Gene NEK8a (Sea Urchin)

NEK8a

Species: Sea Urchin
Alias: SPU_004595, NEK8a, Spk178, SPU_005411
External Links: Sea Urchin Project Link ,
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK8

Sequence

Name Sequence Type Origin Length Description Download
NEK8a.AA Protein None 645 None Fasta, JSON
NEK8a.kin_dom Protein Kinase Domain None 37 None Fasta, JSON

Protein domain

Protein domains of NEK8a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK8a.AA NEK8 40-213 49 8.8e-123 352.4 In-house 84-278 (278) Show / Hide 
Range on Protein: 40-213
Range on HMM: 84-278/278
Sequence Identity: 49% (97 aa)

GGTVFEYLQQRGNALIEEDE-----------------VLRLMAQILLSMKHVHSKQILHRDLKTQNILLNRDCDVIKIGDFGISKILSSKSKAFT---VV
|||  ...| . | | || .                 .|  . |...   |.|.. |||||||||||...|.  |.||||||||||...|... |   ||
GGTLYQMIQHQQNKLFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVV

GTPSYISPELCEGKPYNQKSDMWAIGCVLYELLTLRRAFEANNLPALVMKIMRG-SVAPISDRYSDQLKRLLLRMLHLDPDKRPTIDQVMAEPII
||| |.|||.||||||||||||||.||||||...|.||||| ||||||.|||..   .||||.||  .. | .  | .||..||. .|.|| | .
GTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK8a.AA NEK 40-213 41 3.3e-93 315.94 In-house 91-286 (286) Show / Hide 
Range on Protein: 40-213
Range on HMM: 91-286/286
Sequence Identity: 41% (81 aa)

GGTVFEY---LQQR--GNALIEEDEVLRLMAQILLSMKHVHSK-----QILHRDLKTQNILLNR-DC--DVIKIGDFGISKILSSK-SKAFT-VVGTPSY
||. ..    ....   . ..||..... ..|..| .|..|..      |||||.|.||| |.. ..  ...|||||||||.|... ..| | .|||| |
GGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYY

ISPELCEGKPYNQKSDMWAIGCVLYELLTL--RRAFEAN--NLPALVMKIMRG-SVAPISDR--YSDQLKRLLLRMLHLDPDKRPTIDQVMAEPII
.|||.|..||||.|||.|..||||||. ||  ...|||.  |.|.|.||||.|   .||...  ||..|..|. .||. ||..||...|... |.|
MSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK8a.AA NEK1 48-213 42 8.8e-77 261.4 In-house 94-276 (276) Show / Hide 
Range on Protein: 48-213
Range on HMM: 94-276/276
Sequence Identity: 42% (77 aa)

QQRGNALIEEDEVLRLMAQILLSMKHVHSKQILHRDLKTQNILLN-RDCD---------------VIKIGDFGISKILSSKSK-AFTVVGTPSYISPELC
| | . |. ||. .    || | ..|.|.. |||||.|.||| |   . .               ..|.|||||...|..    | |..||| |.|||.|
QKRKGKLFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEIC

EGKPYNQKSDMWAIGCVLYELLTLRRAFEANNLPALVMKIMRGSVAPISDRYSDQLKRLLLRMLHLDPDKRPTIDQVMAEPII
. ||||.|||.|. |||||||.|| ..|||||...||.|| .|...||. .||  |. |.  |.  .|  || . |.   |.|
QNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK8a.AA NEK4 40-213 42 6.5e-63 215.33 In-house 84-257 (257) Show / Hide 
Range on Protein: 40-213
Range on HMM: 84-257/257
Sequence Identity: 42% (75 aa)

GGTVFEYLQQRGNALIEEDEVLRLMAQILLSMKHVHSKQILHRDLKTQNILLNRDCDVIKIGDFGISKILS-SKSKAFTVVGTPSYISPELCEGKPYNQK
||  .. |.|. |...||  |.    || . .   | |.||||||||||| | .   .|||||||||..|  .   | |..||| |.|||.   .||. |
GGDLYRKLKQQKNQFLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKK-NIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYK

SDMWAIGCVLYELLTLRRAFEANNLPALVMKIMRGSVAPISDRYSDQLKRLLLRMLHLDPDKRPTIDQVMAEPII
||.|..|| .||. ||. ||.| ... |. .|. |   |..  || .|. |.  ||   |.||| | ...  | |
SDIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
S_TKc NEK8a.AA S_TKc 4-213 28 2.6e-56 194.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-213
Range on HMM: 1-231/231
Sequence Identity: 28% (73 aa)

YEKIKVVGRGAFGTVYLCRRLHDMKLIIIKQIP----------------------------------XXXG--GTVFEYLQQRGNAL----IEEDEVLRL
||.....|.||||.||.||  .. ..  ||.|.                                     |  |..|.|...||       . | .. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

MAQILLSMKHVHSKQILHRDLKTQNILLNRDCDVIKIGDFGISKILSSKSKAFTVVGTPSYISPELCEGKPYNQ-KSDMWAIGCVLYELLTLRRAFEANN
|.||.. ... ||..|.||||| .||||..   .|||.|||....|       |..||| |..||..   .|.  |.|.|..||.|||.|. .  |.  .
MYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--Q

LPALVMKIMRGSVAPISDRYSDQLKRLLLRMLHLDPDKRPTIDQVMA-------EPII
. ..  ||.           |...| .. ..|. ||.||||. ....        | .
MQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK8a.AA CAMK 40-213 25 2.8e-52 166.36 In-house 144-425 (425) Show / Hide 
Range on Protein: 40-213
Range on HMM: 144-425/425
Sequence Identity: 25% (71 aa)

GG----TVFEYLQQRGN-------------ALIEEDEVLRLMAQILLSMKHVHSKQILHRDLKTQNILLNRDCD----------------VIKIGDFGIS
||     .|.|....|.               ..|.|. |.. ||.  ... ||. | |||||  ||||. . |                 ||| ||| .
GGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA

KILSS------------------------KSKAFTVVGTPSYIS-PELCEG--------------KPYNQKSDMWAIGCVLYELLTLRRAFEAN------
... .                          |  |..|||.|.. ||. .|              ..|..|.|||..|..|| .|. .  |..       
NKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEIC

-------NLPALVMKIMRGSVA-P------------------ISDR----YSDQLKRLLLRMLHLDPDKRPTIDQVMAEPII
       |.. |  |||.|    |                  |||      |.. | |. .||  ||.||.||.|... | .
EDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NEK8a.AA NEK-Unclassified 52-213 34 3.7e-50 164.09 In-house 91-258 (258) Show / Hide 
Range on Protein: 52-213
Range on HMM: 91-258/258
Sequence Identity: 34% (59 aa)

NALIEEDEVLRLMAQILLSMKHVHSKQILHRDLKTQNILLNRDCDVIKIGDFGISKIL-SSKSKAFTVVGTPSYISPELCEGKPYNQKSDMWAIGCVLYE
|  ..|  . .   |.   .  .|.. |.|||||.||| |  | |.. .||||||.|.   . || | |||. ..||| |. .||| .|| |. ||..||
NEPFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDD-DTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYE

LLTLRRAFEANNLPALVMKIMRGSV------APISDRYSDQLKRLLLRMLHLDPDKRPTIDQVMAEPII
. |   .| . |.  . ||| ..         |.|  ||  |  ..  ||  ....||    ..  . |
MCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase NEK8a.AA Pkinase 40-213 29 2e-48 172.02 Pfam 84-293 (293) Show / Hide 
Range on Protein: 40-213
Range on HMM: 84-293/293
Sequence Identity: 29% (62 aa)

GG----TVFEYLQ-QRGNAL-IEEDEVLRLMAQILLSMKHVHSKQILHRDLKTQNILLNRDCDV---IKIGDFGISKI--LSSKSKAFTVVGTPSYISPE
||      |.|.. .|....  .|.|. . | |||  ... ||. |.||||| .|||.......   .||.|||..|   . ..| . |..||| |..||
GGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE

LCE-GKPYNQKSDMWAIGCVLYELLTLRRAFEAN------NLPALVMKIMRGSVAPISDRYS--------------------DQLKRLLLRMLHLDPDKR
..  |..| .|.|||..||.|||.|. |  |         .  ... .||.. .   ..  .                    . .| .. ..|..|| ||
VIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

PTIDQVMAEPII
||..|..  | .
PTAEQILQHPWF
Kinase NEK8a.AA Ciliate-E2 40-213 24 3.5e-47 159.99 In-house 118-365 (365) Show / Hide 
Range on Protein: 40-213
Range on HMM: 118-365/365
Sequence Identity: 24% (65 aa)

GGTVFEYLQQR---GNALIE------EDEVLRLMAQILL---------------SMKHVHSKQ-ILHRDLKTQNILLNRDCDVIKIGDFGISKILSSK--
||. |.|....    |  ||      | |....|.|||                 ... |||  |.|||.| .|||.      ||| |||.||... .  
GGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQ

------------------------------SKAFTVVGTPSYISPELCEGKP---------YNQKSDMWAIGCVLYELLTLRRAFEANNLPALVMKIMRG
                                ..|..||| | .||  .||.         |. |.|.|..|..|||.|. .. |          .|. .
NRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQC

SVA-P----------------ISDRYSDQLKRLLLR----MLHLDPDKRPT-IDQVMAEPII
 .  |                . .  |.. | |. .    ||  ||.||.| ..|..  |..
KIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK8a.AA Ciliate-E2-Unclassified 40-213 24 1.8e-45 155.66 In-house 105-352 (352) Show / Hide 
Range on Protein: 40-213
Range on HMM: 105-352/352
Sequence Identity: 24% (60 aa)

GGTVFEYLQQRGN---------------ALIEEDEVL-----RLMAQILLSMKHVHSKQ-ILHRDLKTQNILLNRDCD--VIKIGDFGISKILS------
||. ..|...|..                 ..| ...     ...||||.  .. |.|. |.|||.| .|||.. ..    ||| |||||| .       
GGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD

----------SKSKAFTVVGTPSYI----SPELCEGKPYN----QKSDMWAIGCVLYELLTLRRAFEANNLPA----------------LVMKIMRGSVA
          .. .. |..|||.|.    .||. .|. |.     |.|.|. |..|||.|. .. |..||                   |  .|. . . 
TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQ

PIS-------DRYSDQLKRLLL----RMLHLDPDKRPTIDQVMAEPII
  .       .. |.. | ..     .||  .|.||.|..|..  |..
FPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase NEK8a.AA ULK 40-213 24 1.9e-45 156.59 In-house 104-329 (329) Show / Hide 
Range on Protein: 40-213
Range on HMM: 104-329/329
Sequence Identity: 24% (55 aa)

GGTVFEYLQQRGN--------ALIEEDEVLRLMAQILLSMKHVHSKQILHRDLKTQNILLNRD-----------CDVIKIGDFGISKILSSK------SK
||. ..|......          ..|.|..  . |||  .|. |...| |||.| ||||.. .             |.||.||| .| ...        .
GGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMM

AFT----VVGTPSYISPELCE----GKPYN-QKSDMWAIGCVLYELLTLRRAFEANNLPALVMKIMRGSVA------------PISDR-------YSDQL
...    . ||| | .|.. .    .|||.  |.|.| .||..||.|. .  |.|.    .. .|..  .             |.  .        |...
TCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPEC

KRLLLRMLHLDPDKRPTIDQVMAEPII
| |. |||  |...| ..... . |..
KDLIRRMLQYDEKDRISWEELFNHPWF
Kinase NEK8a.AA ULK 40-213 22 5.3e-44 152.51 In-house 101-324 (324) Show / Hide 
Range on Protein: 40-213
Range on HMM: 101-324/324
Sequence Identity: 22% (51 aa)

GGTVFEYLQQRGN-------ALIEEDEVLRLMAQILLSMKHVHSKQILHRDLKTQNILLNRD-----------CDVIKIGDFGISKILSSKSKAFTVV--
||. ..|......         ..|.|..  . ||.  .|. |...| |||.| ||||.. .             |.||.||| .|.. . ... ..   
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

--------GTPSYISPELCE----GKPYN-QKSDMWAIGCVLYELLTLRRAFEANNLPALV-------------MKIMRGSVAPISD-----RYSDQLKR
        ||| | .|.. .    .|||.  |.|.| .||..||.|. .  |...    ..             . ...    .. .       |...| 
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LLLRMLHLDPDKRPTIDQVMAEPII
|. |||  |...| ..... . |..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase NEK8a.AA NEK8 4-36 57 7.1e-20 53.32 In-house 1-35 (278) Show / Hide 
Range on Protein: 4-36
Range on HMM: 1-35/278
Sequence Identity: 57% (20 aa)

YEKIKVVGRGAFGTVYLCRRLHDM--KLIIIKQIP
||.| |||||||| . |.||  |   .|.|.|||.
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQIN
Kinase NEK8a.AA NEK 4-35 43 2.9e-12 39.85 In-house 1-37 (286) Show / Hide 
Range on Protein: 4-35
Range on HMM: 1-37/286
Sequence Identity: 43% (16 aa)

YEKIKVVGRGAFGTVYLCRRLHDMKL-----IIIKQI
||.||..|.|.||.||..||  | |       ..|.|
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKI
Kinase NEK8a.AA TyrKc 4-213 18 8.1e-12 -31.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-213
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

YEKIKVVGRGAFGTVYLCR--------RLHD-------------MKL------------IIIKQ-------------IPXXXGGTVFEYLQQRGNALIEE
 ...|. |.||||.||...         |..             .||            ....|                  .|   .||. ...  .  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-LCM

DEVLRLMAQILLSMKHVHSKQILHRDLKTQNILLNRDCDVIKIGDFGISKILSSK------SKAFTV---VGTPS-----YISPELCEGKPYNQKSDMWA
.. |  . ||   | . |||.. |||| . |.|....  ..||.||| |. . ..      ..  ..    |. .       .||    . .. ||| |.
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS

IGCVLYELLTLRRAFEAN------NLPALVMKIMRGSVAPISDR--------YSDQLKRLLLRMLHLDPDKRPTIDQVMAEPII
 | ...|..|.      .      .   .. ....|   |. .          .| . .. ..  | ||..|||  ..    ..
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase NEK8a.AA Pkinase_Tyr 45-154 27 1.1e-11 40.18 Pfam 96-210 (270) Show / Hide 
Range on Protein: 45-154
Range on HMM: 96-210/270
Sequence Identity: 27% (33 aa)

EYLQQR---GNALIEEDEVLRLMAQILLSMKHVHSKQILHRDLKTQNILLNRDCDVIKIGDFGISKILSSKSKAFTVVGT-----PSYISPE-LCEGKPY
.||...   ...|  .|  |   .||   | . .||.. |||| . |.|....  |.||.||| .. . ...   .....         .|| . .|| .
DYLRKHREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK-F

NQKSDMWAIGCVLYELLTL
. ||| |. | ...|..|.
TTKSDVWSFGVLMWEIFTY
Kinase NEK8a.AA Ciliate-E2 4-35 43 6e-08 23.35 In-house 1-32 (365) Show / Hide 
Range on Protein: 4-35
Range on HMM: 1-32/365
Sequence Identity: 43% (14 aa)

YEKIKVVGRGAFGTVYLCRRLHDMKLIIIKQI
|..||. |.|.||.||.|..  . |...||.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKII
Kinase NEK8a.AA NEK4 4-35 40 6.7e-08 24.65 In-house 1-32 (257) Show / Hide 
Range on Protein: 4-35
Range on HMM: 1-32/257
Sequence Identity: 40% (13 aa)

YEKIKVVGRGAFGTVYLCRRLHDMKLIIIKQI
|. .||||.| .| |.| |   | |  ..| .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKM
Kinase NEK8a.AA Pkinase 4-36 33 9.1e-08 28.54 Pfam 1-33 (293) Show / Hide 
Range on Protein: 4-36
Range on HMM: 1-33/293
Sequence Identity: 33% (11 aa)

YEKIKVVGRGAFGTVYLCRRLHDMKLIIIKQIP
|......|.|.||.||.|..  . |.  .|.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK
Kinase NEK8a.AA Ciliate-E2-Unclassified 4-35 37 1.6e-07 22.14 In-house 1-37 (352) Show / Hide 
Range on Protein: 4-35
Range on HMM: 1-37/352
Sequence Identity: 37% (14 aa)

YEKIKVVGRGAFGTVYLCRRLHD-----MKLIIIKQI
|..||. |.|.||.||.|..  .     || .. .||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQI
Kinase NEK8a.AA ULK 4-36 27 3e-06 17.79 In-house 1-37 (329) Show / Hide 
Range on Protein: 4-36
Range on HMM: 1-37/329
Sequence Identity: 27% (10 aa)

YEKIKVVGRGAFGTVYLCRRLHD----MKLIIIKQIP
|..... | |.||.||  |   .     .....|.|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMID
Kinase NEK8a.AA NEK1 4-35 37 4e-06 17.37 In-house 1-32 (276) Show / Hide 
Range on Protein: 4-35
Range on HMM: 1-32/276
Sequence Identity: 37% (12 aa)

YEKIKVVGRGAFGTVYLCRRLHDMKLIIIKQI
|..||..| |.|| ..| ..  | ..  || |
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEI
Kinase NEK8a.AA ULK 4-36 27 8e-06 16.81 In-house 1-37 (324) Show / Hide 
Range on Protein: 4-36
Range on HMM: 1-37/324
Sequence Identity: 27% (10 aa)

YEKIKVVGRGAFG-TVYLCRRLHD---MKLIIIKQIP
|..... | |.|| .||  |   .    ... .|.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMID
Kinase NEK8a.AA CAMK 9-36 27 3.6e-05 11.81 In-house 1-40 (425) Show / Hide 
Range on Protein: 9-36
Range on HMM: 1-40/425
Sequence Identity: 27% (11 aa)

VVGRGAFGTVYLCRRLHDM------------KLIIIKQIP
. |||.||.|.||.. ..             .   || |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIID
Kinase NEK8a.AA NEK-Unclassified 4-22 52 0.001418 7.36 In-house 1-19 (258) Show / Hide 
Range on Protein: 4-22
Range on HMM: 1-19/258
Sequence Identity: 52% (10 aa)

YEKIKVVGRGAFGTVYLCR
|.||  .| |  | ||| |
YDKITTLGQGGGGAVYLVR
Kinase NEK8a.AA Pkinase_Tyr 4-22 42 0.002838 11.71 Pfam 1-19 (270) Show / Hide 
Range on Protein: 4-22
Range on HMM: 1-19/270
Sequence Identity: 42% (8 aa)

YEKIKVVGRGAFGTVYLCR
 ...|. |.||||.||...
ITFGKKLGEGAFGEVYKGT
RCC1 NEK8a.AA RCC1 344-370 24 0.265415 7.11 Pfam 25-52 (52) Show / Hide 
Range on Protein: 344-370
Range on HMM: 25-52/52
Sequence Identity: 24% (7 aa)

YIPRY-LEGQSA-VSIQNVSCGDLFVACL
..|.  .|.    |... |.||. ....|
HVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK8a.AA RCC1 373-422 35 9.7e-10 34.49 Pfam 1-52 (52) Show / Hide 
Range on Protein: 373-422
Range on HMM: 1-52/52
Sequence Identity: 35% (19 aa)

RGILMTFGSGAHGCLG--HGNYQDLSQAKI-VEALLG-YEVALVSCGASHVMAV
 | . |.|.. .|.||  ||.  . .  .  || | | ..|  |.||..|.||.
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK8a.AA RCC1 425-474 27 7.2e-16 54.4 Pfam 1-52 (52) Show / Hide 
Range on Protein: 425-474
Range on HMM: 1-52/52
Sequence Identity: 27% (15 aa)

EHEVFSWGRGDNGRLG--LDSQESVSSPQA-VVLPPQ-HRARSVCCGVDCSMLI
. .|..||..|.|.||  ...  ... ||  | ..    | ..|.|| . .|..
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK8a.AA RCC1 477-532 17 0.044738 9.62 Pfam 1-52 (52) Show / Hide 
Range on Protein: 477-532
Range on HMM: 1-52/52
Sequence Identity: 17% (11 aa)

EGVVIACGSNRCNKLGLDQGEQQIEEVFSLTQVATHPLPQL-----N---ITSAAIGTSHSAFI
.| | ..|.|.   ||.            ..       ||.     .   ....| | .|....
DGRVYTWGCNDYGQLGR-----------IHGDT-NCHVPQQIVEFLGNVRVVQVACGWQHTMAL
RCC1 NEK8a.AA RCC1 535-585 37 9.2e-14 47.56 Pfam 1-52 (52) Show / Hide 
Range on Protein: 535-585
Range on HMM: 1-52/52
Sequence Identity: 37% (20 aa)

KGECYTLGSNQFGQLG-CRTETTTPRIPCK-PSFPDD-VTLTQVACGDMFTVAI
.|..|| |.|..||||   . |   ..|..  .|. . |  .|||||...|.|.
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK8a.AA RCC1 588-637 24 8.6e-08 28.18 Pfam 1-52 (52) Show / Hide 
Range on Protein: 588-637
Range on HMM: 1-52/52
Sequence Identity: 24% (13 aa)

DDKVFSWGKGARGRIG---RPLQDTSAPRQ-VRLVDQDINVLSVSCSHSNTIIA
| .|..||.. .|. |       . . |.| | .    . | .|.| .. |.. 
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL