Gene PKCd (Sea Urchin)

PKCd

Species: Sea Urchin
Alias: SPU_008678, Spk019, PKCd
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: PKC
Subfamily: PKCd

Sequence

Name Sequence Type Origin Length Description Download
PKCd.AA Protein None 756 None Fasta, JSON
PKCd.kin_dom Protein Kinase Domain None 337 None Fasta, JSON

Protein domain

Protein domains of PKCd.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2_PKD PKCd.AA C2_PKD 1-169 28 2.3e-38 131.8 In-house 1-183 (183) Show / Hide 
Range on Protein: 1-169
Range on HMM: 1-183/183
Sequence Identity: 28% (53 aa)

MVFLRVRVLQVDSKEIELP------------GSVLFDPFVAVNVKESVKDANGQTQLRQKRKTAFVEWNKCFDSHLYDGRVIQVIVYNRP----ESYLAE
|.|.|||....| .   .             .  ..||...|.|.|..  . .  |. ||.||   |||||||.|.|.||.|| ......    .. .||
MGFCRVRLCRADGLKPKMFQHWHNLTFGKPADCEAIDPYCVVHVDEKHENQ-HIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAE

ANYKVNELAAMCGM-DGRIETKWLDLMPYGRLQVQLRCFPEEGGGGDPMNSVRSTVSHHNSDMDKKDD-TTGLLTKRRV-AIRKAKVH
.  |. ....||.  .|  .. |..| | |.. ||...|.|    .|. . .          |.| .    .... ||  |.|.||.|
CTMKLEDCIEMCKTNSGITHI-WINLEPQGKVHVQIKWFNED---TDHKHHCDMIHPVPVLKMMKEFKRQRPGFNRRRGNAMRHAKIH
C1_1 PKCd.AA C1_1 174-227 36 5.7e-19 73.3 Pfam 1-55 (55) Show / Hide 
Range on Protein: 174-227
Range on HMM: 1-55/55
Sequence Identity: 36% (20 aa)

HKFTPH-YFRTPAYCSYCNEFIWGLVGTQGYRCMECELSVHKRCFNQVLGKCPGT
|.. .|  |. |..|..|.||.||. | ||..| .| . .|.||...|  .|.. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCd.AA C1 174-224 32 2.1e-14 55.1 SMART 1-61 (61) Show / Hide 
Range on Protein: 174-224
Range on HMM: 1-61/61
Sequence Identity: 32% (20 aa)

HKFTPHYFRTPAYCSYCNEFIWGLVG----TQGYRCMECELSVHKRCFNQVLG-------KC
|..  . | .|.||..|...|||.      .||||| .| . .||.|. .|.         |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCd.AA C1_3 202-217 37 2e-06 17.89 Pfam 15-30 (30) Show / Hide 
Range on Protein: 202-217
Range on HMM: 15-30/30
Sequence Identity: 37% (6 aa)

GYRCMECELSVHKRCF
.|.||.|. ..|..| 
FYHCMQCDFMLHEDCA
C1_1 PKCd.AA C1_1 247-263 50 0.000119 20.72 Pfam 1-18 (55) Show / Hide 
Range on Protein: 247-263
Range on HMM: 1-18/55
Sequence Identity: 50% (9 aa)

HRFKVN-NYKSPTFCDHC
|....  |.|.||||.||
HHWVHHWNFKQPTFCCHC
C1 PKCd.AA C1 247-281 20 0.0003 14.15 SMART 1-61 (61) Show / Hide 
Range on Protein: 247-281
Range on HMM: 1-61/61
Sequence Identity: 20% (13 aa)

HRFKVNNYKSPTFCDHC--------------------VCNVNVHHKCKNNVPN-------LC
|...  .. .||.|.||                    .|....|.||. .||.        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 PKCd.AA C1_1 264-284 47 0.000466 18.55 Pfam 35-55 (55) Show / Hide 
Range on Protein: 264-284
Range on HMM: 35-55/55
Sequence Identity: 47% (10 aa)

VCNVNVHHKCKNNVPNLCGVN
.|..|.||.| ..||..|| |
WCHYNCHHRCHMKVPPECGCN
Kinase PKCd.AA PKC 350-519 74 4.5e-143 466.7 In-house 1-170 (262) Show / Hide 
Range on Protein: 350-519
Range on HMM: 1-170/262
Sequence Identity: 74% (126 aa)

FMLQKVLGKGSFGKVMLAEQKGTKKYFAIKALKKEVVLEDDDIECTMVERHVLGLAWAHPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQSSLRFEEK
|...|||||||||||||||.|||..|.|||.|||.|...|||.||||.|..|| ||| |||||||.|.||....|||||||.||||||||||.. ||.|.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPE
.||||||||||.|||||..|||||||||||||||..||||||||||||.|.......|||||||||||||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPE
Kinase PKCd.AA AGC 350-519 33 7.2e-128 332.35 In-house 1-277 (395) Show / Hide 
Range on Protein: 350-519
Range on HMM: 1-277/395
Sequence Identity: 33% (92 aa)

FMLQKVLGKGSFGKVMLAEQK------GTKKYFAIKALKKEV-VLEDD--DIECTMVE------------RHVLGLAWA---------HPFLTH-LYCTF
| . ||.||||||||.|.. |      .|.||.|.| |||.. .....  ..|.||.|            |..| ..           |||... |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QSKEH--LFFVMEYLN---------GG-DLMFHIQ---SSLRFEEKRARFYAAE-------IICGLQFLHK-RGIIYRD-LKLDNVLLDRDGHIKIADFG
|.|.|  |.|||||..         || .|..|.|    . ||.|.||||||||       |...|..||. .|||.|| ||..|.|||.|||||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKQNITGE--------------------------------------------------TKASTFCG--TPDYIAPE
.||......                                                   ...||||  ||.|.|||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPE
Kinase PKCd.AA Delta 350-519 83 1e-127 430.61 In-house 1-170 (259) Show / Hide 
Range on Protein: 350-519
Range on HMM: 1-170/259
Sequence Identity: 83% (142 aa)

FMLQKVLGKGSFGKVMLAEQKGTKKYFAIKALKKEVVLEDDDIECTMVERHVLGLAWAHPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQSSLRFEEK
|...|||||||||||||||.||..||.|||.|||.|||||||.|||||||.||.|||.||||.||.||||.|||||||||||||||||.|||.. ||.||
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPE
||||||.|||||||||||.|||||||||||||||.|||||||||||||.|..||.|||||||||||||||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPE
Kinase PKCd.AA PKC 535-686 66 5.5e-121 393.95 In-house 104-262 (262) Show / Hide 
Range on Protein: 535-686
Range on HMM: 104-262/262
Sequence Identity: 66% (105 aa)

FYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPEILKGQKYAASVDWWSFGVLLYEMLIGQSPFHGE
||||||||.|||||..|||||||||||||||..||||||||||||.|.......|||||||||||||||..|.| .|||||.||||.|||..||||||||
FYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPFHGE

DEDQLFDCILHDAPHFPRWLTKDAHSCLIQLLERTPEVRLGV-------KGDVRAHQFF
|||.||..|.|| ||.||||.|.|.|.. ......|| |||.       ..|.|.|.||
DEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCd.AA AGC 535-686 29 2.3e-110 286.02 In-house 150-395 (395) Show / Hide 
Range on Protein: 535-686
Range on HMM: 150-395/395
Sequence Identity: 29% (74 aa)

FYAAE-------IICGLQFLHK-RGIIYRD-LKLDNVLLDRDGHIKIADFGMCKQNITGE----------------------------------------
|||||       |...|..||. .|||.|| ||..|.|||.|||||..|||.||......                                        
FYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMS

----------TKASTFCG--TPDYIAPEILKGQKYAASVDWWS--FGVLLYEMLIGQSPFHGE----------DEDQLFDCIL------HDAPHFP----
           ...||||  ||.|.|||||    |  ..||||  .|.|.||||.|..||.|.          .....|. |.      .. ..||    
QEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPED

------RWLTKDAHSCLIQLLERTPEVRLGVKGD---------VRAHQFF
      ||....| . . .||.. || ||| .|.         ...| .|
PQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCd.AA Delta 535-686 77 1e-109 370.84 In-house 104-259 (259) Show / Hide 
Range on Protein: 535-686
Range on HMM: 104-259/259
Sequence Identity: 77% (121 aa)

FYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPEILKGQKYAASVDWWSFGVLLYEMLIGQSPFHGE
|||.|||||||||||.|||||||||||||||.|||||||||||||.|..||.||||||||||||||||.|||||..||||||||||.|||||||||||||
FYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPFHGE

DEDQLFDCILHDAPHFPRWLTKDAHSCLIQLLERTPEVRLGV----KGDVRAHQFF
|||.||..|..|.|..|||.||.|..||..|.||.||.||||    |||.|.|.||
DEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase PKCd.AA Eta 350-519 67 8e-104 351.23 In-house 1-170 (261) Show / Hide 
Range on Protein: 350-519
Range on HMM: 1-170/261
Sequence Identity: 67% (114 aa)

FMLQKVLGKGSFGKVMLAEQKGTKKYFAIKALKKEVVLEDDDIECTMVERHVLGLAWAHPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQSSLRFEEK
|   |||||||||||||||.|||   .||| |||.|.. |||.|||| |. .| ||  ||||| |.|.|| |. ||||||| |||||||.|| . .|.| 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPE
||||||||..| |.|||..|.|||||||||.|||..|| |.|||||||  |  .   .||||||||||||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPE
Kinase PKCd.AA Alpha 350-519 64 4.1e-101 342.23 In-house 1-170 (259) Show / Hide 
Range on Protein: 350-519
Range on HMM: 1-170/259
Sequence Identity: 64% (110 aa)

FMLQKVLGKGSFGKVMLAEQKGTKKYFAIKALKKEVVLEDDDIECTMVERHVLGLAWAHPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQSSLRFEEK
|   .||||||||||||||.|||.  .||| ||| |.  |||.||||||. || |    |||. .  .||    |.||||| ||||||.|||   .| | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPE
 | ||||||  || |||..||||||||||||.||..|||||||||||| |.....   ||||||||||||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPE
Kinase PKCd.AA Akt 350-519 51 5.8e-97 310.5 In-house 1-172 (264) Show / Hide 
Range on Protein: 350-519
Range on HMM: 1-172/264
Sequence Identity: 51% (89 aa)

FMLQKVLGKGSFGKVMLAEQKGTKKYF-AIKALKKEVVLEDDDIECTMVERHVLGLAWAHPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQSSLRFEE
| . |||||||||||.|...| |.|.. |.|.|||.. .. . .| |. || .|     |||.. |.  ||....|.|||.| |||.| .|.|   || |
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

KRARFYAAEIICGLQFLHKRGIIYRD-LKLDNVLLDRDGHIKIADFGMCKQN-ITGETKASTFCGTPDYIAPE
.|||||.||||.....||...||||| ||. |.|.|.||||...|||.||.| |.   |. |||||| |.|||
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPE
Kinase PKCd.AA S_TKc 350-686 27 2.5e-91 310.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 350-686
Range on HMM: 1-231/231
Sequence Identity: 27% (97 aa)

FMLQKVLGKGSFGKVMLAEQKGTKKYFAIKALKKEVVLEDDDIECTMVERHVLGLAWAHPFLTHLYCTFQSKEHLFFVMEYLNG--GDLMFHIQSSLR--
. . ...|||.||||...  |.|....||| .|          | .. |. .|     ||.. .|| .||. .||..||||..|  |||. .|..  |  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FEEKRARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPENTIAEIGGRSGVDRGFYAAEII
    | | .||||...|.|.|...|..|||.|||| .|.|||.  ||||.|||...|                                           
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------------------

CGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPEILKGQKYAA-SVDWWSFGVLLYEMLIGQSPFHGEDEDQLF
                                               .||||||.|.|||.|   .|   ..||||.|..||||| |. ||.  .....|
-----------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMF

DCILHDAPHFPRWLTKDAHSCLIQLLERTPEVRLGVKGDVR------AHQFF
. |.          ...| . . ..|.. || |...    .      .|..|
KKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCd.AA Alpha 535-686 58 7.3e-83 281.6 In-house 104-259 (259) Show / Hide 
Range on Protein: 535-686
Range on HMM: 104-259/259
Sequence Identity: 58% (91 aa)

FYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPEILKGQKYAASVDWWSFGVLLYEMLIGQSPFHGE
||||||  || |||..||||||||||||.||..|||||||||||| |.....   |||||||||||||   | |  |||||.||||||||. || || ||
FYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPFDGE

DEDQLFDCILHDAPHFPRWLTKDAHSCLIQLLERTPEVRLGV----KGDVRAHQFF
||| ||  |    . .|. . | | .    .| . |  |||     . |.|.|.||
DEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKCd.AA SGK 350-519 42 3.3e-82 253.58 In-house 1-195 (283) Show / Hide 
Range on Protein: 350-519
Range on HMM: 1-195/283
Sequence Identity: 42% (82 aa)

FMLQKVLGKGSFGKVMLAEQKGT------------------KKYFAIKALKKEVVL-------EDDDIECTMVERHVLGLAWAHPFLTHLYCTFQSKEHL
| . ||.||||||||.... |..                  .| .|.| |.|. ..              .| || |.     |||.  |   || |. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVMEYLNGGDLMFHIQSSLRFEEKRARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPE
.|||.|.|||.. .|.|   .| | |||||||||.| |  ||.  ||||||| .|.||| .||... ||| ||..|  ... .|||||| | |||
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPE
Kinase PKCd.AA Akt 535-686 42 6.5e-81 258.37 In-house 104-264 (264) Show / Hide 
Range on Protein: 535-686
Range on HMM: 104-264/264
Sequence Identity: 42% (69 aa)

FYAAEIICGLQFLHKRGIIYRD-LKLDNVLLDRDGHIKIADFGMCKQN-ITGETKASTFCGTPDYIAPEILKGQKYAASVDWWS-FGVLLYEMLIGQSPF
||.||||.....||...||||| ||. |.|.|.||||...|||.||.| |.   |. |||||| |.|||||.|. .  .||||. .|...|||. |. ||
FYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF

HGEDEDQLFDCILHDAPHFP--RWLTKDAHSCLIQLLERTPEVRLG-VKG---DVRAHQFF
. .| .|.|. |.     ||  .|. ... . ...||.. |. |||  ..   ....| .|
YNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKCd.AA Iota 350-519 55 2.1e-80 267.47 In-house 1-170 (271) Show / Hide 
Range on Protein: 350-519
Range on HMM: 1-170/271
Sequence Identity: 55% (95 aa)

FMLQKVLGKGSFGKVMLAEQKGTKKYFAIKALKKEVVLEDDDIECTMVERHVLGLAWAHPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQSSLRFEEK
| | .|.|.||. ||...| | |.. .|.| .|||.| .|.||.    |.||   |  ||||  |   || .  ||||.|. ||||||||.|   .  | 
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

RARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPE
 ||||.|||.  |.|||.|||||||||||||||| .||||. |.|||| .|      ||||||| |||||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPE
Kinase PKCd.AA SGK 535-686 44 8.8e-77 236.54 In-house 129-283 (283) Show / Hide 
Range on Protein: 535-686
Range on HMM: 129-283/283
Sequence Identity: 44% (69 aa)

FYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPEILKGQKYAASVDWWSFGVLLYEMLIGQSPFHGE
||||||.| |  ||.  ||||||| .|.||| .||... ||| ||..|  ... .|||||| | |||.|..| .  .||||. | .||||..|  ||   
FYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSR

DEDQLFDCILHDAPHFPRWLTKDAHSCLIQLLERTPEVRLGVK---GDVRAHQFF
.  |..| |..    .|.  . || . . .||.. |. ||| |   .... |.||
NKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase PKCd.AA Eta 535-686 55 1.3e-76 260.86 In-house 104-261 (261) Show / Hide 
Range on Protein: 535-686
Range on HMM: 104-261/261
Sequence Identity: 55% (87 aa)

FYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPEILKGQKYAASVDWWSFGVLLYEMLIGQSPFHGE
|||||..| |.|||..|.|||||||||.|||..|| |.|||||||  |  .   .||||||||||||||. ..| .||||| .|||.|||. ||.||  .
FYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPFEAD

DEDQLFDCILHDAPHFPRWLTKDAHSCLIQLLERTPEVRLGVKG------DVRAHQFF
 ||.||. ||||   .| || |.| | |   . . |. |||         ..|.| ||
NEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCd.AA PKN 350-519 52 8.7e-74 251.44 In-house 1-171 (260) Show / Hide 
Range on Protein: 350-519
Range on HMM: 1-171/260
Sequence Identity: 52% (90 aa)

FMLQKVLGKGSFGKVMLAEQKGTKKYFAIKALKKEVVLEDDDIECTMVERHVLGLA--WAHPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQSSLRFE
| .  |||.| ||||.|.. |.| .|.|||||||. ..  |..|  |.|. ..  .    ||||  |.  || .|| .|||||. ||||| || .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHEDV-FS

EKRARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPE
| ||.|||| .. |||.||.. ||||||||||.|||..|..||||||.|| ..    . |||||||...|||
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE
Kinase PKCd.AA PKN 535-686 50 1.4e-66 227.39 In-house 105-260 (260) Show / Hide 
Range on Protein: 535-686
Range on HMM: 105-260/260
Sequence Identity: 50% (79 aa)

FYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPEILKGQKYAASVDWWSFGVLLYEMLIGQSPFHGE
|||| .. |||.||.. ||||||||||.|||..|..||||||.|| ..    . |||||||...|||.|  . |   ||||  |||.||||.| .|| |.
FYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGECPFPGD

DEDQLFDCILHDAPHFPRWLTKDAHSCLIQLLERTPEVRLGVKG----DVRAHQFF
||. .||||. |   .||.|  .| . . .|| ..|| |||       |.. ..||
DEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKCd.AA Iota 535-686 50 1.7e-65 217.0 In-house 104-271 (271) Show / Hide 
Range on Protein: 535-686
Range on HMM: 104-271/271
Sequence Identity: 50% (85 aa)

FYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPEILKGQKYAASVDWWSFGVLLYEMLIGQSPFH--
||.|||.  |.|||.|||||||||||||||| .||||. |.|||| .|      ||||||| |||||||.|. |  |||||  |||..||. | |||   
FYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIV

G-------EDEDQLFDCILHDAPHFPRWLTKDAHSCLIQLLERTPEVRLGVKGDV-------RAHQFF
|         || ||  ||      || |   | . |   | . |. ||| . ..       . |.||
GNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase PKCd.AA RSK 535-686 38 5.5e-65 222.2 In-house 108-278 (278) Show / Hide 
Range on Protein: 535-686
Range on HMM: 108-278/278
Sequence Identity: 38% (66 aa)

FYAAEIICGLQFLHKRGIIYRDLKLDNVLLDR---DGHIKIADFGMCKQ-NITGETKASTFCGTPDYIAPEILK---GQK-YAASVDWWSFGVLLYEMLI
||.|||.. ...||..|||.||||..|.|.|    .||||. ||| ||| ..  . .. |||.| .|.|||.||   .|. . ...||||.|||.|||| 
FYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLT

GQSPFHG---EDEDQLFDCILHDA--PHFPRW--LTKDAHSCLIQLLERTPEVRLG-----VKGDVRAHQFF
|..||.|   .. ..... |..    . .|.|  |...| . . ..|.| |. |||     .. ....|..|
GCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAE-EIKQHPWF
Kinase PKCd.AA RSK 353-519 41 1.3e-63 217.68 In-house 1-178 (278) Show / Hide 
Range on Protein: 353-519
Range on HMM: 1-178/278
Sequence Identity: 41% (74 aa)

QKVLGKGSFGKVMLAEQK---GTKKYFAIKALKKEVVLEDD-DIECTMVERHVLGLAWAHPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQSSLR---
 ||||.|..||| |   .    |....| | ||| ..   . |.. || || .| .   |||. .|. .|| ...|. .|||..||.|  |.|   .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FEEKRARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDR---DGHIKIADFGMCKQ-NITGETKASTFCGTPDYIAPE
| |..|.||.|||.. ...||..|||.||||..|.|.|    .||||. ||| ||| ..  . .. |||.| .|.|||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPE
Kinase PKCd.AA Pkinase 350-519 37 9.7e-58 202.93 Pfam 1-181 (293) Show / Hide 
Range on Protein: 350-519
Range on HMM: 1-181/293
Sequence Identity: 37% (70 aa)

FMLQKVLGKGSFGKVMLAEQKGTKKYFAIKALKKEVVLEDDDIECTM-VERHVLGLAWAHPFLTHLYCTFQSKEHLFFVMEYLNGG----DLMFHIQ--S
. . ...|.||||.| ..  ||| | .|.| .||.   .. |.. .   | ...     ||.   ||..|..| |. .||||..||    ||. .|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

SLRF--EEKRARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHI----KIADFGMCKQ--NITGETKASTFCGTPDYIAPE
. .|  .|. ..||. .|..||...|..|||.||||..|.|.|..|||    ||.||| .||  .  ..  ..||||||.|.|||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPE
Kinase PKCd.AA Pkinase 532-686 33 3.3e-52 184.54 Pfam 109-293 (293) Show / Hide 
Range on Protein: 532-686
Range on HMM: 109-293/293
Sequence Identity: 33% (63 aa)

DRGFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHI----KIADFGMCKQ--NITGETKASTFCGTPDYIAPEILK-GQKYAASVDWWSFGVLLYEM
.  ||. .|..||...|..|||.||||..|.|.|..|||    ||.||| .||  .  ..  ..||||||.|.|||... ||.|  .||.||.|..||||
ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM

LIGQSPFHGE------DEDQLFDCILHDAPHFPRWLT---------------------KDAHSCLIQLLERTPEVRLGVKGDVRAHQFF
| |. || |.      |..|... |..  .||... .                     ... . .  .|.. |. |.. . ..  | .|
LCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE-QILQHPWF
Kinase PKCd.AA S_TK_X 687-750 41 2e-28 101.65 SMART 1-79 (79) Show / Hide 
Range on Protein: 687-750
Range on HMM: 1-79/79
Sequence Identity: 41% (33 aa)

KSIDFEKLER--RELPPPFKPKIK----SDGDASNFDPEFTMEKVALSPTDTSMLSSINQRQ---------FRGFSFTN
..||..||..  .|..||||||||    |..|.|||||||| |.. |.|.|. ...|..|..         ||||.. .
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCd.AA Pkinase_C 706-752 48 1.1e-18 68.9 Pfam 1-46 (46) Show / Hide 
Range on Protein: 706-752
Range on HMM: 1-46/46
Sequence Identity: 48% (23 aa)

KIKSDGDASNFDPEFTMEKVALSPTDTSMLSSINQRQFRGFSFTNPT
..||. |.|||||||| |.. ..| |.. .||..|..||||...|| 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCd.AA TyrKc 350-686 19 1.9e-12 -21.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 350-686
Range on HMM: 1-280/280
Sequence Identity: 19% (71 aa)

FMLQKVLGKGSFGKVMLAEQKGTKKYFAIKALKKEVVLEDDDIECTMVERHVLGLAW-AHPFLTHLY--CTFQSK-----EHLFFVMEYLNGGDLMFHIQ
  | |.|| | ||.|.... |      |.| ||..       .|  | |  ..      || .  ||  || |.      | |. ||||  .|||  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SSLRFEEKRARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPENTIAEIGGRSGVDRGFYAAEII
.. .                                                                                   .  |   ..  | 
KHRPK---------------------------------------------------------------------------------LCMKDLLSFCWQIA

CGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITG-------ETKASTFCGTPD------YIAPEILKGQKYAASVDWWSFGVLLYEML-IG
|| ..||....| |||   |.|.......||.|||...    .       ... ..  .  .        ||| ..  |.    | |||||...|..  |
CGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYG

QSPFHG-----EDEDQLFDCILHD-APHFPRW--------LTKDAHSCLIQLLERTPEVRLGVKGDVRAHQFF
|.|  |      . .... .. .   .  |           ... ..   |  .. || |   .     |..|
QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS---EIHECF
Kinase PKCd.AA Pkinase_Tyr 421-497 27 3.2e-08 28.49 Pfam 77-159 (270) Show / Hide 
Range on Protein: 421-497
Range on HMM: 77-159/270
Sequence Identity: 27% (23 aa)

KEH--LFFVMEYLNGGDLMFHIQS----SLRFEEKRARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCK
.|.  .. ||||  .|||  . ..      ..  |.   ....| .|...|. ...| |||   |.|.......||.|||...
GEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKCd.AA Pkinase_Tyr 536-579 31 2.2e-07 25.61 Pfam 116-159 (270) Show / Hide 
Range on Protein: 536-579
Range on HMM: 116-159/270
Sequence Identity: 31% (14 aa)

YAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCK
....| .|...|. ...| |||   |.|.......||.|||...
MCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKCd.AA Pkinase_Tyr 350-382 37 0.003527 11.39 Pfam 1-37 (270) Show / Hide 
Range on Protein: 350-382
Range on HMM: 1-37/270
Sequence Identity: 37% (14 aa)

FMLQKVLGKGSFGKVMLAEQK----GTKKYFAIKALK
  . |.||.|.||.|.... |    .||   |.| ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK
Kinase PKCd.AA Pkinase_Tyr 599-631 40 0.004922 10.9 Pfam 182-216 (270) Show / Hide 
Range on Protein: 599-631
Range on HMM: 182-216/270
Sequence Identity: 40% (14 aa)

APEILKGQKYAASVDWWSFGVLLYEMLI-GQSP-F
||| ..  |.    | ||||||..|..  |..| .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY