MAPKAPK5a

Species: Sea Urchin
Alias: Spk067, SPU_013910, MAPKAPK5a
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: MAPKAPK
Subfamily: MK2

Sequence

Name Sequence Type Origin Length Description Download
MAPKAPK5a.AA Protein None 207 None Fasta, JSON
MAPKAPK5a.kin_dom Protein Kinase Domain None 157 None Fasta, JSON

Protein domain

Protein domains of MAPKAPK5a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAPKAPK5a.AA MAPKAPK 19-191 58 7.29999999999e-116 391.22 In-house 1-177 (268) Show / Hide
Range on Protein: 19-191
Range on HMM: 1-177/268
Sequence Identity: 58% (104 aa)

IDWTQKLGTGINGPVRPCQHKRSEDRFALKLLLDKPGARAEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFDRISKQ--KR
. |.|.|| ||||.|..|.|||....||||.|.|.|.||.||.||..||||..||.||.|..|..|||.||.|...||.|||.|.|||||.||...  ..
QIWKQVLGIGINGKVMQCYHKRTQQKFALKVLRDSPKARREVELHWMCSGHPHIVQIIDVYENMYQFPHEPSPRKCLLIVMECMEGGELFHRIQERGDQH

FTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDSPVKLSDFGFAKVDDG--TLMTPHFTPYYVAPQV
||||.|....|||..|| .|||.|||||||||||||.||.......||.||||||....  |||||..|||||||.|
FTEREAAQIMKQICQAVQHCHSMNIAHRDLKPENLLYKDTQPNCVLKLTDFGFAKETTRHNTLMTPCYTPYYVAPEV

Kinase MAPKAPK5a.AA MAPKAPK 19-191 47 1.2e-107 334.41 In-house 1-185 (292) Show / Hide
Range on Protein: 19-191
Range on HMM: 1-185/292
Sequence Identity: 47% (90 aa)

IDWTQKLGTGINGPVRPCQHKRSEDRFALKLLLDK-----PGARAEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFDRISK
. |...|| ||.|.|. |.|||.....|.|.|.|.     . || ||.||..|.||.|||.||..|.|..||      ......|||.|.|||||..|..
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQF------DKCFYLVMECMEGGELFQHIQQ

--QKRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDSPVKLSDFGFAKV-------DDG----TLMTPHFTPYYVAPQV
  .|.||||.|. ..|.|.||| ..||.|||||||||||.| .|.....||||.||||||.       ...    .||||..||||.||.|
RGHKHFTEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEV

Kinase MAPKAPK5a.AA CAMK 24-191 25 5.1e-60 191.76 In-house 1-291 (425) Show / Hide
Range on Protein: 24-191
Range on HMM: 1-291/425
Sequence Identity: 25% (75 aa)

KLGTGINGPVRPCQHKRSE------------DRFALKLLL---------------------------------DKPGARAEVNLHSRCSG------HANI
.||.|  | |. |.||..              ..| | .                                  |.   | |........|      | ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKIIEVFSNEVQFP----------GEPAPKSRLLVVM---ELMDGGEL----FDRISKQ---------------KRFTERQAVILTKQIASAVLQCHSLN
.|..||. .. .|.              .....  ||   |...||||    ||.| ..               .|||||.|  . .||.|||  |||.|
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IAHRDLKPENLLLKDNSEDSP--------------VKLSDFGFAKVDDG--------------------------TLMTPHFTPYYVA-PQV
|.||||||||.|| ||..||.              .|..|||||.. |.                           . |.  ||.|.| | |
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV

Kinase MAPKAPK5a.AA CAMK1 17-193 34 2.8e-53 153.22 In-house 1-186 (276) Show / Hide
Range on Protein: 17-193
Range on HMM: 1-186/276
Sequence Identity: 34% (68 aa)

YTIDWTQKLGTGINGPVRPCQHKRS---EDRFALKLLL--DKPGA---------RAEVNLHSRCS--GHANIVKIIEVFSNEVQFPGEPAPKSRLLVVME
| .  . ..|.|  . |. |.||..   .. .|.| .   .             . |.. . ..|   | ||.|..|..            .. .  |||
YEF--GKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYES----------DNHFYLVME

LMDGGELFDRISKQKRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDSPVK--LSDFGFAKVDD-G--TLMTPHFTPYYVAPQVST
|. |||||||| . . .||..|. . |||.|||  .||..|.||||||||||..|..|||..|  ..||| .|  | .  .. |.  ||.|||| | .
LVTGGELFDRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLE

Kinase MAPKAPK5a.AA Pkinase 19-189 29 3.9e-40 142.99 Pfam 1-180 (293) Show / Hide
Range on Protein: 19-189
Range on HMM: 1-180/293
Sequence Identity: 29% (58 aa)

IDWTQKLGTGINGPVRPCQHKRSEDRFALKLLLDKPGARA----------EVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGG---
.   .|.| |  | |. |.|| .....|.| .  . ...           |. .. |. .| |||.....| .          |... .|||...||   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED----------KDHIYMVMEYCEGGLYV

-ELFDRIS--KQKRF--TERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLK-DNSEDSPVKLSDFGFA----KVDDGTLMTPHFTPYYVAP
 .|||.||  ....|  .|...    .||....  ||| .| ||||||||.|.. ..  |..||..|||.|       .. ..|.  ||.|.||
MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAP

Kinase MAPKAPK5a.AA CDPK 97-191 43 4.4e-38 114.55 In-house 78-185 (271) Show / Hide
Range on Protein: 97-191
Range on HMM: 78-185/271
Sequence Identity: 43% (47 aa)

VVME--LMDGGELFDRISKQKRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDS----PVKLSDFGFAKVDD-------GTLMTPHFT
.|||  .  ||||||.|  ...|||..|    .|| |||  ||| || ||||||||.|.. ...||    ..|. |.| .|  |        ....   |
IVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGT

PYYVAPQV
|||.|| |
PYYIAPEV

Kinase MAPKAPK5a.AA RAD53 69-189 33 3.2e-35 102.0 In-house 63-195 (305) Show / Hide
Range on Protein: 69-189
Range on HMM: 63-195/305
Sequence Identity: 33% (47 aa)

HANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFDRISKQKR----FTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDS----
| .|..|...| .             .  |.|||.|||||..|  .||    |.| ..  . .|.  ||.  |...|.|||||||| |.....|.     
HPCIIRIYDIFDTP---------QKYYYMVLELMTGGELFNKIVSNKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQ

-----------PVKLSDFGFAK-VDDGTLMTPHF-TPYYVAP
            .|..||| .| |..|..|. .  || ||||
LGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAP

Kinase MAPKAPK5a.AA MSK 19-191 30 1.9e-34 113.85 In-house 1-176 (277) Show / Hide
Range on Protein: 19-191
Range on HMM: 1-176/277
Sequence Identity: 30% (56 aa)

IDWTQKLGTGINGPVRPCQHKRSEDRFALKLLL-------DKPGAR--AEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFD
.    ..| |  . .| | |. ..  .| | |         |  .   .|.    .| .| |||.  ..|.           .. .  |||.  ||||| 
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQD----------QCHTYLVMEYCNGGELFT

RISKQKRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDSPVKLSDFGFAKVDDGT----LMTPHFTPYYVAPQV
.|.| ..|.|  . .   .. .|| . |.. | ||||||||.|. |.... .|||.|||||.         . .| ||  | || .
HIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEM

Kinase MAPKAPK5a.AA DCAMKL 69-189 37 6.2e-34 102.54 In-house 74-188 (279) Show / Hide
Range on Protein: 69-189
Range on HMM: 74-188/279
Sequence Identity: 37% (47 aa)

HANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFDRISKQKRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKD-NSEDSPVKLSDF
| .|....|... | .          .  |||.  || ||| |..  .||||.|.|.. ....|    |..|| |||.||||||...  .    .|| ||
HPHIIQLYEHWDTETH----------YYLVMEYVQGGDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDF

GFAKVDDG---TLMTPHFTPYYVAP
| |.. .|    | |   || ||||
GLACHVNGDFGPLYTVCGTPTYVAP

Kinase MAPKAPK5a.AA RSK 33-191 33 5.3e-33 115.95 In-house 15-179 (278) Show / Hide
Range on Protein: 33-191
Range on HMM: 15-179/278
Sequence Identity: 33% (59 aa)

VRPCQHKRSEDRFALKLLLDK----PGAR------AEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFDRISKQKR---FTE
.| |.|. ..  .| |  |.|    . ..      .|.|  .|| .| .||.  ..|  |          . |  .||.. |||||....|.|.   |.|
CRKCTHHDTGQIYAMK-VLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTE----------GKLYLIMEYCRGGELFTHLQKEKHFGCFSE

RQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSED-SPVKLSDFGFAKV---D-DGTLMTPHFTPYYVAPQV
. | .   .|..||   |.. | |||||||| |. | | .   .||.||||.|    |  . .||. .|  |.|| .
DEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEM

Kinase MAPKAPK5a.AA RSK 20-189 33 2.2e-29 102.09 In-house 2-174 (271) Show / Hide
Range on Protein: 20-189
Range on HMM: 2-174/271
Sequence Identity: 33% (62 aa)

DWTQKLGTGING---PVRPCQHKRSEDRFALKLLL-DKPGAR-----AEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFDR
.  ...|.|  .    .. |||| ... .| | .  ..  ..      |.    | . |..|||  .||  | .          .  .|..| ||.||||
ELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGK----------VYMIMDFMRGGDLFDR

ISKQKRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDN-SEDSPVKLSDFGFAK---VDDGTLMTPHFTPYYVAP
..||| |.|| . .    ||.|.   ||. |.|||||||| |. |   . . .|. ||||||    ..| |||.  |  |.||
LLKQKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAP

Kinase MAPKAPK5a.AA S_TKc 19-204 25 2.5e-18 68.12 SMART 1-231 (231) Show / Hide
Range on Protein: 19-204
Range on HMM: 1-231/231
Sequence Identity: 25% (65 aa)

IDWTQKLGTGINGPVRPCQHKRSEDRFALKLLLDKPGARAEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDG--GELFDRISKQKR
 .  .|.| |  | |. |.||..  ..|.| .     .| |......  .| ||||...|| .           ..| .|||..||  |.|||.| |..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-----------DHLYMVMEYCDGDLGDLFDYIKKRGR

------FTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDSPVKLSDFGFAKVDDGTLMTPHFTPYYVAPQVSTSLTP-------------
      |.| .|  ...||..|.  |||..| ||||||||.|| .      .|..|||.|..     .|   ||.|.|| |  . ..             
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILY

-------------------------------------------IAQ-------LEYK
                                           . |        .. 
EMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF

Kinase MAPKAPK5a.AA TyrKc 19-207 15 5e-05 -141.34 SMART 1-280 (280) Show / Hide
Range on Protein: 19-207
Range on HMM: 1-280/280
Sequence Identity: 15% (46 aa)

IDWTQKLGTGINGPVRPCQHKRSEDRFALKLLLDKPGARAEVNLHSRCSGHANIVKIIEVFSNE-------VQFPGEPAPK-------SRLLVVMELMDG
|   .||| |  | |. .. |      | | | .                .. . . ... ..        |.. |    .         |..|||.|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

GELFDRISKQKR-FTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDSPVKLSDFGFAKVDDGT----------------LMT--------
| | |.. | .. .. .. .    |||.     || |. ||||   | |...|     || |||| ..  .                             
GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

----------------------------------PH-----FTPYYVAPQVSTS--LTPIAQ-------------------------------LEYKLHF
                                  |       ... |  .| .   . . .                                 | .  |
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF





Kinase MAPKAPK5a.AA CDPK 19-48 34 0.226487 0.21 In-house 1-32 (271) Show / Hide
Range on Protein: 19-48
Range on HMM: 1-32/271
Sequence Identity: 34% (11 aa)

IDWTQKLGTGINGPVRPCQHK-RS-EDRFALK
..   .||.|  | || ..||  . . |.| |
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMK