Gene MLCKb (Sea Urchin)

MLCKb

Species: Sea Urchin
Alias: MLCKb, SPU_000442, Spk074
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: MLCK

Sequence

Name Sequence Type Origin Length Description Download
MLCKb.AA Protein None 429 None Fasta, JSON
MLCKb.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of MLCKb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FN3 MLCKb.AA FN3 6-89 17 3.9e-08 34.29 SMART 1-69 (69) Show / Hide 
Range on Protein: 6-89
Range on HMM: 1-69/69
Sequence Identity: 17% (17 aa)

PEPPADK--PFAAKCTKD------TINLVWAGTTYDGGSIVTGYMVEMSEDGGKKWKNVAKDVFSTSYACKGVTEG----KKYQFRVSCINA--KGKS
| || .   . .   |..      ...| |          ..||                       |  .| ..|    ..|.|||...|.  .| .
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase MLCKb.AA MLCK 134-387 63 7.1e-235 626.83 In-house 1-257 (257) Show / Hide 
Range on Protein: 134-387
Range on HMM: 1-257/257
Sequence Identity: 63% (162 aa)

YEIREELGRGKFGTVNKCIAKESKKTWAAKFIKAEKPADKEEVEHEIEIMMILQHPKLLQLYDAFATGSNMVMILEYVSGGELFDRVVDEEFELTEAVVV
|.|.|||||||||.| .|| |...|||||||||..||.|||.|..|||||..|.||.|.|..||| |...||||.||.||||||.|.|||.|.|||..|.
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI

FLMRQICEGVKFMHEKGVLHLDMKPENILCVRKNSNKIKIIDFGLAQKYTKN---LQVSCGTPEFLAPEVVSYDDVAYGTDMWSVGVICYILLSGFSPFM
. ||||||||..||.....|||.|||||.|. ..|..|||||||||.|| ..   ..| .|||||.|||||.|| | ..|||||||||||.||||.||||
HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPFM

GDNEGETMSNILKLEWDFEDECFDEISDLAKQFIENLLVEEKNDRLTCPQCLESEWL
|||..|||.|... ||||.|||||.||| ||.||..|||..|..|.|. .||...||
GDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
Kinase MLCKb.AA DAPK 136-387 44 2.9e-125 347.0 In-house 1-264 (264) Show / Hide 
Range on Protein: 136-387
Range on HMM: 1-264/264
Sequence Identity: 44% (117 aa)

IREELGRGKFGTVNKCIAKESKKTWAAKFIKAEKPADK------EEVEHEIEIMMILQ-HPKLLQLYDAFATGSNMVMILEYVSGGELFDRVVD--EEFE
..||||||.|  | ||. |.. |  ||||||  . .        || |||| | . .. ||..  | ... | . ...|||||||||||| ..   ||  
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREEC-

LTEAVVVFLMRQICEGVKFMHEKGVLHLDMKPENILCVRKNSNK--IKIIDFGLAQK--YTKNLQVSCGTPEFLAPEVVSYDDVAYGTDMWSVGVICYIL
|.|.... .|.|| |||...| . . |||.||.||.   .|. .  ||||||||. |     ..    ||||..|||.|.|.     |||||.||| ||.
LCEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIM

LSGFSPFMGDNEGETMSNILKLEWDFEDECFDEISDLAKQFIENLLVEEKNDRLTCPQCLESEWL
|||.||| ||.  || .|| ..  ||..| |.  | .|| ||  ||| . ..|.|  .||.  |.
LSGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase MLCKb.AA CAMK 139-387 26 8.4e-116 374.78 In-house 1-425 (425) Show / Hide 
Range on Protein: 139-387
Range on HMM: 1-425/425
Sequence Identity: 26% (111 aa)

ELGRGKFGTVNKCIAKESK------------KTWAAKFIKAE----------------------------KPADKEEVEHEIEIMMILQ-------HPKL
.|||| ||.| .|| |...            . .|.|.|. .                            .| |...|..|||||. ||       || .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LQLYDAFA------------TGSN--------MVMIL---EYVSGGEL----FDRVVDE--------------EFELTEAVVVFLMRQICEGVKFMHEKG
..||...             | |.        |.|..   ||.|||||    ||..|.               .. .||. . ...||||..|...|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VLHLDMKPENILCVRKNS---------------NKIKIIDFGLAQKYTKN--------------------------LQVSCGTPEFLA-PEVVSY-----
. |.| ||||||.. .|.               |.|||||||.|.|....                          .. .|||||. | |||...     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------DDVAYGTDMWSVGVICYILLSGFSPFMGD-------------NEGETMSNILKLEWDFEDECFDE------------ISDL--------AK
         . . . .||||.|||.||.|.|..|| ||             |. |.. .|.| ..||... |..            |||         .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

QFIENLLVEEKNDRLTCPQCLESEWL
..| ..|. . ..|.|. |||. .|.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MLCKb.AA Trio 134-387 38 2.3e-114 294.56 In-house 1-258 (258) Show / Hide 
Range on Protein: 134-387
Range on HMM: 1-258/258
Sequence Identity: 38% (100 aa)

YEIREELGRGKFGTVNKCIAKESKKTWAAKFIKAEKPADKEEVEHEIEIMMILQHPKLLQLYDAFATGSNMVMILEYVSGGELFDRVVDEEFELTEAVVV
|.. ||.||| |. | .|. | ...| |||||   .. ||| | || |..  |||| ...| |.. |    . |||  ..||| .... . ....|. | 
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFI-PYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLM-RWGSYCESEVK

FLMRQICEGVKFMHEKGVLHLDMKPENILCVRKNS--NKIKIIDFGLAQKYTKN----LQVSCGTPEFLAPEVVSYDDVAYGTDMWSVGVICYILLSGFS
. |.|. |.|   |  ..|||| ||||.. .  |    .|||.||| ||...      .    |.||| |||..  . | |||| ||.||. |..||| |
TYMWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGIS

PFMGDNEGETMSNILKLEWDFEDECFDEISDLAKQFIENLLVEEKNDRLTCPQCLESEWL
|| ...  ||  ||...  .|... |  .|  || ||  .|.|    | .  .||.  |.
PFYDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase MLCKb.AA DAPK 134-387 42 5.2e-99 286.21 In-house 1-264 (264) Show / Hide 
Range on Protein: 134-387
Range on HMM: 1-264/264
Sequence Identity: 42% (113 aa)

YEIREELGRGKFGTVNKCIAKESKKTWAAKFIKAEKPA------DKEEVEHEIEIMMILQ-HPKLLQLYDAFATGSNMVMILEYVSGGELFDRVVDEEFE
|...||.| | |  | ||  |   |  ||||||  . .        |..| |. |   .. ||    | |.. . .  |.||| |||||||| . ..|  
YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKE-C

LTEAVVVFLMRQICEGVKFMHEKGVLHLDMKPENILCVRKNSNK--IKIIDFGLAQKYTKNLQVS--CGTPEFLAPEVVSYDDVAYGTDMWSVGVICYIL
|.| .      || .||..|| | . |.|.|||||    .|  .  ||||||||| .      .    ||||| |||.| |      |||||.||| |||
LNEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYIL

LSGFSPFMGDNEGETMSNILKLEWDFEDECFDEISDLAKQFIENLLVEEKNDRLTCPQCLESEWL
||| |||.||.  ||..||   . .|..| | . | .|| ||  ||| .   |.|  .||.  | 
LSGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI
Kinase MLCKb.AA CAMK1 134-387 38 5.7e-98 285.39 In-house 1-276 (276) Show / Hide 
Range on Protein: 134-387
Range on HMM: 1-276/276
Sequence Identity: 38% (108 aa)

YEIREELGRGKFGTVNKCIAKES---KKTWAAKFIK-AEKPADK-----EEVEHEIEIMM---ILQHPKLLQLYDAFATGSNMVMILEYVSGGELFDRVV
||...|.||| |..| .|. ||.   .| .| | |.  .  . |     | .| |||||     ..||   ..|. . . .   ...|.|.|||||||.|
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

DEEFELTEAVVVFLMRQICEGVKFMHEKGVLHLDMKPENILCVRK-NSNKIK--IIDFGLAQKYT-K--NLQVSCGTPEFLAPEVVSY-DDVAYGT--DM
. .   ||   . .|.||.. |..||.||. | | ||||.|.. | .  |||  |.||||....  .  ...  ||||.. ||||. .  | .|.   ||
EKG-NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM

WSVGVICYILLSGFSPFMGDN-EGETMSNILKLEWDFEDECFDEISDL-AKQFIENLLVEEKNDRLTCPQCLESEWL
||.||| |||| |..|| ..| . | .. |.| |..|    .|.|||  ||.|| ..|. . . |.|| |||.  |.
WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase MLCKb.AA DRAK 137-387 40 2.1e-92 287.44 In-house 2-259 (259) Show / Hide 
Range on Protein: 137-387
Range on HMM: 2-259/259
Sequence Identity: 40% (104 aa)

REELGRGKFGTVNKCIAKESKKTWAAKFIKAEKPAD--KEEVEHEIEIMMILQH-PKLLQLYDAFATGSNMVMILEYVSGGELFD-RVVDEEFELTEAVV
  |.|||||  | ||| |.. . .||||.|  . .   ..|. ||| ..|  |  |..  | . . | |.|...||| .|||.|.  | |.|  ..|. |
AKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKDV

VFLMRQICEGVKFMHEKGVLHLDMKPENILCVRKNSNK-IKIIDFGLAQKYTKNLQVS--CGTPEFLAPEVVSYDDVAYGTDMWSVGVICYILLSGFSPF
. .|||| |||...|.. . |||.|| |||     .   |||.|||.. .  .   |    |||...|||. .|| .   |||||.||. |..|...|||
QRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISPF

MGDNEGETMSNILKLEWDFEDECFDEISDLAKQFIENLLVEEKNDRLTCPQCLESEWL
.||   ||  ||  .  |. .| |. .|..|  ||  |.| . .||.|  .||.  ||
VGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase MLCKb.AA S_TKc 134-387 31 1.2e-89 305.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 134-387
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

YEIREELGRGKFGTVNKCIAKESKKTWAAKFIKAEKPADKEEVEHEIEIMMILQHPKLLQLYDAFATGSNMVMILEYVSG--GELFDRVVDEEFE-----
||| ...|.| ||.| ||. |....  | | ||       | .. ||.|..  .|| . .|||.| . ... |..||..|  |.|||. ..   .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTEAVVVFLMRQICEGVKFMHEKGVLHLDMKPENILCVRKNSNKIKIIDFGLAQKYTKNLQVSCGTPEFLAPEVVSYDDVAY-GTDMWSVGVICYILLSG
..| .. |.|.|||......|..|..| | ||||||. .     |||.||||| ..       ||||...||||.      .   |.||.|.| |..|.|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

FSPFMGDNEGETMSNILKLEWDFEDECFDEISDLAKQFIENLLVEEKNDRLTCPQCLE-------SEWL
  ||   .. ... .|.              |. ||.||...|. . ..|.|. ..|.        .|.
YPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLCKb.AA Pkinase 134-387 31 4.7e-84 290.34 Pfam 1-293 (293) Show / Hide 
Range on Protein: 134-387
Range on HMM: 1-293/293
Sequence Identity: 31% (92 aa)

YEIREELGRGKFGTVNKCIAKESKKTWAAKFIKAEKPADKEEVEH----EIEIMMILQHPKLLQLYDAFATGSNMVMILEYVSGG----ELFDRVV-DEE
|.| . .|.| ||.| ||. | . |..| | || ..  ......|    ||.||  |.||  ..|||.| ..... |..||. ||    .|||..  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

FEL--TEAVVVFLMRQICEGVKFMHEKGVLHLDMKPENILCVRKNSNK---IKIIDFGLA----QKYTKNLQVSCGTPEFLAPEVVS-YDDVAYGTDMWS
  .  .| .. | |.||..|....|..|..| |.||||||.. .| .    .||.|||||          ... ||||...||||.  . .  .  ||||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGVICYILLSGFSPFMGD------NEGETMSNILKLEWDFEDECFDEIS-----------------DLAKQFIENLLVEEKNDRLTCPQCLESEWL
.|.|.|..|.|  || |.      .. . . .|.. ...|. .  ..||                 . .|.||...|    ..|.|..|.|...|.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLCKb.AA Ciliate-E2a 134-387 33 9.8e-77 225.4 In-house 1-275 (275) Show / Hide 
Range on Protein: 134-387
Range on HMM: 1-275/275
Sequence Identity: 33% (92 aa)

YEIREELGRGKFGTVNKCIAKESKKTWAAKFIKAEKPADKE----EVEHEIEIMMILQHPKLLQLYDAFATGSNMVMILEYVSGGELFDRVVDEE-FELT
|..  ..| |.|| | .   |. .|  |.| ..  | ....    ... || ||  | || ...||. . . .|  ...||..||||.|. .    |   
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

EAVVVFLMRQIC-EGVKFMHEKGVLHLDMKPENILCV--RKNS---NKIKIIDFGLAQKY--TKN--LQVSCGTPEFLAPEVVSYDDV----AYGT--DM
. ..  .|.|.  .|.  || ....| | ||||||     |||    .|||||||||...   ..  . . |||| ..||||  . .|     |.|  ||
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM

WSVGVICYILLSGFSPFMGDNEGETMSNILKLEWDFEDEC-FDEISDLAKQFIENLLVEEKNDRLTCPQCLESEWL
||.||| ||||.| .|| | .. |.  .. | . ||..   . ..|. .|...  .|.   . |.|. |.|.. | 
WSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase MLCKb.AA Ciliate-E2 134-387 23 1.7e-71 243.85 In-house 1-365 (365) Show / Hide 
Range on Protein: 134-387
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

YEIREELGRGKFGTVNKCIAKESKKTWAAKF--------------------IKAEKPADKEEVEHEIEIMM----------------ILQHPKLLQLYDA
|.. . .|.| ||.| ||  .. .|  | |.                    .|  |. ..|... || ||.                .|.|| ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FA--TGSNMVMILEYVSGGELFDRVV------DEEFE----LTEAVVVFLMRQICE---------------GVKFMHEKG-VLHLDMKPENILCVRKNSN
|   . .|. ...||..||.|||.        ..|.|    .||  . ..|.||..               .....|.|. ..| | ||||||       
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

KIKIIDFGLAQKYTKNLQVS----------------------------------CGTPEFLAPEVVSYDDVA---------YGTDMWSVGVICYILLSGF
 ||||||||..||... |                                    ||||...|||.... .           |  |.||.||| |..|.| 
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

SPFMGDNEGETMSNILKLEWDFEDEC--------------FDEISDLAKQFIEN----LLVEEKNDRLT-CPQCLESEWL
 ||        . .|.. ..||  ..              ....|. .|..| .    .|. . . |.|   |.|. .|.
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MLCKb.AA CAMK-Unique 134-387 23 1.1e-66 219.07 In-house 1-363 (363) Show / Hide 
Range on Protein: 134-387
Range on HMM: 1-363/363
Sequence Identity: 23% (84 aa)

YEIREELGRGKFGTVNKCIAKESKKTWAAKFIKAEKPA-DKEEV-------------------EHEIEIMMILQHPKLLQLYDA----FATGS-------
|.  . .| | || | .|. .| .| || | .| ...  .|  .                   . |..|.  . || ...|||     | .         
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NMVMILEYVSGGELFDRVVDE-------------------EFELTE--AVVVFLMRQICEGVKFMHEKGVLHLDMKPENILCVRKN------
        .|....||. ||.||| ...                    .  ..|  . . |.|... . |..||.... | | |.|||. |...      
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIM-VCYSFKDNNH

---------SNKIKIIDFGLAQKYT---KN--LQVSCGTPEFLAP--------------EVVSYDDVAYGT----DMWSVGVICYILLSGFSPFMGDNEG
          ..||..||||. .|    ..  .|. ||||...||              ||.  ..  .      | || ||| |..|.| .|| ...| 
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECED

--------ETMSNILKLEW-DFEDECFDE---ISDLAKQFIENLLVEEKNDRLTCPQCLESEWL
        |. ..|.| .  .|. . ..    ||. ||.|...... . . |... . ||..|.
RDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase MLCKb.AA Pkinase_Tyr 134-253 25 3e-14 48.9 Pfam 1-134 (270) Show / Hide 
Range on Protein: 134-253
Range on HMM: 1-134/270
Sequence Identity: 25% (34 aa)

YEIREELGRGKFGTVNKCIAK----ESKKTWAAKFIKAEKPAD---KEEVEHEIEIMMIL-QHPKLLQLYDAFA-TGSN--MVMILEYVSGGELFDRVVD
 .. ..||.| ||.| |...|    . | . | | .|     .   .|.  .|..||. | .||....|| .    |    . ...||. .| | |   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E---EFELTEAVVVFLMRQICEGVKFMHEKGVLH
    .  ||    .   .||..|  . ..|.  |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH
Kinase MLCKb.AA TyrKc 134-387 22 4e-14 5.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 134-387
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

YEIREELGRGKFGTVNKCIAKESKKTWAAKFIKAEKPADKEEVEHEIEIMMIL--QHPKLLQLYDAFATG-------SNMVMILEYVSGGELFDRVVDEE
 .  ..||.| ||.| |...|    . | | .|...   .|.  .|..||. |  .|| ...|| .  ..         . ...||...| | |.  . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

FELTEAVVVFLMRQICEGVKFMHEKGVLHLDMKPENILCVRKNSNKIKIIDFGLAQKYTKN-------LQVSC----GTPE-----FLAPEVVSYDDVAY
 .|. .  .  . ||..|  . |.|.. | |    |.|  ...   .|| ||||. . .            .     |.        .|||.       |
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NY

G-----TDMWSVGVICY-ILLSGFSPFMGD----NEGETMSNILKLE--WDFEDE--------CFDEISDLAKQFIENLLVEEKNDRLTCPQCLESEWL
|     .| || || .. |.  | .|  |.     . . . . .|     .  ..        | ||. .. ||  .    |. .|| |  ..   | .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH----EDPEDRPTFSEI--HECF