Gene STK33 (Sea Urchin)

STK33

Species: Sea Urchin
Alias: STK33, SPU_024676, Spk090
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: STK33

Sequence

Name Sequence Type Origin Length Description Download
STK33.AA Protein None 363 None Fasta, JSON
STK33.kin_dom Protein Kinase Domain None 194 None Fasta, JSON

Protein domain

Protein domains of STK33.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase STK33.AA CAMK-Unique 7-198 38 1.4e-115 383.06 In-house 109-363 (363) Show / Hide 
Range on Protein: 7-198
Range on HMM: 109-363/363
Sequence Identity: 38% (99 aa)

RMYLVMEICDEGELNKLFNH--------------------EGVFSE--ADTRTIIQRLTSAVAYLHKNDIVHRDIKLENILVSKNPDE-------PSD--
.||.|||.|..|.|......                    .|.|||  .||..|.|.|.|||||.|..||||||.|||||.|......       |.|  
YMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWS

RLNIKLTDFGLSVVKGGVGSD--IQNMCGTPMYMAP--------------EVIDNQGYSQQC----DIWSIGVIAFLLICGEPPFTGQDED--------G
...|||.||||.. . .. ..  .|.|||||.||||              |||..|.|.|||    ||||.|||.....||.|||....||        .
NWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKE

LYDSIRKGDL-DFSTDAWQR---ISDEAKNAIQGLLKVDPAHRLTASELLDHPWI
....|.|||. .|....|..   ||.|||........|||.||..|.|||.|.||
IFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase STK33.AA CAMK 5-198 27 1.3e-85 275.71 In-house 129-425 (425) Show / Hide 
Range on Protein: 5-198
Range on HMM: 129-425/425
Sequence Identity: 27% (83 aa)

KTRMYLVM---EICDEG----E-LNKLFNH--------------EGVFSEADTRTIIQRLTSAVAYLHKNDIVHRDIKLENILVSKNPDEP---------
...||.||   | |. |    . ....  |              .| |.|...|.... . |||.|.|...|||||.|.||||...| |.          
DKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIF

-SDRLNIKLTDFGLSVVKGGV-----------------------GSDIQNMCGTPMYMA-PEVIDN--------------QGYSQQCDIWSIGVIAFLLI
 ... |||..|||.. .. .                        |   . .|||| ||| |||.                ..|...||.||.||| . . 
DWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIML

CGEPPFTGQ-------------DEDGLYDSIRKGDLDFSTDA------------WQRISDE--------AKNAIQGLLKVDPAHRLTASELLDHPWI
||.||| |              ..  |.  |.||. ||  .             | .||||        .|. |...|.||| .|.|... |.|||.
CGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase STK33.AA AGC 5-198 24 7.5e-82 210.6 In-house 103-395 (395) Show / Hide 
Range on Protein: 5-198
Range on HMM: 103-395/395
Sequence Identity: 24% (76 aa)

KTR--MYLVMEI---------CDEG-EL-NKLFN--HEGVFSEADTRTIIQR-------LTSAVAYLHK-NDIVHRD-IKLENILVSKNPDEPSDRLNIK
|..   |.|||          |  | ||   |..  .||.|.|  .| ..         ...|. |||. ..|.||| .|.||||  ..        .||
KDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED-------GHIK

LTDFGLSVVKGGVGSD----------------------------------------------------IQNMCG--TPMYMAPEVIDNQGYSQQCDIWS-
||||||.  | |....                                                     . .||  || |||||..    |...||.|| 
LTDFGLC--KEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSF

-IGVIAFLLICGEPPFTGQ----------DEDGLYDSIRKGDLDFSTD------------AWQRISDEAKNAIQGLLKVDPAHRLT----------ASEL
  |.. . ...| |||.|.          ... ....|..|.. .. .            ... .|.|||. |..||..||..||.          |.|.
GLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEI

LDHPWI
 .||| 
KNHPWF
Kinase STK33.AA CAMK1 28-198 40 1.1e-78 228.38 In-house 103-276 (276) Show / Hide 
Range on Protein: 28-198
Range on HMM: 103-276/276
Sequence Identity: 40% (72 aa)

GVFSEADTRTIIQRLTSAVAYLHKNDIVHRDIKLENILVSKNPDEPSDRLNIK--LTDFGLSVVKGGVGSD-IQNMCGTPMYMAPEVIDN---QGYSQQC
|...| | |.|.. . ||| |.|...|||||.| ||.| .     ...   ||  . |||||   .. ...  . .|||| |.||||. .   ..|.. |
GNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYY----DKDEDSKIKRSIADFGLSKIFDH-DENLMKTACGTPGYVAPEVLECKKDKPYDKAC

DIWSIGVIAFLLICGEPPFTGQD-EDGLYDSIRKGDLDFSTDAWQRISDE-AKNAIQGLLKVDPAHRLTASELLDHPWI
|.|||||| . | || ||| . . .. |.. | |....| .. |  |||. ||..| ..|.|||  |.|... |.||||
DMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase STK33.AA CDPK 9-198 41 9.8e-72 219.35 In-house 77-271 (271) Show / Hide 
Range on Protein: 9-198
Range on HMM: 77-271/271
Sequence Identity: 41% (82 aa)

YLVME--ICDEGELNKLFNHEGVFSEADTRTIIQRLTSAVAYLHKNDIVHRDIKLENILV-SKNPDEPSDRLNIKLTDFGLSVVKGGV----GSDIQNMC
|.|||  .|  |||      .| |.| ... |.. . |||.| |.| |||||.| ||||  ||..|      |||. |.|.|   ..     . ..  .|
YIVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWV-IYNIKVIDWGTSKKFDQNQKIEDKKMSQRC

GTPMYMAPEVIDNQGYSQQCDIWSIGVIAFLLICGEPPFTGQDEDGLYDSIRKGDLDFSTDAWQRISDEAKNAIQGLLKVDPAHRLTASELLDHPWI
||| |.||||.. . | ..|||||.||| . |.||.||| |. .   .....||  .|  . |. ||||||. |. .| .||  |..|.. |.|||.
GTPYYIAPEVLQKK-YNEKCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase STK33.AA Ciliate-E2a 9-198 36 7.2e-71 207.84 In-house 75-275 (275) Show / Hide 
Range on Protein: 9-198
Range on HMM: 75-275/275
Sequence Identity: 36% (74 aa)

YLVMEICDEGELN-KLFNHEGVFSE-ADTRTIIQRLTS-AVAYLHKNDIVHRDIKLENILVS-KNPDEPSDRLNIKLTDFGLSVVKGGVGSD-IQNMCGT
||||| |. |||  |. ..   |.|  . . |.| |.. ...|.|.. |.|||.|.||||   .... . . ..||. ||||.    .   . .  .|||
YLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSI-QNSDIKIIDFGLATFIDKDEKKYMFQKCGT

PMYMAPEVIDNQG------YSQQCDIWSIGVIAFLLICGEPPFTGQDEDGLYDSIRKGDLDFSTDA-WQRISDEAKNAIQGLLKVDPAHRLTASELLDHP
| |.||||. |        |...||.||.||| ..|.||.||| |....    ...|  .||.    |. .|.|.|. ....|..|| .|.|| ..|.||
PGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHP

WI
| 
WF
Kinase STK33.AA DCAMKL 3-198 41 7e-69 213.24 In-house 85-279 (279) Show / Hide 
Range on Protein: 3-198
Range on HMM: 85-279/279
Sequence Identity: 41% (83 aa)

SCKTRMYLVMEICDEGELNKLFNHEGVFSEADTRTIIQRLTSAVAYLHKNDIVHRDIKLENILVSKNPDEPSDRLNIKLTDFGL-SVVKG--GVGSDIQN
...| .|||||    | |       . |.| | . ..  | .|  |||   |||||||.|| || |..|     . .|| ||||  .|.|  |.   .  
DTETHYYLVMEYVQGGDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDG---EKSLKLCDFGLACHVNGDFGP---LYT

MCGTPMYMAPEVIDNQGYSQQCDIWSIGVIAFLLICGEPPFTGQ--DEDGLYDSIRKGDLDFSTDAWQRISDEAKNAIQGLLKVDPAHRLTASELLDHPW
 |||| | |||..   ||.  .|||..|||   | || ||| ..  |.. | | |  |...|    |  ||| ||. |. .|.|||  | ||.. ..|||
VCGTPTYVAPEILMETGYGCKVDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPW

I
.
V
Kinase STK33.AA RAD53 9-198 36 1.4e-67 200.19 In-house 81-305 (305) Show / Hide 
Range on Protein: 9-198
Range on HMM: 81-305/305
Sequence Identity: 36% (83 aa)

YLVMEICDEGEL-NKLFNHEGV---FSEADTRTIIQRLTSAVAYLHKNDIVHRDIKLENILVSKNPDEP-------------SDRLNIKLTDFGLSVVKG
|.|.|  . ||| ||.  ...    |.|.. ...   .  || ||| | |.|||.| |||| . . .|              |  . ||.|||||| .  
YMVLELMTGGELFNKIVSNKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEIS--FLIKITDFGLSKF--

GVGSD--IQNMCGTPMYMAPEVIDNQ---------------GYSQQCDIWSIGVIAFLLICGEPPFT-GQDE----DGLYDSIRK-GDLDFSTDAWQRIS
 || .   . ||||| | ||||| ..               ||.  .|.||.|.| ... || |||  . ..    . |...|.. | . |..  | |||
-VGEGSFMKTMCGTPQYVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRIS

DEAKNAIQGLLKVDPAHRLTASELLDHPWI
.|||. |...|.||| .|.|. |.| |||.
EEAKDLIKWMLCVDPEKRYTIDEALNHPWM
Kinase STK33.AA Ciliate-E2 5-198 26 7.9e-67 228.34 In-house 106-365 (365) Show / Hide 
Range on Protein: 5-198
Range on HMM: 106-365/365
Sequence Identity: 26% (74 aa)

KTRMYLVMEICDEGELNK-------LFNHE----GVFSEADTRTIIQRLTS---------------AVAYLHKND-IVHRDIKLENILVSKNPDEPSDRL
.. .||||| |. |.| .        .|||    . |.|   ..|.. ...               |. |||..  |.|||||.||||.           
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----------

NIKLTDFGL-----------SVVKGGVGSDIQNM----------------------CGTPMYMAPEVIDNQG---------YSQQCDIWSIGVIAFLLIC
 ||..||||           .  | . .  ..                        ||||.|||||.. ...         |. .|||||.||| . ...
-IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GEPPFTGQDEDGLYDSIRKGDLDFSTD--------------AWQRISDEAKNAIQG----LLKVDPAHRLT-ASELLDHPWI
|.|||        .. | ....||.                 |. .|.|.|. |.     .|..||  |.| ....|.|||.
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase STK33.AA Pkinase 5-198 32 1.4e-65 229.01 Pfam 72-293 (293) Show / Hide 
Range on Protein: 5-198
Range on HMM: 72-293/293
Sequence Identity: 32% (74 aa)

KTRMYLVMEICDEG----ELNKLFN--HEGVF--SEADTRTIIQRLTSAVAYLHKNDIVHRDIKLENILVSKNPDEPSDRLNIKLTDFGLSVVK-GGVGS
|...|.||| |. |    .|  .     .|.|  || . . ..  . ....|.|.. |.|||.|.||||...|.. ..    .|..||||. ..    .|
KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---CVKICDFGLAKQFDY-NNS

DIQNMCGTPMYMAPEVID-NQGYSQQCDIWSIGVIAFLLICGEPPFTGQ------DEDGLYDSIRKGDLDFSTDAWQRIS-----------------DEA
  .  |||| |||||||  .|.|.. .|.||.|.| . ..||.||| |.      |.. ... |....|.|. . | .||                 .|.
-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

KNAIQGLLKVDPAHRLTASELLDHPWI
|  | ..|..||. |.|| ..| |||.
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase STK33.AA RSK 9-198 35 2.1e-62 213.64 In-house 77-278 (278) Show / Hide 
Range on Protein: 9-198
Range on HMM: 77-278/278
Sequence Identity: 35% (73 aa)

YLVMEICDEGELNKLFNHEGV---FSEADTRTIIQRLTSAVAYLHKNDIVHRDIKLENILVSKNPDEPSDRLNIKLTDFGLSVV-KGGVGSDIQNMCGTP
||.|| |  ||| .   .|.    ||| . . ..  ...|| .||. .|.|||.|.||||     ||  ..  |||||||..   .   ..  .  |.| 
YLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYD---DES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTI

MYMAPEVID----NQGYSQQCDIWSIGVIAFLLICGEPPFTG---QDEDGLYDSIRKGDLDFSTDAWQRISDEAKNAIQGLLKVDPAHRLT-----ASEL
 |||||..     . |....||.|| ||. . .  | |||.|   .. . . . |.||..... ..|| .|.|||. |...|..||. ||.     |.|.
EYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEI

LDHPWI
..|||.
KQHPWF
S_TKc STK33.AA S_TKc 1-198 28 2.9e-47 164.24 SMART 17-231 (231) Show / Hide 
Range on Protein: 1-198
Range on HMM: 17-231/231
Sequence Identity: 28% (71 aa)

MGSCKT--------------------------------------RMYLVMEICDE--GELNKLFNHEGV------FSEADTRTIIQRLTSAVAYLHKNDI
 .  |                                       ..|.||| ||   |.| ..  . |       |.| ..| ... . .|..|.|.. |
KCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGI

VHRDIKLENILVSKNPDEPSDRLNIKLTDFGLSVVKGGVGSDIQNMCGTPMYMAPEVIDNQGYSQ-QCDIWSIGVIAFLLICGEPPFTGQDEDGLYDSIR
.|||.| ||||...         .||..||||. .          .|||| ||||||.   ||.   ||.||.|.| . ..||.|||   ... ... |.
IHRDLKPENILLDE---------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG

KGDLDFSTDAWQRISDEAKNAIQGLLKVDPAHRLTASELLD-------HPWI
              |.|||. |...|..||..|.|| |.|        |||.
--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc STK33.AA TyrKc 1-198 17 2.1e-08 -86.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-198
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

M----------------------------------------------G------------SCK--------TRMYLVMEICDEGELNKLF-NHEGVFSEA
                                               |              .          ...||| .. | |..   .|.. .. .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

DTRTIIQRLTSAVAYLHKNDIVHRDIKLENILVSKNPDEPSDRLNIKLTDFGLSVVKGGV-----GSDIQNM----CGTPM----YMAPEVIDNQGYSQQ
|   .     .  .|||.. ..|||.   |.||..|         .| .|||||   .        .|   .    .|  |     ||||.|.   .. .
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

CDIWSIGVIAF-LLICGEPPFTG-----QDEDGLYDSIRKGDLDFSTDA-----WQRISDEAKNAIQGLLKVDPAHRLTASELLDHPWI
 |.|| ||  . ..  |..|  |      . . ..  ...|.     .        . .||  . ..   . ||. | | ||.  |  .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase STK33.AA Pkinase_Tyr 47-87 31 5.1e-05 17.63 Pfam 125-158 (270) Show / Hide 
Range on Protein: 47-87
Range on HMM: 125-158/270
Sequence Identity: 31% (13 aa)

AYLHKNDIVHRDIKLENILVSKNPDEPSDRLNIKLTDFGLS
.||. . ..|||.   |.||..        . .| .||||.
EYLESKNCIHRDLAARNCLVTE-------NNVVKICDFGLA
Kinase STK33.AA Pkinase_Tyr 107-125 42 0.009326 9.96 Pfam 181-199 (270) Show / Hide 
Range on Protein: 107-125
Range on HMM: 181-199/270
Sequence Identity: 42% (8 aa)

MAPEVIDNQGYSQQCDIWS
||||.| .  .. . |.||
MAPECINYGKFTTKSDVWS