Gene MRCK (Sea Urchin)

MRCK

Species: Sea Urchin
Alias: Spk005, SPU_020069, MRCK
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: DMPK
Subfamily: GEK

Sequence

Name Sequence Type Origin Length Description Download
MRCK.AA Protein None 1780 None Fasta, JSON
MRCK.kin_dom Protein Kinase Domain None 270 None Fasta, JSON

Protein domain

Protein domains of MRCK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MRCK.AA DMPK 209-478 72 7.4e-298 748.1 In-house 1-270 (270) Show / Hide 
Range on Protein: 209-478
Range on HMM: 1-270/270
Sequence Identity: 72% (196 aa)

FETLKIIGRGAFGEVAVVKLKNSDDVFAMKLLNKWEMLKRAETACFVEERDVLVHGDSRWITNLHYAFQDDDFLYLVMDYYSGGDLLTLISKFDDRLPED
||.||.||||.||||.||. |...||.|||..|||||||||||||| ||||..|||.|||||.|||||||...||.||.|. |||||||.|...||.|||
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

MARFYVAEMVLAIDSVHMLRYVHRDIKPDNVLLDKHGHIRLADFGSCLRMLPDNTVMSNVAVGTPDYISPEILRAMEDG-KGRYGPECDWWSLGVCMYEM
|||||.|||||||.|.|...||||||||||.|||.||||.|||||||..| .|..|.|.||||||||||||.|.||||. ||||||||||||.|||||||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LFGETPFYAESLVETYGKIMNH-KNQFDFPPETEEEVAISEDAKDLILSLICSAEARLGRNGLQDFKDHPFF
|.|||||||.|||||||||||| ||...||....  ...||.||||| .|.|..|.||||||..|||.||||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPK--WDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase MRCK.AA GEK 209-478 82 1.4e-207 695.89 In-house 1-269 (269) Show / Hide 
Range on Protein: 209-478
Range on HMM: 1-269/269
Sequence Identity: 82% (222 aa)

FETLKIIGRGAFGEVAVVKLKNSDDVFAMKLLNKWEMLKRAETACFVEERDVLVHGDSRWITNLHYAFQDDDFLYLVMDYYSGGDLLTLISKFDDRLPED
||.||.|||||||||||||.||.|.|.|||.|||||||||||||||.|||||||.||.||||||||||||...||||||||.|||||||.|||.||||||
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

MARFYVAEMVLAIDSVHMLRYVHRDIKPDNVLLDKHGHIRLADFGSCLRMLPDNTVMSNVAVGTPDYISPEILRAMEDGKGRYGPECDWWSLGVCMYEML
|||||.||||.||||||.|.||||||||||||||..|||||||||||||| .|..|.||||||||||||||||.||||||||||||||||||||||||||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

FGETPFYAESLVETYGKIMNHKNQFDFPPETEEEVAISEDAKDLILSLICSAEARLGRNGLQDFKDHPFF
.|||||||||||||||||||||..|.||..... ...||.||||| .||||.|.||||||.||||.||||
YGETPFYAESLVETYGKIMNHKDHFQFPSQETD-WDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase MRCK.AA AGC 209-478 30 4.6e-171 446.62 In-house 1-395 (395) Show / Hide 
Range on Protein: 209-478
Range on HMM: 1-395/395
Sequence Identity: 30% (122 aa)

FETLKIIGRGAFGEVAVVKLK------NSDDVFAMKLLNKWE--------MLKRAETAC-------FVEERDVLVHGD----------SRWITN-LHYAF
|| ||.||.|.||.|  |. |       .....||| |.|..        |.... |..       . |||..|.. .          . .|.. |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDDDF--LYLVMDYYS---------GG-DLLTLISK--FDDRLPEDMARFYVAE-------MVLAIDSVHM-LRYVHRD-IKPDNVLLDKHGHIRLADFG
||.|   ||.||.|..         || .|.. . .     |..|..|||| ||       .|||... |  . ..||| .||.|.|||..|||.|.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

SCLRMLPDN-------------------------------------------------TVMSNVAVG--TPDYISPEILRAMEDGKGRYGPECDWWS--L
.| ..  |.                                                 ... .  .|  ||.|..||||         ||..|||||  |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---------YGKACDWWSFGL

GVCMYEMLFGETPFYAESLV----------ETYGKIM------NHKNQFDFPP--ETEEEVAISEDAKDLILSLIC-SAEARLGRN-------GLQDFKD
|..|||||.| .|||... .          |.. |||      |.| .|.||   ...|.. .|..|||||  |.|   | ||| .       | .. |.
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HPFF
||.|
HPWF
Kinase MRCK.AA ROCK 209-478 57 2.1e-136 459.48 In-house 1-263 (263) Show / Hide 
Range on Protein: 209-478
Range on HMM: 1-263/263
Sequence Identity: 57% (154 aa)

FETLKIIGRGAFGEVAVVKLKNSDDVFAMKLLNKWEMLKRAETACFVEERDVLVHGDSRWITNLHYAFQDDDFLYLVMDYYSGGDLLTLISKFDDRLPED
|. .|.||||||||| .|. | |  |.|||.|.| ||.||.. | | ||||.. |  | ||  |||||||| .||.||||  ||||  |.|..|  .|| 
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYD--VPEK

MARFYVAEMVLAIDSVHMLRYVHRDIKPDNVLLDKHGHIRLADFGSCLRMLPDNTVMSNVAVGTPDYISPEILRAMEDGKGRYGPECDWWSLGVCMYEML
 |||| .|.|||.|..| . ..|||.||||.||||.||..||||| |..|  .  | .. |||||||||||.|..   . |.|| |||||| || .||||
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQG-QDGEYGRECDWWSVGVFIYEML

FGETPFYAESLVETYGKIMNHKNQFDFPPETEEEVAISEDAKDLILSLICSAEARLGRNGLQDFKDHPFF
.|.|||||.||| ||.|||.|||   ||    ..| ||..|||||   .  .| ||||||..| | |.||
VGDTPFYADSLVGTYSKIMDHKNSLKFP----DDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase MRCK.AA CRIK 209-478 45 1e-121 389.96 In-house 1-272 (272) Show / Hide 
Range on Protein: 209-478
Range on HMM: 1-272/272
Sequence Identity: 45% (127 aa)

FETLKIIGRGAFGEVAVVKLKNSDDVFAMKLLNKWEMLKRAETACFVEERDVLVHGDSRWITNLHYAFQDDDFLYLVMDYYSGGDLLTLISKFDDRLPED
||   .||.| ||.| ||  |   |..||| . | ..| . . . | ||||..    | |...| |||||.| |||.| |  ||||| |.. .|| . |.
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

MARFYVAEMVLAIDSVHMLRYVHRDIKPDNVLLDKHGHIRLADFGSCLRMLPDNTVMSNVAVGTPDYISPEILRAMED---GKGRYGPECDWWSLGVCMY
||||| || ..|. |.|   ||||||||.|.|.|  ||| ||||||   |  .|.| |   ||||||. ||.|  |     .|| || .|||||.|.  |
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMLFGETPFYAESLVETYGKIMN------HKNQFDFPPETEEEVAISEDAKDLILSLICSAEARLGRNGLQDFKDHPFF
||  | |||   . ..|| .|||       .    ||        .| .. ||| ||.|   .||.  .|   . ||||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFP----DDPKVSPNYRDLIQSLLCNQSKRLKYEQL---CCHPFF
Kinase MRCK.AA S_TKc 209-478 31 1.3e-88 301.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 209-478
Range on HMM: 1-231/231
Sequence Identity: 31% (88 aa)

FETLKIIGRGAFGEVAVVKLKNSDDVFAMKLLNKWEMLKRAETACFVEERDVLVHGDSRWITNLHYAFQDDDFLYLVMDYYSG--GDLLTLISKFDDR--
.| |..||.||||.|  .. |... ..|.| ..            .  |...| . .  .| .|...||| |.||.||.| .|  |||...| |   .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPEDMARFYVAEMVLAIDSVHMLRYVHRDIKPDNVLLDKHGHIRLADFGSCLRMLPDNTVMSNVAVGTPDYISPEILRAMEDGKGRYGP-ECDWWSL
   .|| .||||......|..  | .. .|||.||.|.|||.  || ..|||.. ..        .  .|||.|..||.|         ||. .|||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--------GYGKCKCDWWSC

GVCMYEMLFGETPFYAESLVETYGKIMNHKNQFDFPPETEEEVAISEDAKDLILSLIC-SAEARLGRNGLQD----FKDHPFF
|...|||| |..||.   . ... ||.                  |..|||.|  . .   | |..   .       | ||.|
GCILYEMLCGYPPFP--QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MRCK.AA RSK 212-478 35 2.1e-82 280.1 In-house 1-278 (278) Show / Hide 
Range on Protein: 212-478
Range on HMM: 1-278/278
Sequence Identity: 35% (100 aa)

LKIIGRGAFGEVAVVKLK---NSDDVFAMKLLNKWEMLKRAE-TACFVEERDVLVHGD-SRWITNLHYAFQDDDFLYLVMDYYSGGDLLTLISKFDDR--
||  |.|..|.| ... .   ... ..||| |.| .. .|.  |.   .||..| .   .  | .||||||... |||.|.| .||.|.| ..|      
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPEDMARFYVAEMVLAIDSVHMLRYVHRDIKPDNVLLDK---HGHIRLADFGSCLRMLPDNTVMSNVAVGTPDYISPEILRAMEDGKGRYGPECDWWSLG
. || |.|| || |||..  | .  .|||.||.|.|.|    .|||.| ||| |  . .|.. . .  ..| .|. ||.|.  . ..| ..  |||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLG

VCMYEMLFGETPFYA---ESLVETYGKIMNHKNQFDFPPETEEEVAISEDAKDLILSLIC-SAEARLG--RNGLQDFKDHPFF
| |||||.| .||..   ..  |.  .|.. |  |... .  ..  .|..|||||  . .   . |||  ...... |.||.|
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGK--FSLTMPNWQY--LSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MRCK.AA NDR 209-353 52 2.1e-80 247.56 In-house 1-149 (350) Show / Hide 
Range on Protein: 209-353
Range on HMM: 1-149/350
Sequence Identity: 52% (78 aa)

FETLKIIGRGAFGEVAVVKLKNSDDVFAMKLLNKWEMLKRAETACFVEERDVLVHGD--SRWITNLHYAFQDDDFLYLVMDYYSGGDLLT---LISKFDD
|| .||||.|||||| .|. |......||| ..| ||... ..|    |||...  |  ..|.. | |.|||...|||||.|  |||. |   |..|. |
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKM-D

RLPEDMARFYVAEMVLAIDSVHMLRYVHRDIKPDNVLLDKHGHIRLADFG
 ..||.|||| ||||.||.||| . |.|||||||| |.||.||| | |||
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase MRCK.AA Akt 209-478 39 1.8e-76 243.91 In-house 1-264 (264) Show / Hide 
Range on Protein: 209-478
Range on HMM: 1-264/264
Sequence Identity: 39% (110 aa)

FETLKIIGRGAFGEVAVVKLKNSDDVF-AMKLLNKWEMLKRAETACFVEERDVLVHGDSRWITNLHYAFQDDDFLYLVMDYYSGGDLLTLISKFDDRLPE
|. ||..|.|.|| |  || |...... ||| | |   ... . .  . || .|.| ..  |.||||.||. | ||.|||| .||.| ..... . | .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQR-KRRFSE

DMARFYVAEMVLAIDSVHMLRYVHRD-IKPDNVLLDKHGHIRLADFGSCLRM-LPDNTVMSNVAVGTPDYISPEILRAMEDGKGRYGPECDWWS-LGVCM
| ||||.||..|||.  |    . ||  || |.|.||.|||.|.||| | .. . |. ..  .  ||| |..||||    .|.| ..  .|||. ||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTF-CGTPEYLAPEIL----NGNG-HTKAVDWWGSLGCVM

YEMLFGETPFYAESLVETYGKIMNHKNQFDFPPETEEEVAISEDAKDLILSLIC-SAEARLG--RNGLQDFKDHPFF
|||..|  |||..   . . ||.| . .|       .  .|| ..|||| .|     . |||   |..|. |.||.|
YEMMCGRPPFYNQDHHQMFKKIKNQPVKF------PDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase MRCK.AA Pkinase 209-478 27 1.7e-61 215.45 Pfam 1-293 (293) Show / Hide 
Range on Protein: 209-478
Range on HMM: 1-293/293
Sequence Identity: 27% (82 aa)

FETLKIIGRGAFGEVAVVKLKNSDDVFAMKLLNKWEMLKRAETACFV-EERDVLVHGDSRWITNLHYAFQDDDFLYLVMDYYSGG----DLLTLIS-KFD
......||.|.||.|   . |.. ...|.| ..| .  .  . . .   |  .. . ..  |  |...|.|.| .|.||.|  ||    || ..|| . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DRL--PEDMARFYVAEMVLAIDSVHMLRYVHRDIKPDNVLLDKHGHI----RLADFGSCLRM-LPDNTVMSNVAVGTPDYISPEILRAMEDGKGRYGPEC
 ..  .|. ..||. ... ...  |  . .|||.||.|.|.|..|||    ...|||..  . .  |.   .. .|||.|..||..|    |   |||..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIR----GGQYYGPKV

DWWSLGVCMYEMLFGETPFYAE------SLVETYGKIMNHKNQFDFPPETEEE-------------VAISEDAKDLILSLIC-SAEARLGRNGLQDFKDH
|.||.|. .||||.|..||. .      .  . . .||  .. ||.| . ..              ...||..||.| ...|   . |..    .. . |
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQH

PFF
|.|
PWF
Kinase MRCK.AA MAST 209-353 39 5.1e-56 169.31 In-house 1-147 (337) Show / Hide 
Range on Protein: 209-353
Range on HMM: 1-147/337
Sequence Identity: 39% (58 aa)

FETLKIIGRGAFGEVAVVKLKNSDDVFAMKLLNKWEMLKRAETACFVEERDVLVHGDSRWITNLHYAFQD--DDFLYLVMDYYSGGDLLTLISKFDDRLP
||..|.|..||.| |  || |.. | |||| .|.  ....        ||..|.  .  .. .. |.||   .. |..||.| .|||  .|.. .  ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EDMARFYVAEMVLAIDSVHMLRYVHRDIKPDNVLLDKHGHIRLADFG
|.||..|.|| ||...  |    ||||.||||.|.|. ||| |.|||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase MRCK.AA MAST 209-353 40 9.2e-55 174.81 In-house 1-144 (334) Show / Hide 
Range on Protein: 209-353
Range on HMM: 1-144/334
Sequence Identity: 40% (58 aa)

FETLKIIGRGAFGEVAVVKLKNSDDVFAMKLLNKWEMLKRAETACFVEERDVLVHGDSRWITNLHYAFQDDDFLYLVMDYYSGGDLLTLISKFDDRLPED
||. |.|..||.| |  || |.. | |||| ..| .|...  .     ||..|   .. .. .. |.|| .. |..||.| .|||. .|.. .  ...|.
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG-YFDEW

MARFYVAEMVLAIDSVHMLRYVHRDIKPDNVLLDKHGHIRLADFG
||..|.||.||...  |    ||||.||||.|.|. ||| |.|||
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase MRCK.AA NDR 369-478 44 5.7e-53 161.37 In-house 241-350 (350) Show / Hide 
Range on Protein: 369-478
Range on HMM: 241-350/350
Sequence Identity: 44% (51 aa)

AVGTPDYISPEILRAMEDGKGRYGPECDWWSLGVCMYEMLFGETPFYAESLVETYGKIMNHKNQFDFPPETEEEVA-ISEDAKDLILSLIC-SAEARLGR
.||||||. ||..   . |   |...|||||||. |||||.| .||....  ||. |||| |...| |... .. | .|..|.|||  |.|  .. |||.
TVGTPDYMAPEVFQQ-KTG---YNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGS

NG--LQDFKDHPFF
.|   ...|.||||
HGKGVDEIKSHPFF
Kinase MRCK.AA MAST 370-478 40 5.2e-37 110.13 In-house 229-337 (337) Show / Hide 
Range on Protein: 370-478
Range on HMM: 229-337/337
Sequence Identity: 40% (46 aa)

VGTPDYISPEILRAMEDGKGRYGPECDWWSLGVCMYEMLFGETPFYAESLVE-TYGKIMNHKNQFDFPPE--TEEEVAISEDAKDLILSLICSA-EARLG
.||||||.||..     |.| ||.  ||||.|. ||| | |..|| ...  | . ..| ||..   .|.|   ... ..|..|.|||  |       |||
CGTPDYIAPEVIL----GQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLG

RNGLQDFKDHPFF
 || .. | ||||
ANGADEIKQHPFF
Kinase MRCK.AA MAST 370-478 39 4.1e-34 107.11 In-house 225-334 (334) Show / Hide 
Range on Protein: 370-478
Range on HMM: 225-334/334
Sequence Identity: 39% (45 aa)

VGTPDYISPEILRAMEDGKGRYGPECDWWSLGVCMYEMLFGETPFYAESLVETYGKIMNHK-NQFDFPPE--TEEEVAISEDAKDLILSLICS-AEARLG
.||||||.||..     |.| .|.  ||||.|..||| | | .||  ..  |....| |.. |.  .|..   ... |.|..|.|||  |     . |||
CGTPDYIAPEVIL----GQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLG

RN-GLQDFKDHPFF
 | | .. | ||||
ANNGADEVKQHPFF
Kinase MRCK.AA S_TK_X 479-541 25 5e-17 63.81 SMART 1-79 (79) Show / Hide 
Range on Protein: 479-541
Range on HMM: 1-79/79
Sequence Identity: 25% (21 aa)

NDIDWQNIRN----MTPPYVPDVK----SATDTSNFDVDEADLRNSEVLPPSSHAAFTGNHLP----------FLGYTFTR
 .|||....|    ..||..|..|    |.||||||| .. .   .  | | . ... ... .          |.|.|. .
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM--LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase MRCK.AA Pkinase_C 496-543 35 2.7e-11 43.03 Pfam 1-46 (46) Show / Hide 
Range on Protein: 496-543
Range on HMM: 1-46/46
Sequence Identity: 35% (17 aa)

DVKSATDTSNFDVDEADLRNSEVLPPSSHAAFTGNHLPFLGYTFTRNS
 |||.|||||||... | . ..   |..   . |...|| |.|... .
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD
Kinase MRCK.AA TyrKc 209-456 19 1.2e-10 -50.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 209-456
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

FETLKIIGRGAFGEVAVVKLKNSDDVFAMKLLNKWEMLKRAETACFVEERDVLVHG--DSRWITNLHYAFQDD-------DFLYLVMDYYSGGDLLTLIS
 . .|..|.||||||   ..|      | | |..         . | .|  .. .   .   | .|. .  ..       . |..|| | ..|||.  . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KFDDRLPEDMARFYVAEMVLAIDSVHMLRYVHRDIKPDNVLLDKHGHIRLADFGSCLRMLPD-------NTVMSNVAVGTPD-----YISPEILRAMEDG
|  ..|. .    .        .  |  ...|||.   |.|... .... .||| .     |        . ..    |. .       .|| .      
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----N

KGRYGPECDWWSLGVCMYEML-FGETPFYA-----ESLVETYGKIMNHKNQFDFPPE--------TEEEVAI------SEDAKD------LILSL
.|.. .. | || ||||.|.. .|..| .       |  | . ....  .  . ||.          .|.         ||..|      ..  .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
TMF_DNA_bd MRCK.AA TMF_DNA_bd 570-597 31 0.200118 8.12 Pfam 47-75 (75) Show / Hide 
Range on Protein: 570-597
Range on HMM: 47-75/75
Sequence Identity: 31% (9 aa)

AQVESLE-RRINKLETEKTELTNRVSELK
.|...|  ..|.||| |  .|..| .. .
KQISELKHKKIEKLEKEIENLEQRLKRAE
TMF_DNA_bd MRCK.AA TMF_DNA_bd 606-639 20 19.380594 1.02 Pfam 41-75 (75) Show / Hide 
Range on Protein: 606-639
Range on HMM: 41-75/75
Sequence Identity: 20% (7 aa)

EVRRLQEEIKSFK-SRIAASEAESKNTRDSYQAMA
... | ..|.. | ..|. .|.|  | .... .. 
KNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
TMF_DNA_bd MRCK.AA TMF_DNA_bd 792-819 27 0.031098 11.01 Pfam 47-75 (75) Show / Hide 
Range on Protein: 792-819
Range on HMM: 47-75/75
Sequence Identity: 27% (8 aa)

NSVGRAK-PDTDKYEKEVARLKQEMEKKE
... ..|    .| |||...|.|.....|
KQISELKHKKIEKLEKEIENLEQRLKRAE
TMF_DNA_bd MRCK.AA TMF_DNA_bd 836-869 31 2.683799 4.09 Pfam 41-75 (75) Show / Hide 
Range on Protein: 836-869
Range on HMM: 41-75/75
Sequence Identity: 31% (11 aa)

EEKILKEQVNENE-DKIVSMRREITSLQDKLGRLQ
..| | .|..|   .|| .  .|| .|...| | .
KNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
TMF_DNA_bd MRCK.AA TMF_DNA_bd 993-1028 29 0.262296 7.7 Pfam 39-75 (75) Show / Hide 
Range on Protein: 993-1028
Range on HMM: 39-75/75
Sequence Identity: 29% (11 aa)

RSKLRSSEARNTELT-DEVAKLTTSVTELEQQLQELK
|.|.. .|.  .||. ....||. .. .||| | . .
RKKNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
C1_1 MRCK.AA C1_1 1105-1157 34 3.7e-16 62.98 Pfam 1-55 (55) Show / Hide 
Range on Protein: 1105-1157
Range on HMM: 1-55/55
Sequence Identity: 34% (19 aa)

HKFMIT-NFQVPAKCAHCTSLMLG-QSRQGMMCEVCHFACHVACAEKAPSMCPIS
|... . ||  |..|.|| ... |  ..||. |..||. ||  |..|.|..|. .
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 MRCK.AA C1 1105-1154 29 3.7e-16 60.94 SMART 1-61 (61) Show / Hide 
Range on Protein: 1105-1154
Range on HMM: 1-61/61
Sequence Identity: 29% (18 aa)

HKFMITNFQVPAKCAHCTSLMLGQSRQ-----GMMCEVCHFACHVACAEKAPS-------MC
|......|  |..|.|| ... |  .|     |..|..|...||  |..|.|.       ||
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
PH MRCK.AA PH 1175-1295 11 5.7e-12 47.01 SMART 1-82 (82) Show / Hide 
Range on Protein: 1175-1295
Range on HMM: 1-82/82
Sequence Identity: 11% (14 aa)

TAYEGVLRIPKPGGVRKGWMKQFVVVCDFKLFLFDVLDGRASEPTNDISHILDMRDEEFSVSSVLASDVIHAPSKDVPCIFKVSVSQLNPPGLCAQLLLL
. .|| |.. .    . .|.| ..|...  |....           . .......| ....                   |...  .         ... 
VIKEGWLYKKS----K-RWKKRWFVLFNDCLYYYKDK---------KPKGSIPLSDCTVRE-P----------------CFEIHH-DR-------TYYFQ

ADSEAEKRKWVDALNNLQRHL
..|| |...|..|........
CESEEEMQEWMQAIQKAIHNN
PH MRCK.AA PH 1175-1293 15 2.9e-10 39.66 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1175-1293
Range on HMM: 1-92/92
Sequence Identity: 15% (19 aa)

TAYEGVLRIPKPGGVRKGWMKQFVVVCDFKLFLFDVLDGRASEPTNDISHILDMRDEEFSVSSVLASDVIHAPSKDVPCIFKVSVSQLNPPGLCAQLLLL
  .|| |.  .    ||.| | ..|... .|....  .        .  ......| ..   .            . |..|...  .        .... 
VIKEGWLHKKG---KRKSWKKRWFVLFNNCLYYYKDDK-------YRPKGSIPLSDCQVTKVPDN----------KRPHCFQIRT-DR------RTYYFQ

ADSEAEKRKWVDALNNLQR
|.|| |.. |..|.. ..|
AESEEEMNDWMQAIQSACR
CNH MRCK.AA CNH 1324-1587 20 1.6e-66 232.09 Pfam 1-336 (336) Show / Hide 
Range on Protein: 1324-1587
Range on HMM: 1-336/336
Sequence Identity: 20% (68 aa)

CADIVDASRFVIG-TEDGLYTVEI---SSGFIVRVDRKQ----IHQVRVLKDEQLVIVI--SGRGRHLRLFPIACLDGEA----TVI-------------
.. . .  .  .| |..|||...|   .  .  . ...     ..|. |.......|.|  .....||...|. .||.       ..             
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRIERI

---------KVEEPRGCTMFTTGIIRQGSTTCMCVAMKR-----TVLIYEFNRNKGRH-------------KRIKE-VTLP----APAQCMEVF---GGR
         |... ..|..|...  ..  ..|.|.|.||     |...||..... ..             . ..| . .|    .....|...     .
MPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLPQEKPK

LCAGYTSGFGLFSIQMQGQHVEPLLNIDDPSLRFLIEI-----PTEALAAVQISER-EYLLCFSTLGVYVDYQGR-RTR--EQELMWPSHPTEIAFNSPY
|| |...|| . ... .||. . |.. .|.|.  . ..       .......|..  |.|||.. ..|||. ||. |.|   .|.||...|...|...||
LCVGCQKGFHIVNLDGTGQP-WWLHDPADHSV--QQDFMARRENCKPICMHRINDDEEFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQSFACCYPY

LIVYSDISVDIYDIGIM-EW---VQTIPIKGTRQLSWDG
|..... ...| ..  . ||   ||.|| .  | |  ..
LLAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS
CNH MRCK.AA CNH 1319-1595 18 4.6e-24 87.18 SMART 1-375 (375) Show / Hide 
Range on Protein: 1319-1595
Range on HMM: 1-375/375
Sequence Identity: 18% (69 aa)

VKVTHCADIVDAS----RFVIGTEDGLYTVEISS--------GFIVRVDRKQIHQVRVLKDEQLVIVISGRGRHLRLFPIACL-----------------
 ... |..| ..       ..|||.|.|. .|.         ...  . |. . .. |........ |||. .||. .|.  |                 
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

-----DGEATVI--KVEEPRG-CTMFTT-GIIRQGSTTCMCVAMKRTVLIY-EFNRNKGRHKRIKE--------------------VTLPAPAQCMEVFG
     ..   |.  |... .| |  ..  . . ..  .. |.||. .| || .  .   ... .|                     ...| ..   . . 
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

--GRLCAGYTS--GFGLFSIQMQGQHV----------EPLLNIDDPSLRFLIEIPT------EALAAVQISE------REYLLCFSTLGVYVDYQG---R
    .| | ..  | |  ...|   |           | ..| .|.|| |... ..      ......|. .       .||||.   ||.|. .|   |
ERPWICIGCDKPVG-GMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWR

RTREQELMWPSHPTEIAFNSPYLIVYSDISVDIYDIGIMEW-VQTIP------IKGTRQLS----WDGSLNLSFVT
|.| ..|.|. .|.. |. .||... .| ...|..|   || .|.|       ... | |.     |.   ..   
RWRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
PBD MRCK.AA PBD 1649-1684 31 1.9e-05 25.38 SMART 1-38 (38) Show / Hide 
Range on Protein: 1649-1684
Range on HMM: 1-38/38
Sequence Identity: 31% (12 aa)

ISAPS-NFSHITHMGPGDS-LSKLQDIPGAESKPVRIK
||.|. || ||.|.||.|   ......|   .. .  .
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC