Gene 25909 (Tetrahymena)

25909

Species: Tetrahymena
Alias: 26.m00261, TTHERM_00286790, 617, 3688.m00056, 25909, PreTt25909
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: PAKA

Sequence

Name Sequence Type Origin Length Description Download
25909.AA Protein None 468 None Fasta, JSON
25909.kin_dom Protein Kinase Domain None 254 None Fasta, JSON
25909.NA RNA None 1407 None Fasta, JSON

Protein domain

Protein domains of 25909.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD 25909.AA PBD 87-136 34 1e-06 26.01 Pfam 1-50 (60) Show / Hide 
Range on Protein: 87-136
Range on HMM: 1-50/60
Sequence Identity: 34% (18 aa)

TVSKP-ENFARVHHIEIDP-SAPYGLKGLPPEWEERFKVQGINTEEVKENPQ
 .|.|  || .. |. .|. .  .   |.||||.. ..  ||  .| |.|||
MISTPLTNFKHTMHVGWDGQTGFFT--GMPPEWQKLLQSSGISKPEQKHNPQ
PBD 25909.AA PBD 88-124 28 0.000448 19.55 SMART 1-38 (38) Show / Hide 
Range on Protein: 88-124
Range on HMM: 1-38/38
Sequence Identity: 28% (11 aa)

VSKPE-NFARVHHIE-IDPSAPYGLKGLPPEWEERFKVQ
.| |  ||  ..|.  .|. .  .. |||..|.  .|. 
ISTPTGNFKHIVHVGPWDG-QTGEFTGLPHQWQHLLKHC
Kinase 25909.AA PAKA 181-434 48 7.89999999999e-171 573.82 In-house 1-260 (260) Show / Hide 
Range on Protein: 181-434
Range on HMM: 1-260/260
Sequence Identity: 48% (127 aa)

YNFGDKLGKGAMCQVFKATKRKTKNEE-FAVRVMKLGDEGSMNKIKIEMAIMKICQHKNIVRYYETFKFMSCLFMVIEYMNGGSLTEIIYQNFK----TI
|.| .|.|.||...|..||..||..|| .|...|.. .......|..|...|| |.|||||.|.........|..|.|||.||.||..|.|...    ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

PEDIIAYILREIIQGLNFIHLQNQAHRDLKSDNILVNKNGEVKVADFGFATQLTQEKQRRKSVVGTPAWMAPELILKKEYNEKVDVWSTGIIAIELAMGE
.|..|||..||..|||.||| ....|||.||||||....|.||..||||..|||||.|.|...||||.|||||.|..|.|.||||.||.||.|||...||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPHLRMPPLKAMYTISSK-APPRLDPANFTQNFCNFVEQCLQKNPDERASFQTLLEHPFL
||.|..|||.|||.|... .|...||....|.||.|...||....|.|||.|.||.||||
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase 25909.AA STE20 181-434 39 6.5e-138 464.48 In-house 1-288 (288) Show / Hide 
Range on Protein: 181-434
Range on HMM: 1-288/288
Sequence Identity: 39% (114 aa)

YNFGDKLGKGAMCQVFKATKRKTKNEE---FAVRVMKLGDE----GSMNKIKIEMAIMKICQHKNIVRYYETFKFM----SCLFMVIEYMNGGSLTEIIY
|.. .|.|.|. ..|.||....|....    |...|.| ..     ... |. |  ||| |.|.|||.||...  .    ..|..|.||..|||||.|. 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

QNFK--------TIPEDIIAYILREIIQGLNFIHLQNQAHRDLKSDNILVNKNGEVKVADFGFATQLTQ-----EKQRRKSVVGTPAWMAPELILK----
...|        .. |. ||||.||. |||...| ... |||.|.||||....|||| ||||.. |||.     ....|...|||| |||||.|..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-KEYNEKVDVWSTGIIAIELAMGEPPHLRMPPLKAMYTIS--SKAPPRLD---PANFTQNFCNFVEQCLQKNPDERASFQTLLEHPFL
 |.|..|.|.|| || |||.| ||||.. |.|..||..|   .. ||.|    | .....|..||..||||.|..|.. . ||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 25909.AA STE 181-434 29 6.8e-114 384.67 In-house 1-359 (359) Show / Hide 
Range on Protein: 181-434
Range on HMM: 1-359/359
Sequence Identity: 29% (109 aa)

YNFGDKLGKGAMCQVFKATKR------KTKNE--------EFAVRVMKLGDEGS-----------------MNKIKIEMAIMKICQ--HKNIVRYYETFK
. . .|.||||  .|.|| ..      ||...         .|. .|.| .. .                 |..|. |. ||| |.  |.|||.|| .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

FM-------SCLFMVIEYMNGGSLTEIIYQNFKT-------------IPEDIIAYILREIIQG-LNFIHLQNQAHRDLKSDNILVNKNGEVKVADFGFAT
         . |... |||.||||..|| .....             .||..||||.|.|..| |...| ..  |||.|..|||.     || .|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLTQE----------------KQRRKSVVGTPAWMAPELILK------KEYNEKVDVWSTGIIAIELAMGEPPHLRMPPLKAMYTISSK-----------
|||..                .|.|...|||| ||||| |..      |.|..|.|.|| |. .||.| |.||.  |.|..||. |  .           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----APPRLD------------------PANFTQNFCNFVEQCLQKNPDERASFQTLLE--HPFL
     ||.|                   | .....|..|...||||.|..|.. . ||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 25909.AA YSK 181-434 35 1.8e-90 272.59 In-house 1-257 (257) Show / Hide 
Range on Protein: 181-434
Range on HMM: 1-257/257
Sequence Identity: 35% (91 aa)

YNFGDKLGKGAMCQVFKATKRKTKNEEFAVRVMKL-GDEGSMNKIKIEMAIMKICQHKNIVRYYETFKFMSCLFMVIEYMNGGSLTEIIYQ-NFKTIPED
.   .. |.|    |.|.  ..| ..  |. .  |  .|     |  |  .   |   .| .|| ..   . |  . ||  |||.   . .     ..| 
FTKQECIGRGSFGEVYKGIDNRT-QRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEK

IIAYILREIIQGLNFIHLQNQAHRDLKSDNILVNKNGEVKVADFGFATQLTQEKQRRKSVVGTPAWMAPELILK--KEYNEKVDVWSTGIIAIELAMGEP
 || |||||..|| ..| ..  ||| |. |.|....|.||..||| | |.|.  ..|   |||| |||||.| .   .|..|.|.|| || |.|.| |||
YIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEP

PHLRMPPLKAMYTISSKAPPRLDPANFTQNFCNFVEQCLQKNPDERASFQTLLEHPFL
|.  . |...|  | .. ||.|   ... .| .||| || |.| .| | ..|| | | 
PYCDYHPMRVMFLIPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase 25909.AA S_TKc 181-434 29 6.8e-89 302.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 181-434
Range on HMM: 1-231/231
Sequence Identity: 29% (79 aa)

YNFGDKLGKGAMCQVFKATKRKTKNEEFAVRVMKLGDEGSMNKIKIEMAIMKICQHKNIVRYYETFKFMSCLFMVIEYMNG--GSLTEIIYQNFK-----
| ...|.||||. .|.|....|  ....|. ..|       ..|. |..|.|  .|.|||..|..|   ..|.|| ||..|  |.| ..| .. .     
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

TIPEDIIAYILREIIQGLNFIHLQNQAHRDLKSDNILVNKNGEVKVADFGFATQLTQEKQRRKSVVGTPAWMAPELILKKEYNE-KVDVWSTGIIAIELA
 .||  .......|...|...| ..  ||||| .|||...  ..|..|||.|.||       ....||| .||||..    |.  |.|.|| |.| .|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

MGEPPHLRMPPLKAMYTISSKAPPRLDPANFTQNFCNFVEQCLQKNPDERASFQTLLE-------HPFL
 |.||      ...|. .             .. ...|...||||.|..| .   .|.       ||..
CGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 25909.AA MST 181-434 40 2.4e-79 251.87 In-house 1-254 (254) Show / Hide 
Range on Protein: 181-434
Range on HMM: 1-254/254
Sequence Identity: 40% (103 aa)

YNFGDKLGKGAMCQVFKATKRKTKNEEFAVRVMKLGDEGSMNKIKIEMAIMKICQHKNIVRYYETFK--FMSCLFMVIEYMNGGSLTEIIYQNFKTIPED
.   .||| |.  .|.||. ..| ... |. ...   .. .. |. |  ||. |. |.||.||  .     . .  |.|| ..||.  |.    .|  |.
FDIVEKLGQGSYGSVYKAIHKQT-GKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQ

IIAYILREIIQGLNFIHLQNQAHRDLKSDNILVNKNGEVKVADFGFATQLTQEKQRRKSVVGTPAWMAPELILKKEYNEKVDVWSTGIIAIELAMGEPPH
 || ||.   |||   |     |||.|. |||.|. || | |||| . |||     | .|.||| ||||| | .  |. |.| || || |||.| |.|| 
QIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPY

LRMPPLKAMYTISSKAPPRL-DPANFTQNFCNFVEQCLQKNPDERASFQTLLEHPFL
    |  ||  | .| || . ||  . |.| .|| .||||||..|..   ||.||| 
SDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase 25909.AA Pkinase 181-434 28 1.9e-72 251.79 Pfam 1-293 (293) Show / Hide 
Range on Protein: 181-434
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

YNFGDKLGKGAMCQVFKATKRKTKNEEFAVRVMKLGDEGSMNKIKI----EMAIMKICQHKNIVRYYETFKFMSCLFMVIEYMNGG----SLTEIIY-QN
| .| |.|.|.. .|.|.....|   ..|| ..|. .| |  ..      | .||| ..|.||||.|..|   . . || ||..||    .| ..|  ..
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

FKTI--PEDIIAYILREIIQGLNFIHLQNQAHRDLKSDNILVNKNGEV----KVADFGFATQL-TQEKQRRKSVVGTPAWMAPELIL-KKEYNEKVDVWS
 ...  .|. .  ....|..||...| ..  |||||..|||...||..    |..|||.| |. .  ..  ....||| .||||.|.  ..|  |||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

TGIIAIELAMGEPPHLRM----PPLKAMYTISSKAPPRLDPANF----------------------TQNFCNFVEQCLQKNPDERASFQTLLEHPFL
 |.| .|.. |.||        . .  |. |  . .|.|.   .                      ..... |.. ||.|.| .| ... .|.||..
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 25909.AA KHS 181-434 39 7.7e-72 240.88 In-house 1-258 (258) Show / Hide 
Range on Protein: 181-434
Range on HMM: 1-258/258
Sequence Identity: 39% (103 aa)

YNFGDKLGKGAMCQVFKATKRKTKNEEFAVRVMKLGDEGSMNKIKIEMAIMKICQHKNIVRYYETFKFMSCLFMVIEYMNGGSLTEIIYQNFKTIPEDII
|.   ..| |   .|.|| ...  .|  ||.|.|.  .  .  |. |. .|| |.| ||| |.  .     |....||  |||| . ||.    . |  |
YELLQRVGSGTYGDVYKA-RDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQD-IYHVTGPLSELQI

AYILREIIQGLNFIHLQNQAHRDLKSDNILVNKNGEVKVADFGFATQLTQEKQRRKSVVGTPAWMAPELI---LKKEYNEKVDVWSTGIIAIELAMGEPP
||. ||..|||...| . . |||.|  |||....|.||.|||| ..|.|.   .||| .||| |||||      |  ||.  |.|..|| |||||   ||
AYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPP

HLRMPPLKAMY--TISSKAPPRL-DPANFTQNFCNFVEQCLQKNPDERASFQTLLEHPFL
   . |..|..  | |.  ||.| |   ..|.| .|| ..| |||  | . . ||.|||.
MFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase 25909.AA SLK 181-434 33 6.2e-69 231.67 In-house 1-259 (259) Show / Hide 
Range on Protein: 181-434
Range on HMM: 1-259/259
Sequence Identity: 33% (87 aa)

YNFGDKLGKGAMCQVFKATKRKTKNEEFAVRVMKLGDEGSMNKIKIEMAIMKICQHKNIVRYYETFKFMSCLFMVIEYMNGGSLTEIIYQNFKTIPEDII
..    || ||  .| || ..  ..   | ..... ||  ..   .|. |.  |.| |||. ||.. .   |.|.||. .|| . .|.    ... || |
WEIIGELGDGAFGKVYKAQHK-EQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQI

AYILREIIQGLNFIHLQNQAHRDLKSDNILVNKNGEVKVADFGFATQLTQEKQRRKSVVGTPAWMAPELIL-----KKEYNEKVDVWSTGIIAIELAMGE
.|. ......||..| ..  |||||  |||.  .|.|..|||| . ..... |.| . .||| |||||...      . |  |.|.|| ||  ||.| .|
QYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQME

PPHLRMPPLKAMYTISSKAPPRL-DPANFTQNFCNFVEQCLQKNPDERASFQTLLEHPFL
|||  | |.. .  |    ||.|  |. ....| .|...||.|.|. | . . |..|...
PPHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase 25909.AA PAKB 227-434 43 3e-66 226.43 In-house 46-252 (252) Show / Hide 
Range on Protein: 227-434
Range on HMM: 46-252/252
Sequence Identity: 43% (90 aa)

EMAIMKICQHKNIVRYYETFKFMSCLFMVIEYMNGGSLTEIIYQNFKTIPEDIIAYILREIIQGLNFIHLQNQAHRDLKSDNILVNKNGEVKVADFGFAT
|  ||   ||.|||. |. .     |  | |.| ||.|| |. .    . |. ||.. | . | | . | |   ||| ||| ||  . | ||  ||||  
EVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHT--RMNEEQIATVCRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA

QLTQEKQRRKSVVGTPAWMAPELILKKEYNEKVDVWSTGIIAIELAMGEPPHLRMPPLKAMYTISSKAPPRL-DPANFTQNFCNFVEQCLQKNPDERASF
|. .|  .||| |||| |||||.|    |  .||.|| ||  ||.  ||||    |||.||  |  ..|||| . .       .|....| ..| .|.. 
QVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPLQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTA

QTLLEHPFL
| ||.||||
QELLRHPFL
Kinase 25909.AA Ciliate-E2 181-434 21 4.3e-65 222.4 In-house 1-365 (365) Show / Hide 
Range on Protein: 181-434
Range on HMM: 1-365/365
Sequence Identity: 21% (80 aa)

YNFGDKLGKGAMCQVFKATKRKTKNEE----------------------FAVRVMK------LGDEGSMN--------KIKIEMAIMKICQHKNIVRYYE
|.|  |.|.|.  .|.|....|.....                      .|. .||      .  | ...        || .|. |... .|.||...||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

TFK--FMSCLFMVIEYMNGGSLTEIIYQN---FKTIPE-------DIIAYILREIIQ---------------GLNFIHLQN-QAHRDLKSDNILVNKNGE
.|.    .....| || .||.| ..|..|   .. ..|         |.|| ..|.|               .|...| .|   |||.| .|||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKVADFGFATQLTQEKQRR-------------------------------KSVVGTPAWMAPELILKKE---------YNEKVDVWSTGIIAIELAMGEP
.|..|||........ |.|                               ....|||  |||| . .|.         |..|.|.|| |.|  |. .|.|
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PHLRMPPLKAMYTISSKAPPRLD-----------------PANFTQNFCNFVEQ----CLQKNPDERAS-FQTLLEHPFL
|          . .  . . ...                 . . .|.  ..  .    .|||.|..| . .. .|.||..
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 25909.AA PAKL 181-434 38 4.4e-64 219.2 In-house 1-256 (256) Show / Hide 
Range on Protein: 181-434
Range on HMM: 1-256/256
Sequence Identity: 38% (100 aa)

YNFGDKLGKGAMCQVFKATKRKTKNEEFAVRVMKLGDEGSMNKIKIEMAIMKICQHKNIVRYYETFKFM-SCLFMVIEYMNGGSLTEIIYQNFKTIPEDI
. |  ||| |.   |.||. . | |   |. |. .        |  |  | | |   ||| |.       . .    .|   ||   ..    ||  |  
FEFQEKLGQGSYGSVYKAIHKDT-NFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQ

IAYILREIIQGLNFIHLQNQAHRDLKSDNILVNKNGEVKVADFGFATQLTQEKQ-RRKSVVGTPAWMAPELILKKEYNEKVDVWSTGIIAIELAMGEPPH
|. ||.    ||   | .|  ||| |. ||| |  . ||.||||   ||  |     .. .||| ||||| |.|. || |.|.|| || |||.| |.|||
ISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPH

LRMPPLKAMYTISSKAPPRL-DPANFTQNFCNFVEQCLQKNPDERASFQTLLEHPFL
  ||| .||| |  . || . .|  .   | .|. ||..| | .|.|   || |||.
YDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase 25909.AA Pkinase_Tyr 181-363 30 1.1e-19 67.29 Pfam 1-199 (270) Show / Hide 
Range on Protein: 181-363
Range on HMM: 1-199/270
Sequence Identity: 30% (61 aa)

YNFGDKLGKGAMCQVFKATKR-KTKNEEFAVRVMKLGDEGSMNK------IKIEMAIMKIC-QHKNIVRYYETFK-FMSC--LFMVIEYMNGGSLTEIIY
  || |||.||  .|.|.| . . .|..  | | .|  ||.| .         |..|||   .|.||||.|           ...| ||| .|.| .   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

QN---FKTIPEDIIAYILREIIQGLNFIHLQNQAHRDLKSDNILVNKNGEVKVADFGFATQLTQEKQRRKSVVGT-----PAWMAPELILKKEYNEKVDV
..    . ..   .  . ..| .|... . .|  ||||   |.||..|. ||..||| |  . ...    .....       ||||| |  .....| ||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDV

WS
||
WS
Kinase 25909.AA TyrKc 181-434 25 2.2e-18 68.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 181-434
Range on HMM: 1-280/280
Sequence Identity: 25% (73 aa)

YNFGDKLGKGAMCQVFKATKRKTKNEEFAVRVMKLGDEGSMNKIKIEMAIMKIC--QHKNIVRYYETFKFM-------SCLFMVIEYMNGGSLTEIIYQN
  .|.||| || ..|.|.| .    .. || ..| .    .  .  |. ||.    .|.|||| |               |..| ||| .|.| . .  .
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

FKTIPEDIIAYILREIIQGLNFIHLQNQAHRDLKSDNILVNKNGEVKVADFGFATQLTQE-------KQRRKSV-VGTP-----AWMAPELILKKEYNEK
 .... .   ..   | .| ...| .|  ||||   |.||..|. ||..||| .  .. .       .  ||.   |.       ||||| | ......|
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

VDVWSTGIIAIELA-MGEPPHLR-----MPPLKAMYTISSK-APPRLDPAN--------FTQNFCNFVEQCLQKNPDERASFQTLLEHPFL
 |||| |.   |.   |..|.       |..  ..  . .   .|.  |.|         ..   .  .|| . .|..| .|...  | ..
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQ--PPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 25909.AA Pkinase_Tyr 413-434 31 0.817591 3.38 Pfam 251-270 (270) Show / Hide 
Range on Protein: 413-434
Range on HMM: 251-270/270
Sequence Identity: 31% (7 aa)

QCLQKNPDERASFQTLLEHPFL
|| ...|..| .|. .  | .|
QCWHYDPEDRPTFSEI--HEQL