Gene PRKX (Sea Urchin)

PRKX

Species: Sea Urchin
Alias: PRKX, SPU_020398, Spk012
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: PKA

Sequence

Name Sequence Type Origin Length Description Download
PRKX.AA Protein None 237 None Fasta, JSON
PRKX.kin_dom Protein Kinase Domain None 181 None Fasta, JSON

Protein domain

Protein domains of PRKX.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PRKX.AA PKA 1-181 65 3.1e-143 482.17 In-house 77-263 (263) Show / Hide 
Range on Protein: 1-181
Range on HMM: 77-263/263
Sequence Identity: 65% (123 aa)

MLLEYACGGELFTYLRNSGRFNNDTGKFYAM-EIISAIDYLHKETIVYRDLKPENILLDSEGHVKLTDFGFAKKLVDNRTWTLCGTPEYLAPEIIQSK-G
|..||..|||.|.|||.||||.|...||||. .|..|..|||.. |.||||||||||.|..||.|.||||||||..| |||||||||||||||||||| |
MVMEYVPGGEMFSYLRKSGRFSNPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD-RTWTLCGTPEYLAPEIIQSKNG

HGKAVDWWALGILIYEMLAGYPPFYDE--NPFGIYEKILACKIDWPQSIGSKP---KKLIEGLLVIDRTKRLGCMRAGSNDIKNSDWF
|||.||||||||||||||||||||||.  .|..|||||...||..|... |.    | ||. ||. |.|||.|.|..|.|||||  ||
HGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase PRKX.AA AGC 1-181 33 1.3e-129 336.96 In-house 110-395 (395) Show / Hide 
Range on Protein: 1-181
Range on HMM: 110-395/395
Sequence Identity: 33% (97 aa)

MLLEYAC---------GG-ELFTYLR---NSGRFNNDTGKFYAME-------IISAIDYLHK-ETIVYRD-LKPENILLDSEGHVKLTDFGFAKKLVD--
...||..         || |||..|.   ..|||. .. .||| |       |..|..|||.   |..|| |||||||||..||.||||||..|....  
FVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDG

--------------------------------------------------NRTWTLCG--TPEYLAPEIIQSKGHGKAVDWWA--LGILIYEMLAGYPPF
                                                  .||||.||  ||||.||||.    .|||.|||.  ||.|.||||.|||||
EKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPF

YDEN----------PFGIYEKIL------ACKIDWP----------QSIGSKPKKLIEGLLVIDRTKRLGCMRA-----GSNDIKNSDWF
|..|          |. ...||.       .|. .|          ... .  | ||..||. |..|||||..      | ..|||  ||
YGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PRKX.AA SGK 1-181 45 6.1e-93 287.34 In-house 102-283 (283) Show / Hide 
Range on Protein: 1-181
Range on HMM: 102-283/283
Sequence Identity: 45% (83 aa)

MLLEYACGGELFTYLRNSGRFNNDTGKFYAMEIISAIDYLHKETIVYRDLKPENILLDSEGHVKLTDFGFAKKLV--DNRTWTLCGTPEYLAPEIIQSKG
. ..|. |||.| .|.  ..|  |  .||| ||..|..|||.  |.||||||||||||..||..||||| .|  .   . | | ||||||||||... ..
FVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQP

HGKAVDWWALGILIYEMLAGYPPFYDENPFGIYEKILACKIDWPQSIGSKPKKLIEGLLVIDRTKRLGCMRAGSNDIKNSDWF
|...|||| ||.. |||. | ||||. |    |..|.  ..  |... .. . ||.|||  |..||||  .... .|||  .|
HDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLG-TKRDFMEIKNHPFF
Kinase PRKX.AA Akt 3-181 47 1.4e-91 293.02 In-house 79-264 (264) Show / Hide 
Range on Protein: 3-181
Range on HMM: 79-264/264
Sequence Identity: 47% (89 aa)

LEYACGGELFTYLRNSGRFNNDTGKFYAMEIISAIDYLHKETIVYRD-LKPENILLDSEGHVKLTDFGFAKKL-VDN--RTWTLCGTPEYLAPEIIQSKG
..|. |||||..|.  .||. |. .||. |||.||..||.  |.||| |||||||.|..||..||||| .|.  . .  .| |.|||||||||||.. .|
MDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNG

HGKAVDWWA-LGILIYEMLAGYPPFYDENPFGIYEKILACKIDWP--QSIGSKPKKLIEGLLVIDRTKRLGCMRAGSNDIKNSDWF
|.||||||. ||...|||. | ||||...    ..||. ...  |    |  . | ||.|||  |..||||    . ..||.  ||
HTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PRKX.AA AktR 2-181 46 2.3e-85 289.92 In-house 79-268 (268) Show / Hide 
Range on Protein: 2-181
Range on HMM: 79-268/268
Sequence Identity: 46% (88 aa)

LLEYACGGELFTYLRNSGRFNNDTGKFYAMEIISAIDYLHKE-TIVYRDLKPENILLDSEGHVKLTDFGFAK--KL--VDNRTWTLCGTPEYLAPEIIQS
..|| .|||||..|.....|.... .||. .|. |..|||..  |.||||||||||||..||||.|||| .|  .    | .. ..||||||.|||.|. 
IMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITK

-KGHGKAVDWWALGILIYEMLAGYPPFYDENPFGIYEKILACK-IDWPQS--IGSKPKKLIE-GLLVIDRTKRLGCMRAGSNDIKNSDWF
 |||.|.|||||.||.||||..|.||||..|   ...||. .  .  |..  . |. |.||. .||  . .||||  ..|  .||.  ||
KKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PRKX.AA RSK 1-181 43 1.1e-78 267.75 In-house 78-278 (278) Show / Hide 
Range on Protein: 1-181
Range on HMM: 78-278/278
Sequence Identity: 43% (88 aa)

MLLEYACGGELFTYLRNSGR---FNNDTGKFYAMEIISAIDYLHKETIVYRDLKPENILLDS---EGHVKLTDFGFAKK-LVD--NRTWTLCGTPEYLAP
. .||  |||||| |.. ..   |  |. .||. ||..|...||.  |..|||||||||.|.   |||.|||||||.|.   |  ..| | |.| ||.||
LIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAP

EIIQ----SKGHGKAVDWWALGILIYEMLAGYPPFYD---ENPFGIYEKILACK--IDWP--QSIGSKPKKLIEGLLVIDRTKRLGCMRAGSNDIKNSDW
|..      .||.||.||| ||.|.||||.|.|||.    .|.  | ..|. .|   . |  |..    | || ..|  |  ||||| . . ..||.. |
EMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPW

F
|
F
Kinase PRKX.AA PKG 1-181 50 2.1e-73 250.2 In-house 77-260 (260) Show / Hide 
Range on Protein: 1-181
Range on HMM: 77-260/260
Sequence Identity: 50% (92 aa)

MLLEYACGGELFTYLRNSGRFNNDTGKFYAMEIISAIDYLHKETIVYRDLKPENILLDSEGHVKLTDFGFAKKLVDNR-TWTLCGTPEYLAPEIIQSKGH
||.|   |||| | ||  |.| ..| .||.  .. | ||||.  |.||||||||..|| .| .|| |||||||.  .| ||| |||||| |||||  |||
MLMEACMGGELWTILRDRGHFDDKTTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGH

GKAVDWWALGILIYEMLAGYPPFYDENPFGIYEKILAC--KIDWPQSIGSKPKKLIEGLLVIDRTKRLGCMRAGSNDIKNSDWF
  .||.||||||..| | | |||   .|  .|  ||    ....|  |. .....|  |     | |||  . | ||||   ||
DRSVDYWALGILMCELLTGNPPFSGSDPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase PRKX.AA p70 2-181 43 1.3e-70 240.93 In-house 106-299 (299) Show / Hide 
Range on Protein: 2-181
Range on HMM: 106-299/299
Sequence Identity: 43% (84 aa)

LLEYACGGELFTYLRNSGRFNNDTGKFYAMEIISAIDYLHKETIVYRDLKPENILLDSEGHVKLTDFGFAKKLV--DNR----------TWTLCGTPEYL
.|||  |||||. |   | .  || .||. ||| |. .||.  |.||||||||..|.. |||.|||||  |. .  .            |.|.|||.|| 
ILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCGTIEYM

APEIIQSKGHGKAVDWWALGILIYEMLAGYPPFYDENPFGIYEKILACK--IDWPQSIGSKPKKLIEGLLVIDRTKRLGCMRAGSNDIKNSDWF
||||.  .||..|||||.||.|.| || | |||  ||.  . .||| .|  .  |       . ||  ||  . |.|.|       ||.   .|
APEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase PRKX.AA PKC 3-181 40 2.2e-67 217.43 In-house 79-262 (262) Show / Hide 
Range on Protein: 3-181
Range on HMM: 79-262/262
Sequence Identity: 40% (74 aa)

LEYACGGELFTYLRNSGRFNNDTGKFYAMEIISAIDYLHKETIVYRDLKPENILLDSEGHVKLTDFGFAKKLV--DNRTWTLCGTPEYLAPEIIQSKGHG
.||  || |     ...||.    .||| |||.|  .||.  |.||||| .|.|||.|||.|..||| .|  .  ...| | ||||.|.||||.| .  |
MEYVNGGDLMFHIQQQRRFKEEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYG

KAVDWWALGILIYEMLAGYPPFYDENPFGIYEKILACKIDWPQSIGSKPKKLIEGLLVIDRTKRLGCMRAG---SNDIKNSDWF
|.|||||.|.| |||.|| .||  |.   . . |.  ..  | ..  . .....|..  . .|||||....   ..||.    |
KSVDWWAFGVLMYEMMAGQSPFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PRKX.AA Pkinase 1-181 30 1.2e-65 229.24 Pfam 77-293 (293) Show / Hide 
Range on Protein: 1-181
Range on HMM: 77-293/293
Sequence Identity: 30% (69 aa)

MLLEYACGG----ELFTYLR--NSGRF--NNDTGKFYAMEIISAIDYLHKETIVYRDLKPENILLDSEGHV----KLTDFGFAKK--LVDNRTWTLCGTP
| .||. ||    .||.|..  ..|.|    .. |||. .|.....|.|.. |..|||||||||.|..||.    |..|||.||.  .  |...|.||||
MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTP

EYLAPEIIQ-SKGHGKAVDWWALGILIYEMLAGYPPFYDE------NPFGIYEKILACKIDWPQSIG---------------------SKPKKLIEGLLV
.|.|||.|. ....|..||.|..|...|||| |.|||...      ..  ....|. ...... .                       .  |..|...| 
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

IDRTKRLGCMRAGSNDIKNSDWF
 | .||..       .|....||
KDPKKRPT-----AEQILQHPWF
Kinase PRKX.AA RSK 1-181 39 3.7e-61 209.48 In-house 78-271 (271) Show / Hide 
Range on Protein: 1-181
Range on HMM: 78-271/271
Sequence Identity: 39% (77 aa)

MLLEYACGGELFTYLRNSGRFNNDTGKFYAMEIISAIDYLHKETIVYRDLKPENILLDSE----GHVKLTDFGFAKKLVDN--RTWTLCGTPEYLAPEII
| .. . ||.||. | . . |  .  |||. || .| .|||.  ||.|||||||||.|.|    ||.|..||||||.| |    . | |.| .|.|||..
MIMDFMRGGDLFDRLLKQKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVL

QSKGHGKAVDWWALGILIYEMLAGYPPFYDENPFGIYEKILACKIDW-------PQSIGSKPKKLIEGLLVIDRTKRLGCMRAGSNDIKNSDWF
  .||..|.||| .|.| ||||.|..||.  .     ..|.  |          ...|    | |. ..| .| ..|||. . | ..||. .||
KRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase PRKX.AA S_TKc 2-181 29 5e-41 143.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 2-181
Range on HMM: 1-231/231
Sequence Identity: 29% (74 aa)

L----------------------------------------------------------------LEYACG--GELFTYLRNSGR------FNNDTGKFY
                                                                 .||. |  |.||.|... ||      |.  . .||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

AMEIISAIDYLHKETIVYRDLKPENILLDSEGHVKLTDFGFAKKLVDNRTWTLCGTPEYLAPEIIQSKGHGK-AVDWWALGILIYEMLAGYPPFYDENPF
. .|..|..|.|.  |..|||||||||||.  |.|..|||.|..|      |.||||.|.|||..   |.|| ..|||..|...||||.|||||.  ...
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQ

GIYEKILACKIDWPQSIGSKPKKLIEGLLVIDRTKRLGCMRAGS--NDIKNSDWF
 ...||.           .  | .|...|. | .||...  |     |||.  ||
MMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PRKX.AA S_TK_X 182-237 22 1.5e-18 68.89 SMART 1-79 (79) Show / Hide 
Range on Protein: 182-237
Range on HMM: 1-79/79
Sequence Identity: 22% (18 aa)

ESIDWENVRQ--RQLKPPIVPKLS----HAGDTSNFD-EYPEENWETDASPVKS------------------DVLKLFKDF
 .|||.....  ....||..||..    ...|||||| |..|| .   ..|. .                  . . ....|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM--LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PRKX.AA TyrKc 2-175 13 4e-06 -124.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 2-175
Range on HMM: 1-280/280
Sequence Identity: 13% (38 aa)

L---------------------------------------------L-------------------------------EYACGGELFTYLRNSGR-FNND
.                                             |                               ||...| |  |||.... ....
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

TGKFYAMEIISAIDYLHKETIVYRDLKPENILLDSEGHVKLTDFGFAKKLVDN-------RTWTL----CGTP----EYLAPEIIQSKGHGKAVDWWALG
.   ..  | .  .|||.  .. |||   |.|......|| .||| .... |         . .     .|        .||| |. .    . | |. |
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG

ILIYEMLA-GYPPFYD-----ENPFGIYEKILACKIDWPQSIGS------KPKKLIEGLL---VIDRTKRLGCMRAGSNDI
....|..  | .| ..      ... ..|.. . .   .   .        |... .  .     |  .|  ....   ..
VCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-TFSEIHECF