Gene Nek8b (Sea Urchin)

Nek8b

Species: Sea Urchin
Alias: Nek8b, SPU_010590, Spk174
External Links: Sea Urchin Project Link ,
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK8

Sequence

Name Sequence Type Origin Length Description Download
Nek8b.AA Protein None 383 None Fasta, JSON
Nek8b.kin_dom Protein Kinase Domain None 86 None Fasta, JSON

Protein domain

Protein domains of Nek8b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Nek8b.AA NEK8 1-92 53 1.5e-70 200.61 In-house 36-143 (278) Show / Hide 
Range on Protein: 1-92
Range on HMM: 36-143/278
Sequence Identity: 53% (58 aa)

MHELNANERQMALNEIRVLSMLDHPNIISYYDSFEEEGTLMIEMEYADGGTLAEYLASNQGKSEMEER----------------EILIMFQQMVSGIRHV
||..  .|||||.|||.|||||.|||||||||.|.|..||||||||||||||.......|.|...|||                .||..|.||.|...|.
MHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHM

HDHMILHR
|.|.||||
HQHNILHR
Kinase Nek8b.AA NEK 1-92 38 5.5e-41 142.2 In-house 39-143 (286) Show / Hide 
Range on Protein: 1-92
Range on HMM: 39-143/286
Sequence Identity: 38% (40 aa)

MHELNANERQMAL-NEIRVLSMLDHPNIISYYDSFEEEG--TLMIEMEYAD-GGTLAEY---LASNQG-KSEMEEREILIMFQQMVSGIRHVHDH-----
| ...  |.|.|. ||.|.|..|.||||..|||||.||.  .|.|.|||.. ||.|..    .  ... .  .||..|. .|.||.......||.     
MGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQR

MILHR
 ||||
KILHR
Kinase Nek8b.AA NEK8 101-142 73 1.8e-33 92.82 In-house 194-235 (278) Show / Hide 
Range on Protein: 101-142
Range on HMM: 194-235/278
Sequence Identity: 73% (31 aa)

CEGKPYNGKSDIWALGCILYEMACRQKTFEGTNLPALVNKIM
||||||| |||.|||||.||||.|  ..||..||||||.|||
CEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIM
Kinase Nek8b.AA NEK1 8-92 41 9.2e-26 86.44 In-house 41-128 (276) Show / Hide 
Range on Protein: 8-92
Range on HMM: 41-128/276
Sequence Identity: 41% (37 aa)

ERQMALNEIRVLSMLDHPNIISYYDSFEEEGT--LMIEMEYADGGTLAEYLASN--QGKSEMEEREILIMFQQMVSGIRHVHDHMILHR
||. ..||  .|....||||..|..||||.|   | | |||.||| |.        .||.   | .|.  | |.. .  |.||  ||||
EREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL-FSEDQIMHWFCQICLALNHIHDRKILHR
Kinase Nek8b.AA CAMKL 15-92 33 2.1e-24 74.66 In-house 62-151 (297) Show / Hide 
Range on Protein: 15-92
Range on HMM: 62-151/297
Sequence Identity: 33% (30 aa)

EIRVLSMLD---HPNIISYYDSFEEEGT------LMIEMEYADGGT--LAEYLASNQGKS-EMEEREILIMFQQMVSGIRHVHDHMILHR
||. ..||.   |||||. |. .| . .      . . |||..||   | .|. .. ..   |.|.|   .|.|.||.. . |.|.| ||
EIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHR
Kinase Nek8b.AA NEK 100-182 43 2.2e-24 83.07 In-house 195-286 (286) Show / Hide 
Range on Protein: 100-182
Range on HMM: 195-286/286
Sequence Identity: 43% (40 aa)

QCEGKPYNGKSDIWALGCILYEMACR--QKTFEGT--NLPALVNKIMKVG-HKGPNSQR--P--RVQVFVQDMLQRKPEYRPSANA-LDFNHI
.|..|||| |||||.|||.||||..    . ||..  |.|.|..|||| | .  | ...       | ... |||. || |||.|  | .  |
VCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMK-GPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase Nek8b.AA CAMK 5-92 23 7.5e-22 66.56 In-house 71-203 (425) Show / Hide 
Range on Protein: 5-92
Range on HMM: 71-203/425
Sequence Identity: 23% (31 aa)

NANERQMALNEIRVLSM-------LDHPNIISYYDSFE------------EEGT--------LMIEM---EYADGG----TLAEYLASNQGKSE------
... |.. ..||.....       |||||||. |. .|               .        . . |   ||..||     | .|. .. ...|      
RPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFD

------MEEREILIMFQQMVSGIRHVHDHMILHR
      ..|||   .|.|..|.... |.| | ||
IVERGRFTEREARRYFRQICSAVHYCHSHNIVHR
Kinase Nek8b.AA NEK1 101-177 43 7.8e-22 72.64 In-house 193-270 (276) Show / Hide 
Range on Protein: 101-177
Range on HMM: 193-270/276
Sequence Identity: 43% (34 aa)

CEGKPYNGKSDIWALGCILYEMACRQKTFEGTNLPALVNKIMKVGHKGPNSQRP--RVQVFVQDMLQRKPEYRPSANAL
|. |||| |||||.|||.|||       ||. |...||.|| . |.  | ....   .|  |  |..| |. |||.|..
CQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQ-GTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQI
Kinase Nek8b.AA ULK 14-92 33 3.8e-20 67.11 In-house 59-154 (329) Show / Hide 
Range on Protein: 14-92
Range on HMM: 59-154/329
Sequence Identity: 33% (32 aa)

NEIRVLSMLD--------HPNIISYYDSFEEE--GTLMIEMEYADGGTLAEYLASNQGKSEME-------EREILIMFQQMVSGIRHVHDHMILHR
|||... .|.        ||||. .|| ||.     . | ||| .||.| .|.  |....| .       | |... |.| ..| .. |.| | ||
NEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHR
Kinase Nek8b.AA Ciliate-E2 13-93 23 1e-19 64.32 In-house 70-186 (365) Show / Hide 
Range on Protein: 13-93
Range on HMM: 70-186/365
Sequence Identity: 23% (28 aa)

LNEIR----------VLSMLDHPNIISYYDSFE--EEGTLMIEMEYADGGTLAEYLASNQGKS--------EMEEREILIMFQQMVS-------------
..||.          .|. |.||||| .|..|.   . .. . |||..||.| .|. .|. |.         . |.||. ...| ..             
MREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACI

--GIRHVHDHM-ILHRN
  .... |    |.||.
ILALEYLHSKNNIIHRD
Kinase Nek8b.AA Pkinase 7-92 28 2.6e-17 62.32 Pfam 40-132 (293) Show / Hide 
Range on Protein: 7-92
Range on HMM: 40-132/293
Sequence Identity: 28% (27 aa)

NERQMALN--EIRVLSMLDHPNIISYYDSFEEEGTLMIEMEYADGG----TLAEYLA--SNQGKSEMEEREILIMFQQMVSGIRHVHDHMILHR
...| ...  ||... .|.||||. .||.||... . . |||..||     |..|.   .. . . ..|.|.  .. |...|. . |.. |.||
WKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHR
Kinase Nek8b.AA STE 5-92 30 1.3e-16 55.33 In-house 68-176 (359) Show / Hide 
Range on Protein: 5-92
Range on HMM: 68-176/359
Sequence Identity: 30% (33 aa)

NANERQMALNEIRVLSMLD--HPNIISYYDSFEEEG-------TLMIEMEYADGGTLAEYLASNQGKSE-----------MEEREILIMFQQMVSG-IRH
| .|.|  |.||.... ..  ||||. ||.... ||       .| | ||| |||.| . . .. |. .           ..| .| .. .| . |   .
NHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYY

VHDHMILHR
 |.| | ||
LHSHHIIHR
Kinase Nek8b.AA NEK-Unclassified 14-92 35 5.5e-15 45.75 In-house 42-121 (258) Show / Hide 
Range on Protein: 14-92
Range on HMM: 42-121/258
Sequence Identity: 35% (28 aa)

NEIRVLSMLDHPNIISYYDSFEEEGTLMIEMEYADGGTLAEYLASNQGK-SEMEEREILIMFQQMVSGIRHVHDHMILHR
| | .|| | || |. | ||| |   |    .| ||| | . .    .|   ..|  |   . ||.  .  .|   |.||
NKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRKIIHR
Kinase Nek8b.AA S_TKc 1-184 22 9.5e-15 39.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-184
Range on HMM: 1-231/231
Sequence Identity: 22% (56 aa)

MHELN------------ANERQ------------MALNEIRVLSMLDHPNIISYYDSFEEEGTLMIEMEYADG--GTLAEYLASNQGK---SEMEEREIL
 . |.            . ..             ....||..|.. .||||. .||.|.. . | . |||.||  |.| .|. .....   . . | .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

IMFQQMVSGIRHVHDHMILHR-----NCMICP---------------------------LQCEGKPYNG-KSDIWALGCILYEMACRQKTFEGTNLPALV
 ...|..... . |.| |.||     | ...                            |     .|.. |.|.|..|||||||.|..  |.  .. .. 
FYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMF

NKIMKVGHKGPNSQRPRVQVFVQDMLQRKPEYRPSANALD-----FNHIPV
.||.           | .  |.. .||. || ||.| ||       .|  .
KKIG----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase Nek8b.AA NEK4 104-173 36 2e-14 48.37 In-house 177-247 (257) Show / Hide 
Range on Protein: 104-173
Range on HMM: 177-247/257
Sequence Identity: 36% (26 aa)

KPYNGKSDIWALGCILYEMACRQKTFEGTNLPALVNKIMKVGHKGPNSQR--PRVQVFVQDMLQRKPEYRPS
.||. |||||.||| .|||.     |.  ... |. .|.. |.  | ..   .  |  |  ||...|. |||
RPYDYKSDIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQ-GQPPPMPPNYSQDLQNLVYQMLEKQPTKRPS
Kinase Nek8b.AA NEK4 8-92 35 5.1e-14 46.9 In-house 41-126 (257) Show / Hide 
Range on Protein: 8-92
Range on HMM: 41-126/257
Sequence Identity: 35% (31 aa)

ERQMALNEIRVLSMLDHPNIISYYDSFEEEGT--LMIEMEYADGGTLAEYLASNQGKSEMEEREILIMFQQMVSGIRHVHDHMILHR
||. |. |...|| | ||||..| .|.| |    | | | . .|| | . |    ..  .||. ..  | |   .    |.  ||||
ERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQF-LEEYQVVEWFVQIAMALQYMHEKHILHR
Kinase Nek8b.AA NEK-Unclassified 94-143 40 1.1e-12 37.95 In-house 162-211 (258) Show / Hide 
Range on Protein: 94-143
Range on HMM: 162-211/258
Sequence Identity: 40% (20 aa)

CMICPLQCEGKPYNGKSDIWALGCILYEMACRQKTFEGTNLPALVNKIMK
| . |  |. .||| .||.|.||||.|||.     |   |.  .  || .
CWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQ
Kinase Nek8b.AA Pkinase 102-182 21 9.8e-12 42.57 Pfam 185-293 (293) Show / Hide 
Range on Protein: 102-182
Range on HMM: 185-293/293
Sequence Identity: 21% (24 aa)

EGKPYNGKSDIWALGCILYEMACRQKTFEGT------NLPALVNKIMKVGHKGPNSQR---------------------PRVQVFVQDMLQRKPEYRPSA
.|..|  |.|.|..|||||||.|..  | |       .  .....||.   . . ..                      .  . |. ..|...|. ||.|
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

NALDFNH--I
  . ..|  .
EQI-LQHPWF
Kinase Nek8b.AA Ciliate-E2 100-184 23 4e-11 34.41 In-house 267-365 (365) Show / Hide 
Range on Protein: 100-184
Range on HMM: 267-365/365
Sequence Identity: 23% (25 aa)

QCEGKPYNGKSDIWALGCILYEMACRQKTFEGTNLPALVNKIMKVGHKGP------------------NSQRPRVQVFVQD----MLQRKPEYRPS-ANA
| ..|.|. |.|||.||.||||| . .  |         ..|..   . |                  ..  . .. . .     |||..|| |.. .. 
QQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQ

LDFNHIPV
. .||   
I-LNHPWF
Kinase Nek8b.AA STE 99-177 21 3.2e-10 32.43 In-house 234-351 (359) Show / Hide 
Range on Protein: 99-177
Range on HMM: 234-351/359
Sequence Identity: 21% (25 aa)

LQCEG----KPYNGKSDIWALGCILYEMACRQKTF-EGTNLPALVNKIMK--------------VGH---KG-----------------PNSQRPRVQVF
.|..|    |.|. |.||| ||| . |||. .  . ..... |. .....               ..   .                  | .  |  . |
IQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDF

VQDMLQRKPEYRPSANAL
..  ||. |. ||.|. |
INKCLQKDPNKRPTASQL
Kinase Nek8b.AA CAMK 101-174 23 3.2e-10 28.41 In-house 306-416 (425) Show / Hide 
Range on Protein: 101-174
Range on HMM: 306-416/425
Sequence Identity: 23% (26 aa)

CEGKPYNGKSDIWALGCILYEMACRQKTFEGT-------------NLPALVNKIMKVGHKGPNSQRPR------------------------VQVFVQDM
.| ..|. |.|.|..|.||| | |    |.|              |.. |  ||||     | .. .                         .. ... |
EEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKM

LQRKPEYRPSA
||. || |...
LQVDPEKRMTI
Kinase Nek8b.AA ULK 102-143 39 1.2e-08 26.35 In-house 228-269 (329) Show / Hide 
Range on Protein: 102-143
Range on HMM: 228-269/329
Sequence Identity: 39% (17 aa)

EGKPYN-GKSDIWALGCILYEMACRQKTFEGTNLPALVNKIMK
|.|||.  |.||| ||||.|||   .  |..     ....|..
EQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQ
Kinase Nek8b.AA TyrKc 4-189 15 1.1e-07 -98.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-189
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

LNANE----------------------------RQMALNEIRVLSML--DHPNIISYYDSFEEE-------GTLMIEMEYADGGTLAEYLASNQGKSEME
.  ..                            |.. ..|.|....|  .||||.  |    ..       . ||| |||...| | .|| ....|    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--LC

EREILIMFQQMVSGIRHVHDHMILHR-----NCMICPLQ----------CEGKPY----------------NGK---------------------SDIWA
 .. | .  |  .| .. |.. . ||     ||..   .           ... .                .||                     ||.|.
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS

LGCILYEMACRQKTFEGT-----NLPALVNKIMKVGHKGPNSQR----------PRVQVFVQDMLQRKPEYRPSANALDFNHIPVLMEKF
 |  ..|.  . ..           .. | .  | |.  |  .           . .    ..  ...|| ||. ...         |.|
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--------HECF
Kinase Nek8b.AA CAMKL 101-174 31 1.4e-07 20.1 In-house 205-288 (297) Show / Hide 
Range on Protein: 101-174
Range on HMM: 205-288/297
Sequence Identity: 31% (27 aa)

CEG--KPYN-GKSDIWALGCILYEMACRQKTFEGTNLP-------ALVNKIMKVGHKGPNSQRP-RVQVFVQDMLQRKPEYRPSA
..|  |||.  | |||..| ||| | | .  |.. ...        | .|||.  .. |   .. ... . . |||..||.||..
FQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTI
Kinase Nek8b.AA Pkinase_Tyr 13-56 31 0.000185 15.73 Pfam 51-98 (270) Show / Hide 
Range on Protein: 13-56
Range on HMM: 51-98/270
Sequence Identity: 31% (15 aa)

LNEIRVLSML-DHPNIISYYDSFE-EEGT--LMIEMEYADGGTLAEYL
..|..... | .||||...|     ...   ..| |||. .| | .||
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL
RCC1 Nek8b.AA RCC1 229-254 21 3.662016 3.41 Pfam 26-52 (52) Show / Hide 
Range on Protein: 229-254
Range on HMM: 26-52/52
Sequence Identity: 21% (6 aa)

IPFK-IELPTI-LKIRQVAVSRTHIALV
.| . .|..    ...|||  ..| ...
VPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 Nek8b.AA RCC1 260-305 42 4.9e-16 54.93 Pfam 4-51 (52) Show / Hide 
Range on Protein: 260-305
Range on HMM: 4-51/52
Sequence Identity: 42% (21 aa)

VYSWGEGSKGQLG--HGDLDPRNVPTS-VEALKG-KSITRVACGAGFSVF
||.|| .. ||||  |||   ..||.  || | | .... ||||. ....
VYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMA
RCC1 Nek8b.AA RCC1 309-358 33 5.9e-13 44.94 Pfam 1-52 (52) Show / Hide 
Range on Protein: 309-358
Range on HMM: 1-52/52
Sequence Identity: 33% (18 aa)

NGIVMTCGDGSTGCLG--HGDYHSASRPRL-IETLLS-VDVTSISCGPEHVVGV
.| | |.| .. |.||  |||  . . |.. .|.| . | |....|| .|.. .
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 Nek8b.AA RCC1 361-382 37 3.4e-07 26.22 Pfam 1-23 (52) Show / Hide 
Range on Protein: 361-382
Range on HMM: 1-23/52
Sequence Identity: 37% (9 aa)

DGEIFAWGKGKDGRLG--LGDEED
||....||.. .|.||  .||. .
DGRVYTWGCNDYGQLGRIHGDT-N