Gene PDK1 (Sea Urchin)

PDK1

Species: Sea Urchin
Alias: PDK1, Spk014, SPU_023401
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: PDK1

Sequence

Name Sequence Type Origin Length Description Download
PDK1.AA Protein None 731 None Fasta, JSON
PDK1.kin_dom Protein Kinase Domain None 264 None Fasta, JSON

Protein domain

Protein domains of PDK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PDK1.AA PDK1 276-539 55 1.4e-213 661.4 In-house 1-307 (307) Show / Hide 
Range on Protein: 276-539
Range on HMM: 1-307/307
Sequence Identity: 55% (171 aa)

FRFGTILGEGSYSEVVLATEIAT----GNQYAIKVLEKRHIIREKKEKYVLREKEVLSRLD-----HPFFVRLYFTFQDNYKLYFGLSLAKRGELLPYIK
|.||...||||||.|.||.|..|    ...||||..|||.|||||| ||| ||||....|.     ||..|.|||||||...|||.|.....|.||.|.|
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK

K--LGSFDESSSRFYTSEIILALEYLHSMGIIHRDLKPENILLNEKMHIQITDFGTA---KIIGA---------------DDKKEG------QPRAKSFV
|  .||||....|||..|||.|||.|||.||||||||||||||...|||.|||||||   ||. .               ..|...      |.|.||||
KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKILPEYQSQQQNQFQQQFQQHNKGMDKPEEDKQTRCKSFV

GTAQYVSPELLTEKSATKSSDLWALGCIVYQLQAGLPPFRAS-----NEYMIFQKIIKLEYDFPDG--FSQTARDLVSKLLVIDPSKRLG-CDECGGYPA
|||.||||||||.|..|.|.|.||||||.||..||.||||..     |||..||||.|..|||||.  |...|.|||.||||.||..||. |||||||..
GTAEYVSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTFQKIMKCQYDFPDNFRFPPCAKDLVKKLLVRDPNDRLTSCDECGGYQQ

LKAHPFL
.||||| 
IKAHPFF
Kinase PDK1.AA AGC 276-539 30 3.4e-158 412.57 In-house 1-395 (395) Show / Hide 
Range on Protein: 276-539
Range on HMM: 1-395/395
Sequence Identity: 30% (123 aa)

FRFGTILGEGSYSEVVLATEI------ATGNQYAIKVLEKRH-IIREK--KEKYVLRE------------KEVLSRLD----------HPFFVR-LYFTF
|.| ...|.||...| |. .       .|| .||.|||.|.| |.. |  .......|            ...|....          ||| |. |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDNYK--LYFGLSLAK---------RG-ELLPYIK---KLGSFDESSSRFYTSE-------IILALEYLHS-MGIIHRD-LKPENILLNEKMHIQITDFG
||. .  ||| . ...          | ||. ...   | |.|||. .|||..|       |.|||||||| ||||||| ||||||||.|. || .||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TAKIIGADDKK---------------------------------------------EGQPRAKSFVG--TAQYVSPELLTEKSATKSSDLWA--LGCIVY
 .|..  |. |                                             ... |...|.|  |..|..|| |     .|. | |.  |||. |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

QLQAGLPPFRASN----------EYMIFQKII--------KLEYDFP--------DGFSQTARDLVSKLLVIDPSKRLGCDECG----GYPALKAHPFL
.. .|.|||.. |          .. .||||.        |....||        . ||. |.||..|||. ||.||||| . .    |.  .|.||. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PDK1.AA S_TKc 276-539 35 1.4e-96 328.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 276-539
Range on HMM: 1-231/231
Sequence Identity: 35% (97 aa)

FRFGTILGEGSYSEVVLATEIATGNQYAIKVLEKRHIIREKKEKYVLREKEVLSRLDHPFFVRLYFTFQDNYKLYFGLSLAKR--GELLPYIKKLGS---
.... ..|.|....| ..... || ..|||..           . ..|| ..|.. .||. |.|| .|||  .||. . ..    |.|. |||| |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDESSSRFYTSEIILALEYLHSMGIIHRDLKPENILLNEKMHIQITDFGTAKIIGADDKKEGQPRAKSFVGTAQYVSPELLTEKSATK-SSDLWALG
   |.|   |||. .|..||||.||.||||||||||||||.|  || |.||| |...            ..|.||  |..||.|   . .| ..| |..|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

CIVYQLQAGLPPFRASNEYMIFQKIIKLEYDFPDGFSQTARDLVSKLLVIDPSKRLGCDECGG-YPALKAHPFL
||.| . .| |||.  ...|.|.||           |. |.|...|.|. ||.||... |.     . |.||..
CILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PDK1.AA AktR 276-539 38 1e-87 297.74 In-house 1-268 (268) Show / Hide 
Range on Protein: 276-539
Range on HMM: 1-268/268
Sequence Identity: 38% (108 aa)

FRFGTILGEGSYSEVVLATEI-ATGNQYAIKVLEKRHIIREKKEKYVLREKEVLS-RLDHPFFVRLYFTFQDNYKLYFGLSLAKRGELLPYIKKLGSFDE
|..  .||.| ...|.|...   .. |||.|.. | .||..........|. ..    .|||.|.|...||...||.| ..  ..|||. ..|| . |.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

SSSRFYTSEIILALEYLHSM-GIIHRDLKPENILLNEKMHIQITDFGTAK--IIGADDKKEGQPRAKSFVGTAQYVSPELLTE-KSATKSSDLWALGCIV
. .||| ..|.|||||||.   || |||||||||| |  |. ||||| .|  .. ..| |     |.||.|| .|..|| .|. |  .||.|.||.|. .
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEK-----AYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFI

YQLQAGLPPFRASNEYMIFQKIIKLE-YDFPDG--FSQTARDLVS-KLLVIDPSKRLG-----CDECGGYPALKAHPFL
| . .|.||| ..|   .||||.. .   ||.   ||....||.  |||  .| ||||      .|      .| ||. 
YEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEE------IKSHPWF
Kinase PDK1.AA Akt 276-539 40 3.2e-85 272.35 In-house 1-264 (264) Show / Hide 
Range on Protein: 276-539
Range on HMM: 1-264/264
Sequence Identity: 40% (109 aa)

FRFGTILGEGSYSEVVLATEIATGNQY-AIKVLEKRHIIREKKEKYVLREKEVLSRLDHPFFVRLYFTFQDNYKLYFGLSLAKRGELLPYIKKLGSFDES
|.|  .|| ||.  |.|. . .|.. | |.||| |..||  .. .... |. .| . .||| | |.. ||.. |||| .  .. |||  .... . |.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

SSRFYTSEIILALEYLHSMGIIHRD-LKPENILLNEKMHIQITDFGTAK-I-IGADDKKEGQPRAKSFVGTAQYVSPELLTEKSATKSSDLWA-LGCIVY
  ||| .|||||.|.|||..|| || |||||||. .. || .|||| .| . |  .||      .|.| ||. | .|| |  . .||..| |. |||. |
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDK------TKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMY

QLQAGLPPFRASNEYMIFQKIIKLEYDFP--DGFSQTARDLVSKLLVIDPSKRLGCDECGGYPALKAHPFL
 .  |.||| . .    |.||   .. ||  | .|. ..||.|.||  ||.||||    ..   .|.||..
EMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGG-GPNDAQEIKRHPWF
Kinase PDK1.AA PKA 276-524 40 7.6e-85 288.18 In-house 1-249 (263) Show / Hide 
Range on Protein: 276-524
Range on HMM: 1-249/263
Sequence Identity: 40% (105 aa)

FRFGTILGEGSYSEVVLATEIATGNQYAIKVLEKRHIIREKKEKYVLREKEVLSRLDHPFFVR-LYFTFQDNYKLYFGLSLAKRGELLPYIKKLGSFDES
| . . || ||.  | |. .  .|| ||.|.| |. |.|.| .  |. || .|. ..||| |. .|.||||. .||. . ..  ||.  |. | |.|...
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

SSRFYTS-EIILALEYLHSMGIIHRDLKPENILLNEKMHIQITDFGTAKIIGADDKKEGQPRAKSFVGTAQYVSPELLTEK-SATKSSDLWALGCIVYQL
 ..||   .|.||||||||. ||.|||||||||.... ||.||||| || .      ..  | ..  || .|  || .. |    || | ||||...| .
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKV------DD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEM

QAGLPPFRAS--NEYMIFQKIIKLEYDFPDGFSQTA---RDLVSKLLVIDPSKRLGC
 || |||...  .   |..||.. ...||  |.. |   .||..|||. |..||.|.
LAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGN
Kinase PDK1.AA CAMK 281-539 23 6.3e-84 270.21 In-house 1-425 (425) Show / Hide 
Range on Protein: 281-539
Range on HMM: 1-425/425
Sequence Identity: 23% (101 aa)

ILGEGSYSEVVLATEIATG------------NQYAIKVLEKRHII-------------------------REKKEKYVLREKEVLSR-------LDHPFF
.||.||...| |.... |.             ..|||...|. .                          |.|..| |.|| |....       ||||  
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLYFTFQD-------------------NYKLYFGL---SLAKRGEL----LPYIKKLGS---------------FDESSSRFYTSEIILALEYLHSMGI
..|| ...|                   . ..|. .    ..  |||    . ||.. |.               |.|.  |.|   |. |..|.||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPENILLNEKM-----------------HIQITDFGTAKIIGADD-------KKEGQPRAKS-------------FVGTAQYVS-PELLTEKS--
.|||||||||||....                  | |.||| |...  ..       .|.|.   ..             |.||  |.. ||.|  |.  
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------------ATKSSDLWALGCIVYQLQAGLPPFRAS-------------NEYMIFQKIIKLEYDFPDG------------------------FSQTA
             ....| |..|.| | .  | |||...             |.| .|.||.| .||||.                         .|| .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

RDLVSKLLVIDPSKRLGCDECGGYPALKAHPFL
.||..|.|. ||.||. ...|      ..||..
KDLIRKMLQVDPEKRMTIEQC------LNHPWM
Kinase PDK1.AA RSK 276-539 35 1.6e-83 283.77 In-house 1-278 (278) Show / Hide 
Range on Protein: 276-539
Range on HMM: 1-278/278
Sequence Identity: 35% (100 aa)

FRFGTILGEGSYSEVVLATEIATGNQYAIKVLEKRHIIREKK-EKYVLREKEVLSRLD-HPFFVRLYFTFQDNYKLYFGLSLAKRGELLPYIKKLGS---
 .  . .| |... .   |  .|| .|| |||.|. |.. .|  .....| ..|.|   ||| |.|. .||.. |||  . . . |||.  ..| ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDESSSRFYTSEIILALEYLHSMGIIHRDLKPENILLNE---KMHIQITDFGTAKIIGADDKKEGQPRAKSFVGTAQYVSPELLT---EKS-ATKSSDLW
|.|.  .|| .||.||.|.||. |||||||||||||...     || .|||| .|.  .|...    ....|..|..|. ||.|.    ..  .|. |.|
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQ----WTMTFCYTIEYMAPEMLKRANQQGGHDKACDWW

ALGCIVYQLQAGLPPFRA---SNEYMIFQKIIKLE--YDFP--DGFSQTARDLVSKLLVIDPSKRLGCDECGGYPALKAHPFL
 ||.. | . .| |||..   .|   |...| | .   ..|  .  ||.|.||..|.|  ||.|||||   ..   .|.||..
SLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGP-QDAEEIKQHPWF
Kinase PDK1.AA SGK 276-539 35 2.1e-82 254.24 In-house 1-283 (283) Show / Hide 
Range on Protein: 276-539
Range on HMM: 1-283/283
Sequence Identity: 35% (104 aa)

FRFGTILGEGSYSEVVLATEIAT------------------GNQYAIKVLEKRHII-------REKKEKYVLREK-EVLSRLDHPFFVRLYFTFQDNYKL
|.| ...|.||. .| ..   ..                  .  ||.||| | |||       . |..|... |.  .|. . ||| | | . ||   ||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YFGLSLAKRGELLPYIKKLGSFDESSSRFYTSEIILALEYLHSMGIIHRDLKPENILLNEKMHIQITDFGTAK-IIGADDKKEGQPRAKSFVGTAQYVSP
|| .  .  ||.  .... ..| |. .|||..||..|||||||  ||.||||||||||  . |. .|||| .|  | . |.       ..| ||  |  |
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDT------TFTFCGTPEYLAP

ELLTEKSATKSSDLWALGCIVYQLQAGLPPFRASNEYMIFQKIIKLEYDFPDGFSQTARDLVSKLLVIDPSKRLGCDECGGYPALKAHPFL
| |  .   .. | | |||. | .  |||||   |    ...||. .  .| ..| .|.||   ||  ||.||||  .  .    | ||| 
EVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKR--DFMEIKNHPFF
Kinase PDK1.AA Pkinase 276-539 28 2.1e-81 281.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 276-539
Range on HMM: 1-293/293
Sequence Identity: 28% (88 aa)

FRFGTILGEGSYSEVVLATEIATGNQYAIKVLEKRHIIREKKEKYVL-REKEVLSRLDHPFFVRLYFTFQDNYKLYFGLSLAKRG----ELLPYIK--KL
...| ..|.||...| ..... || ..|.|...|||.  .|..  .. .| ... ||.||. |||| .|.|. ..|. . ..  |    .|  ||.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GSF--DESSSRFYTSEIILALEYLHSMGIIHRDLKPENILLNEKMHI----QITDFGTAKIIGADDKKEGQPRAKSFVGTAQYVSPELLT-EKSATKSSD
|.|  .|   .||  .|. .|||.||||||||||||||||.....||     |.||| || .        .. ...|.||  |..||..   .  ....|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

LWALGCIVYQLQAGLPPFRAS------NEYMIFQKIIKLEYDFPDGFS---------------------QTARDLVSKLLVIDPSKRLGCDECGGYPALK
 |..|||.|..  | |||. .      ... ....| . ...|.   .                     ....|.....|  ||.||..       . ..
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT------AEQIL

AHPFL
 ||..
QHPWF
Kinase PDK1.AA RSK-Unclassified 276-539 36 1.9e-79 249.09 In-house 1-283 (283) Show / Hide 
Range on Protein: 276-539
Range on HMM: 1-283/283
Sequence Identity: 36% (103 aa)

FRFGTILGEGSYSEVVLATEIATGNQYAIKVLEKRHIIREKKEKYVLREKEVLSRLDHPFFVRLYFTFQDNYKLYFGLSLAKRGELLPYIK--KLGSFDE
|     .| |.  .| |  .  |   ||.|||.|  .|| .| |||. |.....  .||| |.||. || . .||  .     |..       |   | |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

SSSRFYTSEIILALEYLHSMGIIHRDLKPENILLNEKMHIQITDFGTAKIIGADDKKEGQP-----------------RAKSFVGTAQYVSPELLTEKSA
   ||| ||...||||||  ..| |||||.||.|    |.  |||.   | . | ||                     |..||.||  |. ||..     
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLS-IQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGH

TKSSDLWALGCIVYQLQAGLPPFRASNEYMIFQKIIKLEYDFP--DGFSQTARDLVSKLLVIDPSKRLGCDECGGYPALKAHPFL
||  | | || ..| .  |.||... |.  .|. | | .  ||     |...|||. |||   |.|||||   |     |.||| 
TKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKM-GDADDIKRHPFF
Kinase PDK1.AA Ciliate-E2 276-539 24 5.2e-79 268.8 In-house 1-365 (365) Show / Hide 
Range on Protein: 276-539
Range on HMM: 1-365/365
Sequence Identity: 24% (93 aa)

FRFGTILGEGSYSEVVLATEIATGNQ-----------------------YAIKVLEKRHIIREKKEKYVL----------REKEVLSRLDHPFFVRLYFT
. |  ..|.|... | ... . ...|                       ||.|...|. |.  |.|....           ||..|..|.||. ...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DNYKLYFGLSLAKRGELLPYIK-------------------KLGSFDESSSR-------FYTSEIILALEYLHSMG-IIHRDLKPENILLNEKMHI
||  |. ..|. . ... |.|. |||                   . . . .   .       ||  .|||||||||| . |||||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

QITDFGTAKIIGAD-----------DKKEGQ----------------PRAKSFVGTAQYVSPELLTEKS---------ATKSSDLWALGCIVYQLQAGLP
 |.|||..|..  |            ... .                  .....||. |..|| |  |.          ....|.|.||.| |..  | |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFRASNEYMIFQKIIKLEYDFP------------------DGFSQTARDLVSK----LLVIDPSKRLGCDECGGYPALKAHPFL
||        .|.|.. ..|||                  .  || . || .|    .|. ||.||..     |.  .. ||..
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT-----GWEQILNHPWF
Kinase PDK1.AA TyrKc 276-533 21 2.2e-13 -6.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 276-533
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FRFGTILGEGSYSEVVLATEIATGNQYAIKVLEKRHIIREKKEKYVLREKEVLSRL--DHPFFVRLYFTFQDN-------YKLYFGLSLAKRGELLPYIK
 ..| .|||| . ||...| .    | |.|.| . .      ..  .|| .....|  .||  ||||    .          |.  . ... | |. |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KLGS-FDESSSRFYTSEIILALEYLHSMGIIHRDLKPENILLNEKMHIQITDFGTAKIIGAD--------DKKEGQPRAKSFVGTAQYVSPELLTEKSAT
| .  .  .    .   |    |||||...|||||   |.|..|. .. |.||| .. |. |         ..  . . . ..      .|| . ..  |
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KSSDLWALGCIVYQL--QAGLPPFR-----ASNEYMIFQKIIKLEYDFPDG--------FSQTARDLVSKLLVIDPSKRLGCDECGGYPAL
  || |. |   . .    . |.        ||. .| .       . |.          ..   .. ..    ||..|    |.  .  .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase PDK1.AA Pkinase_Tyr 386-419 47 9.4e-07 23.49 Pfam 123-156 (270) Show / Hide 
Range on Protein: 386-419
Range on HMM: 123-156/270
Sequence Identity: 47% (16 aa)

ALEYLHSMGIIHRDLKPENILLNEKMHIQITDFG
..|||.|...|||||   |.|..|.... |.|||
GMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase PDK1.AA Pkinase_Tyr 276-340 30 0.002378 11.97 Pfam 1-70 (270) Show / Hide 
Range on Protein: 276-340
Range on HMM: 1-70/270
Sequence Identity: 30% (22 aa)

FRFGTILGEGSYSEVVLATEI----ATGNQYAIKVLEKRHIIREKK--EKYVLREKEVLSRL-DHPFFVRLY
 .||  ||||.. ||...|       |. . |.|.|  ..   ..    .  .|| .... | .||  ||||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
PDK1_PH PDK1.AA PDK1_PH 626-725 55 3.3e-64 219.61 In-house 1-112 (112) Show / Hide 
Range on Protein: 626-725
Range on HMM: 1-112/112
Sequence Identity: 55% (62 aa)

NKWHRFV--EGNLILKNGWVDKRKGLFA----RRRMLLLTEGPHLYYVDPENMVLKGEIPWS-PQLKVEAK-----NFKTYFVHTPNRTYYLIDPESDAV
..||.|.  ||..||| |||.|||||||    .||.|.||.||.|.|||| .||.||||||| ..|.||.|     |||..|.||||||||..||...| 
TPWHQFLMPEGEHILKCGWVYKRKGLFAKPKKKRRQLILTDGPRLFYVDPMTMVIKGEIPWSSKDLYVEYKPDRKNNFKHFFIHTPNRTYYFEDPKGCAN

EWCQAIKEMYRH
.||.|| .....
KWCEAIEKVCKR