Gene NEK11 (Sea Urchin)

NEK11

Species: Sea Urchin
Alias: SPU_014659, NEK11, SPU_004690, Spk175
External Links: Sea Urchin Project Link ,
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK11

Sequence

Name Sequence Type Origin Length Description Download
NEK11.AA Protein None 214 None Fasta, JSON
NEK11.kin_dom Protein Kinase Domain None 191 None Fasta, JSON

Protein domain

Protein domains of NEK11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK11.AA NEK 24-214 46 4.7e-111 375.26 In-house 1-208 (286) Show / Hide 
Range on Protein: 24-214
Range on HMM: 1-208/286
Sequence Identity: 46% (97 aa)

YRVEKKLGSGNFGTAFLVFDMKANPDKGEEEWKVLKEISCGDLAPDETVDAM-HEAKLLSKLHHPNIVKFYDSFLDGE--FFCIITEYCE-GGDLDDK--
|.. ||.|.|.||....| . . .  .. |.. |.|.|. | . . |. .|. .|...|..|.||||||.||||.. .  ..||. |||| ||||..|  
YEIIKKIGQGSFGKVYKVRRKSDGKHLV-EKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIK

-ITAWKKAGKKFDQNVIMDWFVQLALAVQHMHKR-----RVLHRDLKTRNIFLKK-NM----IKIGDFGISRVLMGTTDMAST-FTGTPYYMSPEVLKHE
 |  .|..|| |. ..|.|||.|..||...||.|     ..||||.|. |||| | |.    .||||||||.||. |||||.| ..||||||||||....
SIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

GYNSKSDVW
.||.|||.|
PYNNKSDIW
Kinase NEK11.AA NEK11 24-214 62 3.4e-103 349.12 In-house 1-188 (259) Show / Hide 
Range on Protein: 24-214
Range on HMM: 1-188/259
Sequence Identity: 62% (120 aa)

YRVEKKLGSGNFGTAFLVFDMKANPDKGEEEWKVLKEISCGDLAPDETVDAMHEAKLLSKLHHPNIVKFYDSFLDGEFFCIITEYCEGGDLDDKITAWKK
| . .||||| ||| .|| | ||   |  || ||||||| |.| | ||| |  ||.|||.|||| ||.|  ||.. . |||||||||| |||..|  .|.
YVLQQKLGSGSFGTVYLVSDKKA---KRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQ

AGKKFDQNVIMDWFVQLALAVQHMHKRRVLHRDLKTRNIFLKKNMIKIGDFGISRVLMGTTDMASTFTGTPYYMSPEVLKHEGYNSKSDVW
||| |  | |..||.|| | |  || ||.|||||| .||||| |..||||||.||.|||  |.| | |||| ||||| ||| || .|||.|
AGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIW
Kinase NEK11.AA NEK1 24-214 40 3.8e-74 252.65 In-house 1-205 (276) Show / Hide 
Range on Protein: 24-214
Range on HMM: 1-205/276
Sequence Identity: 40% (85 aa)

YRVEKKLGSGNFGTAFLVFDMKANPDKGEEEWKVLKEISCGDLAPDETVDAMHEAKLLSKLHHPNIVKFYDSFLDGEF--FCIITEYCEGGDLDDKITAW
| . |..|.|.|| |.||       .| .    |.|||.     . |. ..| |...|.|. ||||||...||  .      |. |||.||||  || . 
YHYIKQIGEGSFGKAWLVK------HKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQ

KKAGKKFDQNVIMDWFVQLALAVQHMHKRRVLHRDLKTRNIFLK---KN---------------MIKIGDFGISRVLMGTTDMASTFTGTPYYMSPEVLK
|  || |    ||.||.|. ||..|.|.|..||||.|. ||||    .                ..|.|||||.|.|  |.. |.|  ||||| |||   
KRKGKLFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQ

HEGYNSKSDVW
  .|| |||.|
NKPYNNKSDIW
Kinase NEK11.AA NEK4 24-214 45 6.3e-67 228.66 In-house 1-186 (257) Show / Hide 
Range on Protein: 24-214
Range on HMM: 1-186/257
Sequence Identity: 45% (89 aa)

YRVEKKLGSGNFGTAFLVFDMKANPDKGEEEWKVLKEISCGDLAPDETVDAMHEAKLLSKLHHPNIVKFYDSFL--DGEFFCIITEYCEGGDLDDKITAW
|   |  | | .|  .||   .   ||      |.| .        |. .| |||.|||.| |||||.. .|.   .| | .|.  .||||||  |    
YCHMKVVGKGSYGEVWLV---RHRRDKKQ---YVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLK--

KKAGKKFDQNVIMDWFVQLALAVQHMHKRRVLHRDLKTRNIFL-KKNMIKIGDFGISRVLMGTTDMASTFTGTPYYMSPEVLKHEGYNSKSDVW
.. ..  . . ...|||| |.| | ||....||||||| |||| |||.||||||||||||    |||.|  |||||||||.     |. |||.|
QQKNQFLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIW
Kinase NEK11.AA NEK8 57-214 36 1e-63 180.76 In-house 30-206 (278) Show / Hide 
Range on Protein: 57-214
Range on HMM: 30-206/278
Sequence Identity: 36% (65 aa)

VLKEISCGDLAPDETVDAMHEAKLLSKLHHPNIVKFYDSFLDGEFFCIITEYCEGGDLDDKITAWKKAGKKFDQN----------------VIMDWFVQL
..|.|   .. . |  .|. |  .||.|.||||.  ||.|..     |  ||..|| | ..| .  .. . ..                   | . |.| 
IWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMI-QHQQNKLFEEERQLKQVNHCFNIYFNEQMILWYFFQM

ALAVQHMHKRRVLHRDLKTRNIFLKKN--MIKIGDFGISRVLMGTTDMA-S-TFTGTPYYMSPEVLKHEGYNSKSDVW
 .|| |||.  .||||||| |||. .    .|||||||| ..   . |. . |  |||||||||  .   || |||.|
CSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMW
Kinase NEK11.AA Pkinase 24-214 29 1.4e-54 192.4 Pfam 1-196 (293) Show / Hide 
Range on Protein: 24-214
Range on HMM: 1-196/293
Sequence Identity: 29% (60 aa)

YRVEKKLGSGNFGTAFLVFDMKANPDKGEEEWKVLKEISCGDLAPDETVDAMH--EAKLLSKLHHPNIVKFYDSFLDGEFFCIITEYCEGG----DLDDK
|....|.|||.||. ..  . . .         ..|.|.  .  ... . . .  |.... .|.|||||..||.| |.   ....||||||    || | 
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

ITAWKKAGKKF--DQNVIMDWFVQLALAVQHMHKRRVLHRDLKTRNIFLK-KNMI----KIGDFGISRVL-MGTTDMASTFTGTPYYMSPEVLK-HEGYN
|..  .....|  . ... ... |.. .....|.....|||||  ||... .. |    ||.|||.....       ..||.|||.||.|||.. ...| 
IST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

SKSDVW
.|.|.|
PKVDMW
Kinase NEK11.AA CAMK 29-214 20 3.4e-52 166.1 In-house 1-318 (425) Show / Hide 
Range on Protein: 29-214
Range on HMM: 1-318/425
Sequence Identity: 20% (66 aa)

KLGSGNFGTAFLVFDMKANPDKGE------EEWKVLKEISCGDLA--------------------------PDETVDAMHEAKLLSK-------LHHPNI
.||.|.||. .|... . . .. .       .    | |.   |                           |      ..| ....|       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFYDSFLDGEF-------------------FCIIT---EYCEGG----DLDDKITAWKKAG-----------KKFDQNVIMDWFVQLALAVQHMHKRRV
.|.|. . |...                   .....   |||.||    || |.|.. .. |           ..|.      .| |.. ||...|.. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKTRNIFLKKNM------------------IKIGDFGISRVLMG-----------------------TTDMASTFTGTPYYMS-PEVLKH------
 |||||  || | .|.                  ||| ||| ......                       .... .|| |||.||. ||||.       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------EGYNSKSDVW
        ..|. |.|.|
QNATDEEKPYYGPKCDMW
Kinase NEK11.AA NEK-Unclassified 80-214 45 3.4e-49 160.88 In-house 46-181 (258) Show / Hide 
Range on Protein: 80-214
Range on HMM: 46-181/258
Sequence Identity: 45% (63 aa)

LLSKLHHPNIVKFYDSFLDGEFFCIITEYCEGGDLDDKITAWKKAGK--KFDQNVIMDWFVQLALAVQHMHKRRVLHRDLKTRNIFL-KKNMIKIGDFGI
.||.| || || . ||| .        .||.||.|| .|   |. .|   ||   || |..|.  |||  | |...|||||. |||| .  .. .|||||
ILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQ--KHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGI

SRVLMGTTDMASTFTGTPYYMSPEVLKHEGYNSKSDVW
||..  | | | |  ||. .|||||..   || .||||
SRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVW
Kinase NEK11.AA Ciliate-E2 24-214 23 6.7e-48 162.5 In-house 1-280 (365) Show / Hide 
Range on Protein: 24-214
Range on HMM: 1-280/365
Sequence Identity: 23% (71 aa)

YRVEKKLGSGNFGTAFLV-------------------------------FDMKANPDKGEEEWK----VLKEISCGDLAPDETVDAMHEAK------LLS
| . ||.|.||||. ...                               . || .  .. |..|    ...|| | .             |      .|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-F-----------Y-KKINEKNILE

KLHHPNIVKFYDSFL--DGEFFCIITEYCEGGDLDDKITAWKK--------AGKKFDQNVIMDWFVQLAL---------------AVQHMHKRR-VLHRD
.| ||||.|.|..|   | . . ...|||.|||| | |   ||        . |.|. . | . . |..                |....|..  ..|||
QLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRD

LKTRNIFLKKNMIKIGDFGISR------------VLMG-------------------TTDMASTFTGTPYYMSPEVLK---------HEGYNSKSDVW
.|  ||..    ||| |||.|.            ....                     .|. |. |||.||.||.|.         ..||. |.|.|
IKPENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIW
Kinase NEK11.AA ULK 24-214 26 1e-47 164.62 In-house 1-240 (329) Show / Hide 
Range on Protein: 24-214
Range on HMM: 1-240/329
Sequence Identity: 26% (65 aa)

YRVEKKLGSGNFGTAFLVFDMKANPDKGEEEWKVLKEISCGDLAPDETVDA--------MHEAKLLSKLH--------HPNIVKFYDSFLDGEF--FCII
| . ..||.| ||. .  ...| . |    |  . | |.   .  ..  .         . | |.. ||.        ||||||.|| | .  .  . ||
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

TEYCEGGDLDDKITAWKK------AGKKFDQNVIMDWFVQLALAVQHMHKRRVLHRDLKTRNIFLKKN-------------MIKIGDFGISRVLMGT---
.|||.||||.. |   ||       .|.. .. .   | |.. . ...||... |||.|  || ....              .||.||| .....     
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

TDMASTFT------GTPYYMSPEVLK----HEGYN-SKSDVW
 .|. |..      |||.||.|..|.    .. |. .|.|.|
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIW
Kinase NEK11.AA ULK 77-214 29 5.5e-44 152.44 In-house 60-236 (324) Show / Hide 
Range on Protein: 77-214
Range on HMM: 60-236/324
Sequence Identity: 29% (53 aa)

EAKLLSKLH---HPN--IVKFYDSFLDG--EFFCIITEYCEGGDLDDKITAWKK-----AGKKFDQNVIMDWFVQLALAVQHMHKRRVLHRDLKTRNIFL
| ... ||.   |||  |||.|| | .    ...||.|||.||||.. |   ||      .|.. .. .   | |.. . ...||. . |||.|  || .
EIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI

KKN-------------MIKIGDFGISRVLMGTT---DMASTFT------GTPYYMSPEVLK----HEGYN-SKSDVW
...              .||.||| .....  .   .|  |.       |||.||.|..|.    .. |. .|.|.|
HNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIW
Kinase NEK11.AA S_TKc 24-214 27 6.9e-31 109.85 SMART 1-220 (231) Show / Hide 
Range on Protein: 24-214
Range on HMM: 1-220/231
Sequence Identity: 27% (68 aa)

YRVEKKLGSGNFGTAFLVFDMKANPDKGEEEWKVLKEISCGDLAPDETVDAMHEAKLLSKLHHPNIVKFYDSFLDGEFFCIITEYCEG--GDLDDKITAW
|.. .|.|.| ||. ... . |        .   .|.|.          ... | ..|.| |||||||.||.| | .......|||.|  ||| | |   
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

KKAGKK--FDQNVIMDWFVQLALAVQHMHKRRVLHRDLKTRNIFLKKNMIKIGDFGISRVLMGTTDMASTFTGTPYYMSPEVLKHEGYNS-KSDV-----
.. |..  |.  ..  .. |...|....|.....|||||  ||.| .  |||.|||..|.|       .|| |||.||.||||   ||.  |.|.     
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

------------------------------------------------W
                                                 
ILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ
Kinase NEK11.AA Pkinase_Tyr 75-214 30 9.7e-29 97.96 Pfam 51-198 (270) Show / Hide 
Range on Protein: 75-214
Range on HMM: 51-198/270
Sequence Identity: 30% (46 aa)

MHEAKLLSKL-HHPNIVKFYDSFL-DGEF--FCIITEYCEGGDLDDKITAWKKAGKKFDQNVIMDWFVQLALAVQHMHKRRVLHRDLKTRNIFLK-KNMI
|.|||....| ||||||..|   . .||    .|..||...|||.|   . .  .....   . .. .| | . .. . ..  |||| .||. .. .| .
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVV

KIGDFGISRVLMGTTDMASTFTG---TPY-YMSPEVLKHEGYNSKSDVW
||.||| .| .. .    .. .|    |   |.||....  ...|||||
KICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVW
Kinase NEK11.AA TyrKc 24-214 18 4.8e-12 -27.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-214
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

YRVEKKLGSGNFGT---AFLVFDMKANPDKGEEE--WKVLKEISCGDLAPDETVDAMHEAKLLSKL--HHPNIVKFYDSFLDG-------EFFCIITEYC
 . .||||.|.||.   . .            ..   |.||| .          | |.||....||  ||||||..|   ...       |  .|..||.
ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM

EGGDLDDKITAWKKAGKKFDQNVIMDWFVQLALAVQHMHKRRVLHRDLKTRNIFLKKNM-IKIGDFGISRVLMGT--------TDMA-----ST------
..|||.| . . ..    .      .. .| |   .. |.... |||| .||. ...|  .||.||| || .           . ..     .       
PHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

------------------------------FTGTPYY------MSP----EVLKHEGYNSKSDV------------------------------------
                              . ..||.      ||.    | .|. ..  . .                                     
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

-W
 .
CF
Kinase NEK11.AA ULK 24-39 35 0.008543 5.82 In-house 1-17 (324) Show / Hide 
Range on Protein: 24-39
Range on HMM: 1-17/324
Sequence Identity: 35% (6 aa)

YRVEKKLGSGNFG-TAF
| . ..||.| || . .
YCLNHCLGKGSFGVKVY
Kinase NEK11.AA Pkinase_Tyr 24-37 50 0.758679 3.49 Pfam 1-14 (270) Show / Hide 
Range on Protein: 24-37
Range on HMM: 1-14/270
Sequence Identity: 50% (7 aa)

YRVEKKLGSGNFGT
 .  ||||.|.||.
ITFGKKLGEGAFGE