLQ------------EKLEQYLQEIALLNHLE--HPNIVKYYDC-
 |. | .|.||.|.|||.  .|               ||...|.||..|  ..|.. .            |...|.|.|| .....   ||||||||.| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

------KHEEDNILIYMEQMPGGSLSSMLE-KF-------------GRFEEALIKKFVKQIISG-LAYLHSQGIVHRDIKLTYINKILQGANILTDGNGT
      ....|.. |.|| |.||||..... |.             .||.| .|.....||. | |.||||..|.|||||         .||||      
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIK---------PANILL-----

VKLADFGAARYRDT-------------ICLPTADGSEFCNSIKGSLYWMAPELLNQ------ESHGRKSDIWSLGCTMIEMATGKHPWPDCRTFPQLALI
|||.||| .   .              |    ..... .|.. |.  ||||| ..|        ...|.||||||||.|||||||.|| |   .  . .|
VKLCDFGVCGQLTDSMANIQSNNIIDCI----ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMI

VKT--------------NQCPPIPE-------------------HLSDECKDFIRQCCTFDKKERPTADVLLK--HPFL
 .               ...||.|.                   ..|.|.||||..|.. | ..||||. |||  |||.
PFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 23105.AA S_TKc 959-1232 33 1.1e-89 305.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 959-1232
Range on HMM: 1-231/231
Sequence Identity: 33% (97 aa)

VELRELLGEGAYGKVYKGFIKKTGKFIAVKQLKLGLKDNNKLQEKLEQYLQEIALLNHLEHPNIVKYYDCKHEEDNILIYMEQMPG--GSLSSMLEKFGR
 |. ...|.||.|||||.  ||||.  |.|..|             |. ..||..| .  ||||||.||. .. |.. . || ..|  |.| ....| ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------FEEALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGANILTDGNGTVKLADFGAARYRDTICLPTADGSEFCNSIKGSLYWMAPELLNQ
      | |  ......||...|.|.||.||.|||.|          .||| |   ..|..||| ||                ... |....||||.|  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKP---------ENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--

ESHGR-KSDIWSLGCTMIEMATGKHPWPDCRTFPQLALIVKTNQCPPIPEHLSDECKDFIRQCCTFDKKERPTADVLLK-------HPFL
 ..|. |.|.||.||...||..|. |.|      |.... |           |.|.|||||.|...| ..||||  .|.       ||..
-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 23105.AA Pkinase 959-1232 31 1.6e-85 295.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 959-1232
Range on HMM: 1-293/293
Sequence Identity: 31% (99 aa)

VELRELLGEGAYGKVYKGFIKKTGKFIAVKQLKLGLKDNNKLQEK--LEQYLQEIALLNHLEHPNIVKYYDCKHEEDNILIYMEQMPGG----SLSSMLE
 .. . .|.|..|.|||.  |.|||  |||..|.  .. .|.|..  |    .||.....| |||||..||. ...|.| . || ..||    .|.....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--KFGRF--EEALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGANILTDGNGTV----KLADFGAAR-YRDTICLPTADGSEFCNSIKGSLYWM
  . |.|  .|  .|....||..||.|.||.||.|||.|.         .||| | ||..    |..||| |. ..          .. .... |....|
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKP---------ENILIDNNGHIDACVKICDFGLAKQFD-------Y-NNS-MTTFCGTPWYM

APELLN-QESHGRKSDIWSLGCTMIEMATGKHPWPDC----RTFPQLALIVKTNQCPPIPEH----------------------LSDECKDFIRQCCTFD
|||... .. .|.|.|.||.||...||..|. |.|..    .   |...|... ..|.  .                       .|.||||||. |...|
APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD

KKERPTADVLLKHPFL
 |.||||. .|.||..
PKKRPTAEQILQHPWF
Kinase 23105.AA MEKK15 960-1232 40 9.7e-80 271.22 In-house 2-264 (264) Show / Hide 
Range on Protein: 960-1232
Range on HMM: 2-264/264
Sequence Identity: 40% (111 aa)

ELRELLGEGAYGKVYKGFIKKTGKFIAVKQLKLGLKDNNKLQEKLEQYLQEIALLNHLEHPNIVKYYDCKHEEDNILIYMEQMPGGSLSSMLEKFGRFEE
.  ..|| |||| || |    ||. ||||| .|   |  | ...  .   |. ||  | | ||| |     |.  . |.|. .||||.||.. .||  .|
KKGNILGKGAYGTVYCGLT-NTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLDE

ALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGANILTDGNGTVKLADFGAARYRDTICLPTADGSE--FCNSIKGSLYWMAPELLNQESHGRKS
    |. |||. | .|||   .||||||         |.|..    | .|| ||| |.    .|.   ....     |..|  |||||| ..   .||||
MVFCKYTKQILQGVQYLHENCVVHRDIK---------GNNVMLMPTGIIKLIDFGCAK---RLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKS

DIWSLGCTMIEMATGKHPWPDCRTFPQLALIVKT-NQCPPIPEHLSDECKDFIRQCCTFDKKERPTADVLLKHPFL
||||.|||. ||||.| || |      .  |    .  |..|.. |.. ..|.| | | |..|||||  ||||||.
DIWSIGCTVFEMATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase 23105.AA MEKK2 960-1232 39 1.6e-73 250.56 In-house 2-262 (262) Show / Hide 
Range on Protein: 960-1232
Range on HMM: 2-262/262
Sequence Identity: 39% (109 aa)

ELRELLGEGAYGKVYKGFIKKTGKFIAVKQLKLGLKDNNKLQEKLEQYLQEIALLNHLEHPNIVKYYDCKHEED--NILIYMEQMPGGSLSSMLEKFGRF
 .  ||| ||.|.||  .   ||. .|||| .    ||   .   .   .|| ||  | |. ||.|| | ...    . |.|| |||||.   |  .|  
RRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFD-PDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGAL

EEALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGANILTDGNGTVKLADFGAARYRDTICLPTADGSEFCNSIKGSLYWMAPELLNQESHGRKS
 |.  .|. .||. |..|||.. |||||||         ||||| |  | |||.||||..   |||.          |. |  |||.||..| |  ||| 
TETVTRKYTRQILEGMHYLHDHMIVHRDIK---------GANILRDSSGNVKLGDFGASKRLQTICMHITG----MKSVTGTPYWMSPEVINGEGYGRKA

DIWSLGCTMIEMATGKHPWPDCRTFPQLALIVKTNQCPPIPEHLSDECKDFIRQCCTFDKKERPTADVLLKHPFL
|.||.|||..|| | | || .      .  |   .  | .|.|.|.. .||...|    |..|| |. ||.| | 
DVWSIGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase 23105.AA CAMK 964-1232 19 1.4e-68 219.86 In-house 1-425 (425) Show / Hide 
Range on Protein: 964-1232
Range on HMM: 1-425/425
Sequence Identity: 19% (83 aa)

LLGEGAYGKVYKGFIKKTG------------KFIAVKQLKLGLKDNNK----------------------LQEKLEQYLQEIALLNH-------LEHPNI
 ||.|..|||.... |.|.            .  |.| ..    ....                       ...... ..||.....       | ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKYYDCKHE-------------------EDNILIYM---EQMPGG----SLSSMLEKF---------------GRFEEALIKKFVKQIISGLAYLHSQGI
.| |.                       .... . |   | ..||     | ... .                |||.|.  .....||.|...|.||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKLTYINKILQGANILTDGN-----------------GTVKLADFGAARYRDTICL----------------PTADGSEFCNSIKGSLYWMA-PEL
||||.|.          ||| | |                 ...|..||| |.. |                    .| .  . ..   |... || ||.
VHRDLKP---------ENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV

LNQ--------------ESHGRKSDIWSLGCTMIEMATGKHPWPDCR------------TFPQLALIVKTNQCPPIPEH---------------------
||.              . .|.|.|.||.|. .  | .|. |. .              . ..|   ... ..  .|..                     
LNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFH

--LSDECKDFIRQCCTFDKKERPTADVLLKHPFL
  .|.||||.||.. . | ..|.|..  |.||..
HFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 23105.AA ULK 959-1232 30 9.4e-63 214.79 In-house 1-324 (324) Show / Hide 
Range on Protein: 959-1232
Range on HMM: 1-324/324
Sequence Identity: 30% (104 aa)

VELRELLGEGAYG-KVYKGFIKKT---GKFIAVKQLKLGLKDNNKLQ-------EKLEQYLQEIALLNHLEHPN--IVKYYDCKHEE--DNILIYMEQMP
 .|.. ||.|..| |||||. |||   ....|.|.  .    ..|..       ..|..  |..  |..| |||  |||.||.. .   .|| | ||  .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGSLSSMLEKF---------GRFEEALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGANIL-TDGN-----------GTVKLADFGAARYRD--
|| |.. ..|          .|..|  ...| |||..|. .||...|.|||||.         .||| ..|.           |..|.|||| |.  |  
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKP---------QNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNN

----TICLPTA-DGSEFCNSIKGSLYWMAPELLN----QESHG-RKSDIWSLGCTMIEMATGKHP---WPDCRTFP---QLA------LIVKTNQCPPIP
    ..|  .  .  .    |||. . |||..|.    |. ..  |.||||||| . || .|| |   |  . ..    .|       .|   ||  ..|
NMEQQMCQTCVNE--K---RIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFP

-----EHLSDECKDFIRQCCTFDKKERPTADVLLKHPFL
      ..|.||||.||.. ..| |.| . . ...||..
KPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 23105.AA Ciliate-E2 959-1232 23 6.1e-61 207.92 In-house 1-365 (365) Show / Hide 
Range on Protein: 959-1232
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

VELRELLGEGAYGKVYKGFIKKTGKFIAVKQLKLGL--------KDNNKL-------QEKLEQYLQEIALLNHLE----------------HPNIVKYYD
 .. ...|.|..|.|||.  .|..| .| |. .  .        |...|.       . ..|| .||| ... ..                ||||.|.|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CKH--EEDNILIYMEQMPGGSLSSMLEKF-----------GRFEEALIKKFVKQIIS---------------GLAYLHSQG-IVHRDIKLTYINKILQGA
|     ..|| . ||   ||.| . ....           ..| |  ||.. |||..               .| ||||.. |.|||||.          
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP---------E

NILTDGNGTVKLADFGAARYRDT------------ICLPTADGSEFCNSIK-------------GSLYWMAPELLNQES---------HGRKSDIWSLGC
|||      .|..||| ... |.            ...      . . ..              |... |||| || ..         .. |.||||||.
NILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

TMIEMATGKHPWPDCRTFPQLALIVKTN-----QCPP-------------IPEHLSDECKDFIRQ----CCTFDKKERPT-ADVLLKHPFL
.. || .||.|.          .. . .     .||              .....|.||||.|..    .   | ..|.| .. .|.||..
ILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 23105.AA Dicty2 960-1116 41 2.2e-42 145.42 In-house 2-153 (264) Show / Hide 
Range on Protein: 960-1116
Range on HMM: 2-153/264
Sequence Identity: 41% (67 aa)

ELR-ELLGEGAYGKVYKGFIKKTGKFIAVKQLKLGLKDNNKLQEKLEQYLQEIALLNHLEHPNIVKYYDCKHEEDNILIYMEQMPGGSLSSMLEKFGRFE
 .  | .| || |.||||  ..|| | | || ..  | ..   | .    ||| ||  | |.|||||..    |... | .| . .||||  ..||| | 
QIGDEKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENGSLSKIIKKFGCFP

EALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGANILTDGNGT---VKLADFGAA
| |.  ...|.  ||.|||.||..|||||         .||||.  .|    .|||||| |
ESLCCIYIYQVLKGLVYLHRQGVIHRDIK---------AANILITKEGKSGVIKLADFGVA
Kinase 23105.AA STE20 960-1114 36 9e-37 128.49 In-house 2-162 (288) Show / Hide 
Range on Protein: 960-1114
Range on HMM: 2-162/288
Sequence Identity: 36% (64 aa)

ELRELLGEGAYGKVYKGFIK-KTGKF----IAVKQLKLGLKDNNKLQEKLEQYLQEIALLNHLEHPNIVKYYDCKHEE----DNILIYMEQMPGGSLSSM
|| | .|.|.||||||. .. .||.     .|.|...|  .|| .  ...|  ..||  .. . ||||||||..   .    |.. | || . ||||. .
ELLEKIGQGSYGKVYKA-YHKPTGEYCNQRVAIKKMNLEKCDNEQ--DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDI

LE---KFG------RFEEALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGANILTDGNGTVKLADFG
..   | |      ...|. |    ...  ||.||||..|.|||||         ..||| . .| |||||||
MKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIK---------ADNILLTEDGEVKLADFG
Kinase 23105.AA TyrKc 959-1232 28 2e-31 111.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 959-1232
Range on HMM: 1-280/280
Sequence Identity: 28% (88 aa)

VELRELLGEGAYGKVYKGFIKKTGKFIAVKQLKLGLKDNNKLQEKLEQYLQEIALLNHL--EHPNIVKYYDCKHEE-------DNILIYMEQMPGGSLSS
..| . |||||.|.||||  |      ||| || .          .|  ..|. .. .|  .|||||. | .  ..       . ..| || ||.|.| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

MLEKFGR-FEEALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGANILTDGNGTVKLADFGAARYRDTI---CLPTADGSEFCN----SIK--GS
 | | .. .  .   .|  || .| .||||....|||.            |.| . |.||| .||| .|. .         . ..        . |    
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAA---------RNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLP

LYWMAPELLNQESHGRKSDIWSLGCTMIEMAT-GKHPWPDC----RTFPQLALIVKTNQCPPIPEH--------LSDECKDFIRQCCTFDKKERPTADVL
. ||||| .|      |||.|| | .| |. | |. |.|.      .  ..   ||.   .|.|..         .||  . ..||. .| ..|||   .
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

LKHPFL
  | ..
--HECF
Kinase 23105.AA STE20 1138-1232 39 5.1e-30 106.05 In-house 184-288 (288) Show / Hide 
Range on Protein: 1138-1232
Range on HMM: 184-288/288
Sequence Identity: 39% (41 aa)

GSLYWMAPELLNQ-----ESHGRKSDIWSLGCTMIEMATGKHPWPDCRTFPQLALIV-KTNQCPPIPE----HLSDECKDFIRQCCTFDKKERPTADVLL
|. ||||||....       .. |.|||||| | ||||.|. |  |.  .  . .|   .|. |.  .    . |.| .||. .| . | ..||||. ||
GTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLL

KHPFL
||||.
KHPFI
Kinase 23105.AA Dicty2 1141-1232 42 2.5e-27 92.28 In-house 172-264 (264) Show / Hide 
Range on Protein: 1141-1232
Range on HMM: 172-264/264
Sequence Identity: 42% (40 aa)

YWMAPELLNQES--HGRKSDIWSLGCTMIEMATGKHPWPDCRTFPQLALIVKTNQCPPIPEHLSDECKDFIRQCCTFDKKERPTADVLLKHPFL
||||||        .  ..||||||||.||. ||  |  |  . . .  .|  ...||.|.  | |||||  ||   |  .|.||  ||.|| .
YWMAPEVIQMSGNHCCTACDIWSLGCTIIELLTGNPPYWDLNPMHAMFRMVQ-DDHPPLPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase 23105.AA Pkinase_Tyr 959-1086 31 6e-21 71.56 Pfam 1-137 (270) Show / Hide 
Range on Protein: 959-1086
Range on HMM: 1-137/270
Sequence Identity: 31% (45 aa)

VELRELLGEGAYGKVYKGFIK----KTGKFIAVKQLKLGLKDNNKLQE-KLEQYLQEIALLNHL-EHPNIVKYYDCKH-EEDN--ILIYMEQMPGGSLSS
... . |||||.|.||||  |    .|.   ||| ||    ..   .. ..|  ..|.... .|  |||||..| .   ...   |.| || ||.|.| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

MLEK----FGRFEEALIKKFVKQIISGLAYLHSQGIVHRDI
 | |     ...    . ..  || .|..||.|....|||.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 23105.AA Pkinase_Tyr 1142-1232 35 3.4e-12 41.92 Pfam 180-270 (270) Show / Hide 
Range on Protein: 1142-1232
Range on HMM: 180-270/270
Sequence Identity: 35% (33 aa)

WMAPELLNQESHGRKSDIWSLGCTMIEMAT-GKHP-WPDCRTFPQLALIVKTNQCPPIPEHLSDECKDFIRQCCTFDKKERPTADVLLKHPFL
||||| .|      |||.|| | .| |. | |. | .|..  .  ...| . ..  |.||. .||  | ..||  .| ..|||   .  | .|
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
Kinase 23105.AA Pkinase_Tyr 1099-1114 50 3.316968 1.32 Pfam 141-156 (270) Show / Hide 
Range on Protein: 1099-1114
Range on HMM: 141-156/270
Sequence Identity: 50% (8 aa)

NILTDGNGTVKLADFG
|.| . |..|| .|||
NCLVTENNVVKICDFG