Gene 6622 (Tetrahymena)

6622

Species: Tetrahymena
Alias: TTHERM_00193390, 887, PreTt06622, 6622, 16.m00278
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: STE11-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
6622.AA Protein None 775 None Fasta, JSON
6622.kin_dom Protein Kinase Domain None 265 None Fasta, JSON
6622.NA RNA None 2328 None Fasta, JSON

Protein domain

Protein domains of 6622.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6622.AA STE11-Unclassified 506-770 46 2.4e-176 592.17 In-house 1-308 (308) Show / Hide 
Range on Protein: 506-770
Range on HMM: 1-308/308
Sequence Identity: 46% (144 aa)

AQVGELIGQGAYGRVYKGFVKSTGKFIAIKEMKEEMML--GEDAHSL-LESICKEIQLLKQLSHKNIVNYIGSK--KQEGSVYIYMEYMPGGSISEMLKK
.|.||.||.|..|.|||.....||.|.|.|.......   .||...  ..||.||...||||.|||||.|.| .  |.|....|.|||||||||..||.|
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

YGGFDEEVIQKFVKQLLEGLIYLHSKGVIHRDLKGANILSDGQGNVKLADFGAARNIE------------------NILQHSLSQSEFCNSIKGSLY---
|| |||.||.|..||.||||.||||.|.||||.|||||| |..|..||.|||.|..||                  .| ||. ||...|.|..|..|   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

WMAPELIK---NEKHGRRIDVWSLGCTVIEMASAQHPWENIKK--FSDLAN-AVIEQQPIPIPQHLS-----------EECKDFISKCCTYDKKMRPKSQ
|||||.||   ...|.|..|.|||||||||||...|||.|...  |..... .|...|...||.|||           .|||||..||...|.|.||...
WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTAN

QLFNHPFL
||..|||.
QLLQHPFI
Kinase 6622.AA STE11 506-770 43 9.3e-158 530.39 In-house 1-303 (303) Show / Hide 
Range on Protein: 506-770
Range on HMM: 1-303/303
Sequence Identity: 43% (133 aa)

AQVGELIGQGAYGRVYKGFVKSTGKFIAIKEMKEEMMLG--EDAHSLLES------ICKEIQLLKQLSHKNIVNYIGSKK---QEGSVYIYMEYMPGGSI
 | ||.||.||.|.|||.. ..||...|.|.......    ||..  ..|      |..||.|.|.|.||||| |.|..    |...|.|.|||.||||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

SEMLK-KYGG--FDEEVIQKFVKQLLEGLIYLHSKGVIHRDLKGANILSDGQGN-VKLADFGAARNIENILQHSLSQSE---FCNSIKGSLY--------
|.||. |.|   ||| ||.|..||.|||| ||||.|.||||.|||||| | .|| .||||||.|. ...|.... ....   .|.|..|..|        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPELIKNEK---HGRRIDVWSLGCTVIEMASAQHPWENIK--KFSDLANAVIE-QQPIPIPQHLS------EECKDFISKCCTYDKKMRPKSQQLFNH
||||| ||.|.   .||. |.|||||||||||....||.|..  ..  .. ..   ....|||.|.|      |||.||...|...|.|.|| ..||..|
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFL
||.
PFI
Kinase 6622.AA STE 507-770 29 7.6e-109 367.91 In-house 1-359 (359) Show / Hide 
Range on Protein: 507-770
Range on HMM: 1-359/359
Sequence Identity: 29% (108 aa)

QVG-ELIGQGAYGRVYKGFVKS---------------TGKFIAIKEMKEEMMLGEDAH------------SLLESICKEIQLLKQLS--HKNIVNYIGSK
. | | ||.||.| |||.  .                ||...|||.|. |    .| .            . ...| |||...|...  |.|||.|.|. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

KQEG-------SVYIYMEYMPGGSISEMLK-KYGGFD-------------EEVIQKFVKQLLEG-LIYLHSKGVIHRDLKGANILSDGQGNVKLADFGAA
 .||       ...|.||||.|||.....| ||| ..             |..| ....|.|.| | ||||...||||.|.||||      |||.||| .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

RNIENILQHS---------LSQSEFCNSIKGSLYWMAPELIKN------EKHGRRIDVWSLGCTVIEMASAQHPWENIKKFSDLANAVIE----------
 ...... ..         ..... .|.. |.  ||||| |..       ..... |.||||||.||||  ..|| . . .. . .. ..          
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----QQPIPIPQ-------------------HLSEECKDFISKCCTYDKKMRPKSQQLFN--HPFL
    ..| |.|.                   ..|.|.||||.||...| . ||...|| .  |||.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 6622.AA S_TKc 506-770 30 5.6e-90 306.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 506-770
Range on HMM: 1-231/231
Sequence Identity: 30% (86 aa)

AQVGELIGQGAYGRVYKGFVKSTGKFIAIKEMKEEMMLGEDAHSLLESICKEIQLLKQLSHKNIVNYIGSKKQEGSVYIYMEYMPG--GSISEMLKKYGG
 .....||.||.|.|||.  |.||.  |||..|             |.|..|||.||.  |.|||.....    ...|. |||..|  |.  ...||.|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------FDEEVIQKFVKQLLEGLIYLHSKGVIHRDLKGANILSDGQGNVKLADFGAARNIENILQHSLSQSEFCNSIKGSLYWMAPELIKNEKHGR-RID
      |.| .......|....| |.||.|.|||||| .||| |   ..|..||| || .              ... |....||||..   ..|. ..|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCD

VWSLGCTVIEMASAQHPWENIKKFSDLANAVIEQQPIPIPQHLSEECKDFISKCCTYDKKMRPKSQQLFN-------HPFL
.||.||...||.. . |..       . . .            |.|.||||.||...| . ||   ....       ||..
WWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6622.AA Pkinase 506-770 29 9.1e-84 289.39 Pfam 1-293 (293) Show / Hide 
Range on Protein: 506-770
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

AQVGELIGQGAYGRVYKGFVKSTGKFIAIKEMKEEMMLG--EDAHSLLESICKEIQLLKQLSHKNIVNYIGSKKQEGSVYIYMEYMPGG----SISEMLK
 ..|. ||.|..|.|||.  |.|||  |.|..| .      . .| .|     |||..| |.|.||| ....   ....|. |||..||    . .....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--KYGGF--DEEVIQKFVKQLLEGLIYLHSKGVIHRDLKGANILSDGQGNV----KLADFGAARNIENILQHSLSQSEFCNSIKGSLYWMAPELIK-NEK
  ..|.|  .|........|.|.|| |.||.|.|||||| .||| | .|..    |..||| |. ..      .  .. .... |....||||.|. ...
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQY

HGRRIDVWSLGCTVIEMASAQHPWENI----KKFSDLANAVIEQQ---PIPIPQHLS-------------------EECKDFISKCCTYDKKMRPKSQQL
.|...|.||.||...||.. . |. .     .  ....  .   .   . ..|.  |                   |||||||..|...| | ||  .|.
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

FNHPFL
..||..
LQHPWF
Kinase 6622.AA MEKK15 507-770 39 9e-80 271.33 In-house 2-264 (264) Show / Hide 
Range on Protein: 507-770
Range on HMM: 2-264/264
Sequence Identity: 39% (104 aa)

QVGELIGQGAYGRVYKGFVKSTGKFIAIKEMKEEMMLGEDAHSLLESICKEIQLLKQLSHKNIVNYIGSKKQEGSVYIYMEYMPGGSISEMLKKYGGFDE
. |...|.|||| || |   .||. ||.| .. . .  | |.     .  |..||| | ||||| |.|   ..  | |.|...|||||| .. ..|  ||
KKGNILGKGAYGTVYCGLT-NTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLDE

EVIQKFVKQLLEGLIYLHSKGVIHRDLKGANILSDGQGNVKLADFGAARNIENILQ-HSLSQSEFCNSIKGSLYWMAPELIKNEKHGRRIDVWSLGCTVI
 |  |. ||.|.|  |||   |.|||.||.|..    | .|| ||| |. .   .|  . ..|.   |..|  |||||| |.   .||. |.||.|||| 
MVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRL--CWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCTVF

EMASAQHPWENIKKFSDLANAVIEQQPIP-IPQHLSEECKDFISKCCTYDKKMRPKSQQLFNHPFL
|||  . || .. .   .     ...|.| .|.. ||. ..|.  | | |.. ||   ||  |||.
EMATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase 6622.AA MEKK2 507-770 39 9e-77 261.36 In-house 2-262 (262) Show / Hide 
Range on Protein: 507-770
Range on HMM: 2-262/262
Sequence Identity: 39% (106 aa)

QVGELIGQGAYGRVYKGFVKSTGKFIAIKEMKEEMMLGEDAHSLLESICKEIQLLKQLSHKNIVNYIGSKKQEG--SVYIYMEYMPGGSISEMLKKYGGF
. | |.||||.||||  .   ||. .|.| .. .     ..    ...  |||||| | |. || | |  ....   . |.||||||||. . || ||  
RRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPD-NPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGAL

DEEVIQKFVKQLLEGLIYLHSKGVIHRDLKGANILSDGQGNVKLADFGAARNIENILQHSLSQSEFCNSIKGSLYWMAPELIKNEKHGRRIDVWSLGCTV
 |.|  |. .|.|||. |||.. ..|||.|||||| |  |||||.||||.. .  |  |         |. |  |||.||.|  |  ||. ||||.||||
TETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITG----MKSVTGTPYWMSPEVINGEGYGRKADVWSIGCTV

IEMASAQHPWENIKKFSDLANAVIEQQPIPIPQHLSEECKDFISKCCTYDKKMRPKSQQLFNHPFL
.||   . || .      .     ..    .|||.|.. .||. .|    |. ||  . |  | | 
VEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase 6622.AA STE20 507-770 36 7e-72 245.11 In-house 2-288 (288) Show / Hide 
Range on Protein: 507-770
Range on HMM: 2-288/288
Sequence Identity: 36% (108 aa)

QVGELIGQGAYGRVYKGFVKSTGKF----IAIKEMKEEMMLGEDAHSLLESICKEIQLLKQLSHKNIVNYIGSKKQE----GSVYIYMEYMPGGSISEML
.  | ||||.|| |||.  |.||.     .||| |. |    |     .|.| |||. .||. |.|||.|.||   .     . .| |||. |||.....
ELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ--DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

K---KYGG------FDEEVIQKFVKQLLEGLIYLHSKGVIHRDLKGANILSDGQGNVKLADFGAARNIENILQHSLSQSEFC-NSIKGSLYWMAPELIKN
|   | |.      ..|| |    ...|.|| ||||...||||.|..||| . .|.||||||| .  ...   .      |  |.. |. ||||||.|. 
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHG-R-D-TMQFKRNTFVGTPYWMAPEVIQC

-----EKHGRRIDVWSLGCTVIEMASAQHPWENIKKFSDLANAVIEQQPIP---I--PQHLSEECKDFISKCCTYDKKMRPKSQQLFNHPFL
      ... . |.|||| | ||||  . |  ..  .. .     .| | |      | . | | .||..|| ..| . || ..|| .|||.
MEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 6622.AA CAMK 511-770 16 4.7e-66 211.57 In-house 1-425 (425) Show / Hide 
Range on Protein: 511-770
Range on HMM: 1-425/425
Sequence Identity: 16% (71 aa)

LIGQGAYGRVYKGFVKSTG------------KFIAIKEMKEEMMLGED----------------------AHSLLESICKEIQLLKQLS-------HKNI
 .|.|..| |.... |.|.            .  ||| .. . . .                          . .... .||...|.|.       |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNYIG---------------SKKQ-----EGSVYIYM---EYMPGG----SISEMLKKYGG---------------FDEEVIQKFVKQLLEGLIYLHSKG
.. .                . ..     .  .|. |   ||..||     . ..... |.               |.|.  .....|..... |.||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHRDLKGANILSDGQ-----------------GNVKLADFGAARNIENILQ----------------HSLSQSEFCNSIKGSLYWMA-PELIKN-----
..|||||  ||| |                   .|.|..||| |. ..   .                 .  . . ..   |... || ||...      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EKHGRRIDVWSLGCTVIEMASAQHPWENIK------------KFSDLANAVIEQQPIPIPQH-----------------------LSEECK
         . .|. .|.||.|.    | .   |..  .              ..|   ... .   .| .                       .|.|||
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFISKCCTYDKKMRPKSQQLFNHPFL
|.|.|. ..| . |.. .|  |||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 6622.AA Ciliate-E2 506-770 23 9.1e-63 214.29 In-house 1-365 (365) Show / Hide 
Range on Protein: 506-770
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

AQVGELIGQGAYGRVYKGFVKSTGKFIAIK---------------EMKEEMMLGE-----DAHSLLESICKEIQ----------LLKQLSHKNIVNYIGS
  . ..||||..| |||. |....| .|||                .|.  |         . .  ..|..||.          .|.||.|.||.... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

KK--QEGSVYIYMEYMPGGSISEMLK------------KYGGFDEEVIQKFVKQLLE---------------GLIYLHSKG-VIHRDLKGANILSDGQGN
 .  .. ..|. |||  ||.  . .|            . . |.|. |... ||.|.               .| |||||. .||||.|  |||      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKLADFGAARNIENILQ---HSLSQSEFCNSIK-----------------------GSLYWMAPELIKNEK---------HGRRIDVWSLGCTVIEMASA
.|..||| .... .  |   | ..|.. .   |                       |... |||| ....|         ..  .|.||||..  || . 
IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

QHPWENIKKFSDLANAVIEQQPIPIP------------------QHLSEECKDFISK----CCTYDKKMRPK-SQQLFNHPFL
..|.             |.|..| .|                  ...|.||||.|.|    .  .| . |.   .|..|||..
KPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 6622.AA Dicty2 507-707 43 1.8e-62 213.84 In-house 2-202 (264) Show / Hide 
Range on Protein: 507-707
Range on HMM: 2-202/264
Sequence Identity: 43% (92 aa)

QVG-ELIGQGAYGRVYKGFVKSTGKFIAIKEMK---EEMMLGEDAHSLLESICKEIQLLKQLSHKNIVNYIGSKKQEGSVYIYMEYMPGGSISEMLKKYG
|.| | ||.|| | ||||  . || | |||  .   .     |. |.   || .|| ||| |.| ||| ||.. . |   || .||. .|| |  .||.|
QIGDEKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQ---SIMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENGSLSKIIKKFG

GFDEEVIQKFVKQLLEGLIYLHSKGVIHRDLKGANILSDGQGN---VKLADFGAARNIENILQHSLSQSEFCNSIKGSLYWMAPELIKNEK--HGRRIDV
 | |. .  ...| |.|| |||..|||||| |.||||    |    .|||||| |  |      ..| .    .. |  |||||| |      .    |.
CFPESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHI------DYSDDDSRYTVVGTPYWMAPEVIQMSGNHCCTACDI

WSLGCTVIEM
||||||.||.
WSLGCTIIEL
Kinase 6622.AA Ciliate-E2-Unclassified 508-770 23 5.2e-61 209.0 In-house 3-352 (352) Show / Hide 
Range on Protein: 508-770
Range on HMM: 3-352/352
Sequence Identity: 23% (81 aa)

VGELIGQGAYGRVYKGFVKSTGKFIAIKEMK-------EEMMLGEDAHSLLESICKEIQ-------------LLKQLSHKNIVNYIGSKKQEGSVYIYME
... ||||..| |||   |..... |.|.||         .|  .  ... . . ....             .|... | .||...  ....  .|| ||
IIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

YMPGGSISEMLKKYGG-----------------FDEEVIQ-----KFVKQLLEGLIYLHSKG-VIHRDLKGANILSDGQG---NVKLADFGAARNIENI-
|..||. ....||...                 |.|. ..     .. .|.|.|| |||.|. .||||.|  ||| | .|   ..|..||| ......  
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN

-------LQHSLSQSEFCNSIKGSLYWM----APELIKNEKHGRR----IDVWSLGCTVIEMASAQHPWENIKKFS---------------DLANAVIEQ
        . .  ... .... |... |    |||........ .    .|.||||.   ||   ..| .  .. .                | .  ...
NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK

----QPIP---IPQHLSEECKDFIS----KCCTYDKKMRPKSQQLFNHPFL
    .. |   ||.|.|.|.||||.    |.  .. . |.  .|..|||..
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 6622.AA TyrKc 506-770 27 6.9e-33 116.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 506-770
Range on HMM: 1-280/280
Sequence Identity: 27% (81 aa)

AQVGELIGQGAYGRVYKGFVKSTGKFIAIKEMKEEMMLGEDAHSLLESICKEIQLLKQL--SHKNIVNYIGSKKQE-------GSVYIYMEYMPGGSISE
 . |. .| ||.|.||||  |      |.| .||.          .| ...|......|  .|.|||. .|   |.       . ..| |||||.|.  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

MLKKYGG-FDEEVIQKFVKQLLEGLIYLHSKGVIHRDLKGANILSDGQGNVKLADFGAARNIENI-LQHSLSQSEFCN----SIK--GSLYWMAPELIKN
 |.|... .  .   .|  |  .|  |||||..|||||   |.| . .. || .||| .|.|..   |   |..        . |    . ||||| |. 
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINY

EKHGRRIDVWSLGCTVIEMAS-AQHPWENI----KKFSDLANAVIEQQPIPIPQH--------LSEECKDFISKCCTYDKKMRPKSQQLFNHPFL
 |     |||| | .  |. .  | |....    .. ... . | .    |.|..         ..|  . ...|. .| ..||  ...  | ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 6622.AA Pkinase_Tyr 506-659 35 5.4e-28 95.44 Pfam 1-163 (270) Show / Hide 
Range on Protein: 506-659
Range on HMM: 1-163/270
Sequence Identity: 35% (59 aa)

AQVGELIGQGAYGRVYKGFVK----STGKFIAIKEMKEEMMLGEDAHSLLESICKEIQLLKQL-SHKNIVNYIGSKK-QEGS--VYIYMEYMPGGSISEM
 . |. .|.||.|.||||  |    .|.   |.| .||  |  .    ..|.  .|....||| .|.|||...|    |...  .|| |||||.|.  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LKKY----GGFDEEVIQKFVKQLLEGLIYLHSKGVIHRDLKGANILSDGQGNVKLADFGAARNIEN
|.|     . .. . . ..  |  .|. ||.||. |||||   |.| . .. || .||| || |.|
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYN
Kinase 6622.AA Pkinase_Tyr 680-770 26 2e-06 22.24 Pfam 180-270 (270) Show / Hide 
Range on Protein: 680-770
Range on HMM: 180-270/270
Sequence Identity: 26% (25 aa)

WMAPELIKNEKHGRRIDVWSLGCTVIEMAS-AQHP-WENIKKFSDLANAV-IEQQPIPIPQHLSEECKDFISKCCTYDKKMRPKSQQLFNHPFL
||||| |.. |     |||| | .  |. .  . | .... . ... ...  . .  |.|.. ..|  | . .|  || ..||  ...  | .|
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
Kinase 6622.AA Dicty2 734-770 40 3e-06 17.81 In-house 228-264 (264) Show / Hide 
Range on Protein: 734-770
Range on HMM: 228-264/264
Sequence Identity: 40% (15 aa)

PIPQHLSEECKDFISKCCTYDKKMRPKSQQLFNHPFL
|.|   | |||||   |   |   |.  .|| .|| .
PLPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI