Gene SGK (Sea Urchin)

SGK

Species: Sea Urchin
Alias: SGK, SPU_007222, Spk030
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: SGK

Sequence

Name Sequence Type Origin Length Description Download
SGK.AA Protein None 345 None Fasta, JSON
SGK.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of SGK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SGK.AA SGK 92-288 68 7.79999999999e-174 541.65 In-house 1-222 (283) Show / Hide 
Range on Protein: 92-288
Range on HMM: 1-222/283
Sequence Identity: 68% (151 aa)

FDFLKVIGKGSFGKVLLAKHKID------------------GKVYAVKVLQKAAIV-------KRNEAKHIMAERSVLLKNLKHPFLVSLHYSFQTADKL
|||||||||||||||...||| |                  .|.||.|||||..|.       |..|.|||||||.|.|||.||||.|.|||.|||..||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YFVLDYVNGGELFFHLQREKSFPEVRAKFYAAEIASAIGYLHSLDIIYRDLKPENILLDHDGHVRLTDFGLCKEGIAAKKTTSTFCGTPEYLAPEVLRKQ
|||.|||||||.|.||||||.||| ||.||||||..|..||||.||||||||||||||||.||..|||||||||||....||.|||||||||||||||||
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

EYDRSVDWWCLGAVLFEMMSGL
..||.|||||||.||.|||.||
PHDRTVDWWCLGCVLYEMMYGL
Kinase SGK.AA AGC 92-289 39 2.3e-158 413.01 In-house 1-303 (395) Show / Hide 
Range on Protein: 92-289
Range on HMM: 1-303/395
Sequence Identity: 39% (122 aa)

FDFLKVIGKGSFGKVLLAKHK------IDGKVYAVKVLQKAA-IVKRN--EAKHIMAE------------RSVLLKNLK---------HPFLVS-LHYSF
|.||||||||||||| |...|        ||.||.|||.|.  ||...  . .|.|.|            | .| |  .         |||.|. |||||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTADK--LYFVLD----YVN-----GG-ELFFHLQ---REKSFPEVRAKFYAAE-------IASAIGYLHS-LDIIYRD-LKPENILLDHDGHVRLTDFG
|. |.  ||||..    |||     || |||.|||   .|..|.| ||.|||||       |..|. |||| ..||.|| |||||||||.|||..|||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEGIA--------------------------------------------------AKKTTSTFCG--TPEYLAPEVLRKQEYDRSVDWWC--LGAVLF
|||||.                                                    ...|.||||  ||||.|||.|    |....|||.  ||....
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMMSGLS
||..|..
EMLTGYP
Kinase SGK.AA Akt 92-288 61 1.6e-137 442.2 In-house 1-200 (264) Show / Hide 
Range on Protein: 92-288
Range on HMM: 1-200/264
Sequence Identity: 61% (124 aa)

FDFLKVIGKGSFGKVLLAKHKIDGKVY-AVKVLQKAAIVKRNEAKHIMAERSVLLKNLKHPFLVSLHYSFQTADKLYFVLDYVNGGELFFHLQREKSFPE
||||||.||||||||.|.| | ..|.| | |||.|  |...|. .|...|| . |.. .|||.|.|||||||.||||||.||.||||||.||||.. |.|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNI-LQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

VRAKFYAAEIASAIGYLHSLDIIYRD-LKPENILLDHDGHVRLTDFGLCKEG-IAAKKTTSTFCGTPEYLAPEVLRKQEYDRSVDWWC-LGAVLFEMMSG
 ||.||.||| .||..||| .||||| |||||||.|.|||..|||||||||. |    .| ||||||||||||.| .. ....||||  ||.|..||| |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

L
.
R
Kinase SGK.AA PKC 92-287 55 3.2e-115 374.97 In-house 1-196 (262) Show / Hide 
Range on Protein: 92-287
Range on HMM: 1-196/262
Sequence Identity: 55% (109 aa)

FDFLKVIGKGSFGKVLLAKHKIDGKVYAVKVLQKAAIVKRNEAKHIMAERSVLLKNLKHPFLVSLHYSFQTADKLYFVLDYVNGGELFFHLQREKSFPEV
|.||||.||||||||.||..|   ..||.||| | .|..       |.|. ||    |||||..|| .||| |.|.||. ||||| | || |. . |.| 
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RAKFYAAEIASAIGYLHSLDIIYRDLKPENILLDHDGHVRLTDFGLCKEGIAAKKTTSTFCGTPEYLAPEVLRKQEYDRSVDWWCLGAVLFEMMSG
.|.||||||..|  .||. .||||||| .|.||||.||....|||.|||..   .|||||||||.|.|||.|. |||  ||||| .|  ..||| |
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAG
Kinase SGK.AA AktR 92-288 49 2.6e-107 362.82 In-house 1-202 (268) Show / Hide 
Range on Protein: 92-288
Range on HMM: 1-202/268
Sequence Identity: 49% (99 aa)

FDFLKVIGKGSFGKVLLAKHK-IDGKVYAVKVLQKAAIVKRNEAKHIMAERSVLLKNLKHPFLVSLHYSFQTADKLYFVLDYVNGGELFFHLQREKSFPE
|...|..||| |||| |...|  ..|.|| |.. |  |..|| ..|.  || .. .  .|||.| |||.||| .||.|...|. |||||.||...| | |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

VRAKFYAAEIASAIGYLHSL-DIIYRDLKPENILLDHDGHVRLTDFGLCK-EGIAAK-KTTSTFCGTPEYLAPEVLRK-QEYDRSVDWWCLGAVLFEMMS
 .|.||.|.|  |. |||.  .|||||||||||||| ||||..||||| | ... ..  .. .|||||||.|||...| . ...|||||..|....||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GL
|.
GC
Kinase SGK.AA RSK 95-287 49 6.9e-105 354.76 In-house 1-208 (278) Show / Hide 
Range on Protein: 95-287
Range on HMM: 1-208/278
Sequence Identity: 49% (102 aa)

LKVIGKGSFGKVLLAKHKI---DGKVYAVKVLQKAAIVKRNE-AKHIMAERSVLLKNLKHPFLVSLHYSFQTADKLYFVLDYVNGGELFFHLQREKS---
||| |.|..||| | . ..    |..||.|||.|| ||.|.  ..| |.||..|.   .|||.|.|||.||| .||| ...|..||||| |||.||.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPEVRAKFYAAEIASAIGYLHSLDIIYRDLKPENILLDH---DGHVRLTDFGLCKEGIAA-KKTTSTFCGTPEYLAPEVLR---KQE-YDRSVDWWCLGA
| | .|.||.|||..|. .||...||.|||||||||.|.   .||..|||||.||.. .  .. | |||.| ||.|||.|.   .|. .|...||| ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VLFEMMSG
...|| .|
LMYEMLTG
Kinase SGK.AA PKA 92-287 47 6.1e-102 344.98 In-house 1-195 (263) Show / Hide 
Range on Protein: 92-287
Range on HMM: 1-195/263
Sequence Identity: 47% (94 aa)

FDFLKVIGKGSFGKVLLAKHKIDGKVYAVKVLQKAAIVKRNEAKHIMAERSVLLKNLKHPFLV-SLHYSFQTADKLYFVLDYVNGGELFFHLQREKSFPE
|......|.||||.| |..||..|. || |.| |. ||...   |.. |... |.|.||||.| .. ..||....||.|..||.|||.| .|.....|..
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNI-LQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSN

VRAKFYAA-EIASAIGYLHSLDIIYRDLKPENILLDHDGHVRLTDFGLCKEGIAAKKTTSTFCGTPEYLAPEVLRKQ-EYDRSVDWWCLGAVLFEMMSG
  |||||| .| .|. ||||..||||||||||||.| .||. .||||  |. .     |.| ||||||||||..     . .|||||.|| . .||..|
PHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKK-VDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAG
Kinase SGK.AA Eta 92-287 55 2.1e-100 339.84 In-house 1-196 (261) Show / Hide 
Range on Protein: 92-287
Range on HMM: 1-196/261
Sequence Identity: 55% (109 aa)

FDFLKVIGKGSFGKVLLAKHKIDGKVYAVKVLQKAAIVKRNEAKHIMAERSVLLKNLKHPFLVSLHYSFQTADKLYFVLDYVNGGELFFHLQREKSFPEV
|.|.||.||||||||.||..|  . |||.|||.| .|..  .    |.|. .|    ||||| .|| .||| |.|.||..|||||.| |..|| . | | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RAKFYAAEIASAIGYLHSLDIIYRDLKPENILLDHDGHVRLTDFGLCKEGIAAKKTTSTFCGTPEYLAPEVLRKQEYDRSVDWWCLGAVLFEMMSG
||.|||||. .|. .||  ..|||||| .||||||.|| .| |||.|||||   .||.||||||.|.|||.|. .||  ||||| .| ...|||.|
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCG
Kinase SGK.AA p70 92-287 43 1.3e-94 320.61 In-house 1-234 (299) Show / Hide 
Range on Protein: 92-287
Range on HMM: 1-234/299
Sequence Identity: 43% (102 aa)

FDFLKVIGKGSFGKVLLAKHKI---DGKVYAVKVLQKAAIVKRNEA-KHIM-------------------------AERSVLLKNLKHPFLVSLHYSFQT
|  |||.||| .|||.. .       ||.|| |||.|| ||    .  |                           |||.. |   ||||.. |||.|||
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNI-LEEVKHPFICDLHYAFQT

ADKLYFVLDYVNGGELFFHLQREKSFPEVRAKFYAAEIASAIGYLHSLDIIYRDLKPENILLDHDGHVRLTDFGLCKEGIAAKKT----------TSTFC
  ||| .|.|  ||||| || |.  ..|  |.||..||  |...||...||||||||||..|.. ||| ||||||||| |   .           | |||
NGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFC

GTPEYLAPEVLRKQEYDRSVDWWCLGAVLFEMMSG
||.|| |||.|..  ... |||| ||. .. |. |
GTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTG
Kinase SGK.AA Alpha 92-287 52 8.4e-93 314.61 In-house 1-196 (259) Show / Hide 
Range on Protein: 92-287
Range on HMM: 1-196/259
Sequence Identity: 52% (102 aa)

FDFLKVIGKGSFGKVLLAKHKIDGKVYAVKVLQKAAIVKRNEAKHIMAERSVLLKNLKHPFLVSLHYSFQTADKLYFVLDYVNGGELFFHLQREKSFPEV
| ||.|.||||||||.||  |     ||.|.|.|  |.        | |. ||    | ||||..|  ||| | ||||. ||||| | .|.|.   | | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RAKFYAAEIASAIGYLHSLDIIYRDLKPENILLDHDGHVRLTDFGLCKEGIAAKKTTSTFCGTPEYLAPEVLRKQEYDRSVDWWCLGAVLFEMMSG
 | ||||||| .  .||. .|||||||  |..|| .||....|||.|||..  ..|| ||||||.|.|||.   | | .|||||  |  |.||| |
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAG
Kinase SGK.AA S_TKc 92-330 34 1.7e-80 274.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 92-330
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FDFLKVIGKGSFGKVLLAKHKIDGKVYAVKVLQKAAIVKRNEAKHIMAERSVLLKNLKHPFLVSLHYSFQTADKLYFVLDYVNG--GELFFHLQREKS--
...|..||||.|||| ...|| .|...|.|..           .||. |...| |  .||..| |...||. |.||.|..|..|  |.|| .... ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FPEVRAKFYAAEIASAIGYLHSLDIIYRDLKPENILLDHDGHVRLTDFGLCKEGIAAKKTTSTFCGTPEYLAPEVLRKQEYDR-SVDWWCLGAVLF
    ||| .|.||...|..|. |.||. ||.|||||||||||.  |. ..||||...        .||||||.|.|||||    |.. ..||| .| .|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMMSGLS----DSMDVKNIDPEFVREPVPNSVGK-------SVDPN---TVSASVQ-----DADNVF
||..|      . |  |.|           . .|        .||.   |.    |      ..  |
EMLCGYPPFPQMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SGK.AA Pkinase 92-287 38 1.3e-76 265.58 Pfam 1-208 (293) Show / Hide 
Range on Protein: 92-287
Range on HMM: 1-208/293
Sequence Identity: 38% (81 aa)

FDFLKVIGKGSFGKVLLAKHKIDGKVYAVKVLQKAAIVKRNEAKHIM-AERSVLLKNLKHPFLVSLHYSFQTADKLYFVLDYVNGG----ELFFHLQ--R
. ....||.||||.| ...|| .||..|||.. |  . .  .  |.  .| .....  .||. | |...|.. |..|.|..|..||    .|| ...  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

EKSF--PEVRAKFYAAEIASAIGYLHSLDIIYRDLKPENILLDHDGHV----RLTDFGLCKEG-IAAKKTTSTFCGTPEYLAPEVLR-KQEYDRSVDWWC
...|  .|  .|||. .|.... |.||  ||.|||||||||.|..||.    ...||||.|   .  .  ..||||||.|.||||.|  |.|...||.| 
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGAVLFEMMSG
.| .|.||..|
CGCILYEMLCG
Kinase SGK.AA TyrKc 92-340 19 3.1e-13 -8.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 92-340
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

FDFLKVIGKGSFGKVLLAKHKIDGKVYAVKVLQKAAIVKRNEAKHIMAERSVLLKNL--KHPFLVSLHYSFQTA-------DKLYFVLDYVNGGELFFHL
  ..|..| | ||.| ... |      |||.|.. |       . .| |   ....|  .|| .| |.    .        . |. |. |. .| |  .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMRE-ARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QREKS-FPEVRAKFYAAEIASAIGYLHSLDIIYRDLKPENILLDHDGHVRLTDFGLCKEGIAA-------KKTTSTF--CGTP----EYLAPEVLRKQEY
.. .  ..      ..  ||.   ||||  .| |||   |.|......|. .||||....          .  ...   .|        .|||.... ..
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DRSVDWWCLGAVLFEMMS-------G-----LSDSMDVKNIDPEFVREPVPN----SVGKSVDPNTVSASVQDADNVFE--------------GFTYVPP
    | |  | ...|...       |     .|..  .....  . ... ||    |            .|   | ...               |. .  
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

TV
  
CF
Kinase SGK.AA Pkinase_Tyr 92-286 23 5.8e-13 44.53 Pfam 1-209 (270) Show / Hide 
Range on Protein: 92-286
Range on HMM: 1-209/270
Sequence Identity: 23% (51 aa)

FDFLKVIGKGSFGKVLLAKHK-----IDGKVYAVKVLQKAAIVKRNE--AKHIMAERSVLLKNL-KHPFLVSLHYSFQ-TADK--LYFVLDYVNGGELFF
  |.|..|.|.||.| ... |      . .| |||.| |       .   .  |.| .. .|.| .|| .|.|.       .   .| |. |. .| |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV-AVKML-KE-GAMHEQNCREDFMREAKI-MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

HLQR----EKSFPEVRAKFYAAEIASAIGYLHSLDIIYRDLKPENILLDHDGHVRLTDFGLCKEG-------IAAKKTTSTFCGTPEYLAPEVLRKQEYD
.|..    .....  .   ....||..  ||.|  .| |||   |.|......|. .||||..          .....      .    |||...  .. 
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFT

RSVDWWCLGAVLFEMMS
   | |  | ...|...
TKSDVWSFGVLMWEIFT
Kinase SGK.AA Pkinase_C 287-339 33 4.7e-09 35.17 Pfam 1-46 (46) Show / Hide 
Range on Protein: 287-339
Range on HMM: 1-46/46
Sequence Identity: 33% (18 aa)

GLSDSMDVKNIDPEFVREPVPNSVGKSVDPNTVSASVQDADNVFEGFTYVPPT
 ...  |. | |||| .||.. ..   .|..  |.. |.    |.|||||.| 
QVKSPTDTSNFDPEFTDEPPMDTP---PDWR-MSSGDQE---PFRGFTYVNPD
Kinase SGK.AA S_TK_X 270-337 22 0.00038 11.54 SMART 1-79 (79) Show / Hide 
Range on Protein: 270-337
Range on HMM: 1-79/79
Sequence Identity: 22% (20 aa)

RSVDWWCLGAVLFE---MMSG-----LS----DSMDVKNIDPEFVREPVPNSVGKSVDPNTVSASVQDA-------DNVFEGFTYVP
|..||.     |.    ..       ..    .  |..| |||| .|..      ..|. ..|.|..         .. |.||||| 
RGIDWD----KLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM----LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF