Gene ATR (Sea Urchin)
ATR
Sequence
Protein domains of ATR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | ATR.AA | ATR | 125-391 | 58 | 2.5e-151 | 509.05 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 125-391 Range on HMM: 1-267/267 Sequence Identity: 58% (157 aa) VYIIGFDDTVEVLPSLQRPKKIGIQGSDGRLYVMMCKPKDDLRKDNRLMEFNGIINKCLRKNVESRRRELYIRTYTVIPLNEECGLIEWVSNTAGLRPIL || |||| ||.| |||.|||| ..||||..|.|||||||||||| |.|.|| .||.|.|| |.|||.. .|||.|||||..|..|||| |||.||||| AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL HKIYREKGLYTSGSELKAMIPSLSAPIDEKLNIFENKLMPRYPPVFGEWFQKTFTDPTSWYLSRLAYARTMAVMSMVGYILGLGDRHGENILFDSTNGDC |...||. | . .|. .|. ||. .| . |.||.||.| .|| ..| ||..|| || .| |..||..|||||.||||||..|||.|. ||.| DKLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGEC VHVDFNCLFNKGETFDWPERVPFRLTHNMVCAMGPMGYEGVFRRACEGTMKVMRDQRDPLMSVLKTF ||||.||.||.||.|. || |||||||||| .||||. .|.|||||| .|..|||.||..|||...| VHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | ATR.AA | PIKK | 126-391 | 41 | 1.5e-134 | 453.32 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 126-391 Range on HMM: 1-290/290 Sequence Identity: 41% (121 aa) YIIGFDDTVEVLPSLQRPKKIGIQGSDGRLYVMMCKPKDDLRKDNRLMEFNGIINKCLRKNVESRRRELYIRTYTVIPLNEECGLIEWVSNTAGLRPILH .| ..|. |.|....|.|||| | |.||. |...||...|||.| |.|......|.||.|. |...|.| ||||.|||.. .||||||| |...|..|. RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK KIYREKG------LYT-----------------SGSELKAMIPSLSAPIDEKLNIFENKLMPRYPPVFGEWFQKTFTDPTSWYLSRLAYARTMAVMSMVG . . .|. .. . ... .. ..| .||. .|. . .. |..| .|| .|.||..|. .| .|.|. |||.||| QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG YILGLGDRHGENILFDSTNGDCVHVDFNCLFN-KGETFDWPERVPFRLTHNMVCAMGPMGYEGVFRRACEGTMKVMRDQRDPLMSVLKTF |||||||||.|||..|...|..||.||.|.|. ...... || ||||||.||| |||||| ||||||.|| .|..||..|..||.|...| YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | ATR.AA | PI3Kc | 157-458 | 29 | 2.9e-98 | 333.65 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 157-458
Range on HMM: 1-336/336
Sequence Identity: 29% (101 aa)
VMMCKPKDDLRKDNRLMEFNGIINKCLRKNVESRRRELYIRTYTVIPLNEECGLIEWVSNTAGLRPILHKIYREKGLYTSGSELKA--------------
...|..||||.|.| |......||...|. |.||| |..|.| .||....||.||||.|.. |..|..| . .|... .. ...
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
----------MIPSLSAPIDEKLNIFENKLMPRYPPVFGEWFQKTFTDP-TSWYLSRLAYARTMAVMSMVGYILGLGDRHGENILFDSTNGDCVHVDFNC
|... . ..|.| || ...| |||. .||...|.|| .|. .| ..| .|...||.||||.||||..||..| ..| |.|.||..
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
LFNKGETFDWP-----ERVPFRLTHNMVCAMG----PMGYEGVFRRACEGTMKVMRDQRDPLMSVLKTFIYDPL-VEWSKPSRGRSNALSESGEINNEKA
.|..|... . |||||||||.|| .|| |.||.| ||. |. ....|| ... .|... ...|||. .|.. .. . ...
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--------EKDIKYLRQRF
RLN-HLKYSALVHVRD------IEQRLQGILKIKNKSRTLPLSI
||. . . |. .. . || ... .. . . . .
RLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | ATR.AA | PI3_PI4_kinase | 155-401 | 29 | 5.5e-87 | 300.1 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 155-401 Range on HMM: 1-300/300 Sequence Identity: 29% (88 aa) LYVMMCKPKDDLR--KDNRLMEFN-----------------------GIINKCLRKNVESRRRELYIRTYTVIPLNEECGLIEWVSNTAGLRPILHKIYR | ...| .|||| .|.|.|.. ...|||..|. ..|||.. ...| .||....||.|||| |. ....|. . . WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV EKGLYTSGSELKAMIPSLSAPID----EKLNIFENKLMPRYPPVFGEWFQKTFTDP-TSWYLSRLAYARTMAVMSMVGYILGLGDRHGENILF--DSTNG ... .|.| .. . . .. .|. .||...|. ..|.. .|| |...|. . | .| ..| .|.|..|.||||.||||..||.. | |.| KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG DCVHVDFNCLFN--KGETFDWPERVPFRLTH------NMVCAM------GPMGYEGVFRRACEGTMKVMRDQRDPLMSVL-------KTFIYDPLVEWSK ..|.||.. |. |...|. |||||||.|| .|| || .|.|..| ||. |. .. ..| . . .|..| ....|.|..|.. HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | ATR.AA | ATM | 268-399 | 48 | 1.3e-46 | 146.69 | In-house | 117-248 (304) | Show / Hide |
Range on Protein: 268-399 Range on HMM: 117-248/304 Sequence Identity: 48% (64 aa) PVFGEWFQKTFTDPTSWYLSRLAYARTMAVMSMVGYILGLGDRHGENILFDSTNGDCVHVDFNCLFNKGETFDWPERVPFRLTHNMVCAMGPMGYEGVFR ||| . | || |. |||| | .| |.||||||||||| ||| . ||.| | .| || |||||| .| || | ||||| PVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFR RACEGTMKVMRDQRDPLMSVLKTFIYDPLVEW | || || ||| . |. . .|||| .| RCCEKTMEVMRNSQETLLTIVEVLLYDPLFDW |
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| Kinase | ATR.AA | FRAP | 284-401 | 46 | 1.7e-36 | 127.59 | In-house | 133-251 (251) | Show / Hide |
Range on Protein: 284-401 Range on HMM: 133-251/251 Sequence Identity: 46% (55 aa) WYLSRLAYARTMAVMSMVGYILGLGDRHGENILFDSTNGDCVHVDFNCLFNKGETFD-WPERVPFRLTHNMVCAMGPMGYEGVFRRACEGTMKVMRDQRD |. | | | .|.|||.|||||||||| ||. . | ||.|| | . . ||..||||| .| || | || .| .|| |||.|.... WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE PLMSVLKTFIYDPLVEWSK .| || |.|||| | SVMAVLEAFVYDPLFYWRL |
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| Kinase | ATR.AA | SMG1 | 279-343 | 52 | 2.5e-23 | 74.01 | In-house | 178-242 (242) | Show / Hide |
Range on Protein: 279-343 Range on HMM: 178-242/242 Sequence Identity: 52% (34 aa) TDPTSWYLSRLAYARTMAVMSMVGYILGLGDRHGENILFDSTNGDCVHVDFNCLFNKGETFDWPE | | |. .||| |||||||||.|||||| .|.| | | |. ||.|.. | || || TTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
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| Kinase | ATR.AA | DNAPK | 125-231 | 41 | 1.7e-21 | 74.82 | In-house | 2-108 (301) | Show / Hide |
Range on Protein: 125-231 Range on HMM: 2-108/301 Sequence Identity: 41% (44 aa) VYIIGFDDTVEVLPSLQRPKKIGIQGSDGRLYVMMCKPKDDLRKDNRLMEFNGIINKCLRKNVESRRRELYIRTYTVIPLNEECGLIEWVSNTAGLRPIL | | |||. | |. || |||.| | | | | . | ||| | | . | . ||| ||| .||. |||||| || |. || VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL HKIYREK . . .| NNEMQQK |
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| Kinase | ATR.AA | DNAPK | 291-401 | 33 | 7e-21 | 72.59 | In-house | 190-301 (301) | Show / Hide |
Range on Protein: 291-401 Range on HMM: 190-301/301 Sequence Identity: 33% (37 aa) YARTMAVMSMVGYILGLGDRHGENILFDSTNGDCVHVDFNCLFN-KGETFDWPERVPFRLTHNMVCAMGPMGYEGVFRRACEGTMKVMRDQRDPLMSVLK ..|. || ..||| |||| .| . ||| . .|| | . || ||||| . | ||. |... |. .| .| |. FIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCD TFIYDPLVEWSK || ||.. | . VFINDPSFDWKN |
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| Kinase | ATR.AA | FATC | 454-486 | 60 | 1.1e-19 | 66.06 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 454-486 Range on HMM: 1-33/33 Sequence Identity: 60% (20 aa) LPLSIEGHVDHLIREATDKKNLCLMYIGWAAYM .|||.|..||.||.|||| .||| |||||.... EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| Kinase | ATR.AA | FRAP | 156-231 | 39 | 1.3e-16 | 57.71 | In-house | 2-76 (251) | Show / Hide |
Range on Protein: 156-231 Range on HMM: 2-76/251 Sequence Identity: 39% (30 aa) YVMMCKPKDDLRKDNRLMEFNGIINKCLRKNVESRRRELYIRTYTVIPLNEECGLIEWVSNTAGLRPILHKIYREK |. . | ..|.| | | | |.||. |. | |.....| |. | .||| . ||| || . |. || . ||.| YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLH-ILIRDYRKK |
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| Kinase | ATR.AA | SMG1 | 134-214 | 35 | 1.9e-12 | 37.37 | In-house | 1-81 (242) | Show / Hide |
Range on Protein: 134-214 Range on HMM: 1-81/242 Sequence Identity: 35% (29 aa) VEVLPSLQRPKKIGIQGSDGRLYVMMCKPKDDLRKDNRLMEFNGIINKCLRKNVESRRRELYIRTYTVIPLNEECGLIEWV . .|| .|||. ||||. | . | .|| | |.| | |.| | | | || ||| || ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV |
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| Kinase | ATR.AA | ATM | 158-213 | 39 | 1.8e-11 | 32.54 | In-house | 2-57 (304) | Show / Hide |
Range on Protein: 158-213 Range on HMM: 2-57/304 Sequence Identity: 39% (22 aa) MMCKPKDDLRKDNRLMEFNGIINKCLRKNVESRRRELYIRTYTVIPLNEECGLIEW . | .||||.| . . | | .| | |.| | | || |.|| | .|| QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW |
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