12330

Species: Tetrahymena
Alias: TTHERM_00522150, 65.m00148, 390, PreTt12330, 12330, 3717.m00027
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: TKL
Family: TKL-ciliate3

Sequence

Name Sequence Type Origin Length Description Download
12330.AA Protein None 1285 None Fasta, JSON
12330.kin_dom Protein Kinase Domain None 261 None Fasta, JSON
12330.NA RNA None 3861 None Fasta, JSON

Protein domain

Protein domains of 12330.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
MORN 12330.AA MORN 85-107 47 1.3e-08 35.98 Pfam 1-23 (23) Show / Hide
Range on Protein: 85-107
Range on HMM: 1-23/23
Sequence Identity: 47% (11 aa)

YEGDWSNDLRHGKGKYFYRNGDI
|||.|.|...||.|.| . .|| 
YEGEWKNGKMHGHGVYTWPDGDR

MORN 12330.AA MORN 106-127 40 2.8e-08 34.76 SMART 1-22 (22) Show / Hide
Range on Protein: 106-127
Range on HMM: 1-22/22
Sequence Identity: 40% (9 aa)

DIYDGSWVKGKKEGKGRMTYYN
|.|.|.|..||. |.|.....|
DRYEGEWHNGKRHGHGVYWWAN

MORN 12330.AA MORN 83-104 54 5.5e-08 33.77 SMART 1-22 (22) Show / Hide
Range on Protein: 83-104
Range on HMM: 1-22/22
Sequence Identity: 54% (12 aa)

ERYEGDWSNDLRHGKGKYFYRN
 ||||.| |..|||.|.| . |
DRYEGEWHNGKRHGHGVYWWAN

MORN 12330.AA MORN 37-58 50 3.7e-07 31.03 SMART 8-29 (22) Show / Hide
Range on Protein: 37-58
Range on HMM: 8-29/22
Sequence Identity: 50% (11 aa)

DKYEGEWYNNLRQGQGKQYYYN
|.||||| |..|.|.|. ...|
DRYEGEWHNGKRHGHGVYWWAN

MORN 12330.AA MORN 39-61 43 8e-06 25.98 Pfam 1-23 (23) Show / Hide
Range on Protein: 39-61
Range on HMM: 1-23/23
Sequence Identity: 43% (10 aa)

YEGEWYNNLRQGQGKQYYYNGDF
||||| |....|.|. .. .|| 
YEGEWKNGKMHGHGVYTWPDGDR

MORN 12330.AA MORN 108-130 34 1.8e-05 24.64 Pfam 1-23 (23) Show / Hide
Range on Protein: 108-130
Range on HMM: 1-23/23
Sequence Identity: 34% (8 aa)

YDGSWVKGKKEGKGRMTYYNNEE
|.|.|..||..|.|..|. .   
YEGEWKNGKMHGHGVYTWPDGDR

MORN 12330.AA MORN 60-81 45 1.9e-05 25.37 SMART 1-22 (22) Show / Hide
Range on Protein: 60-81
Range on HMM: 1-22/22
Sequence Identity: 45% (10 aa)

DFYTGSWNKDKKEGHGQYFYSN
| |.|.| ..|. ||| | ..|
DRYEGEWHNGKRHGHGVYWWAN

MORN 12330.AA MORN 62-84 39 0.000104 21.86 Pfam 1-23 (23) Show / Hide
Range on Protein: 62-84
Range on HMM: 1-23/23
Sequence Identity: 39% (9 aa)

YTGSWNKDKKEGHGQYFYSNNER
| |.| ..|..||| | ...  |
YEGEWKNGKMHGHGVYTWPDGDR

MORN 12330.AA MORN 21-38 38 0.009376 14.76 Pfam 6-23 (23) Show / Hide
Range on Protein: 21-38
Range on HMM: 6-23/23
Sequence Identity: 38% (7 aa)

KQGARHGQGMMHYNNGDK
|.| .||.| ... .||.
KNGKMHGHGVYTWPDGDR

MORN 12330.AA MORN 131-141 54 0.293641 9.33 Pfam 1-11 (23) Show / Hide
Range on Protein: 131-141
Range on HMM: 1-11/23
Sequence Identity: 54% (6 aa)

YDGDWLNDKKH
|.|.| |.|.|
YEGEWKNGKMH

Sam7 12330.AA sam7 322-384 23 2.6e-14 48.78 In-house 1-70 (70) Show / Hide
Range on Protein: 322-384
Range on HMM: 1-70/70
Sequence Identity: 23% (17 aa)

WNTGHICKWLDSIGL---GEFSPSFESNQI-----CGQSICMLTEQELEQSIGMKALGKRKIFLKYQEMLK
|.. ..| ||..||.   ... ..| .. |      |. .| .||..|.. .|.. .| || ...  ....
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLME-MGITRPGHRKKIWNHIQQMR

SAM 12330.AA SAM 319-386 30 3.3e-10 41.15 SMART 1-67 (67) Show / Hide
Range on Protein: 319-386
Range on HMM: 1-67/67
Sequence Identity: 30% (21 aa)

LREWNTGHICKWLDSIGLGEFSPSFESNQICGQSICMLTEQELEQSIGMKALGKRKIFLKYQEMLKKY
   |    .| ||.|||...  . |..|.| |.    ||..|. ...|....| || .||  . .|. 
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ

SAM_2 12330.AA SAM_2 319-383 26 3.7e-10 37.7 Pfam 1-71 (71) Show / Hide
Range on Protein: 319-383
Range on HMM: 1-71/71
Sequence Identity: 26% (19 aa)

LREWNTGHICKWLDSIGL-GEFSPSFESNQICG-QSI-CMLTEQEL--EQSIGMKALGK-RKIFLKYQEML
   |..  .| ||.|||. ... ..|....| | . .   .|...|  .  .|. ..|  .||  | |.|.
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK

SAM_1 12330.AA SAM_1 320-384 27 2.8e-09 35.86 Pfam 1-66 (66) Show / Hide
Range on Protein: 320-384
Range on HMM: 1-66/66
Sequence Identity: 27% (18 aa)

REWNTGHICKWLDSIGLGEFSPSF-ESNQICGQSICMLTEQELEQSIGMKALGKRKIFLKYQEMLK
 .|    .| ||.|||...  ..| ... | .. .  .|...|.. .|.. .| ||  ..  .|||
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK

Kinase 12330.AA TKL-Unique 1010-1266 40 7.29999999999e-144 484.24 In-house 1-290 (290) Show / Hide
Range on Protein: 1010-1266
Range on HMM: 1-290/290
Sequence Identity: 40% (119 aa)

FGKKIGEGSYGQVFKGTWAKTQVAIKQFGKQNSKFHLRKVQDFISEVRVINNLR-HPNIVLYMGVCF----YQSQYFMITEYLQEGSLYDHLH-------
|..|||||.||||.||.|....|||||| . |........|.|..||.....|. |||||.|||.|.    |........||...|||||.||       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--IKHTAFSEAKQIDMIEDMALGMVYLHGRK--VMHCDLKSSNVLIDEN-----WNVKLCDFGLSRIKSTLNKKKNARK----NEGLIGTPQWMAPEIMR
  .... .. .....|..|.|.|| ||| ..  ..|.||||||.|.|.|     ||.|.||||||...|. ||..| ..    |.. .|...|||||..|
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

R--EQYQEHSDVYSFGMIMWEIATRKV------PYLGLSHQQIYGTVGYD-ENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVEEI
.  .||.|.|||||||...|||||||.      || |....|.. .| |. |||...|| . ...| .|...| ...|..||.|.|.....
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase 12330.AA TKL 1014-1266 26 2.8e-99 336.14 In-house 1-364 (364) Show / Hide
Range on Protein: 1014-1266
Range on HMM: 1-364/364
Sequence Identity: 26% (97 aa)

IGEGSYGQVFKGTWAK----------TQVAIKQFGKQNSKFHLRKVQD-----------------------FISEVRVINNLRHPNIVLYMGVCFYQSQ-
||.|..|.|.||.|            . ||.|.| ..|.... .. |.                       .. |......|||||||..||.|.. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YFMITEYLQEGSLYDHLHIKHTAFSEAKQIDMIEDMALGMVYLHGRK--------VMHCDLKSSNVLIDENWN--------------V
            .....|| . |||...||         . .... |.|.|| ||| ..        . |.||||.|.|.||||.              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLCDFGLSRIKSTLNKKKNARKNEG--------------LIGTPQWMAPEIMRRE----------------QYQEHSDVYSFGMIMWEIATRKVPYL-GL
|.||||||| .|. ....   ....               .|||.|||||..| .                .| | .||||||...|||.||..||    
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

SHQQIYG-------TVGYDENYQVEIP------------VRGIPRYLNLMKKCLRRNPQERPTFQEVVEEI
. ..| .        . .|.... .||                |.. .||..|   .|..||.|||.....
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase 12330.AA Dicty4 1008-1269 36 1.3e-84 282.08 In-house 1-277 (277) Show / Hide
Range on Protein: 1008-1269
Range on HMM: 1-277/277
Sequence Identity: 36% (103 aa)

LDFGKKIGEGSYGQVFKGTWAKTQVAIKQFGKQNSKFHLRKVQDFISEVRVINNLRHPNIVLYMGVCF---YQSQYFMI-TEYLQEGSLYDHLHI-----
......||.||.|.|.||||  ..||.| .   | .| .   ..|  ||    ..|||||.| || |     ..  ..| |||.  |.||  ||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-KHTAFS--EAKQ-IDMIEDMALGMVYLHGRK--VMHCDLKSSNVLIDENWNVKLCDFGLSR-IKSTLNKKKNARKNEGLIGTPQWMAPEIMRREQYQEH
 . .  .    |. . |  | |.|| .||..   . | ||||.| |.|.||.|| ||||||. .|   ..| |.    . .||| |||||.|. . | | 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQ---MTACGTPCWMAPEVMMHQPYNEK

SDVYSFGMIMWEIATRKVPYL--GLSHQQIYGTVGYDENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVEE-IFKI
.||||||.. |||.||. ||.  . .  |..  |. ..    .||  . |..  |...|.  .|| ||.|.|.... |   
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVC-NKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase 12330.AA DRK 1008-1268 38 2e-75 254.91 In-house 1-258 (258) Show / Hide
Range on Protein: 1008-1268
Range on HMM: 1-258/258
Sequence Identity: 38% (102 aa)

LDFGKKIGEGSYGQVFKGTWAKTQVAIKQFGKQNSK-FHLRKVQDFISEVRVINNLRHPNIVLYMGVCFYQSQYFMITEYLQEGSLYDHLHIKHTAFSEA
   |  || |.||.|| |||  ||||.|     |     .  ...|  |. .. .||||||...|| |   .    ..||.  ||||  ||      .  
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENF--LNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWP

KQIDMIEDMALGMVYLHGRK--VMHCDLKSSNVLIDENWNVKLCDFGLSRIKST-LNKKKNARKNEGLIGTPQWMAPEIMRREQYQEHSDVYSFGMIMWE
  . |  | | || |||..   ..| |||| | |.||.| ||  ||||    ||   | |        .||| | |||. | . | |  |||||. . ||
LMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGL----STRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWE

IATRKVPYLGLSHQQIYGTVGYDENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVEEIFK
..||. || |    |.   ||  .     .|  . | |  ||. |.  .|| ||..||..| .  
CVTRQDPYFGMPTFQVVFSVGR-HGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA

Kinase 12330.AA Pkinase 1008-1266 25 1.1e-73 255.9 Pfam 1-293 (293) Show / Hide
Range on Protein: 1008-1266
Range on HMM: 1-293/293
Sequence Identity: 25% (75 aa)

LDFGKKIGEGSYGQVFKGTWAKTQ--VAIKQFGKQNSKFHLRKVQDFI-SEVRVINNLRHPNIVLYMGVCFYQSQYFMITEYLQEG----SLYDHLH-IK
. .|.|||.||.|.|.|... .|.  ||.|.. |. .. .  .....  ||... ..|.||||| . ... . . . |..||.. |    .|.|...  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

HTAF--SEAKQIDMIEDMALGMVYLHGRKVMHCDLKSSNVLIDENWNV----KLCDFGLSRIKSTLNKKKNARKNEGLIGTPQWMAPEIMR-REQYQEHS
|..|  ||   ....  .. |. |.| ....|.|||..|.|||.| ..    |.|||||.. ..      | . . .. ||| .||||. | .. |   .
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSFGMIMWEIATRKVPYLGL------SHQQIYGTVGY---DENYQVEIPVRGI---------------PRYLNLMKKCLRRNPQERPTFQEVVEE--I
|..|.| |..| .... |. |       ...|..  ...   ..... .....                 .  . ..|.||...|..|||......   .
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF





Kinase 12330.AA S_TKc 1008-1268 24 2.1e-67 231.15 SMART 1-231 (231) Show / Hide
Range on Protein: 1008-1268
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

LDFGKKIGEGSYGQVFKGTWAK--TQVAIKQFGKQNSKFHLRKVQDFISEVRVINNLRHPNIVLYMGVCFYQSQYFMITEYLQE--GSLYDHLHIKHTA-
 ....|||.|..|.|.|... |   .||||.             .....|...  . .||||| . .|.   . ..|..||.    |.|.|... . .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FSEAKQIDMIEDMALGMVYLHGRKVMHCDLKSSNVLIDENWNVKLCDFGLSRIKSTLNKKKNARKNEGLIGTPQWMAPEIMRREQYQE-HSDVYSF
    |.|     ..  ..... |.| ....|.||| .|.|.||  ..|.|||||.|.               ..||| .||||..   .|    .|..|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GMIMWEIATRKVPYLGLSHQQIYGTVGYDENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVE-------EIFK
| |..| .... |.    .|...  .|              |  .....|||...|..|||  |. .         . 
GCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 12330.AA Pkinase_Tyr 1008-1266 34 6e-63 213.81 Pfam 1-270 (270) Show / Hide
Range on Protein: 1008-1266
Range on HMM: 1-270/270
Sequence Identity: 34% (95 aa)

LDFGKKIGEGSYGQVFKGTWA------KTQVAIKQFGKQNSKFH-LRKVQDFISEVRVINNL-RHPNIVLYMGVCF-YQSQ--YFMITEYLQEGSLYDHL
. ||||.|||..|.|.||||       |..||.|   |...  . . . .||..|...  .| .||||| ..|||   . .  .....|| . |.|.|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HIK---HTAFSEAKQIDMIEDMALGMVYLHGRKVMHCDLKSSNVLIDENWNVKLCDFGLSRIKSTLNKKKNA-RKNEGLIGTPQWMAPEIMRREQYQEHS
. .     ...    ..|  . | || ||. ..  | ||   |.|..||  || |||||.|      .. .  || .|      ||||| ..   . . |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS

DVYSFGMIMWEIAT-RKVP-YLGLSHQQIYGTVGYDENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVEEI
||.|||  |||| |  . | | |.| ...|  . |...|. ..|    .   .|||.| . .|..||||.|..|..
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI-YEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase 12330.AA LISK 1013-1208 33 2.2e-62 201.43 In-house 1-236 (296) Show / Hide
Range on Protein: 1013-1208
Range on HMM: 1-236/296
Sequence Identity: 33% (80 aa)

KIGEGSYGQVFKGTWA--KTQVAIKQFGKQNSKFHLRKVQDFIS-EVRVINNLRHPNIVLYMGVCFY-QSQYFMITEYLQEGSLYDHLHI---KHTAFSE
.||.|..|.|.|||.    . .|||.  .|  .. ..  | |.  || ...|||||||| .||||   ..|....||| . | | . |.    .   .. 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

AKQIDMIEDMALGMVYLHGRKVMHCDLKSSNVLIDEN----WNVKLCDFGLSRIKSTLN------------------------KKKNARKNEGL-----I
 . ..   | |.|| ||| ....| |||| |.|..||    |..|.||||. |. .  |                        |.. .. | .       
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTIC

GTPQWMAPEIMRREQYQEHSDVYSFGMIMWEIATRK
||| |||||... ..| | .||.|||... || ||.
GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRV

Kinase 12330.AA MLK 1008-1266 30 1.2e-60 207.85 In-house 1-291 (291) Show / Hide
Range on Protein: 1008-1266
Range on HMM: 1-291/291
Sequence Identity: 30% (91 aa)

LDFGKKIGEGSYGQVFKGTWAKTQ-----VAIKQFG-----KQNSKFHLRKVQDFISEVRVINNLR-HPNIVLYMGVCFYQ-SQYFMITEYLQEGSLYDH
..| ..||.||.|.|.||.| ..      ||.|..      |. .    .... .. ..|... .  ||.|.  .|||  . .... ..||...||||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHIKHT-------------AFSEAKQIDMIEDMALGMVYLHGRK---VMHCDLKSSNVLIDE------NWNVKLCDFGLSRIKSTL--NKKKNARKNEGL
|| . .               . .  ..   ..| || |||  .   . | ||||.|.||||      . ..| ||||.|| ...   |. .||      
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNA------

IGTPQWMAPEIM---RREQYQEHSDVYSFGMIMWEIATRKVPYL-GLSHQQIYGTVGYDENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVEEI
 ||. |||||.    | |.| | .||.|.|...||. ||.|||  ...  .|   |.| ..  . ||    ..  .|||.|   .| .||.|...|.. 
-GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAY-NGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase 12330.AA RAF 1008-1268 30 2.7e-56 180.89 In-house 1-282 (282) Show / Hide
Range on Protein: 1008-1268
Range on HMM: 1-282/282
Sequence Identity: 30% (87 aa)

LDFGKKIGEGSYGQVFKGTWAKTQVAIKQFG-KQNSKFHLRKVQDFISEVRVINNLRHPNIVLYMGVCFYQSQ---YFMITEYLQEGSLYDHLHIKHT--
.. ...||.||.| |..| |   .||.|    .. .   ..    |  || |  . || ||.|.|| .  . |   |  .|.. .  ||| |.|.. |  
VMVMTRIGSGSFGTVYRGHWH-GDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMG-YMSKPQTNTYAIVTQWCEHSSLYHHIHVQETRE

AFSEAKQIDMIEDMALGMVYLHGRKVMHCDLKSSNVLIDENWNVKLCDFGLSRIKSTLN--KKKNARKNEGLIGTPQWMAPEIMR--------------R
 |   . ||    ...|| ||| ....| |||| |.. .|   ||  |||| ..|.  .   .. .    . |    |||||. |              .
KFDMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWI---LWMAPEVIRNLMIDWRGDVLMQDE

EQYQEHSDVYSFGMIMWEIATRKVPY-LGLSHQ-QIYGTVGYDENYQ-VEIPVRGIPRYLN-LMKKCLRRNPQERPTFQEVVEEIFK
  |   |||||||..|.|. ||. ||    ... ||   .|     .  .   . .|. .  ||. |.  ...||| ||.....|  
NPYSFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV

Kinase 12330.AA TyrKc 1008-1266 33 3.2e-56 194.0 SMART 1-280 (280) Show / Hide
Range on Protein: 1008-1266
Range on HMM: 1-280/280
Sequence Identity: 33% (96 aa)

LDFGKKIGEGSYGQVFKGTWAKTQVAIKQFGKQNSKFHLRKVQDFISEVRVINNL--RHPNIVLYMGVCFYQ-------SQYFMITEYLQEGSLYDHLHI
. .|||.||| .|.|.||||  .|||.|   .         ..||..| |.  .|  .|||||   |||  |        ......||   |.| |.|. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KHTAFSEAKQIDMIEDMALGMVYLHGRKVMHCDLKSSNVLIDENWNVKLCDFGLSRIKSTL----NKKKNARKNE--GLI--GTPQWMAPEIMRREQYQE
..  .. .. ...  . | || ||| ... | ||   |.|..||  || .||||||           |.  || |  |        ||||| ..   . .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

HSDVYSFGMIMWEIATR-KVPYLG-----LSHQQIYGTVGYDENYQVEIPVR--------GIPRYLNLMKKCLRRNPQERPTFQEVVEEI
 |||.|||  |||| |. . || |     .| |...  |  .. |  ..|            .   ..||.| ...| .||||.|..|..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV--KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 12330.AA TKL-ciliate2 1008-1267 33 1.1e-55 184.1 In-house 1-273 (273) Show / Hide
Range on Protein: 1008-1267
Range on HMM: 1-273/273
Sequence Identity: 33% (94 aa)

LDFGKKIGEGSYGQVFKGTWAKTQVAIKQFGKQNSKFHLR-KVQDFISEVRVINNLRHPNIVLYMGVCFYQSQYFMITEYLQEGSLYDHLHIKHTAFSEA
|.   || || || ..|  |  . ||.|.|      .  . ...||..|   .  |||||||...| |     . .| || | |||.  |  .    .  
LEIQNKITEGGYGIIYKAKWREIVVAVKKF---KMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWE

KQIDMIEDMALGMVYLHGRK--VMHCDLK--------------------SSNVLIDENWNVKLCDFGLSRIKSTLNKKKNARKNEGLIGTPQWMAPEIMR
    .  |.| |. |||  .  ..| |||                    | |||.|.|   || |||  |.|   |   |       ||| ||||||...
DRRRIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMTNK------IGTYQWMAPEVIK

REQYQEHSDVYSFGMIMWEIATRKVPYLGLSHQQIYGTVGYDENYQVEIPVRGIPRYLNLMKKCLRRNPQERPTFQEVVEEIF
   | |  ||.|...|.|||| |  || . . . .   |   .|    ||    |.. .||..|   | . ||.|.|.. |. 
AFYYTEKADVFSYSIILWEIASREPPYRNKKGDVVAEKV-MCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE

Kinase 12330.AA LRRK 1008-1211 27 1.4e-54 187.69 In-house 81-363 (351) Show / Hide
Range on Protein: 1008-1211
Range on HMM: 81-363/351
Sequence Identity: 27% (81 aa)

LDFGKKIGEGSYG-QVFKGTWAK----------------------------TQVAIKQFGK------------------------------QNSKFHLRK
| ....||.|..|  |....| .                            . ||||.. .                              ||. . .|.
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

VQDFISEVRVINNLRHPNIVLYMGVCFYQSQYFMITEYLQEGSLYDHLHIKH-TA-------FSEAKQIDMIEDMALGMVYLHGRK--VMHCDLKSSNVL
 . |  || ....|.|||||  .|.|.  . . |..||.. |.||..|| |. ..       .|   ..    . | || ||| ..  . |.|||| |.|
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

I---D---------ENWNVKLCDFGLSR----IKSTLNKKKNARKNEGLIGTPQWMAPEIMR---REQYQEHSDVYSFGMIMWEIATRK-VPY
.   .         .. ..|..|||.||    ..... |        |. |.|.||||||||   .|.| | .|.||||||.||. ||.  |.
LWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAK--------GCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPF

Kinase 12330.AA STE 1008-1261 21 2.3e-54 186.94 In-house 1-350 (359) Show / Hide
Range on Protein: 1008-1261
Range on HMM: 1-350/359
Sequence Identity: 21% (77 aa)

LDFGKKIGEGSYGQVFKGTWA------KTQ-----------VAIKQFGKQNSKF-------------HLRKVQDFISEVRVINNLR--HPNIVLYMGVCF
... .|||.|..|.|.|.         ||.           .||||  ..|..              .  ..|... |... ....  ||||| | | .|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YQ-------SQYFMITEYLQEGSLYDHLHIKH-------------TAFSEAKQIDMIEDMALG-MVYLHGRKVMHCDLKSSNVLIDENWNVKLCDFGLSR
.        .. ... ||.  ||| | .. |.             . |.|   . .. .   | . |||  ...| |.|..|.|.     |||||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

IKSTLNKKK-----------NARKNEGLIGTPQWMAPEIMRR------EQYQEHSDVYSFGMIMWEIATRKVPYLG-LSHQQIYGTV--GYDEN-----Y
. .  . ..           .. |.  ..||| |||||....       .| . .|..|.|  ..| || |.|.     .. .. .   .. ..     .
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

QVEIPVRGIPR------------------------YLNLMKKCLRRNPQERPTFQE
.|. |   .|                           . ..|||...|..||| ..
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ

Kinase 12330.AA LRRK 1239-1268 26 4.8e-08 24.53 In-house 322-351 (351) Show / Hide
Range on Protein: 1239-1268
Range on HMM: 322-351/351
Sequence Identity: 26% (8 aa)

PRYLNLMKKCLRRNPQERPTFQEVVEEIFK
..|..|...|   .|..||.|...|. .  
HMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase 12330.AA LISK 1239-1266 35 1.7e-05 13.63 In-house 269-296 (296) Show / Hide
Range on Protein: 1239-1266
Range on HMM: 269-296/296
Sequence Identity: 35% (10 aa)

PRYLNLMKKCLRRNPQERPTFQEVVEEI
| .| |. .| . .| .||.| |.|. .
PPFLDLCFDCCKYDPKNRPSFKEIVQWL