Gene 1462 (Tetrahymena)

1462

Species: Tetrahymena
Alias: 180.m00082, PreTt01462, TTHERM_00971920, 3749.m00280, 293, 1462
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: MST

Sequence

Name Sequence Type Origin Length Description Download
1462.AA Protein None 1330 None Fasta, JSON
1462.kin_dom Protein Kinase Domain None 253 None Fasta, JSON
1462.NA RNA None 3993 None Fasta, JSON

Protein domain

Protein domains of 1462.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 1462.AA MST 22-274 60 3.9e-212 680.71 In-house 1-254 (254) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-254/254
Sequence Identity: 60% (154 aa)

FSLVEILGQGSYGKVFKALNLQNNKYYAVKVVNTGNGDFDNLKKEISILQDCQSDYIVHYYGSYL--YNEQLWIIMEYCDIGSVNDLMKATQRTLSEVQI
|..||.|||||||.|.||...|..|..|.|.|.. |.|.....|||||.|.|.|.|||.|||||.  .|...||.||||..|||.|.||.|||||.|.||
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV-NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQI

ACILKGVLLGLKYLHNSKKIHRDIKAGNILINKDGACKLADFGVSAQLFNTMGYIESFIGTPYWMSPEVLTQNKYNKKTDIWSLGITAIEMAEGNPPFSN
||||...|.||.|||..|||||||||||||.|..|.|||||||||.||..||......|||||||.|||....||..|.|||||||||||||||.||.|.
ACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSD

FQAVSAMILIIKKPPQGLSDPTKWSQEFNRFVSRCLTINPDIRPTSEELLLDPFI
.....||..|..|||....||..||||||.||..||..||..|.|.|.|| .|||
IHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase 1462.AA STE20 22-274 46 9.40000000001e-155 520.41 In-house 1-288 (288) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-288/288
Sequence Identity: 46% (133 aa)

FSLVEILGQGSYGKVFKALNLQNNKY----YAVKVVNTGNG-----DFDNLKKEISILQDCQSDYIVHYYGSYLYN----EQLWIIMEYCDIGSVNDLMK
. |.| .||||||||.|| . ....|    .|.|..|  .      ......|||||...|.. .||.||||||..    ..|||.||||. ||. |.||
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---ATQR-----TLSEVQIACILKGVLLGLKYLHNSKKIHRDIKAGNILINKDGACKLADFGVSAQLFN----TMG-YIESFIGTPYWMSPEVLTQ----
    ...     ...|.|||.|...|| ||.|||. ..|||||||.|||...|| .|||||||.||| .    ||.    .|.||||||.|||. .    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-NKYNKKTDIWSLGITAIEMAEGNPPFSNFQAVSAMILII--KKPPQGLSD--PTKWSQEFNRFVSRCLTINPDIRPTSEELLLDPFI
 ..|. |.|||||||||||||||.||........|| .|.  ..||  |.|  |.|||.||. ||..||...|. |||...||  |||
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 1462.AA STE 22-274 31 3.4e-126 425.54 In-house 1-359 (359) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-359/359
Sequence Identity: 31% (116 aa)

FSLVEILGQGSYGKVFKALNL------QNNKY---------YAVKVVNTGNGD------------------FDNLKKEISILQDCQ--SDYIVHYYGSYL
. ..|..|.|..|.|.||.|       ....          .|.|..|  | .                  .....|||.|...|.  ...||.|||.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YN-------EQLWIIMEYCDIGSVNDLMK---ATQRTLS----------EVQIACILKGVLLG-LKYLHNSKKIHRDIKAGNILINKDGACKLADFGVSA
..       ..|||.|||.| ||. |..|    ....|.          | |||.|.. .| | |.|||. ..||||||..|||.     .||.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLFN---------------TMG-YIESFIGTPYWMSPEVLTQ------NKYNKKTDIWSLGITAIEMAEGNPPFSNFQAVSAMILIIKK-----------
|| .               ||.    .|.||| ||.|||..|      ..|. | ||||||.|.||||.|.||.....  .|| .|...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----PPQGLSD-----------------PTKWSQEFNRFVSRCLTINPDIRPTSEELLL--DPFI
    ||  | |                 |.|||.||. |...||...|. |||...||    |||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 1462.AA YSK 22-274 44 1.1e-117 356.02 In-house 1-257 (257) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-257/257
Sequence Identity: 44% (115 aa)

FSLVEILGQGSYGKVFKALNLQNNKYYAVKVVN--TGNGDFDNLKKEISILQDCQSDYIVHYYGSYLYNEQLWIIMEYCDIGSVNDLMKA-TQRTLSEVQ
|.  |  | ||.| |.|. . . .. .|.|...      . . . .|| .| .| | ||  ||||||    ||||||||  ||. ||||.     . | .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IACILKGVLLGLKYLHNSKKIHRDIKAGNILINKDGACKLADFGVSAQLFNTMGYIESFIGTPYWMSPEVLTQ--NKYNKKTDIWSLGITAIEMAEGNPP
|| ||. .|.||.|||  .|||||||| |.|....|  ||.||||..|. .|.   . |.|||||| |||  |   .|. | |||||||||.||| |.||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

FSNFQAVSAMILIIKKPPQGLSDPTKWSQEFNRFVSRCLTINPDIRPTSEELLLDPFI
 .   .  .| ||.|..|  |..  ..|  |  ||  ||  .|  ||. .|||   ||
YCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase 1462.AA PAKL 22-274 46 2.4e-106 359.58 In-house 1-256 (256) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-256/256
Sequence Identity: 46% (119 aa)

FSLVEILGQGSYGKVFKALNLQNNKYYAVKVVNTGNG-DFDNLKKEISILQDCQSDYIVHYYGSYLYN-EQLWIIMEYCDIGSVNDLMKATQRTLSEVQI
| . | ||||||| |.||.    |   |.||       .   . |||.||  | . .|| |.||      ..|| |.|| .||.||.|. .  || | ||
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

ACILKGVLLGLKYLHNSKKIHRDIKAGNILINKDGACKLADFGVSAQLFNTMG-YIESFIGTPYWMSPEVLTQNKYNKKTDIWSLGITAIEMAEGNPPFS
. ||. .|.|| ||| .  ||||||| |||.| |.  |.|||||| ||  . .    . ||||||| ||.. .  || | |||||||||||||.| || .
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPHY

NFQAVSAMILIIKKPPQGLSDPTKWSQEFNRFVSRCLTINPDIRPTSEELLLDPFI
      ||  |  .||  .|.| .|| .|| |. .|..  |  |.   .||  |||
DMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase 1462.AA PAKA 22-274 40 3.4e-98 332.52 In-house 1-260 (260) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-260/260
Sequence Identity: 40% (105 aa)

FSLVEILGQGSYGKVFKALNLQNNKY--YAVKVVNTGNGDFD-NLKKEISILQDCQSDYIVHYYGSYLYNEQLWIIMEYCDIGSVNDLMKATQR----TL
.  .| .|||. |.|..| |...|.    |.|. |  | .   ... ||... .|. . || |. |||....||..||| . |.  |. .....    ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

SEVQIACILKGVLLGLKYLHNSKKIHRDIKAGNILINKDGACKLADFGVSAQLFNTMGYIESFIGTPYWMSPEVLTQNKYNKKTDIWSLGITAIEMAEGN
.| |||.... .| ||...|. . ||||||  |||...||  |..|||  |||       ..  ||||||.|||.....|..| ||||||| ||||.|| 
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPFSNFQAVSAMILIIKK--PPQGLSDPTKWSQEFNRFVSRCLTINPDIRPTSEELLLDPFI
||. |.  . || || ..  |.  . ||.||||||..|...|| ...| |....||| .||.
PPYLNEPPLRAMYLIATNGKPD--IKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase 1462.AA S_TKc 22-274 29 2e-93 317.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-231/231
Sequence Identity: 29% (79 aa)

FSLVEILGQGSYGKVFKALNLQNNKYYAVKVVNTGNGDFDNLKKEISILQDCQSDYIVHYYGSYLYNEQLWIIMEYCDI--GSVNDLMKATQR-----TL
. .....|.|..|||.|. .   ....|.|...      .....||.||.  . ..||..|...   . |...|||||   |.. |..|  .|      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SEVQIACILKGVLLGLKYLHNSKKIHRDIKAGNILINKDGACKLADFGVSAQLFNTMGYIESFIGTPYWMSPEVLTQNKYNK-KTDIWSLGITAIEMAEG
.| ....... ....|.|.|. . ||||.|  |||...    |..|||...||        .|.|||..|.||||   .|.| | |.||.|.. .||. |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

NPPFSNFQAVSAMILIIKKPPQGLSDPTKWSQEFNRFVSRCLTINPDIRPTSEELLL-------DPFI
 |||.    . .|. .|.            |.|.  |...||. .|. |||  |.|        .|..
YPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 1462.AA KHS 22-274 47 8.7e-93 312.42 In-house 1-258 (258) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-258/258
Sequence Identity: 47% (124 aa)

FSLVEILGQGSYGKVFKALNLQNNKYYAVKVVNTGNGD-FDNLKKEISILQDCQSDYIVHYYGSYLYNEQLWIIMEYCDIGSVNDLMKATQRTLSEVQIA
. |.  .| | || |.|| . | ..  ||||.    || |  ...|| ...||.   || |.|||| ...|||.||||  ||. |. ..|   |||.|||
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGP-LSELQIA

CILKGVLLGLKYLHNSKKIHRDIKAGNILINKDGACKLADFGVSAQLFNTMGYIESFIGTPYWMSPEVLTQNK---YNKKTDIWSLGITAIEMAEGNPPF
 . . .| ||.|||. .|.|||||  |||....|  ||||||||||.  |..   ||||||||| ||| . ..   ||.  |||..||||||.||  ||.
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPM

SNFQAVSAMILIIK---KPPQGLSDPTKWSQEFNRFVSRCLTINPDIRPTSEELLLDPFI
 .   . |..|. |   .||. | | .|||| |  ||  .|| ||  |||.| ||  ||.
FDLHPMRALFLMTKSNFQPPK-LKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase 1462.AA Ste20-DD1 22-274 45 4e-88 299.08 In-house 1-268 (268) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-268/268
Sequence Identity: 45% (123 aa)

FSLVEILGQGSYGKVFKA-------LNLQNNKYYAVKVVNTGN---GDFDNLKKEISILQDC-QSDYIVHYYGSYLYNEQLWIIMEYCDIGSVNDLMKAT
|  ||. ||||.| |           |  ||.  |.| |        .  |||||| || .     ||| | | |.    | |.||||| ||. | |.  
FQIVEVIGQGSFGVVCTCRWMKKKDRNTNNNRVIACKFVEMNADDVEENSNLKKEIDILKNTMDCPYIVKYHGCYIKENMLMIVMEYCDGGSILDIMQMC

QRTLSEVQIACILKGVLLGLKYLHNSKKIHRDIKAGNILINKDGACKLADFGVSAQLFNTMGYIESFIGTPYWMSPEVLTQ----NKYNKKTDIWSLGIT
  .| | ||| |. ..  || |||  . .||||||||.|.|| |  ||||||||. . |.       || |||||||.       . |  | ||||||||
SKRLIEEQIAAICYQIVKGLVYLHSNRITHRDIKAGNVLVNKEGQPKLADFGVSTIAVNQGFKMNTVIGSPYWMSPEIIMPPKGSQGYDQKADIWSLGIT

AIEMAEGNPPFSNFQAVSAMILIIKKPPQGLSDPTKWSQEFNRFVSRCLTINPDIRPTSEELLLDPFI
||||||  ||  |   |     |  ..|  |  |  || ||| |.. ||  ||| ||   .||  |||
AIEMAESKPPRFNVNPVRVIFVIPHQQPPTLKIPSNWSPEFNDFIKQCLNMNPDKRPSAQQLLNHPFI
Kinase 1462.AA MSN 22-274 42 5.6e-84 277.17 In-house 1-265 (265) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-265/265
Sequence Identity: 42% (113 aa)

FSLVEILGQGSYGKVFKALNLQNNKYYAVKVVNTGNGDFDNLKKEISILQD-CQSDYIVHYYGSYL------YNEQLWIIMEYCDIGSVNDLMKATQ-RT
|.|||..|.| ||.|.| .  .  .  |.||..  . . ...|.|| .|.       |. ||| ..       ..|||..||.|  ||| ||.| |. ..
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQS

LSEVQIACILKGVLLGLKYLHNSKKIHRDIKAGNILINKDGACKLADFGVSAQLFNTMGYIESFIGTPYWMSPEVLT-----QNKYNKKTDIWSLGITAI
| |  || | . .| || .|| .| ||||||  |.|. ..   || ||||||||  |.|   .|||||||| |||.      .  |  . |.||.|||||
LKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITAI

EMAEGNPPFSNFQAVSAMILIIKKPPQGLSDPTKWSQEFNRFVSRCLTINPDIRPTSEELLLDPFI
|||||.||  ... . |..|| ..||  |    |||. |. |. .||  |   ||..|..|  |||
EMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase 1462.AA SLK 22-274 39 3.2e-83 280.59 In-house 1-259 (259) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-259/259
Sequence Identity: 39% (102 aa)

FSLVEILGQGSYGKVFKALNLQNNKYYAVKVVNTGNG-DFDNLKKEISILQDCQSDYIVHYYGSYLYNEQLWIIMEYCDIGSVNDLMKATQRTLSEVQIA
. ..  || | .||| || . ..... | |.... .. . ..   || || .|.  .||. |..| |...||...|.|| | |. .|   ...| | ||.
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

CILKGVLLGLKYLHNSKKIHRDIKAGNILINKDGACKLADFGVSAQLFNTMGYIESFIGTPYWMSPEVLT-----QNKYNKKTDIWSLGITAIEMAEGNP
 . | .. .|..||. | ||||.||||||.  ||  .||||||||.. .||   ..|||||||| |||.       . |  |.|||||||| ||||.. |
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PFSNFQAVSAMILIIKKPPQGLSDPTKWSQEFNRFVSRCLTINPDIRPTSEELLLDPFI
| .. . .  .. | |  |  |  | .||.||. |. .||  .|. |.|...|.  ...
PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase 1462.AA Pkinase 22-274 28 3.4e-80 277.52 Pfam 1-293 (293) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

FSLVEILGQGSYGKVFKALNLQNNKYYAVKVVNTGNGDFDNLKK-----EISILQDCQSDYIVHYYGSYLYNEQLWIIMEYCDIG----SVNDLMK-ATQ
. .....|.||.|.|.|. .  ..| .|||...  . . . ..      ||.|.. .....|| .|... ..  ....||||. |    .  |...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RTL--SEVQIACILKGVLLGLKYLHNSKKIHRDIKAGNILINKDGAC----KLADFGVSAQL-FNTMGYIESFIGTPYWMSPEVLT-QNKYNKKTDIWSL
...  || .. .... .| ||.|.|. . ||||.|  ||||...| .    |..|||...|.     .   .| |||..|.|||.  ...| .| |.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GITAIEMAEGNPPFS------NFQAVSAMILIIKKPPQGLSDPTK-------------------WSQEFNRFVSRCLTINPDIRPTSEELLLDPFI
|.. .||. |.|||.      |     .||  |..||   . |..                   ||.|.  |...||. .|  ||| |..| .|..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 1462.AA Pkinase_Tyr 22-164 23 3.2e-23 79.28 Pfam 1-158 (270) Show / Hide 
Range on Protein: 22-164
Range on HMM: 1-158/270
Sequence Identity: 23% (37 aa)

FSLVEILGQGSYGKVFKALNL----QNNKYYAVKVV--NTGNGD--FDNLKKEISILQDC-QSDYIVHYYGSYL-YNEQ--LWIIMEYCDIGSVNDLMKA
 .. . ||.|..|.|.|.       ...   |||..  ..   .   . . .|..|.    . . || .||  .   |.  ..|.|||.  |.  |  ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

T---QRTLSEVQIACILKGVLLGLKYLHNSKKIHRDIKAGNILINKDGACKLADFGVS
    .. |.  .. ..   .  |. ||.. . ||||. | |.|..... .| .||| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 1462.AA TyrKc 22-273 24 1.9e-21 78.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-273
Range on HMM: 1-280/280
Sequence Identity: 24% (69 aa)

FSLVEILGQGSYGKVFKALNLQNNKYYAVKVVNTGNGDFDNLKKEISILQDC--QSDYIVHYYGSYLYN-------EQLWIIMEYCDIGSVNDLMKATQR
 .| ..|| | .|.|.|.         |||... .      . .|..|.     . . ||  ||  .         |.|.|.|||.. |. .|  .....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

TLSEVQIACILKGVLLGLKYLHNSKKIHRDIKAGNILINKDGACKLADFGVSAQLFNT------MGYIES--FIGTP-----YWMSPEVLTQNKYNKKTD
.|.  .   .   .  |  |||  . ||||. | |.|..... .| .||| |  . .         |. .    |.       ||.||..  .|.. |.|
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

IWSLGITAIEMAE-GNPPFSN--FQAVSAMILIIKKPPQG--LSDPTK--------WSQEFNRFVSRCLTINPDIRPTSEELLLDPF
.|| |..  |.   | .| ..  .| .   . .|..  ||  .  |           ..|  .  ..|   .|. ||| .|.  . |
VWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase 1462.AA Pkinase_Tyr 183-206 41 1e-05 20.06 Pfam 180-203 (270) Show / Hide 
Range on Protein: 183-206
Range on HMM: 180-203/270
Sequence Identity: 41% (10 aa)

WMSPEVLTQNKYNKKTDIWSLGIT
||.||..  .|.. |.|.|| |..
WMAPECINYGKFTTKSDVWSFGVL