GAK

Species: Sea Urchin
Alias: SPU_000818, GAK, Spk167
External Links: Sea Urchin Project Link ,
Annotation:

Classification

Group: Other
Family: NAK
Subfamily: GAK

Sequence

Name Sequence Type Origin Length Description Download
GAK.AA Protein None 1395 None Fasta, JSON
GAK.kin_dom Protein Kinase Domain None 128 None Fasta, JSON

Protein domain

Protein domains of GAK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GAK.AA GAK 34-82 54 2.6e-23 74.23 In-house 1-50 (277) Show / Hide
Range on Protein: 34-82
Range on HMM: 1-50/277
Sequence Identity: 54% (27 aa)

LKVRRVIAE-GFAFVYVAQENSTGKEFALKRLLANDEEKSKEILQEIAIL
. ||.|||| |||||||||.  ||.|.||||.| .|..... | .|| ..
YRVRCVIAEGGFAFVYVAQDVQTGREYALKRMLSHDMQANRAIINEICMM

Kinase GAK.AA NAK 34-82 31 3.9e-16 50.28 In-house 1-60 (299) Show / Hide
Range on Protein: 34-82
Range on HMM: 1-60/299
Sequence Identity: 31% (19 aa)

LKVRRVIAE-GFAFVYVAQ---------ENSTGKEFALKRLLAN-DEEKSKEILQEIAIL
..|....|| ||..||..|          ||.|...||||.. . ||.. ... .|| ..
YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMM

Kinase GAK.AA NAK-Unclassified 34-79 27 2e-06 18.43 In-house 1-61 (405) Show / Hide
Range on Protein: 34-79
Range on HMM: 1-61/405
Sequence Identity: 27% (17 aa)

LKVRRVIAE-GFAFVYVAQ--------E------NSTGKEFALKRLLANDEEKSKEILQEI
 .. | .|| ||.|||...               .|...  .||| .  |||  ..   ||
YTIVRYLAEGGFSFVYLVKFSKYINPPDNTASVPHSNSNMYCLKRMICQDEESLNTMKREI

Kinase GAK.AA BIKE 34-82 30 1.8e-05 15.49 In-house 1-49 (267) Show / Hide
Range on Protein: 34-82
Range on HMM: 1-49/267
Sequence Identity: 30% (15 aa)

LKVRRVIAE-GFAFVYVAQENSTGKEFALKRLLANDEEKSKEILQEIAIL
  |  ..|| ||| |.......    .||||   | |.  .    |. |.
VTVEEQLAEGGFAMVFLVRDHKG-NKCALKRMYVNNEHDLNVCCREHQIM

Kinase GAK.AA CAMK 39-82 10 0.001935 6.15 In-house 1-85 (425) Show / Hide
Range on Protein: 39-82
Range on HMM: 1-85/425
Sequence Identity: 10% (9 aa)

VIAE-GFAFVYVAQENSTG------------KEFALKRLLAN----------------------------DEEKSKEILQEIAIL
.. . .|. |. ... .|.            ...| | .  .                            .... |....||.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIM

Kinase GAK.AA Pkinase 34-82 29 0.022746 9.46 Pfam 1-54 (293) Show / Hide
Range on Protein: 34-82
Range on HMM: 1-54/293
Sequence Identity: 29% (16 aa)

LKVRRVIAEG-FAFVYVAQENSTGKEFALKRLLANDEEKSKEILQ----EIAIL
... |.| .| |. || ... .|||..|.|..   .|...|..      ||.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIM

Kinase GAK.AA Ciliate-E2 34-82 21 0.169895 0.88 In-house 1-70 (365) Show / Hide
Range on Protein: 34-82
Range on HMM: 1-70/365
Sequence Identity: 21% (15 aa)

LKVRRVIAEG-FAFVYVAQENSTGKEFALKR--------------------LLANDEEKSKEILQEIAIL
 |. ..| .| |. || ..  ...|.||.|.                    .  . . . ..|.||| |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIM

Kinase GAK.AA GAK 170-306 65 2.6e-110 367.8 In-house 139-277 (277) Show / Hide
Range on Protein: 170-306
Range on HMM: 139-277/277
Sequence Identity: 65% (91 aa)

ENFLIGSKKTLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLRIINANY
||||||..||.|||||||||.||..||.|||..|||..|||..||||||||.||..|||.|.||.|..|.||.|||||.||||||||||.|||||||.||
ENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSNWPIGHKQDIWAMGCMLYFMCYRQHPFEDGAKLRIINGNY

T--IPEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVAQL
.  ||..|..||..||||||.|||.|..|.    .| ..
MKPIPPQDNQYMCFHDLIRACLQVNPDERLDIAMVVEYM

Kinase GAK.AA NAK 170-306 46 2.6e-81 271.15 In-house 152-299 (299) Show / Hide
Range on Protein: 170-306
Range on HMM: 152-299/299
Sequence Identity: 46% (69 aa)

ENFLIGS---KKTLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFED------SA
||.|...   ....|||||||.| ...||. .|....||...|.....||||||.||..||| |.||.. .|.||||||||.||...|||||      |.
ENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYTTPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSS

KLRIINANYT--IPEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVAQL
||.|.|.||.  ||...  .. .|||||.||..||..||  . .. ||
KLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL

Kinase GAK.AA NAK-Unclassified 181-308 35 4.9e-36 123.19 In-house 272-405 (405) Show / Hide
Range on Protein: 181-308
Range on HMM: 272-405/405
Sequence Identity: 35% (49 aa)

KLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLR-------IIN--ANYTI
|||||||..     .     .  .. |.|.  .|||| ||.||..||| . ||.   |.||||| ||.||.   |||..  |        |..  ..|..
KLCDFGSCCECIITIE---NRQEMQYLQDWINMHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEF

PEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVAQLQE
|        || ||. ||..||..|| .  .  .. .
PSNHNYSNQLHNLIKIMLNEDPIQRPNIYQVLNHICQ

Kinase GAK.AA BIKE 170-297 40 2.5e-29 102.21 In-house 135-259 (267) Show / Hide
Range on Protein: 170-297
Range on HMM: 135-259/267
Sequence Identity: 40% (53 aa)

ENFLIGSKK--TLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLRIINA
|| |. ...     |||||||| |  .|     . .    .||  . ||  || ||  |||   .|    |.|||||||| .|.   ||. | .| | . 
ENILLHDHGPPHYVLCDFGSATNKFLNPQK--HGVN--YVKDEIEKYTTMCYRAPEMIDLYSGKEITTKADIWALGCMLYKLCFFCLPFGES-QLAICDG

NYTIPEDDEEYMILHDLIRAMLQVDPRNRP
|.|||.       .| ||| || .|.  ||
NFTIPDNSKYSREMHCLIRYMLEPDMEKRP

Kinase GAK.AA Ciliate-E2 169-297 18 7.2e-19 61.39 In-house 189-353 (365) Show / Hide
Range on Protein: 169-297
Range on HMM: 189-353/365
Sequence Identity: 18% (36 aa)

LENFLIGSKKTLKLCDFGSAT--------------SKSYQPDS----------SWSSLKRSTLEDEFARHT------------TPMYRPPEILDLYE---
.|| |.     .|..||| ..              .| |.  .          .                             ||.| .||||   .   
PENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD----------------QIIQQNMFNTICGTPGYMAPEILNGKKYDN

---NFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLRIINA-NYTIP----------------EDDEEYMILHDLIRA----MLQVDPRNRP
     . ... |.|.||..|| |.. ..||     ...|   .. .|                . ..      |||.     |||.|| .|.
QQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI

Kinase GAK.AA CAMK 169-300 18 2.8e-16 48.29 In-house 207-417 (425) Show / Hide
Range on Protein: 169-300
Range on HMM: 207-417/425
Sequence Identity: 18% (40 aa)

LENFLIGSKK-----------------TLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFA-------------RHTTPMYRP-PEILD-----------
.|| |. ...                 ..|..||| |. .    ..   | . .                    .  || | . ||.|            
PENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNAT

LYENFPINHAMDVWALGCMLYTMCYRQHPFEDS-----------------AKLRIINANYT-IPED--------DEEYMI-------------LHDLIRA
. |. ... . |.|..|..||.|     ||...                  . .|....|. .|.         ..|.                 |||| 
DEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRK

MLQVDPRNRPPLE
|||||| .|. .|
MLQVDPEKRMTIE

Kinase GAK.AA MPSK 238-306 38 7e-16 53.56 In-house 207-281 (281) Show / Hide
Range on Protein: 238-306
Range on HMM: 207-281/281
Sequence Identity: 38% (29 aa)

DVWALGCMLYTMCYRQHPFE------DSAKLRIINANYTIPEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVAQL
|.| ||| || |||   |..      ||  | . | |  |||.      .|.||  |. |||  ||   ..  |.
DIWSLGCVLYAMCYFHSPYDMIYQRGDSVHLAVQNRNFNIPENSRYSQDMHQLISYMMRVDPMERPHIFWVLNQT

Kinase GAK.AA TKL-ciliate1 207-306 26 1.4e-15 49.81 In-house 168-279 (279) Show / Hide
Range on Protein: 207-306
Range on HMM: 168-279/279
Sequence Identity: 26% (30 aa)

LEDEFARHTTPMYRPPEILD--LYENFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLRIINANYTIPEDD------------EEYMILHDLIRAMLQVD
.  |  | ||.... ||..|  .. | |||   |..|.|  .| .| |  ||.   |.  ||    ..|                   .|.|.  ..  .
MQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQ--KMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQN

PRNRPPLEVIVAQL
|  ||  . |   |
PNKRPNFNEIIQIL

Kinase GAK.AA Pkinase 169-306 20 4.3e-15 54.46 Pfam 136-293 (293) Show / Hide
Range on Protein: 169-306
Range on HMM: 136-293/293
Sequence Identity: 20% (36 aa)

LENFLIGSKKTL----KLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFEDS-----
.||.|| .. ..    |.||||.|  ..          . | . .      || |..||..   .. .. .. |.|..||.|| |. .. || ..     
PENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCG---TPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN

-AKLRIINANYT------IPEDDEEY-----------------MILHDLIRAMLQVDPRNRPPLEVIVAQ--L
  .. .|. .        .|......                   . |.|. .|..||  ||  | |.    .
HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase GAK.AA TKL 170-306 16 6.2e-15 50.23 In-house 169-364 (364) Show / Hide
Range on Protein: 170-306
Range on HMM: 169-364/364
Sequence Identity: 16% (33 aa)

ENFLIGSKKT--------------LKLCDFGSATSKSYQPDSSWSS--------LKRSTLEDEFARHTTPMYRPPEILD---LYEN----------FPIN
.| |. .. |              .|.|||| ....|   ... ..        .. .. .    .  || . .||.|.    |..          |. .
KNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS

HAMDVWALGCMLYTMCYRQHPFEDSAKLRII---------NANY------TIPE--------DDEEYM--ILHDLIRAMLQVDPRNRPPLEVIVAQL
 ..||.. | .|. .. |..|..|     .|           ..      .||.         .....   . .|.    . ||..||  . |. .|
EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase GAK.AA Ciliate-E2-Unclassified 169-297 18 8.9e-15 47.71 In-house 172-341 (352) Show / Hide
Range on Protein: 169-297
Range on HMM: 172-341/352
Sequence Identity: 18% (32 aa)

LENFLIGSKK---TLKLCDFGSATSKSYQPDSSWSSL--KRSTLEDEFARHT--TPMYR----PPEIL--DLYE--NFPINHAMDVWALGCMLYTMCYRQ
.|| |. ...    .|..|||..    .....   .   |.. . .. . ..  ||.|     .||.|    |.   .   .. |.|.||. || |.. .
PENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---YKCDIWSLGVILYEMLFGY

HPFE--DSAK----------------LRIINANYTIPEDDEEY----MILH--------DLIRAMLQVDPRNRP
.||.  .. .                |. .  .  |  . ..     ....        ||.. ||...| .|.
YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI

Kinase GAK.AA S_TKc 169-310 12 1.5e-05 -95.68 SMART 1-231 (231) Show / Hide
Range on Protein: 169-310
Range on HMM: 1-231/231
Sequence Identity: 12% (33 aa)

L---------------------------------------------------------------------------------------------------
                                                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYM

----------------------ENFLIGSKKTLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINH-AMDVWALGCML
                      || |. .  ..|.||||.|.                          || |..||.|      . .. . |.|..||.|
YQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCIL

YTMCYRQHPFEDSAKLRIINANYTIPEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVA-----QLQEIA
| |.... ||.     ....              . |.|| .||.||..||    . .      . .  
YEMLCGYPPFP--QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

PTEN_C2 GAK.AA PTEN_C2 552-693 21 7.1e-25 91.16 Pfam 1-141 (141) Show / Hide
Range on Protein: 552-693
Range on HMM: 1-141/141
Sequence Identity: 21% (33 aa)

PHQRVLLIKSLRL-TPVPLYNKMRSGCPSVRPYVRTSVPDELI-RFGGHEVKGQRGFEVEDASAFIDLNIPVCGDVMVVVYHAR-ST--FGGKVQGKVTG
|. . | ......  ..|   |.. ||  .|||..    |. .  . .   ....  . ...  ... ..||.|||.. .|| . |.     ...     
PPPKPLFLHCIIMDHGIPNF-KQGGGC--WRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEEC-----

LKMFQFQFNTGFIEPGTKEISFNRYELD-FFEL---DKFAEHFHASLDVVV
  ||.|.|||.||| ..... |...||| ..     ..| . |.. .    
--MFRFWFNTCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE

DnaJ GAK.AA DnaJ 1330-1391 25 0.000116 17.03 SMART 1-72 (72) Show / Hide
Range on Protein: 1330-1391
Range on HMM: 1-72/72
Sequence Identity: 25% (18 aa)

EDRWKPVGMHQLVEHNQVKKWYRKAVLSAHPDKQVGTPN----------EELAKLIFMELSDAWSAFEEAGA
.| ..  | ..    ...|| ||| ..  ||||  | |           .| |.  |.|.. |..       
RDYYEILGVPRDADDDEIKKAYRKLAKKYHPDKNPGDPERSCWKLCWEEKEEAEEKFKEINEAYEVLSDPEK