Gene PKCa (Sea Urchin)

PKCa

Species: Sea Urchin
Alias: SpPKC1, SPU_001048, SPU_001049, Spk018, PKCa, SPU_010876
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: PKC
Subfamily: PKCa

Sequence

Name Sequence Type Origin Length Description Download
PKCa.AA Protein None 658 None Fasta, JSON
PKCa.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of PKCa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PKCa.AA C1_1 28-80 43 8.4e-24 90.2 Pfam 1-55 (55) Show / Hide 
Range on Protein: 28-80
Range on HMM: 1-55/55
Sequence Identity: 43% (24 aa)

HKFIPR-FFKQPTFCSHCKDFIWG-FGKQGFQCTVCSFVVHKRCHEFVTFMCPGI
|..... .|||||||.||..|.|| .|.||..|..| ...|.|||..|. .|.. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
Kinase PKCa.AA C1 28-77 35 3.1e-19 71.13 SMART 1-61 (61) Show / Hide 
Range on Protein: 28-77
Range on HMM: 1-61/61
Sequence Identity: 35% (22 aa)

HKFIPRFFKQPTFCSHCKDFIWGFGKQ-----GFQCTVCSFVVHKRCHEFVTF-------MC
|... . | .||.|.||...|||. ||     |..|..| ...||.||..|.        ||
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase PKCa.AA C1_3 58-70 38 0.011819 8.25 Pfam 18-30 (30) Show / Hide 
Range on Protein: 58-70
Range on HMM: 18-30/30
Sequence Identity: 38% (5 aa)

CTVCSFVVHKRCH
|. | |..|..| 
CMQCDFMLHEDCA
Kinase PKCa.AA AGC 24-31 62 0.026705 0.15 In-house 388-395 (395) Show / Hide 
Range on Protein: 24-31
Range on HMM: 388-395/395
Sequence Identity: 62% (5 aa)

EIKNHKFI
|||||.. 
EIKNHPWF
C1_1 PKCa.AA C1_1 93-145 41 7.2e-23 87.1 Pfam 1-55 (55) Show / Hide 
Range on Protein: 93-145
Range on HMM: 1-55/55
Sequence Identity: 41% (23 aa)

HKFEVN-SYNSPTFCDHCGSLLYG-LYHQGMRCGACNMNVHKRCQKSVPNLCGAD
|....  ....||||.|||....| |.|||..| .|..|.|.||.. ||..|| .
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCa.AA C1 93-142 29 6.3e-19 70.12 SMART 1-61 (61) Show / Hide 
Range on Protein: 93-142
Range on HMM: 1-61/61
Sequence Identity: 29% (18 aa)

HKFEVNSYNSPTFCDHCGSLLYGLYHQ-----GMRCGACNMNVHKRCQKSVPN-------LC
|...  .. .||.|.||.....|...|     |.|| .|....||.|.. ||.        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCa.AA C1_3 104-135 25 0.001218 10.76 Pfam 1-30 (30) Show / Hide 
Range on Protein: 104-135
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TFCDHCGSLLYGLYHQGMRCGACNMNVHKRCQ
 .|. ||  .|.  . . .|  |. ..|..| 
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C2 PKCa.AA C2 164-251 47 2.5e-36 126.37 Pfam 1-90 (90) Show / Hide 
Range on Protein: 164-251
Range on HMM: 1-90/90
Sequence Identity: 47% (44 aa)

LKVTVEEAKNLIPMD--PNGLSDPFVKLKLIPDQKNQTKKKTKTIKGNLNPTWGESFEFT--MEESDRNRRLLVGVWDWDRATRNDFMGALS
|.|.| ||.|| |||  .||.|||.||..| .| |...|.|||.||..|||.| |.|.|.   .. ..  .| . |||||| .|.||.|  .
LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQH--TLRFTVWDWDRFGRDDFIGQCC
C2 PKCa.AA C2 163-266 24 3.6e-25 90.86 SMART 1-92 (92) Show / Hide 
Range on Protein: 163-266
Range on HMM: 1-92/92
Sequence Identity: 24% (30 aa)

KLKVTVEEAKNLIPMDPNGLSDPFVKLKLIPDQKNQTKKKTKTIKGNL---NPTWGE---SFEFTMEESDRNRRLLVGVWDWDRATRNDFMGALSFG---
.|.|.. ||.||.        ||.||..           |||..|..|   ||.|.|   .|.|.. .    . | . |||.      ||.| ....   
TLTVHIIEARNLP--------DPYVKVY-----------KTKVVKNTLSGFNPVWNEWMETFYFDVHP----Q-LRFEVWDH------DFIGHCCIPPNN

-----------ISXLMKSGVDGWY
           .| .. .. . |.
PHWHQWDGCIHLSDIL-GYRH-WW
Kinase PKCa.AA Alpha 325-583 85 1.1e-233 782.6 In-house 1-259 (259) Show / Hide 
Range on Protein: 325-583
Range on HMM: 1-259/259
Sequence Identity: 85% (221 aa)

FNFLSVLGKGSFGKVMLAEKKGTDELYAIKILKKDVIIQDDDVECTMTEKRVLALPSKPAFLTALHSCFQTMDRLFFVMEFVNGGDLMFQIQKVGKFKEP
||||.||||||||||||||.|||||||||||||||||||||||||||.||||||||.||.||...||||||||||.||||.|||||||..||.|||||||
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

HAVFYAAEIAVGLFYLHLQGVIYRDLKLDNVLVDAEGHIKIADFGMCKEHMNEGDTTRTFCGTPDYIAPEIVAYQPYGKAVDWWAFGVLLYEMLAEQPPF
||||||||||.|||.|| .|.||||||||||..||||||||||||||||.|.|..||||||||||||||||.|||||||.|||||||||||||.|.||||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

DGEDEDELFQSIMEHVPSYPKSMSKESVSMCKGFLTKHPGRRLGCGPTGEQDIREHQFF
||||||||||.||||..|||||||||.|..|||||||||..||||||.||||||||.||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKCa.AA PKC 325-583 76 5.70000000001e-218 713.37 In-house 1-262 (262) Show / Hide 
Range on Protein: 325-583
Range on HMM: 1-262/262
Sequence Identity: 76% (201 aa)

FNFLSVLGKGSFGKVMLAEKKGTDELYAIKILKKDVIIQDDDVECTMTEKRVLALPSKPAFLTALHSCFQTMDRLFFVMEFVNGGDLMFQIQKVGKFKEP
|||| ||||||||||||||.|||||.||||.||||||||||||||||||||||||..|. |||.||.|||||||||||||.||||||||.||....|||.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

HAVFYAAEIAVGLFYLHLQGVIYRDLKLDNVLVDAEGHIKIADFGMCKEHMNEGDTTRTFCGTPDYIAPEIVAYQPYGKAVDWWAFGVLLYEMLAEQPPF
||.||||||...|..|| .|.|||||||||||.|.||||||||||||||.|..||||.|||||||||||||..||.|||.|||||||||.|||.| |.||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

DGEDEDELFQSIMEHVPSYPKSMSKESVSMCKGFLTKHPGRRLGCGPTG---EQDIREHQFF
.||||||||||||.. |.||...|||.||.||||.||.|..||||.|..   |||||||.||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCa.AA AGC 325-583 33 9.1e-185 482.88 In-house 1-395 (395) Show / Hide 
Range on Protein: 325-583
Range on HMM: 1-395/395
Sequence Identity: 33% (135 aa)

FNFLSVLGKGSFGKVMLAEKK------GTDELYAIKILKKDV-IIQDD--DVECTMTE------------KRVLALPSK---------PAFLTA-LHSCF
|.|| |.||||||||.|..||      .|...||.|.|||.. |....  .||.||||            ...|.. ..           |..  ||..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTMDR--LFFVME----FVN-----GG-DLMFQIQ---KVGKFKEPHAVFYAAE-------IAVGLFYLHL-QGVIYRD-LKLDNVLVDAEGHIKIADFG
|. |.  |.||||    .||     || .|....|   | |.| |..| |||||       |. .| |||  .|.|.|| ||..|.| |..||||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKEHMNEG--------------------------------------------------DTTRTFCG--TPDYIAPEIVAYQPYGKAVDWWA--FGVLLY
.||| ||.|                                                  |.| ||||  ||.|.||||.    ||||.|||.  .|.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLAEQPPFDGE----------DEDELFQSIM------EHVPSYP----------KSMSKESVSMCKGFLTKHPGRRLGCGPT-----GEQDIREHQFF
|||. .||| |.          ...|.||.||      .. . .|          ...|.| .. .|..|.|.| .|||||.      | ..|..| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCa.AA Eta 325-583 67 4.4e-160 538.1 In-house 1-261 (261) Show / Hide 
Range on Protein: 325-583
Range on HMM: 1-261/261
Sequence Identity: 67% (176 aa)

FNFLSVLGKGSFGKVMLAEKKGTDELYAIKILKKDVIIQDDDVECTMTEKRVLALPSKPAFLTALHSCFQTMDRLFFVMEFVNGGDLMFQIQKVGKFKEP
|||. ||||||||||||||.|||||.||||.||||||||||||||||||||.|.|  |  |||.||.|||| ||||||||.|||||||||||.  || ||
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

HAVFYAAEIAVGLFYLHLQGVIYRDLKLDNVLVDAEGHIKIADFGMCKEHMNEGDTTRTFCGTPDYIAPEIVAYQPYGKAVDWWAFGVLLYEMLAEQPPF
 | |||||. . | .|| .|||||||||||.|.|.||| |.|||||||| ...| || |||||||||||||.  . || .|||||.|||.|||.. ||||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

DGEDEDELFQSIMEHVPSYPKSMSKESVSMCKGFLTKHPGRRLGCGP--TGEQDIREHQFF
. . ||.||.||..    ||  ..|| ||. |.|.|| | .||||     ||..||.| ||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCa.AA Delta 325-583 60 1.8e-139 469.65 In-house 1-259 (259) Show / Hide 
Range on Protein: 325-583
Range on HMM: 1-259/259
Sequence Identity: 60% (156 aa)

FNFLSVLGKGSFGKVMLAEKKGTDELYAIKILKKDVIIQDDDVECTMTEKRVLALPSKPAFLTALHSCFQTMDRLFFVMEFVNGGDLMFQIQKVGKFKEP
|.|. |||||||||||||| ||... |||| |||||...|||||||| |.||||| ..  ||. |   ||| . ||||||..||||||. ||....|.| 
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

HAVFYAAEIAVGLFYLHLQGVIYRDLKLDNVLVDAEGHIKIADFGMCKEHMNEGDTTRTFCGTPDYIAPEIVAYQPYGKAVDWWAFGVLLYEMLAEQPPF
 | |||.|| .|| .|| .|.|||||||||||.| .|||||||||||||.|.   .. |||||||||||||.  | | ..||||.||||.||||  | ||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

DGEDEDELFQSIMEHVPSYPKSMSKESVSMCKGFLTKHPGRRLGCGPTGEQDIREHQFF
 ||||||||.||..  | ||. ..||. .. |. . ..| .|||   . . |||.|.||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase PKCa.AA Akt 325-583 46 1.3e-123 397.07 In-house 1-264 (264) Show / Hide 
Range on Protein: 325-583
Range on HMM: 1-264/264
Sequence Identity: 46% (123 aa)

FNFLSVLGKGSFGKVMLAEKKGTDELY-AIKILKKDVIIQDDDVECTMTEKRVLALPSKPAFLTALHSCFQTMDRLFFVMEFVNGGDLMFQIQKVGKFKE
|.|| ||||||||||.|..|| |...| |.|.||||.||| . || |.||...|     | |.. ||  ||| |.|.|||...|||.| . .|. ..|.|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHP-FIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

PHAVFYAAEIAVGLFYLHLQGVIYRD-LKLDNVLVDAEGHIKIADFGMCKEH-MNEGDTTRTFCGTPDYIAPEIVAYQPYGKAVDWWA-FGVLLYEMLAE
. | ||.|||  .. .|| ...|||| ||. |.|.|..|||...|||.|||. . ..|.| |||||| |.||||   . ..||||||. .|...|||.  
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

QPPFDGEDEDELFQSIMEHVPSYP--KSMSKESVSMCKGFLTKHPGRRLGCGPTGEQDIREHQFF
.|||  .| ...|. |..    .|  .  |.|  .  .| |.| | .||| || . |.|..| .|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKCa.AA SGK 325-583 39 1.2e-119 371.25 In-house 1-283 (283) Show / Hide 
Range on Protein: 325-583
Range on HMM: 1-283/283
Sequence Identity: 39% (113 aa)

FNFLSVLGKGSFGKVMLAEKKGT------------------DELYAIKILKKDVII-------QDDDVECTMTEK-RVLALPSKPAFLTALHSCFQTMDR
| ||.|.||||||||.....|..                  | .||.|.|.|. ||       .   .  .|.|.  .| . . | |.  ||  ||| . 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHP-FIVNLHYAFQTKWK

LFFVMEFVNGGDLMFQIQKVGKFKEPHAVFYAAEIAVGLFYLHLQGVIYRDLKLDNVLVDAEGHIKIADFGMCKEHMNEGDTTRTFCGTPDYIAPEIVAY
|.|||..||||.. . .|. ..|.|. | ||||||.  | ||| | .|||||| .|.| |..||... ||| ||| . . ||| |||||| | |||. . 
LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

QPYGKAVDWWAFGVLLYEMLAEQPPFDGEDEDELFQSIMEHVPSYPKSMSKESVSMCKGFLTKHPGRRLGCGPTGEQDIREHQFF
||....||||  | .||||.   |||   .  .... |.      |..|| .  .. .| |.| |  |||    .  .|..|.||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase PKCa.AA Iota 325-583 53 1.4e-119 400.14 In-house 1-271 (271) Show / Hide 
Range on Protein: 325-583
Range on HMM: 1-271/271
Sequence Identity: 53% (145 aa)

FNFLSVLGKGSFGKVMLAEKKGTDELYAIKILKKDVIIQDDDVECTMTEKRVLALPSKPAFLTALHSCFQTMDRLFFVMEFVNGGDLMFQIQKVGKFKEP
|. . |.|.||. ||...| | |. .||.|..||... .|.|..   ||| |    |   ||  |||||||  |||||.|||||||||| .|.  |  | 
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

HAVFYAAEIAVGLFYLHLQGVIYRDLKLDNVLVDAEGHIKIADFGMCKEHMNEGDTTRTFCGTPDYIAPEIVAYQPYGKAVDWWAFGVLLYEMLAEQPPF
|| ||.|||.. | .|| .|.|||||||||||.|.|||||. |.||||| . .|||| |||||| ||||||.  . || .||||| |||..||.|   ||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

D--G-------EDEDELFQSIMEHVPSYPKSMSKESVSMCKGFLTKHPGRRLGCGP-T--GEQDIREHQFF
|  |         || ||| |.|.    |.|.|    .. |||| | |  |||| | |  | .||.||.||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase PKCa.AA PKN 325-583 49 1.2e-108 367.24 In-house 1-260 (260) Show / Hide 
Range on Protein: 325-583
Range on HMM: 1-260/260
Sequence Identity: 49% (130 aa)

FNFLSVLGKGSFGKVMLAEKKGTDELYAIKILKKDVIIQDDDVECTMTEKRVLALPSKPA--FLTALHSCFQTMDRLFFVMEFVNGGDLMFQIQKVGKFK
| ...|||.| ||||.|.. |.|.|.||||.|||  |.  |.||  |.|||...  ..    ||  |..|||| .  .||||.. ||||| .| .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHE-DVFS

EPHAVFYAAEIAVGLFYLHLQGVIYRDLKLDNVLVDAEGHIKIADFGMCKEHMNEGDTTRTFCGTPDYIAPEIVAYQPYGKAVDWWAFGVLLYEMLAEQP
||.|.|||| . .|| ||| . .|||||||||.|.|.||..||||||.||| |  || | ||||||...|||... . | .|||||  |||.||||   .
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFDGEDEDELFQSIMEHVPSYPKSMSKESVSMCKGFLTKHPGRRLGCGPTGEQDIREHQFF
|| |.||.|.|..|...   ||. .| |.... .  | | | |||| |     ||. ..||
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKCa.AA AktR 325-583 39 9.3e-102 344.36 In-house 1-268 (268) Show / Hide 
Range on Protein: 325-583
Range on HMM: 1-268/268
Sequence Identity: 39% (107 aa)

FNFLSVLGKGSFGKVMLAEKK-GTDELYAIKILKKDVIIQDDDVECTMTEKRVLALPSKPAFLTALHSCFQTMDRLFFVMEFVNGGDLMFQIQKVGKFKE
| .. .|||| ||||.|..||  ....||.|..||  ||.    . | ||. ...  ..  |.  || |||| . |||.||.. ||.| . ..| .||.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PHAVFYAAEIAVGLFYLHLQ-GVIYRDLKLDNVLVDAEGHIKIADFGMCK-EHMN-EGDTTRTFCGTPDYIAPEIVAY-QPYGKAVDWWAFGVLLYEMLA
  | ||.|.|  .| ||| .  .|||||| .| | | .||.||.|||. | . |. . .....||||| |.|||..   ....|.|||||||...|||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

EQPPFDGEDEDELFQSIMEHV---PSYPKSMSKESVSMCK-GFLTKHPGRRLGCGPTGEQDIREHQFF
 .|||. ..  ..||.| ..    . ||.  |..  . .. . | |.|  ||| .  | ..|..| .|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKCa.AA S_TKc 325-583 35 4.9e-97 329.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 325-583
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

FNFLSVLGKGSFGKVMLAEKKGTDELYAIKILKKDVIIQDDDVECTMTEKRVLALPSKPAFLTALHSCFQTMDRLFFVMEFVNG--GDLMFQIQKVGK--
. .| ..|||.||||... .|.|....||||.|          | .. | ..|    .  ..  |. .||. |.|..|||...|  |||.  |.| |.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FKEPHAVFYAAEIAVGLFYLHLQGVIYRDLKLDNVLVDAEGHIKIADFGMCKEHMNEGDTTRTFCGTPDYIAPEIVAYQPYGK-AVDWWAFGVLLY
    | | || ||...|. .| |.| .|.|.|||| .|.|.|   ||||.|||....        .||||||.|.|||..   .||| ..|||..|..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLAEQPPFDGEDEDELFQSIMEHVPSYPKSMSKESVSMCKGFLTKHPGRRLGCGPTGE--QDIREHQFF
|||. .|||.  .....|. |.          |.|  .. .. |.| | .|...    .  .||. |..|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCa.AA Pkinase 325-583 31 6.8e-71 246.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 325-583
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

FNFLSVLGKGSFGKVMLAEKKGTDELYAIKILKKDVIIQDDDVECTM-TEKRVLALPSKPAFLTALHSCFQTMDRLFFVMEFVNGG----DLMFQIQ--K
. .....|.||||.| .. .||| ...|.||.||. .  . |.. .  .| ....   .  .   |. .|.. |.. .|||...||    ||.  |.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

VGKF--KEPHAVFYAAEIAVGLFYLHLQGVIYRDLKLDNVLVDAEGHI----KIADFGMCKEH-MNEGDTTRTFCGTPDYIAPEIVA-YQPYGKAVDWWA
 |.|   | .. ||. .|. || |.| .|.|.||||..|.|.| .|||    ||.||| .| .    .  . ||||||.|.|||..  .|.||..||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGVLLYEMLAEQPPFDGE------DEDELFQSIME----HVPSYPKSMS-----------------KESVSMCKGFLTKHPGRRLGCGPTGEQDIREHQF
.|..|||||  .|||.|.      |...... ||.       ... |.|                 .|  . .|. |.| | .|..      ..| .| .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase PKCa.AA S_TK_X 584-646 36 2.8e-21 77.94 SMART 1-79 (79) Show / Hide 
Range on Protein: 584-646
Range on HMM: 1-79/79
Sequence Identity: 36% (29 aa)

RRIDWERLAN--REIQPPFVPTVK----NPRAAENFDPYFTKIPCALTPTDKLIIMNIQEE----------FHGFTFVN
| |||..| |  .||.|||.|..|    .|. ..|||| ||. .  |||.|. ........          | |||.|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCa.AA TyrKc 325-583 23 3.6e-15 22.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 325-583
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

FNFLSVLGKGSFGKVMLAEKKGTDELYAIKILKKDVIIQDDDVECTMTEKRVLALP--SKPAFLTALHSCFQTM------DRLFFVMEFVNGGDLMFQIQ
  .. .|| | ||.|.... |   .  |.| ||.|       .|  | | |..     . |  .  .  | |        . |. |||.. .|||   ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KVGK-FKEPHAVFYAAEIAVGLFYLHLQGVIYRDLKLDNVLVDAEGHIKIADFGMCKEHMNE------GDTTRTFC--GTPD-----YIAPEIVAYQPYG
| .. .. .. . ..  || |  ||| ...| |||   |.||......||.|||..... ..      .|. |.    |. .       |||   |  . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KAVDWWAFGVLLYEM--LAEQPPFD-----GEDEDELFQSIMEHVPSYPKS--------MSKESVSMCKGFLTKHPGRRLGCGPTGEQDIREHQFF
 . | |.|||...|.  . .||. .      .... . .    . .  |..        ...|  .. |      |  |    || ..    |..|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR----PTFSEI---HECF
Kinase PKCa.AA Pkinase_C 603-648 42 2.2e-13 50.37 Pfam 1-46 (46) Show / Hide 
Range on Protein: 603-648
Range on HMM: 1-46/46
Sequence Identity: 42% (20 aa)

TVKNPRAAENFDPYFTKIPCALT-PTDKLIIMNIQEEFHGFTFVNEL
.||.|. ..|||| ||. |. .| |..  .  . ||.|.|||.||. 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCa.AA Pkinase_Tyr 398-538 25 6e-12 41.08 Pfam 81-231 (270) Show / Hide 
Range on Protein: 398-538
Range on HMM: 81-231/270
Sequence Identity: 25% (40 aa)

RLFFVMEFVNGGDLMFQIQK----VGKFKEPHAVFYAAEIAVGLFYLHLQGVIYRDLKLDNVLVDAEGHIKIADFGMCKEHMNEGDT-TRTF--------
... |||.. .|||    .|     .... .. . ....|| |. ||. .. | |||   |.||. ....||.|||... ..|..   . .         
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKW

CGTPDYIAPEIVAYQPYGKAVDWWAFGVLLYEMLA-EQPP-FDGEDEDELFQSI-ME
.      |||  .|  .  . | |.||||..|..   . | . | .  |... |  .
M------APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase PKCa.AA Pkinase_Tyr 325-359 33 0.000133 16.21 Pfam 1-39 (270) Show / Hide 
Range on Protein: 325-359
Range on HMM: 1-39/270
Sequence Identity: 33% (13 aa)

FNFLSVLGKGSFGKVMLAEKK----GTDELYAIKILKKD
  |. .||.|.||.|.... |    .|.   |.|.|| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG