Gene PKCi (Sea Urchin)

PKCi

Species: Sea Urchin
Alias: Spk016, PKCi, SPU_008180
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: PKC
Subfamily: PKCi

Sequence

Name Sequence Type Origin Length Description Download
PKCi.AA Protein None 579 None Fasta, JSON
PKCi.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of PKCi.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C1_1 PKCi.AA C1_1 111-163 32 3.4e-19 74.13 Pfam 1-55 (55) Show / Hide 
Range on Protein: 111-163
Range on HMM: 1-55/55
Sequence Identity: 32% (18 aa)

HTFQPK-RFSRRALCTYCADRIWG-LGRQGYKCVDCKLLVHKKCHRLVKVSCAER
| .... .| . . | .|....|| ||.||.|| .|....|..||..|.  |   
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCi.AA C1 111-160 33 4.1e-16 60.79 SMART 1-61 (61) Show / Hide 
Range on Protein: 111-160
Range on HMM: 1-61/61
Sequence Identity: 33% (21 aa)

HTFQPKRFSRRALCTYCADRIWGLGRQ-----GYKCVDCKLLVHKKCHRLVKV-------SC
|... .|| ... | .| ..|||. .|     ||.| .||. .|||||. |         .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase PKCi.AA Iota 237-505 87 6.6e-227 760.09 In-house 1-271 (271) Show / Hide 
Range on Protein: 237-505
Range on HMM: 1-271/271
Sequence Identity: 87% (238 aa)

FELLRVIGRGSYAKVLLVELKATSRVYAMKVIKKELVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTVSRLFFVIEFVSGGDLMFHMQRQRRLPEE
|||.||||||||||||.||.|.|.|.|||||||||.|.||||||||||||||||.||||||||||||||||.||||||||||.||||||||||||.||||
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

HARFYSSEISLALNFLHEGGVIYRDLKLDNVLLDADGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYDFSVDWWALGVLMFEMLAGRSPF
||||||.||.|||||||| |.|||||||||||||..||||||||||||||.||||||||||||||||||||||||||.|||||||||||||||.||||||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

DIVGNADHPDQNTEDYLFQVILEKPIRIPRSLSVKAASVLKGFLNKNPIERLGCHPQT--GFGDITGHPFF
|||||.|.||||||||||||||||.|||||||||.||.||||||||.|.|||||||||  || ||..||||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase PKCi.AA PKC 237-505 59 1.4e-200 656.08 In-house 1-262 (262) Show / Hide 
Range on Protein: 237-505
Range on HMM: 1-262/262
Sequence Identity: 59% (160 aa)

FELLRVIGRGSYAKVLLVELKATSRVYAMKVIKKELVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTVSRLFFVIEFVSGGDLMFHMQRQRRLPEE
|..|.|.|.||..||.|.|.| | ..||.||.||.....|.|.....|||.|...|..||||..||.|||| .|||||.|.| |||||||.|.|||..||
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

HARFYSSEISLALNFLHEGGVIYRDLKLDNVLLDADGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYDFSVDWWALGVLMFEMLAGRSPF
|||||. ||..||.|||| |.|||||||||||||..||||..|.|||||....|||||||||||.|||||||....| .||||||.||||.||.||.|||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

DIVGNADHPDQNTEDYLFQVILEKPIRIPRSLSVKAASVLKGFLNKNPIERLGCHPQT--GFGDITGHPFF
...         .||.|||.|... ...||.||..|.|..|||..||| .|||||||.  |..||. ||||
HGE---------DEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCi.AA AGC 237-505 32 1e-181 474.81 In-house 1-395 (395) Show / Hide 
Range on Protein: 237-505
Range on HMM: 1-395/395
Sequence Identity: 32% (129 aa)

FELLRVIGRGSYAKVLLVELK------ATSRVYAMKVIKKEL-VTDDE--DIDWVQTE------------KHVFETASN---------HPFLVG-LHSCF
||.|.|||.||. || ||. |      .| ..|||||.||.  . ...  ... ..||            ....|....         |||.|  ||..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTVSR--LFFVIE----FVS-----GG-DLMFHMQ---RQRRLPEEHARFYSSE-------ISLALNFLHE-GGVIYRD-LKLDNVLLDADGHIKLTDYG
|. ..  |.|| |    .|.     || .|..|.|   ...|..||.|||| .|       | ||| .||.  |.|.|| ||..|.|||.|||||||| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKEGLRPG--------------------------------------------------DTTSTFCG--TPNYIAPEILRGEDYDFSVDWWA--LGVLMF
.|||| . |                                                  |.|.||||  ||.|.|||||    |....|||.  ||.||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLAGRSPFDIVGNAD--HPDQNTEDYLFQVIL------EKPIRIP----------RSLSVKAASVLKGFLNKNPIERLGCHPQT----GFGDITGHPFF
|||.|..||    . .  | ...... .|| |.      ......|          |..|. | . .|..|.|.| .||||....    |. .|  ||.|
EMLTGYPPFYGDNPQENRH-PFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCi.AA Eta 237-505 54 2.7e-128 432.53 In-house 1-261 (261) Show / Hide 
Range on Protein: 237-505
Range on HMM: 1-261/261
Sequence Identity: 54% (147 aa)

FELLRVIGRGSYAKVLLVELKATSRVYAMKVIKKELVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTVSRLFFVIEFVSGGDLMFHMQRQRRLPEE
|. ..|.|.||. ||.| |.| |  |||.||.||. .  |.|..   ||| .   | .||||  ||.||||  |||||.|.| ||||||..|| |.  | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

HARFYSSEISLALNFLHEGGVIYRDLKLDNVLLDADGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYDFSVDWWALGVLMFEMLAGRSPF
 ||||  |. .|| |||. |||||||||||.|||..|| || |.||||||.  | ||.|||||| |||||||.  .|  ||||||.||||.||..|..||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

DIVGNADHPDQNTEDYLFQVILEKPIRIPRSLSVKAASVLKGFLNKNPIERLGCHP-QTGFGDITGHPFF
.    ||      || ||. ||.  .  |  |.  | |.||.|. ||| .||||   | |  .|  ||||
E----ADN-----EDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCi.AA Alpha 237-505 52 2.8e-126 425.8 In-house 1-259 (259) Show / Hide 
Range on Protein: 237-505
Range on HMM: 1-259/259
Sequence Identity: 52% (141 aa)

FELLRVIGRGSYAKVLLVELKATSRVYAMKVIKKELVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTVSRLFFVIEFVSGGDLMFHMQRQRRLPEE
|  | |.|.||. ||.| | | |   || |. ||  .  | |..   .|| |    .  |||| .||||||. ||.|| |.| |||||.|.|.  .  | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

HARFYSSEISLALNFLHEGGVIYRDLKLDNVLLDADGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYDFSVDWWALGVLMFEMLAGRSPF
|| ||  ||. .| |||| |.||||||||||.|||.||||..|.|||||.. ...|| ||||||.||||||   . |  |||||| |||..||.||  ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

DIVGNADHPDQNTEDYLFQVILEKPIRIPRSLSVKAASVLKGFLNKNPIERLGCHPQTGFGDITGHPFF
|  |.        || ||| | |.    |.|.|. | .. |||| |.|  |||| |.    ||. ||||
D--GED-------EDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGE-QDIREHPFF
Kinase PKCi.AA SGK 237-505 39 7.79999999999e-121 375.03 In-house 1-283 (283) Show / Hide 
Range on Protein: 237-505
Range on HMM: 1-283/283
Sequence Identity: 39% (116 aa)

FELLRVIGRGSYAKVLLVELKAT------------------SRVYAMKVIKKELVT-------DDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTVSRL
|..| ||| ||. ||..|. |..                    .|||||..|. .          .    ...|. |     .|||.|.||  |||   |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVIEFVSGGDLMFHMQRQRRLPEEHARFYSSEISLALNFLHEGGVIYRDLKLDNVLLDADGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGE
.|| ..| ||.. .|.|| ...||  |||| .|| .||  ||.  .|||||| .|.|||..||..||| | ||||  . |||.|||||| | |||.||..
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

DYDFSVDWWALGVLMFEMLAGRSPFDIVGNADHPDQNTEDYLFQVILEKPIRIPRSLSVKAASVLKGFLNKNPIERLGCHPQTGFGDITGHPFF
 .| .|||| || ...||. |  ||         ..|..  ... |. .|..||.. |..| . ..| |.|.| .|||     .|..|  ||||
PHDRTVDWWCLGCVLYEMMYGLPPFY--------SRNKQ-QMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK--RDFMEIKNHPFF
Kinase PKCi.AA Akt 237-436 49 2e-115 370.45 In-house 1-203 (264) Show / Hide 
Range on Protein: 237-436
Range on HMM: 1-203/264
Sequence Identity: 49% (100 aa)

FELLRVIGRGSYAKVLLVELKATSRVY-AMKVIKKELVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTVSRLFFVIEFVSGGDLMFHMQRQRRLPE
|..|.|.|.||..||.||. |.| ..| ||||.||.   .   .  ..||. . ..   |||.|.||  |||  .|.|| ....||.| .|.||.|| .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

EHARFYSSEISLALNFLHEGGVIYRD-LKLDNVLLDADGHIKLTDYGMCKEG-LRPGDTTSTFCGTPNYIAPEILRGEDYDFSVDWWA-LGVLMFEMLAG
. |||| .||.||. .||. ..|||| ||. |.|.|.||||.||| |.|||. .  .|.| |||||| |.||||| | ... .||||. ||..|.||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

RSPF
| ||
RPPF
Kinase PKCi.AA Delta 237-505 48 4.1e-111 375.45 In-house 1-259 (259) Show / Hide 
Range on Protein: 237-505
Range on HMM: 1-259/259
Sequence Identity: 48% (130 aa)

FELLRVIGRGSYAKVLLVELKATSRVYAMKVIKKELVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTVSRLFFVIEFVSGGDLMFHMQRQRRLPEE
| ...|.|.||. ||.|.||| . . ||.| .||. |  |.|..    |..|   |..||||  |   ||| . ||||.|.. |||||.|.| ..|  |.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

HARFYSSEISLALNFLHEGGVIYRDLKLDNVLLDADGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYDFSVDWWALGVLMFEMLAGRSPF
 ||||..|| ..| |||. |.||||||||||||| |||||. |.||||| .    ..||||||| ||||||..|. | .|||||. ||||.||| | |||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

DIVGNADHPDQNTEDYLFQVILEKPIRIPRSLSVKAASVLKGFLNKNPIERLGCHPQTGFGDITGHPFF
   .         || ||. |..     || ..  |...||. ....| .|||  ...  |||  |.||
HGED---------EDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGV-QYCPKGDIRQHCFF
Kinase PKCi.AA RSK 240-505 38 1e-97 330.92 In-house 1-278 (278) Show / Hide 
Range on Protein: 240-505
Range on HMM: 1-278/278
Sequence Identity: 38% (110 aa)

LRVIGRGSYAKVLLVELK---ATSRVYAMKVIKK-ELVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTVSRLFFVIEFVSGGDLMFHMQRQRR---
|.| |.|.| || |.  .   .| ..|||||.|| ..|. . |.  . ||  . |.  .|||.| ||  ||| . |. . |...||.|  | |....   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPEEHARFYSSEISLALNFLHEGGVIYRDLKLDNVLLDA---DGHIKLTDYGMCKEG-LRPGDTTSTFCGTPNYIAPEILR----GEDYDFSVDWWALGV
. |. |.|| .||.||. .||. |.|.||||..|.|.|    .||||||| | ||.. .. .  | |||.| .|.|||.|.    .. .| ..||| |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMFEMLAGRSPFDIVGNADHPDQNTEDYLFQVILEKP--IRIP--RSLSVKAASVLKGFLNKNPIERLGCHPQTGFGDITGHPFF
||.|||.|..||   .|      |. . ... |...    ..|   .||  | . ... | ..|  |||| || .  .|  ||.|
LMYEMLTGCPPFQG-PND-----NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQ-DAEEIKQHPWF
Kinase PKCi.AA AktR 237-505 38 1.5e-96 327.05 In-house 1-268 (268) Show / Hide 
Range on Protein: 237-505
Range on HMM: 1-268/268
Sequence Identity: 38% (107 aa)

FELLRVIGRGSYAKVLLVELK-ATSRVYAMKVIKKELVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTVSRLFFVIEFVSGGDLMFHMQRQRRLPE
|......|.| ..|| ||. |  . ..||||.|||.   . . .. ..||. . |  .||||.| || |||| . |||..|.. ||.| .| ...... |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EHARFYSSEISLALNFLHEG-GVIYRDLKLDNVLLDADGHIKLTDYGMCK-EGLR-PGDTTSTFCGTPNYIAPEILRG-EDYDFSVDWWALGVLMFEMLA
| ||||...| ||| .||.   .|||||| .| ||| |||.|.||.|. | .. .   ... .||||| |.|||...  . ...||||||.|.. .||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRSPFDIVGNADHPDQNTEDYLFQVILEKP-IRIPRS--LSVKAASVLK-GFLNKNPIERLG--CHPQTGFGDITGHPFF
|  ||         ...   ..|| |..|. ...| .  .| .. . .. . |.||| .|||  |    |. .|  ||.|
GCPPF---------YHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCN---GWEEIKSHPWF
Kinase PKCi.AA S_TKc 237-505 32 1.2e-92 315.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 237-505
Range on HMM: 1-231/231
Sequence Identity: 32% (91 aa)

FELLRVIGRGSYAKVLLVELKATSRVYAMKVIKKELVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTVSRLFFVIEFVSG--GDLMFHMQRQRR--
.|.||.||.|...|| ..  | | |..|.|.||          . .. |  . .   .||..| |. .||. ..|..| |...|  |||. ......|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LPEEHARFYSSEISLALNFLHEGGVIYRDLKLDNVLLDADGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYDF-SVDWWALGVLMF
    .|| |||||  .| .||...|. |.|.|||| .|.|||   |||..| |....        .||||||.|.|||.|    |.. ..|||..|....
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLAGRSPFDIVGNADHPDQNTEDYLFQVILEKPIRIPRSLSVKAASVLKGFLNKNPIERLGCHPQTG-FGDITGHPFF
|||.|. ||.           ... .|..|.          |  | . ... |.|.| .|...        ||  ||.|
EMLCGYPPFP-----------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCi.AA Pkinase 237-505 28 1.2e-80 279.0 Pfam 1-293 (293) Show / Hide 
Range on Protein: 237-505
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

FELLRVIGRGSYAKVLLVELKATSRVYAMKVIKKELVTDDEDIDWVQ-TEKHVFETASNHPFLVGLHSCFQTVSRLFFVIEFVSGG----DLMFHMQ--R
....|.||.||...| .   | |....|.|.|||.   ...|.  .  .| ..     |||. | |. .|.. ... .| |.. ||    ||. ...  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QRRL--PEEHARFYSSEISLALNFLHEGGVIYRDLKLDNVLLDADGHI----KLTDYGMCKEG-LRPGDTTSTFCGTPNYIAPEILR-GEDYDFSVDWWA
....  .|....||  .|  .|...|. |.|.||||..|.|.| .|||    |..| | .|   . ..  ..||||||.|.|||..| |..|. .||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLMFEMLAGRSPFDIVGNADHPDQNTEDYLFQVILEKPIRIPRSLS---------------------VKAASVLKGFLNKNPIERLGCHPQTGFGDIT
.|....||| || ||.   . .|.. ........ |...|.. ... .                       . ...|. |.|.| .|..      . .| 
CGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT------AEQIL

GHPFF
 ||.|
QHPWF
Kinase PKCi.AA S_TK_X 506-569 36 6.6e-26 93.31 SMART 1-79 (79) Show / Hide 
Range on Protein: 506-569
Range on HMM: 1-79/79
Sequence Identity: 36% (29 aa)

KTIDWDRIES--RQVTPPYKPHLQ----SDRDLEHFDPQFTEEPIQLTPDDPGVLSQIDQGE---------FEGFEYIN
. ||||....  ....||.|| ..    |..|.. ||| ||||.. ||||||.......| |         |.|| |..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCi.AA Pkinase_C 525-571 44 1.3e-15 58.12 Pfam 1-46 (46) Show / Hide 
Range on Protein: 525-571
Range on HMM: 1-46/46
Sequence Identity: 44% (21 aa)

HLQSDRDLEHFDPQFTEEPIQLTPDDPGVLSQIDQGEFEGFEYINPL
.. |..| ..|||.||.|| ..||.|.  .|..|| .|.|| | || 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCi.AA Akt 453-505 32 3.2e-13 38.54 In-house 211-264 (264) Show / Hide 
Range on Protein: 453-505
Range on HMM: 211-264/264
Sequence Identity: 32% (18 aa)

LFQVILEKPIRIP--RSLSVKAASVLKGFLNKNPIERLGCHPQTGFGDITGHPFF
.|. |...|...|  . .| .. . ..| |||.| .||| .|..   .|  ||.|
MFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQ-EIKRHPWF
Kinase PKCi.AA TyrKc 237-505 18 5.3e-13 -12.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 237-505
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

FELLRVIGRGSYAKVLLVELKATSRVYAMKVIKKELVTDDEDIDWVQTEKHVFETA-SNHPFLVGLHSCFQTV-------SRLFFVIEFVSGGDLMFHMQ
 .|....|.| . .| . ..|   .  | |..|..       .     |  .      .|| .| |. .  .          |. | |....|||  . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RQRR-LPEEHARFYSSEISLALNFLHEGGVIYRDLKLDNVLLDADGHIKLTDYGMCKEGLRP-------GDTTSTF--CGTP----NYIAPEILRGEDYD
. |. |. ..   ..  |.   ..||. ..| |||   |.|.......| .| |.....             ...   .|         ||| ..   . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

FSVDWWALGVLMFEMLA-GRSPFDI-VGNADHPDQNTEDYLFQV-ILEKPIR--------IPRSLSVKAASVLKGFLNKNPIERLGCHPQTGFGDITGHP
.  | |. ||.|.|..  | .|    . . . ..|    |. |   ...|           |  .     .. |   . .| .|        | .|  | 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEM----YQIMKQCWHEDPEDRP------TFSEI--HE

FF
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CF
Kinase PKCi.AA Pkinase_Tyr 237-384 19 3e-06 22.02 Pfam 1-159 (270) Show / Hide 
Range on Protein: 237-384
Range on HMM: 1-159/270
Sequence Identity: 19% (32 aa)

FELLRVIGRGSYAKVLLVELK----ATSRVYAMKVIKKELVTDDE--DIDWVQTEKHVFETASNHPFLVGLHSCFQ-TVSR--LFFVIEFVSGGDLMFHM
 ......|.|.. .| . ..|     |    | |.. ||  ....    |  . |  .  .  .|| .| |. .         .. | |.. .|||  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QR----QRRLPEEHARFYSSEISLALNFLHEGGVIYRDLKLDNVLLDADGHIKLTDYGMCK
..    ...|. ..   .. .|. ....|.. . | |||   |.|.. ....| .| |...
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKCi.AA Pkinase_Tyr 420-436 42 1.84858 2.18 Pfam 198-216 (270) Show / Hide 
Range on Protein: 420-436
Range on HMM: 198-216/270
Sequence Identity: 42% (8 aa)

WALGVLMFEMLA-GRSP-F
|. ||||.|..  |..| .
WSFGVLMWEIFTYGEQPTY