Gene MLCKc (Sea Urchin)

MLCKc

Species: Sea Urchin
Alias: MLCKc, Spk075, SPU_000435
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: MLCK

Sequence

Name Sequence Type Origin Length Description Download
MLCKc.AA Protein None 1126 None Fasta, JSON
MLCKc.kin_dom Protein Kinase Domain None 367 None Fasta, JSON

Protein domain

Protein domains of MLCKc.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set MLCKc.AA I-set 8-66 26 8.2e-07 25.63 Pfam 1-60 (92) Show / Hide 
Range on Protein: 8-66
Range on HMM: 1-60/92
Sequence Identity: 26% (16 aa)

PLFVKTTEEVFAVKDGKATLSCTLSGDPKPKVVWMREEEILKN-SDNLKVSSQANGVCSL
| |...   | .     |...|. .|||.|.|.| . .. |.. ||  ...   .| ..|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTL
I-set MLCKc.AA I-set 76-166 36 1.5e-23 82.39 Pfam 1-92 (92) Show / Hide 
Range on Protein: 76-166
Range on HMM: 1-92/92
Sequence Identity: 36% (34 aa)

PHFVETYKDTEGTIGQSIRLECSIDGIPEPEVIWSKDGKVIED-FERYQFFYEGEEGFALEINNFDKEDCGVYTLEASNIAGSVSHSAEIYV
|.|. . || | ..|...|.|| ..| |.|.| | |||. .    .|.|. |.|     |.| | ...| |.||  |.| .|... .||  |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG MLCKc.AA IG 82-167 15 1e-09 39.54 SMART 1-58 (58) Show / Hide 
Range on Protein: 82-167
Range on HMM: 1-58/58
Sequence Identity: 15% (14 aa)

YKDTEGTIGQSIRLECSIDGIPEPEVIWSKDGKVIEDFERYQFFYEGEEGFALEINNFDKEDC---GVYTLEASNIAGSVSH--SAEIYVT
 . ...  |....|.| .      .. |.                       |.| |  .||    |.|. .|.  .|...   .....|.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 MLCKc.AA IGc2 88-156 31 3.8e-09 37.63 SMART 1-56 (56) Show / Hide 
Range on Protein: 88-156
Range on HMM: 1-56/56
Sequence Identity: 31% (22 aa)

TIGQSIRLECSIDGIPEPEVIWSKDGKVIEDFERYQFFYEGEEGFALEINNFDKEDCGVYTLEASNIAG
 .|||..|.|  .| |.|.. | | |. ..             .  |.| |. .|| |.|| .|.| .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
Kinase MLCKc.AA MLCK 188-441 50 4.1e-207 552.17 In-house 1-257 (257) Show / Hide 
Range on Protein: 188-441
Range on HMM: 1-257/257
Sequence Identity: 50% (130 aa)

YELLTELGRGAYGVVHKGISKADGSECAVKTIRV-KAGMWEEVRNEIAVMGILDHKRLIKLFDAYETKREVVMAMEILTGGELFERIV-QRDSFSESEAV
|. ..|||||..|.||..| |..| ..|.|.|.. |. ..|.|.||| .| .|.|..||...||.|||.|.|| ||...||||||||| ... ..|.| .
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI

GFLKQLIDGLIYMHDRNVVHLDLKPENILLVAPESDDIKLIDFGLAAVLKEGED-ITCKFGTPEFVAPEVVNKQPVSTGADVWGVGVIAFILLSGISPFA
 ...|...|. .||..|.||||||||||......|..||.||||||. ....|. ....|||||||||||||..||... |.|.||||...||||.|||.
HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPFM

GEDDRQTLLNVRGGQWDFDDEVWDDISDEAQDFIWLLFEMNADKRPGLKEVSEHPWL
|..||.|. ||. ..||||||..|||||||.|||..|. .. .||.  .|  .||||
GDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
Kinase MLCKc.AA CAMK 193-441 23 2.8e-113 366.51 In-house 1-425 (425) Show / Hide 
Range on Protein: 193-441
Range on HMM: 1-425/425
Sequence Identity: 23% (101 aa)

ELGRGAYGVVHKGISKADG------------SECAVKTIRVK-----------------------------AGMWEEVRNEIAVMGI-------LDHKRL
.||||..|.|...| | ..             ..|.| |  |                             . . ..||.||..|         |||. .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLFDAYET-------------------KREVVMAM---EILTGGEL----FERIVQR---------------DSFSESEAVGFLKQLIDGLIYMHDRNV
|||...||.                   .....| |   |  .||||    |..||..                 |.|.||  . .|..... |.|..|.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHLDLKPENILLVAPESDD---------------IKLIDFGLAAVLKE------------------------GEDITCKFGTPEFVA-PEVVNK------
||.|||||||||.  ..|.               ||.||||.|.....                        |.  .  .||||..| |||.|.      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QPVSTGADVWGVGVIAFILLSGISPFAGE-------------DDRQTLLNVRGGQWDFDDEV------------WDDISDE--------AQD
        ....  .|.| .||| .|.|.| .|| |.             .|.... ... |..||...             |||||||        ..|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FIWLLFEMNADKRPGLKEVSEHPWL
.|  . . . .||. .... .|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MLCKc.AA Trio 188-441 35 1.2e-112 290.03 In-house 1-258 (258) Show / Hide 
Range on Protein: 188-441
Range on HMM: 1-258/258
Sequence Identity: 35% (91 aa)

YELLTELGRGAYGVVHKGISKADGSECAVKTIRVKAGMWEEVRNEIAVMGILDHKRLIKLFDAYETKREVVMAMEILTGGELFERIVQRDSFSESEAVGF
|. ..|.|||. .||.. . || | .||.| |  ..   | |. | ...  | | ... | |.||| |  .   |  ..||| .... ..| .|||  ..
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWGSYCESEVKTY

LKQLIDGLIYMHDRNVVHLDLKPENILLVAPES--DDIKLIDFGLAAVLKEG--EDITCKFGTPEFVAPEVVNKQPVSTGADVWGVGVIAFILLSGISPF
. |.  .. | |   . |||.||||......     .||..||| |  |  .  | . .. |.|||.|||... .||| |.|.|..||.....|||||||
MWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGISPF

AGEDDRQTLLNVRGGQWDFDDEVWDDISDEAQDFIWLLFEMNADKRPGLKEVSEHPWL
..|.|| |..|...|  .| ..    .| .| .||  .      ||| . |  .|||.
YDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase MLCKc.AA DAPK 190-441 39 1.8e-108 299.89 In-house 1-264 (264) Show / Hide 
Range on Protein: 190-441
Range on HMM: 1-264/264
Sequence Identity: 39% (104 aa)

LLTELGRGAYGVVHKGISKADGSECAVKTI---RVKAG----MWEEVRNEIAVMGILD-HKRLIKLFDAYETKREVVMAMEILTGGELFERIVQ--RDSF
   |||||   || | ..|  |.. | | |   | ..       ||   |||.   .  | ..| | ..|||. .|..  |  .|||||  ...   ...
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREECL

SESEAVGFLKQLIDGLIYMHDRNVVHLDLKPENILLVAPESDD--IKLIDFGLAAVLKEGEDITCKFGTPEFVAPEVVNKQPVSTGADVWGVGVIAFILL
.| .|. |.||  .|. |.|.||..||||||.||.|   .. .  ||.|||||. ....||..   .||||.||||.||  | |. .| | .|||. |.|
CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIML

SGISPFAGEDDRQTLLNVRGGQWDFDDEVWDDISDEAQDFIWLLFEMNADKRPGLKEVSEHPWL
||||||.|..   |.||.     ||..|  .  | .| |||  |.  ...||.  .|  .|||.
SGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase MLCKc.AA CAMK1 188-441 35 5.70000000001e-102 297.22 In-house 1-276 (276) Show / Hide 
Range on Protein: 188-441
Range on HMM: 1-276/276
Sequence Identity: 35% (98 aa)

YELLTELGRGAYGVVHKGISKA---DGSECAVKTIR-VKAGMW------EEVRNEIAVMG---ILDHKRLIKLFDAYETKREVVMAMEILTGGELFERIV
||.  |.|||| ..|.... |    .| . |.| |   |.         | ..|||..|     .||   ||... ||..... . || .||||||.|||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

QRDSFSESEAVGFLKQLIDGLIYMHDRNVVHLDLKPENILLVAPESD-DIK--LIDFGLAAVLKEGED-ITCKFGTPEFVAPEVVNK---QPVSTGADVW
......| .|.   ||... . |||....|| ||||||.|.. .. | .||  ..||||.  ....|.  .  .|||..|||||..    .| .   |.|
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMW

GVGVIAFILLSGISPFAGED-DRQTLLNVRGGQWDFDDEVWDDISDE-AQDFIWLLFEMNADKRPGLKEVSEHPWL
..||| .||| | .|| .|. | . .  .  ....|.   ||.|||. | |||  . | .  ||.  ... .|||.
SIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase MLCKc.AA DAPK 188-441 39 1.1e-88 255.92 In-house 1-264 (264) Show / Hide 
Range on Protein: 188-441
Range on HMM: 1-264/264
Sequence Identity: 39% (105 aa)

YELLTELGRGAYGVVHKGISKADGSECAVKTI---RVKAG----MWEEVRNEIAVMGILD-HKRLIKLFDAYETKREVVMAMEILTGGELFERIVQRDSF
|.   |.| | . || |   |  | | | | |   | .|       |..  |. .   .  |   | | |.||.| .||.  |  .|||||  . .... 
YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKECL

SESEAVGFLKQLIDGLIYMHDRNVVHLDLKPENILLVAPESDD--IKLIDFGLAAVLKEGEDITCKFGTPEFVAPEVVNKQPVSTGADVWGVGVIAFILL
.| ||  |.||  ||. .||.....|.||||||| |         ||.||||||   . |...   ||||||||||.||  | .  .| | .||| .|||
NEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYILL

SGISPFAGEDDRQTLLNVRGGQWDFDDEVWDDISDEAQDFIWLLFEMNADKRPGLKEVSEHPWL
|| ||| |.    || |.   . .||.|   . |  | |||  |.    .||   .|  .||| 
SGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI
Kinase MLCKc.AA S_TKc 188-441 32 2e-86 294.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 188-441
Range on HMM: 1-231/231
Sequence Identity: 32% (87 aa)

YELLTELGRGAYGVVHKGISKADGSECAVKTIRVKAGMWEEVRNEIAVMGILDHKRLIKLFDAYETKREVVMAMEILTG--GELFERIVQRDS------F
||.| ..|.||.|.|.|.. | .| ..|.| |.      | .|.||...   .|. ..||.|....  .. | || . |  |.||..|..| .      |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SESEAVGFLKQLIDGLIYMHDRNVVHLDLKPENILLVAPESDDIKLIDFGLAAVLKEGEDITCKFGTPEFVAPEVVNKQPVST-GADVWGVGVIAFILLS
.| .|  ...|....| |.|.....| |||||||||       ||..|||||..|      |   |||...||||.   . ..  .|.| .|.| ...|.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GISPFAGEDDRQTLLNVRGGQWDFDDEVWDDISDEAQDFIWLLFEMNADKRPGLKEVSE-------HPWL
|  ||    . |..... |             |.|| |||  ..... .|||.  |. .       |||.
GYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLCKc.AA DRAK 192-441 37 1.2e-81 253.38 In-house 3-259 (259) Show / Hide 
Range on Protein: 192-441
Range on HMM: 3-259/259
Sequence Identity: 37% (96 aa)

TELGRGAYGVVHKGISKADGSECAVKTIRVK---AGMWEEVRNEIAV-MGILDHKRLIKLFDAYETKREVVMAMEILTGGELFE--RIVQRDSFSESEAV
 |.||| . || | |.|  |.. | | ..         .|.  |||| |   |  ..| | . |||. |... .|  .|||.|.     . . |.| ...
KERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKDVQ

GFLKQLIDGLIYMHDRNVVHLDLKPENILLVAPES--DDIKLIDFGLAAVLKEGEDITCKFGTPEFVAPEVVNKQPVSTGADVWGVGVIAFILLSGISPF
  ..|  .|. |.|.||.||||||| ||||   |.  ||||..|||.. ....||..    |||..||||. |  |...  |.| .||.....|..||||
RCMRQILEGVHYLHQRNIVHLDLKPQNILLTS-EYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISPF

AGEDDRQTLLNVRGGQWDFDDEVWDDISDEAQDFIWLLFEMNADKRPGLKEVSEHPWL
.|.|   | ||.     |. .|  . .|..| |||  |   ....|.  .|  .||||
VGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase MLCKc.AA Pkinase 188-441 30 2.1e-80 278.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 188-441
Range on HMM: 1-293/293
Sequence Identity: 30% (89 aa)

YELLTELGRGAYGVVHKGISKADGSECAVKTIRVKAGMWEEVRN-----EIAVMGILDHKRLIKLFDAYETKREVVMAMEILTGG----ELFERIV--QR
|...  .|.|..|.| |.. | .| . |||.|...   ... ..     ||..|  |.|.  ..|.|..|.|... | || . ||    .||..|   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DSF--SESEAVGFLKQLIDGLIYMHDRNVVHLDLKPENILLVAPESDD---IKLIDFGLAAV--LKEGEDITCKFGTPEFVAPEVVN-KQPVSTGADVWG
 .|  || |.  ...|.. || |.|.....| ||||||||..  . .    .|..|||||..  .  ..  |   |||...||||..  |. .. .|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGVIAFILLSGISPFAGE------DDRQTLLNVRGGQWDFDDEVWDDIS-----------------DEAQDFIWLLFEMNADKRPGLKEVSEHPWL
.|.| ...|.|  || |.      |..| . ...|....|| . |..||                 .|..|||  .....  |||. ... .|||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLCKc.AA Ciliate-E2 188-441 19 6.7e-67 228.56 In-house 1-365 (365) Show / Hide 
Range on Protein: 188-441
Range on HMM: 1-365/365
Sequence Identity: 19% (76 aa)

YELLTELGRGAYGVVHKGISKADGS------------------ECAVKT---IRVKAGMWEEVRNEIAVMG----------------ILDHKRLIKLFDA
|...  .|.|..|.| |.  . ..                   ....|     ..|  . |.. .|| .|                 .|.|. .||....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--TKREVVMAMEILTGGELFERIVQRD-----------SFSESEAVGFLKQLID---------------GLIYMHDRN-VVHLDLKPENILLVAPESD
..  ..  . . || . ||.||..| ...           .|.| |.  . ||...               .| |.| .| ..| |.||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

DIKLIDFGLA-----------------AVLKEGEDITCKFG----------------TPEFVAPEVVNKQP---------VSTGADVWGVGVIAFILLSG
 ||.|||||.                   .  . |..  .|                ||...|||..|...          .. .|.| .||| ...|.|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

ISPFAGEDDRQTLLNVRGGQWDFDDE--------------VWDDISDEAQDFIWL----LFEMNADKRPG-LKEVSEHPWL
  ||        . .   ...||. .               |...|.|..|.|      ... . .||..  ... .|||.
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MLCKc.AA RSK 188-441 28 8.4e-64 218.27 In-house 1-271 (271) Show / Hide 
Range on Protein: 188-441
Range on HMM: 1-271/271
Sequence Identity: 28% (78 aa)

YELLTELGRGAYG---VVHKGISKADGSECAVKTIR---VKAG---MWEEVRNEIAVMGILDHKRLIKLFDAYETKREVVMAMEILTGGELFERIVQRDS
|||. ..|.|...   |..| . |. . . |.| |.   ...     |||.|.   ..   .|   .||...... . | | |. . ||.|| |..   .
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERI---ILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKM

FSESEAVGFLKQLIDGLIYMHDRNVVHLDLKPENILLVAP--ESDDIKLIDFGLAAVLKEGEDITCKF-GTPEFVAPEVVNKQPVSTGADVWGVGVIAFI
|||.|.   .  .   . | |   .|| ||||||||...   . . ||. |||.|  |.  . ..  | .| ...||||...|  .  .|.|  ||. ..
FSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYE

LLSGISPFAGEDDRQT---LLNVRGGQWDFDDEVWDDISDEAQDFIWLLFEMNADKRPGL-----KEVSEHPWL
 |.|  ||.. ..  .   ....  |. ..   .|| |||||.| .  .....  .|.|      ... .|||.
MLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase MLCKc.AA RSK 188-441 25 1.2e-63 217.76 In-house 1-278 (278) Show / Hide 
Range on Protein: 188-441
Range on HMM: 1-278/278
Sequence Identity: 25% (71 aa)

YELLTELGRGAYGVVHKGISKADGSECAVKTIRVKAGMWEEV-----RNEIAVMGILD-HKRLIKLFDAYETKREVVMAMEILTGGELFERIVQRDS---
 ..|...| |.. ...| . .. | . |.| .. .  .  ..     . |. ..     |. ...|..|..|. .. . || . |||||... .. .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSESEAVGFLKQLIDGLIYMHDRNVVHLDLKPENILLVAPE-SDDIKLIDFGLAAV-LKEGEDITCKF-GTPEFVAPEVVN---KQP-VSTGADVWGVGV
|||.||   . ...  . ..|.. ..| ||||||||.   . .  |||.|||..     . .  | .| .| |..|||...   .|   .  .|.|  ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

IAFILLSGISPFAG---EDDRQTLLNVRGGQWDFDDEVWDDISDEAQDFIWLLFEMNADKRPG-----LKEVSEHPWL
. . .|.| .||.|   ..  ... ... |. ... . |. .|.||.|.|  .....  ||.|     ..|. .|||.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MLCKc.AA TyrKc 188-441 21 3.6e-14 6.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 188-441
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YELLTELGRGAYGVVHKGISKADGSECAVKTIRVKAGMWEEVRNEIAVMGIL--DHKRLIKLFDAYETK-------REVVMAMEILTGGELFERIVQRDS
 .|. .||.||.|.|.||. |    ..|||...  |   |. ..|. .|  |  .|. ...|. .  ..         . . ||   .| | ...  .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-FSESEAVGFLKQLIDGLIYMHDRNVVHLDLKPENILLVAPESDDIKLIDFGLAAVLKEG-------EDITCKF--GTPEFV-----APEVVNKQPVSTG
 .. .. . |  |  .|  | |..|..| ||   |.|. ..    .|  ||||.  ....       . .. |   |.   .     |||. |.   .| 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

ADVWGVGVIAF-ILLSGISPFAG-----EDDRQTLLNVRGG--QWDFDDEVWDDI-----SDEAQDFIWLLFEMNADKRPGLKEVSEHPWL
 |||  ||  . |.  | .|  |      .... . .|. |      ..     .     .||  . .    . ....||  .|.  |  .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MLCKc.AA Pkinase_Tyr 188-308 21 2.8e-11 38.83 Pfam 1-137 (270) Show / Hide 
Range on Protein: 188-308
Range on HMM: 1-137/270
Sequence Identity: 21% (30 aa)

YELLTELGRGAYGVVHKGISK----ADGSECAVKTIRVKAGM----WEEVRNEIAVMGIL-DHKRLIKLFDAYE-TKRE--VVMAMEILTGGELFERIVQ
 ... .||.||.|.|.||. |     .. ..|||... .|      .|.  .|...|  | .|. ...|  .    ..   . . ||   .| | .   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----RDSFSESEAVGFLKQLIDGLIYMHDRNVVHLDL
    ..... .. ...  |  .|. | ...| .| ||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
I-set MLCKc.AA I-set 567-660 33 7.4e-27 93.66 Pfam 1-92 (92) Show / Hide 
Range on Protein: 567-660
Range on HMM: 1-92/92
Sequence Identity: 33% (32 aa)

PVFELELKDQIIMEMSQLKLTCKVNAHPKPTMTWYHANTKLTKASGGSRGVQIGLEK-GKAFLTIPKIGKRDGGQYKCVATNKAGTAESVANLTV
|.|.  .||. ..| . ....|.|  .|.|. .|.. . .|.     |. .|.  .. | ..||| .. ..| |.|.|||||..|.||. |.|||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP---DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 MLCKc.AA IGc2 579-650 26 5.1e-13 50.49 SMART 1-56 (56) Show / Hide 
Range on Protein: 579-650
Range on HMM: 1-56/56
Sequence Identity: 26% (19 aa)

MEMSQLKLTCKVNAHPKPTMTWYHANTKLTKASGGSRGVQIGLEKGKAFLTIPKIGKRDGGQYKCVATNKAG
 |  .. |||.... | |. .||. ...|                .. .|||  . . | | | |.|.|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP---------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG MLCKc.AA IG 573-661 22 1.7e-12 48.75 SMART 1-58 (58) Show / Hide 
Range on Protein: 573-661
Range on HMM: 1-58/58
Sequence Identity: 22% (21 aa)

LKDQIIMEMSQLKLTCKVNAHPKPTMTWYHANTKLTKASGGSRGVQIGLEKGKAFLTIPKIGKRDG---GQYKCVATNKAGTAES--VANLTVA
 . .  .| . ..||| |.     ...||                          ||| .. . |    | | |.||  .|...|   ..||| 
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
FN3 MLCKc.AA FN3 664-746 19 6.3e-10 40.22 SMART 1-69 (69) Show / Hide 
Range on Protein: 664-746
Range on HMM: 1-69/69
Sequence Identity: 19% (19 aa)

PEAPSR---PKIPLVSAH------EAFVSWKMNHPPKKDDLEGYLLQCRKAGDKQWLEVSDVIKDCNFHVKSLTPE----NEYRFRVACRTP--HGCG
| .|..   ...  |...       . .|||   ||         ...|                  . |. |.|      ||.|||....   .| |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK---PP--------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase MLCKc.AA MLCK 819-1074 31 1.6e-77 203.62 In-house 1-257 (257) Show / Hide 
Range on Protein: 819-1074
Range on HMM: 1-257/257
Sequence Identity: 31% (81 aa)

YEMQEEIGRGRYSVVMRCRKVATCKEYAVKILAH-TKKTQDKCLAEYELLKELSHPHILQLREAFLTNRHVMLVTERYYGGTVLKYLT-KEDTYTESTVV
|.  ||.|||....| ||.  .| |..|.|.  . . | ... ..|.| ...| || ..|. .|| |.. . .. |   || .. . .  ....||. |.
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI

RIVAQVLDALEHLHMMNVVYLDLRHDNLLMESRRKDVVRLIDFGSCRVIQKDGE-SKTK-GIDVLPEFMAPELAVKGGSIDYETDIWPLGVMVFTWLSGT
... |......|.| .|.| |||. .| .. .|. . . .||||  | . .|..  |.. |.   ||| |||  |.   ... ||.| .|| ..  ||| 
HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGT---PEFVAPEV-VNYDPVGFQTDMWSVGVICYMLLSGL

SPFLGRNQEKTIYNITRMKYNIS-SLYPNVSPEAKAFLQAIFKEKPIDRPTVADCLEHSWV
|||.| | . |. |.|  ..    .  ...|.||| |   ...... .|.|...||.| | 
SPFMGDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
S_TKc MLCKc.AA S_TKc 819-1074 24 1.5e-66 228.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 819-1074
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

YEMQEEIGRGRYSVVMRCRKVATCKEYAVKILAHTKKTQDKCLAEYELLKELSHPHILQLREAFLTNRHVMLVTERYYG--GTVLKYLTKEDT------Y
||. ..||.| ...|..||.. | ...|.||.       .. . | ..||.  ||.| .| ..| .  |. .|.|   |  |....|. |  .      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TESTVVRIVAQVLDALEHLHMMNVVYLDLRHDNLLMESRRKDVVRLIDFGSCRVIQKDGESKTKGIDVLPEFMAPELAVKGGSIDY-ETDIWPLGVMVFT
.| .. ....|...|||..| ..... ||  .|.|. .    .. ..|||..|..        . . . |..||||.     . .. . |.| .|.... 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

WLSGTSPFLGRNQEKTIYNITRMKYNISSLYPNVSPEAKAFLQAIFKEKPIDRPTVADCLE-------HSWV
 |.|  ||    |....... .            ||||| |.. ...  | .|||. ..|.       | |.
MLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLCKc.AA CAMK 824-1074 17 5.5e-65 208.08 In-house 1-425 (425) Show / Hide 
Range on Protein: 824-1074
Range on HMM: 1-425/425
Sequence Identity: 17% (73 aa)

EIGRGRYSVVMRCRKV-ATC-----------KEYAVKILAHT-----------------------------KKTQDKCLAEYELLKELS-------HPHI
..|||....| .|.    |.           ...|.||.  .                              |.... . |.|..| |.       ||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LQLREAFL------------TNRH--------VMLVT---ERYYGG----TVLKYLTKE---------------DTYTESTVVRIVAQVLDALEHLHMMN
..| |..             | ..        . .|.   |   ||     .. |...                  .||. . |.. |...|....| .|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VVYLDLRHDNLLMESRRKD---------------VVRLIDFGSCRVIQKDG----------------------ESKTKGIDVLPEFMA-PELAVK-----
.| .||  .|.|. .. .|                . .||||  ......                         | |     ||.|| ||.  .     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------GGSIDYETDIWPLGVMVFTWLSGTSPFLGR-------------NQEKTIYNITRMKYN-ISSLYPNVS--------------------PEAK
           .....|.| .||. .. |.|..|| |              |....  .|.. ||. ...  ...|                    .|.|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

AFLQAIFKEKPIDRPTVADCLEHSWV
 ... . .  | .|.|...||.| |.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Pkinase MLCKc.AA Pkinase 819-1074 24 1.3e-61 215.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 819-1074
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

YEMQEEIGRGRYSVVMRCRKVATCKEYAVKILAHTKKTQDKC-----LAEYELLKELSHPHILQLREAFLTNRHVMLVTERYYGG----TVLKYLT--KE
|.  . ||.| ...| .|... |.|..||||.   ..  .|.     |.| ...|.|.||.|..|...| ...|. .|.|   ||        |..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DTY--TESTVVRIVAQVLDALEHLHMMNVVYLDLRHDNLLMESRRKDV---VRLIDFGSCRVIQKDGESKTKGIDVLPEFMAPELAVKGGSIDYETDIWP
 ..  .| .. ... |.| .||..| |.... ||  .|.|.  .. ..   |...|||......    | .... . |..||||.  .|  .... |.| 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVMVFTWLSGTSPFLGR------NQEKTIYNITRMKYNISSLYP------------------NVSPEAKAFLQAIFKEKPIDRPTVADCLEHSWV
.|....  |.|  || |.      .| . |..| . ..  .. ..                  |.|.|.| |.  ... .| .||| ...|.| |.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLCKc.AA DAPK 821-1074 32 1.7e-57 156.75 In-house 1-264 (264) Show / Hide 
Range on Protein: 821-1074
Range on HMM: 1-264/264
Sequence Identity: 32% (87 aa)

MQEEIGRGRYSVVMRCRKVATCKEYAVKILAHTKKTQD-------KCLAEYELLKELS-HPHILQLREAFLTNRHVMLVTERYYGGTVLKYLTK--EDTY
| ||.|||. .|| .||.  | |.|| | .   ...|.         . |   |.|.. ||..  | |.. |   | |. |   ||    |.    |.  
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREECL

TESTVVRIVAQVLDALEHLHMMNVVYLDLRHDNLLMESRRKDV--VRLIDFGSCRVIQKDGESKTKGIDVLPEFMAPELAVKGGSIDYETDIWPLGVMVF
.|  ..| . |.|... .||  |.. |||   | .  .|.     . .||||  |.| ..||   . |   ||. |||  |    .  .||.|  ||   
CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKI-CNGE-EFRDIMGTPEYVAPEI-VNYEPLSLATDMWSIGVITY

TWLSGTSPFLGRNQEKTIYNITRMKYNIS-SLYPNVSPEAKAFLQAIFKEKPIDRPTVADCLEHSWV
  |||.||||| .   |  ||... |  |  .  ..|..|| | .  .  .| .|.|...||.|.| 
IMLSGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase MLCKc.AA RSK 821-1074 26 9.8e-48 164.9 In-house 1-278 (278) Show / Hide 
Range on Protein: 821-1074
Range on HMM: 1-278/278
Sequence Identity: 26% (73 aa)

MQEE--IGRGRYSVVMRCRKVATCKEYAVKILAHTKKTQ-DK----CLAEYELLKELS-HPHILQLREAFLTNRHVMLVTERYYGGTVLKYLTKEDT---
...   .| | .... .|.  .| ..||.|.|   |  | .|    ...| . |..   || | .| .|| |. .. |..|   ||  .. | || .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

YTESTVVRIVAQVLDALEHLHMMNVVYLDLRHDNLLMESRRKD--VVRLIDFGSCRVIQKDGESKTKGIDVLPEFMAPELAV---KGGSIDYETDIWPLG
 .|...  . |..  |.||||   ... ||  .| | .... .   ..|.||| |.    | ...|.      |.||||.     ..|  |   |.| ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VMVFTWLSGTSPFLG---RNQEKTIYNITRMKYNISSL-YPNVSPEAKAFLQAIFKEKPIDRPT-----VADCLEHSWV
|  .. |.| .|| |    |..... .| . |.. ..   ...|.||| .... ..  | .|..     ... ..|.| 
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MLCKc.AA DRAK 821-1074 30 4.9e-47 143.87 In-house 1-259 (259) Show / Hide 
Range on Protein: 821-1074
Range on HMM: 1-259/259
Sequence Identity: 30% (82 aa)

MQEEIGRGRYSVVMRCRKVATCKEYAVKILAHTKKTQDKCLAEYELLKEL-------SHPHILQLREAFLTNRHVMLVTERYYGGTVLK--YLTKEDTYT
   | |||.. || .| .  | ...| | .   .. ||    . | |.|        . |..  | | . |   . || |   || . .   . ||.  .
TAKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQD---CRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFC

ESTVVRIVAQVLDALEHLHMMNVVYLDLRHDNLLMES-RRKDVVRLIDFGSCRVIQKDGESKTKGIDVLPEFMAPELAVKGGSIDYETDIWPLGVMVFTW
|  |.|.. |.|...  ||  |.| |||.  | |. | .  | ....|||  |.|..  |     |   |...|||   .   |   ||.|  ||. .  
EKDVQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEE--VREIMGTPDYVAPEI-LNYDPITMATDMWSIGVLTYVM

LSGTSPFLGRNQEKTIYNITRMKYNIS-SLYPNVSPEAKAFLQAIFKEKPIDRPTVADCLEHSWV
|...|||.|  .  |  ||  .    |  ..  .||.|  | | .   || ||.|   ||.|.|.
LTHISPFVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase MLCKc.AA Trio 819-961 34 9.6e-47 117.42 In-house 1-145 (258) Show / Hide 
Range on Protein: 819-961
Range on HMM: 1-145/258
Sequence Identity: 34% (50 aa)

YEMQEEIGRGRYSVVMRCRKVATCKEYAVKILAHTKKTQDKCLAEYELLKELSHPHILQLREAFLTNRHVMLVTERYYGGTVLKYLTKEDTYTESTVVRI
|. |||||||| ||| ||.  || .. |.|.     .. .  . |||.|. |.||....| ....| ||  |..|   .|  | .| . ..|.|| |   
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWGSYCESEVKTY

VAQVLDALEHLHMMNVVYLDLRHDNLLMESRRK--DVVRLIDFGS
. |.| |.  ||   .  ||.. .|..|. .      ....|||.
MWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGD
Kinase MLCKc.AA Ciliate-E2 819-1074 19 1.8e-44 150.52 In-house 1-365 (365) Show / Hide 
Range on Protein: 819-1074
Range on HMM: 1-365/365
Sequence Identity: 19% (74 aa)

YEMQEEIGRGRYSVVMRC--RKV---------------------ATCKEYAVKILAHT-KKTQDKCLAEYE-------------LLKELSHPHILQLREA
|. .. ||.| ...| .|  .||                     .. |.||.||. .  .. . . . ..              .|..|.||.|... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FL--TNRHVMLVTERYYGGTVLKYLTKEDT-----------YTESTVVRIVAQVLD---------------ALEHLHMMN-VVYLDLRHDNLLMESRRKD
|   .. .. ||.| . ||. ..|. . ..           .||  . .| .|.|.               |||.||  | ... |.  .|.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

VVRLIDFGSCRVIQKD----------GESKTKG---------------------IDVLPEFMAPELAVKGGS--------IDYETDIWPLGVMVFTWLSG
 . .|||| .. ...|          .. .  .                     |   |..||||   ...          ||. ||| |||. .  |.|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

TSPFLGRNQEKTIYNITRMKYNISSL---------------YPNVSPEAKAFLQA----IFKEKPIDRPT-VADCLEHSWV
  ||        . .|   |.....                . ..|.|.| ...     ... .|  |.|   ..|.| | 
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MLCKc.AA Trio 980-1074 40 4e-44 110.54 In-house 164-258 (258) Show / Hide 
Range on Protein: 980-1074
Range on HMM: 164-258/258
Sequence Identity: 40% (39 aa)

PEFMAPELAVKGGSIDYETDIWPLGVMVFTWLSGTSPFLGRNQEKTIYNITRMKYNISSLYPN-VSPEAKAFLQAIFKEKPIDRPTVADCLEHSWV
|||||||. ..|  ..| ||||. ||  .  ||| |||.. . . |  || |  .  ...|.. || .||.|....  | |  ||. ..||.| | 
PEFMAPEI-IQGNPVSYGTDIWSIGVLTYVMLSGISPFYDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase MLCKc.AA DAPK 863-1074 32 2.7e-39 110.91 In-house 52-264 (264) Show / Hide 
Range on Protein: 863-1074
Range on HMM: 52-264/264
Sequence Identity: 32% (70 aa)

EYELLKELS-HPHILQLREAFLTNRHVMLVTERYYGGTVLKYLTKEDTYTESTVVRIVAQVLDALEHLHMMNVVYLDLRHDNLLMESRRKDV--VRLIDF
|   |.|.. || |  | ... .   | |. |   ||    .|  ..  .|      . |.||.. |.|  ... .||   |     |      ...|||
EVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKECLNEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDF

GSCRVIQKDGESKTKGIDVLPEFMAPELAVKGGSIDYETDIWPLGVMVFTWLSGTSPFLGRNQEKTIYNITRMKYNISSLY-PNVSPEAKAFLQAIFKEK
|  . | ..|.   | |   ||| |||  |       ||| |  ||  .  ||| ||||| ... |. |||. .|. .  |  | |  || |    .   
GLAHRI-EPGN-EFKNIFGTPEFVAPEI-VNYEPLGLETDMWSIGVITYILLSGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKD

PIDRPTVADCLEHSWV
|  | |...||.|.|.
PKKRMTIQECLQHPWI
Kinase MLCKc.AA RSK 819-960 28 6.1e-28 96.9 In-house 1-150 (271) Show / Hide 
Range on Protein: 819-960
Range on HMM: 1-150/271
Sequence Identity: 28% (44 aa)

YEMQEEIGRGRYS---VVMRCRKVATCKEYAVKILAHTKKTQDKC-----LAEYELLKELSHPHILQLREAFLTNRHVMLVTERYYGGTVLKYLTKEDTY
|| .|.||.| .|   |. .|.  .| ..||.||.   |.| |        .|  .| .  || | .|...| . ..| ....   ||  .. | |.   
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIK--KATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMF

TESTVVRIVAQVLDALEHLHMMNVVYLDLRHDNLLMESR--RKDVVRLIDFG
.|. |  . | .. |.|.||   .|. ||  .| |  .     . ... |||
SEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFG
Kinase MLCKc.AA CAMK1 819-935 30 4.3e-25 69.82 In-house 1-130 (276) Show / Hide 
Range on Protein: 819-935
Range on HMM: 1-130/276
Sequence Identity: 30% (40 aa)

YEMQEEIGRGRYSVVMRCRKVAT---CKEYAVKILA---HTKK-TQ---DKCLAEYELLK---ELSHPHILQLREAFLTNRHVMLVTERYYGGTVLKYLT
|| ..|||||  |.| .| .  |    |.||.|..    ..|| ..   .. . | | .|   ...||.| .. | . ...|. ||.|   ||  .    
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

KEDTYTESTVVRIVAQVLDALEHLHMMNVV
. . |||   ..|. |.|.|.|..| ...|
EKGNYTEKDARHIMKQILSAVEYMHSKGIV
Kinase MLCKc.AA RSK 981-1074 25 5.2e-13 42.99 In-house 170-271 (271) Show / Hide 
Range on Protein: 981-1074
Range on HMM: 170-271/271
Sequence Identity: 25% (26 aa)

EFMAPELAVKGGSIDYETDIWPLGVMVFTWLSGTSPFLGRNQEKTIYNITRMKYNI----SSLYPNVSPEAKAFLQAIFKEKPIDRPTV-----ADCLEH
..||||   . |  |   |.| .||  .. |.|. || ... . .  .| | |  .    ..   ..|.|||  | . ..  |  |..      .. ..|
NYMAPEVLKRQG-HDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQH

SWV
.|.
PWF
Kinase MLCKc.AA Pkinase_Tyr 819-935 20 4.2e-10 34.85 Pfam 1-133 (270) Show / Hide 
Range on Protein: 819-935
Range on HMM: 1-133/270
Sequence Identity: 20% (27 aa)

YEMQEEIGRGRYSVVMRCRKV----ATCKEYAVKIL--AHTKKT--QDKCLAEYELLKEL-SHPHILQLREAFL-TNRH--VMLVTERYYGGTVLKYLTK
 .. ...|.| . .|....       |. . |||.|   ....   ... ..| ...|.| .||.|..|  . .   ..  ...|.|   .|  |.|| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----EDTYTESTVVRIVAQVLDALEHLHMMNVV
    ..  | .. . . .|. ...|.|. .| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCI
Kinase MLCKc.AA DAPK 819-848 56 5.6e-09 21.93 In-house 1-30 (264) Show / Hide 
Range on Protein: 819-848
Range on HMM: 1-30/264
Sequence Identity: 56% (17 aa)

YEMQEEIGRGRYSVVMRCRKVATCKEYAVK
|.| |||| | ..|| .||   | |||| |
YDMGEEIGSGQFAVVKKCREKSTGKEYAAK
Kinase MLCKc.AA CAMK1 980-1074 28 2e-06 14.39 In-house 177-276 (276) Show / Hide 
Range on Protein: 980-1074
Range on HMM: 177-276/276
Sequence Identity: 28% (29 aa)

PEFMAPELAVKG---GSIDYETDIWPLGVMVFTWLSGTSPFLGRN-QEKTIYNITRMKYN-ISSLYPNVSPE-AKAFLQAIFKEKPIDRPTVADCLEHSW
|...|||  ...      |.. |.|  ||  .. | | .|| . | ...    |.. .|. .|    |.| . || |.    .  |  |.|...||.| |
PGYVAPEV-LECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPW

V
.
I