Gene PASK (Sea Urchin)
PASK
Sequence
Protein domains of PASK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PAS | PASK.AA | PAS | 39-134 | 15 | 0.000125 | 17.93 | Pfam | 20-120 (120) | Show / Hide |
Range on Protein: 39-134 Range on HMM: 20-120/120 Sequence Identity: 15% (17 aa) RSTKILLASKMAGELFGYDPGELVGKKMTDLLSLPDRN---RPHALMEEHLESTGQVVM------VSGHVFDILDSCGLVIPVSLWMKKLTDEENP--KC ....||.... | ..||... |..|| ||.. .|. |............ | ..| .. .| .... .......|.. EDGWILYWNRAAERMFGWSREEVMGKMLYDLIHHDDHRCCLEFHDQLWQCMQQGEE-RMFEITFRTPG-----QHRDGRPRWCEVRWCPYRDPGGEIHGF LVVMEPV ...| .. CCFMHDI |
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| PAS | PASK.AA | PAS | 21-87 | 20 | 0.000334 | 21.21 | SMART | 1-68 (68) | Show / Hide |
Range on Protein: 21-87 Range on HMM: 1-68/68 Sequence Identity: 20% (14 aa) ALPTTVRNPNKAMLTIEARSTKILLASKMAGELFGYDPGELVGKKMTDLLSLPDR--NRPHALMEEHLE . .. . .. . . .|. .. .| ..||| | ||.|. .||. .|| | . ..... ERYRAILENMPDGIWVWDHDGRITYWNPAACQMFGYSPEELIGQSWWDLIHPEDRNLERFQE-HQRLQQ |
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| Kinase | PASK.AA | PASK | 738-898 | 68 | 4.2e-132 | 415.33 | In-house | 20-185 (260) | Show / Hide |
Range on Protein: 738-898 Range on HMM: 20-185/260 Sequence Identity: 68% (113 aa) HTKSMSEVVVKFIRRAKVLKENWVDDPKLGCIPLEVAYLTKLD---HPNIVKAVDSFQNDEFFQLVMEKHGSG--IDLFEFIDRQPNFDEALASYMFRQV | . .||||||...||....||.|.|.||||||......|. |.||||..|.|.||.|.|||||||||| .|||.||||.||.||.||||.|||| HNECRYIVVVKFIFKEKVCEDCWVRDRKCGCIPLEIHIMQTLNKNPHENIVKVLDFFENDDFYQLVMEKHGSGGCMDLFDFIDRHPNMDEHLASYIFRQV VAAVKYLHEHGIVHRDIKDENVILDEKFQIKLIDFGSAAYMQPGKKFSTFCGTLEYCSPEVLLGNR |||||||||.|||||||||||||.||.|.||||||||||||..||.|.|||||.|||.||||.||. VAAVKYLHEQGIVHRDIKDENVIIDEHFTIKLIDFGSAAYMERGKFFYTFCGTIEYCAPEVLMGNP |
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| Kinase | PASK.AA | CAMKL | 744-898 | 36 | 2e-71 | 227.16 | In-house | 27-210 (297) | Show / Hide |
Range on Protein: 744-898 Range on HMM: 27-210/297 Sequence Identity: 36% (67 aa) EVVVKFIRRAKVLKENWVDDPKLG-------CIPLEVAYLTKLD---HPNIVKAVDSFQNDEF------FQLVMEKHGSG-IDLFEFIDRQPN----FDE .| .|.| . | .. |... |.| .| |.. . .|. ||||.| . ....|. ..|||| ...| .|||..|..... ..| KVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPE ALASYMFRQVVAAVKYLHEHGIVHRDIKDENVILDEKF--QIKLIDFGSAAYMQP-----GKKFSTFCGTLEYCSPEVLLG-NR | .|||.|.||.|.|.||||||||| ||. |||. .||.|||| .....| |.|..||||...|..||...| |. HEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNK |
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| Kinase | PASK.AA | CAMK | 744-896 | 25 | 1.1e-62 | 200.57 | In-house | 33-294 (425) | Show / Hide |
Range on Protein: 744-896 Range on HMM: 33-294/425 Sequence Identity: 25% (66 aa) EVVVKFIRRAKVLK--------------------ENWVDDPKLGCIPLEVAYLTK-------LDHPNIVKAVDSFQN-------------------DEFF .| .|.| . |. . ..|... .. .. |.. . | ||||||.| . ... |... KVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHM QLVM---EKHGSG---IDLFEFIDRQPN---------------FDEALASYMFRQVVAAVKYLHEHGIVHRDIKDENVILDEK----------------- .|| | | .|||..| .... |.|. |...|||.. ||.|.|.|.|||||.| ||. ||.. YMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNN FQIKLIDFGSAAYMQP------------------------GKKFSTFCGTLEYCS-PEVLLG ..||.|||| |....| |.|..|||||.||.. ||||.| NNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG |
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| Kinase | PASK.AA | MARK | 772-896 | 41 | 2.4e-45 | 146.25 | In-house | 49-179 (262) | Show / Hide |
Range on Protein: 772-896 Range on HMM: 49-179/262 Sequence Identity: 41% (55 aa) EVAYLTKLDHPNIVKAVDSFQ--NDEF-FQLVMEKHGSGIDLFEFIDRQ--PNFDEALASYMFRQVVAAVKYLHEHGIVHRDIKDENVILDEKF--QIKL |.... |||||||.| . .. . . . |.|| . || .|...| . | .| .|||.| ||.|.|...||||||| ||. .||. .||. EIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIME-YASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKI IDFGSAAYMQPGKKFSTFCGTLEYCSPEVLLG |||| .. .||.| .|||||..|..||..|. IDFGFSICIPPGQKLNTFCGTPPYMAPEIFLK |
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| Kinase | PASK.AA | Pkinase | 744-898 | 31 | 2.9e-45 | 161.13 | Pfam | 26-187 (293) | Show / Hide |
Range on Protein: 744-898 Range on HMM: 26-187/293 Sequence Identity: 31% (53 aa) EVVVKFIRRAKVLKENWVDDPKLGCIPLEVAYLTKLDHPNIVKAVDSFQNDEFFQLVMEKHGSG---IDLFEFID--RQPNF--DEALASYMFRQVVAAV .|.|| |.. . .. .. . .| |.... .|.|||||. |.|... .||| .. | .|||..| |. .| .| . ...|.. .. IVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGL KYLHEHGIVHRDIKDENVILDEKFQI----KLIDFGSAAY--MQPGKKFSTFCGTLEYCSPEVLLGNR .|.|..||.|||.| ||. .|.. .| |..|||.|. .. ..|||||..|..|||..|.. EYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ |
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| Kinase | PASK.AA | AGC | 776-894 | 25 | 9.3e-43 | 107.18 | In-house | 74-279 (395) | Show / Hide |
Range on Protein: 776-894 Range on HMM: 74-279/395 Sequence Identity: 25% (52 aa) LTKLD----------HPNIVK-AVDSFQNDEF--FQLVMEKHG---------SGIDLFEFI--D-RQPNFDEALASYMFRQ-------VVAAVKYLHE-H |.|.. ||.||| |||... .||| . | .|| . . .. ||| | ... . .| |. |||. . LEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHM GIVHRD-IKDENVILDEKFQIKLIDFGSAAYMQPG---------------------------------------------------KKFSTFCG--TLEY ||.||| .| ||. |||. ||| |||.. . . .. .|||| | || GIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEY CSPEVL .||.| MAPEIL |
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| Kinase | PASK.AA | NuaK | 772-896 | 39 | 1.8e-42 | 109.1 | In-house | 49-172 (252) | Show / Hide |
Range on Protein: 772-896 Range on HMM: 49-172/252 Sequence Identity: 39% (49 aa) EVAYLTKLDHPNIVKAVDSFQNDEFFQLVMEKHGSGIDLFEFIDRQPNFDEALASYMFRQVVAAVKYLHEHGIVHRDIKDENVILDEKFQIKLIDFGSAA |. . |.||.|.. | | . .||| || .|...|.. |. | .|||.| || | | |.|.||| | ||. ||.. .| ||| EIEIMSSLNHPHIIHIYEVFENKDKIVIVME-YASGGELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSN YMQPGKKFSTFCGTLEYCSPEVLLG | . .| |||| | |||. | YYHDQKFLHTFCGSPLYASPEIVNG |
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| Kinase | PASK.AA | RAD53 | 776-897 | 34 | 3.2e-37 | 108.06 | In-house | 58-201 (305) | Show / Hide |
Range on Protein: 776-897
Range on HMM: 58-201/305
Sequence Identity: 34% (50 aa)
LTKLDHPNIVKAVDSFQN-DEFFQLVMEKHGSGIDLFEFI-DRQPN---FDEALASYMFRQVVAAVKYLHEHGIVHRDIKDENVILD----EK-------
|.|| ||.|.. |.|.. .. . .|.|. ..| .||..| .. .. |||. . | |.| . ||||||. ||.|||.| ||. .. |.
LKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGG-ELFNKIVSNKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGP
-------FQIKLIDFGSAAYMQPGKKFSTFCGTLEYCSPEVLLGN
|.||. ||| . .. | |.|||. |. |||....
WDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSK
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| Kinase | PASK.AA | MSK | 781-894 | 38 | 8.9e-36 | 118.42 | In-house | 60-177 (277) | Show / Hide |
Range on Protein: 781-894 Range on HMM: 60-177/277 Sequence Identity: 38% (46 aa) HPNIVKAVDSFQNDEFFQLVMEKHGSGIDLFEFIDRQPNFDEALASYMFRQVVAAVKYLHEHGIVHRDIKDENVILDEK---FQIKLIDFGSAAYMQPG- |||||. . || . . |||| .| ||. | . .|||. ... .|..| ||...|. ||.|||.| ||. .|.. ..||||||.| . .. HPNIVNLHYAFQDQCHTYLVME-YCNGGELFTHIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDE -KKFSTFCGTLEYCSPEVL .. ..|.||.| .||.| EWRMKSPCFTLHYMAPEML |
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| Kinase | PASK.AA | RSK | 781-894 | 36 | 4.6e-32 | 112.86 | In-house | 60-180 (278) | Show / Hide |
Range on Protein: 781-894 Range on HMM: 60-180/278 Sequence Identity: 36% (44 aa) HPNIVKAVDSFQNDEFFQLVMEKHGSGIDLFEFIDRQPN---FDEALASYMFRQVVAAVKYLHEHGIVHRDIKDENVILDE---KFQIKLIDFGSAAYMQ ||.||. ..|| .. . |.|| .| .||. . .. |.| |.. ....| ||..||..||.|||.| ||...|. |||.||| . .. HPFIVTLHYAFQTEGKLYLIME-YCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFR PG--KKFSTFCGTLEYCSPEVL . .. |||.|.||. ||.| CDHNQWTMTFCYTIEYMAPEML |
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| Kinase | PASK.AA | Ciliate-E2 | 776-896 | 28 | 1.4e-31 | 105.66 | In-house | 86-261 (365) | Show / Hide |
Range on Protein: 776-896 Range on HMM: 86-261/365 Sequence Identity: 28% (53 aa) LTKLDHPNIVKAVDSFQ--NDEFFQLVMEKHGSGIDLFEFIDRQ-----------PNFDEALASYMFRQVVA---------------AVKYLHEHG-IVH | .|.||||.| ...|| .|. . |||| .| |||..| . .|.| ..|...|.. |..|||. . |.| LEQLNHPNIIKMYECFQEKDDNNIYLVMEYC-QGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIH RDIKDENVILDEKFQIKLIDFGSA-----------------AYMQPG----------------KKFSTFCGTLEYCSPEVLLG |||| ||... ||.|||| . ||. . | |.|||..| .||.| | RDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNG |
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| S_TKc | PASK.AA | S_TKc | 661-897 | 20 | 1.6e-13 | 21.24 | SMART | 1-220 (231) | Show / Hide |
Range on Protein: 661-897
Range on HMM: 1-220/231
Sequence Identity: 20% (63 aa)
LLSSGPIPEGGF--VGLAKHRDGNLLGILFQVKRVDLDDGETLYCIWMSRDPAEPTDAGHMTSSMANASSFDSTFNQSNHTKSMSEVVVKFIRRAKVLKE
.| .|.| | ...|.. | .. .|...
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK----------------------------------------------------------------
NWVDDPKLGCIPLEVAYLTKLDHPNIVKAVDSFQNDEFFQLVMEKHGS--GIDLFEFIDRQPN------FDEALASYMFRQVVAAVKYLHEHGIVHRDIK
| |.. | | .|||||| |.||. ... .||| . | |||..|.... |.| | ....|.. |..|.|.|||.|||.|
--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLG-DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLK
DENVILDEKFQIKLIDFGSAAYMQPGKKFSTFCGTLEYCSPEVL--------------------------------------------------------
||. ||| .||..|||.|. . .|||||..|..||||
PENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKR
----LGN
. .
PTAEALQ
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| TyrKc | PASK.AA | TyrKc | 693-895 | 12 | 0.000773 | -160.57 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 693-895
Range on HMM: 1-280/280
Sequence Identity: 12% (41 aa)
VDLDD-------GETLYCIWMSRDPAEPTDAGHMTSSMANASSFDSTFNQSNHTKSMSEVVVKFIRRAKVLKENWVDDPKLGCIPLEVAYLTKL--DHPN
. |.. || ..| .| || .. . . . | ..|| .|||
ITLGKKLGEGAFGEVYKGTWK------------------------------------IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPN
IVKAVDSFQND-------EFFQLVMEKHGSGIDLFEFI-DRQPNFDEALASYMFRQVVAAVKYLHEHGIVHRDIKDENVILDEKFQIKLIDFG------S
||. . . | .||| . .. || ... ...|.. . .. |. . |||.....|||. |. ..|....| ||| .
IVRLYGVCTQQGRNFMYIEPLMIVME-YMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYD
A--------AYMQ----PGK-------------KFS-------------------TFCGTLE---------------------------Y--------CS
|.. || ... |.... . |.
DDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP
PEV-----------------------LL
.|. ..
DEMYQIMKQCWHEDPEDRPTFSEIHECF
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