Gene GCN2 (Sea Urchin)

GCN2

Species: Sea Urchin
Alias: Spk186, GCN2, SPU_025674
External Links: Sea Urchin Project Link
Annotation: Secondary Group: STE, Secondary Family: STE-Unique,

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
GCN2.AA Protein None 1349 None Fasta, JSON
GCN2.kin_dom Protein Kinase Domain None 428 None Fasta, JSON
GCN2.kin_dom2 Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of GCN2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GCN2.AA GCN2 208-395 23 8.1e-77 261.52 In-house 260-511 (511) Show / Hide 
Range on Protein: 208-395
Range on HMM: 260-511/511
Sequence Identity: 23% (60 aa)

LEHANIVHYLAMNYNKGKEDINVQLLMEYVGGGNLSQKLENSSLTSFDL-LREYAIDLLSGLQYLHSHAVVHKQLRASQVYVDCDGRLRVANYSMCKR--
..|.|.|||..||..|.||.......|||..|..|.|...|.......  |..|....|.||.|.||....|..|..|....||.|. ..........  
NQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNK

----------------------LNELAQAANEGKQTVRFSDDK------TYGGRGG---------------KKGDVLDL-GLLLLGLLLGTSDVQYP---
                      .||..|......|...||...      ...|..|               .|.|. .| |....... .....|..   
MESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQKSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQ

-------CEVPQDLP-------LDLQDFLNRCIDIDERSRANVQSLLDHPFI
       ||.|||..        | ||....|...|...|...|.||.|.|.
ILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase GCN2.AA PEK 228-395 12 6.1e-42 143.5 In-house 356-655 (655) Show / Hide 
Range on Protein: 228-395
Range on HMM: 356-655/655
Sequence Identity: 12% (38 aa)

INVQLLMEYVGGGNLSQKLENSS--------------------------------------------LTSFDLLREYAIDLLSGLQYLHSHAVVHKQLRA
. ....|||.....|.. ..|..                                             .. |...... ..|.||.|.||....|..|..
HYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKP

SQVYVDCDGR-----LRVANYSMCKR----------------------LNELAQAANEGKQ-----------------------------------TVRF
|....||||.     ...........                      .|. .|. |. .|                                   |...
SNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLY

SDDKTYGGR------GGKKGDVLDLGLLLLGLLLGTSDVQYPCEVPQDLPLD--------------------LQDFLNRCIDIDERSRANVQSLLDHPFI
..   ..|.       ..|.|.  ||.... .. .... ....  ... . |                    ..||.......| . | ..| .|.|.|.
MSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase GCN2.AA PEK 136-227 29 2.4e-29 98.83 In-house 1-90 (655) Show / Hide 
Range on Protein: 136-227
Range on HMM: 1-90/655
Sequence Identity: 29% (27 aa)

VHKGILLGSNPEGSSVYAGMDAHSGDLLTIREWVIKWKQGKGRKPLPDEEEDAEACLKQCASVEQELLSLLRLEHANIVHYLAMNYNKGKED
.... .||..  | .|| ......| .. |......|||.|..... .|.. ...| |.|..|..|  .| ||.| |||.| .....| .|.
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCIT-QECM-IHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEK
Kinase GCN2.AA GCN2 137-207 20 4.1e-23 77.47 In-house 1-72 (511) Show / Hide 
Range on Protein: 137-207
Range on HMM: 1-72/511
Sequence Identity: 20% (15 aa)

HKGILLGSNPE-GSSVYAGMDAHSGDLLTIREWVIKWKQGKGRKPLPDEEEDAEACLKQCASVEQELLSLLR
...| ...... |..|......|.|....|..|.|.|||.|.........|....| .....|...  ....
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIE
Kinase GCN2.AA STE 193-278 21 3.7e-13 42.92 In-house 70-175 (359) Show / Hide 
Range on Protein: 193-278
Range on HMM: 70-175/359
Sequence Identity: 21% (23 aa)

KQCASVEQELLSLLRLE--HANIVHYLAMNYNKGKE---DINVQLLMEYVGGGNLSQKLEN--SSLTS------------FDLLREYAIDLLSG-LQYLH
..  ....|.  . ..   | |||.|. . ...|..   | .. . |||..|| |.. ...  . . .             .... .. ..| | |.|||
EEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLH

SHAVVH
|| ..|
SHHIIH
Kinase GCN2.AA Pkinase 200-278 27 9e-11 39.17 Pfam 49-131 (293) Show / Hide 
Range on Protein: 200-278
Range on HMM: 49-131/293
Sequence Identity: 27% (24 aa)

QELLSLLRLEHANIVHYLAMNYNKGKEDINVQLLMEYVGGG----NLSQKLE--NSSLT--SFDLLREYAIDLLSGLQYLHSHAVVH
.|.  ..|| | ||| .. . ..  | .|   . |||..||     |.  ..  ..     | . .. |.  .|.||.|.||. ..|
SEIQIMKRLNHPNIVRLYDWFED--KDHIY--MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH
Kinase GCN2.AA STE 360-395 34 1.8e-09 29.76 In-house 322-359 (359) Show / Hide 
Range on Protein: 360-395
Range on HMM: 322-359/359
Sequence Identity: 34% (13 aa)

VPQDLPLDLQDFLNRCIDIDERSRANVQSLLD--HPFI
.|  .  ...||.|.| ..| . |.... ||   ||||
YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GCN2.AA Ciliate-E2 353-395 12 3.1e-07 20.86 In-house 304-365 (365) Show / Hide 
Range on Protein: 353-395
Range on HMM: 304-365/365
Sequence Identity: 12% (8 aa)

DVQYPCE--------------VPQDLPLDLQDFLNR----CIDIDERSRAN-VQSLLDHPFI
....||.               ....... .|....    ... |.  | .  . .|.||..
KIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GCN2.AA Ciliate-E2 225-278 22 1e-05 15.65 In-house 104-184 (365) Show / Hide 
Range on Protein: 225-278
Range on HMM: 104-184/365
Sequence Identity: 22% (18 aa)

KEDINVQLLMEYVGGGNLSQKLENSSLTS-----------FDLLREYAIDLLS---------------GLQYLHSHA-VVH
| | |. | |||. ||.| . ..|... .               ...   .|.               .|.||||   ..|
KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIH
Kinase GCN2.AA NEK 234-278 24 1.5e-05 15.91 In-house 85-142 (286) Show / Hide 
Range on Protein: 234-278
Range on HMM: 85-142/286
Sequence Identity: 24% (14 aa)

MEYVG-GGNLSQK---LENSS--LTSFD--LLREYAIDLLSGLQYLHSH-----AVVH
|||   ||.|.||   ...     . |.     .. | ....|.|.|..      ..|
MEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILH
Kinase GCN2.AA Pkinase 364-395 25 1.8e-05 20.47 Pfam 262-293 (293) Show / Hide 
Range on Protein: 364-395
Range on HMM: 262-293/293
Sequence Identity: 25% (8 aa)

LPLDLQDFLNRCIDIDERSRANVQSLLDHPFI
.. ...||...|.. |  .| . . .| ||..
WSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GCN2.AA STE-Unique 225-299 25 3.9e-05 13.55 In-house 364-454 (616) Show / Hide 
Range on Protein: 225-299
Range on HMM: 364-454/616
Sequence Identity: 25% (23 aa)

KEDINVQLLMEYVGGGNLSQKLENSSL----TSFDLLRE-----YAIDLLSGLQYLHSHA--VVHKQLRASQVYVDCDG-----RLRVANY
||   | . |||  .| |.|......         |..|     |.  .| || ||||    ..|  | .. .  . ||     . .....
KEQNWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDF
Kinase GCN2.AA NEK 367-395 31 0.000105 12.94 In-house 258-286 (286) Show / Hide 
Range on Protein: 367-395
Range on HMM: 258-286/286
Sequence Identity: 31% (9 aa)

DLQDFLNRCIDIDERSRANVQSLLDHPFI
|||.......  |  .| .....| .|||
DLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GCN2.AA WEE 234-278 28 0.000885 8.64 In-house 84-135 (297) Show / Hide 
Range on Protein: 234-278
Range on HMM: 84-135/297
Sequence Identity: 28% (15 aa)

MEYVGGG-NLSQKLENSSLTSFD-----LLREYAIDLLSGLQYLHSH-AVVH
|||  || || |..  ... . .     ... .  |.. ||...||.   ||
MEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVH
Kinase GCN2.AA STE-Unique 359-395 21 0.007305 5.33 In-house 580-616 (616) Show / Hide 
Range on Protein: 359-395
Range on HMM: 580-616/616
Sequence Identity: 21% (8 aa)

EVPQDLPLDLQDFLNRCIDIDERSRANVQSLLDHPFI
. | .. ...|.|.  |.. .   |...  || |.. 
NIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase GCN2.AA Pkinase_Tyr 200-283 23 0.008832 10.04 Pfam 52-139 (270) Show / Hide 
Range on Protein: 200-283
Range on HMM: 52-139/270
Sequence Identity: 23% (21 aa)

QELLSLLRL-EHANIVHYLAMNYNKGKEDINVQLLMEYVGGGNLSQKLEN----SSLTSFDLLREYAIDLLSGLQYLHSHAVVHKQLRA
.|.  .  |  | ||| ...  . .|.   .. . |||. .|.|   | .        .   | .....  .|..||.|.  .|  |.|
REAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAA
Kinase GCN2.AA WEE 359-395 24 0.023566 3.79 In-house 261-297 (297) Show / Hide 
Range on Protein: 359-395
Range on HMM: 261-297/297
Sequence Identity: 24% (9 aa)

EVPQDLPLDLQDFLNRCIDIDERSRANVQSLLDHPFI
|...... .|....   .. | . |   |.||.|| .
EFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase GCN2.AA GCN2 443-870 36 4.2e-228 764.07 In-house 1-511 (511) Show / Hide 
Range on Protein: 443-870
Range on HMM: 1-511/511
Sequence Identity: 36% (190 aa)

FEFLAFLGKGGFGNVIK-VRNKLDGNLYAIKKILLNPKSRELNKK--ITREVKLLSRLNHENVVRYYNSWIEVAEEPPTTDTDESRTTGTGETSPDTNGV
||....|||||||.|.| |||..||..|||||. .|.|.|.|..|  |.||||||.||.|..|||||..|||...||..|||.....|.....|.|....
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESEC

GRGAREVPLAVNSLSLSDNIEEQALKLSI--RNSLEWSSSGNIGLIGD----------------------------------------------------
..|..|.| .||. . ..|.||.. . ..  ||. .|...||.....|                                                    
FSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDWDIESNN

-----SDDSSSDDEGVFGRSFLPRSDDSSSDGIDFEGSDRGEESDISLSISNRVKESKGNRGKSKEEDISEDNPVFSPVQYLYIQMEFCEKSTLRTAIDA
     |||.....|.....||.|...|......|.|.....|..|.. ..|....... |. |.|......... ...|.|||||||.||..|||..|| 
VRDMESDDNEWEQEQQNNQSFQPKQEDHQNQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDN

G-MYEDKRRLWTHFREIIEGLAHIHLQGMIHRDLKPVNIFLDSNDFVKIGDFGLATS-------------------EQMAGALTSEVSCHNRLTDSSHSG
. ...|...||..||.|.|||..|| ||||||||||.|||||....||||||||||.                   ...| . ... ..... ..|..|.
HGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQ

EATP--GNHLTGKVGTALYVAPELCKARIGHYNQKVDLYSL-GIIFFEMCYRSLSTGMERVKILGQIRQESIQLPEDFD---EVRNTNENAIVHWLLNHD
. ..  ..|.||||||..|..||..   ..|||||||.||| |||||||.|....|.||||.|| |.|  |...|.|||   ........ ...|.||||
WDQQDEQVHHTGKVGTPFYMCPEQQ---KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR--SCEFPQDFDKKVDNHHKDQQDMIRWCLNHD

PKERPTSQELLESKLL
|..||. |.||....|
PQKRPSAQQLLQHEFL
Kinase GCN2.AA PEK 443-870 27 1.8e-189 635.73 In-house 1-655 (655) Show / Hide 
Range on Protein: 443-870
Range on HMM: 1-655/655
Sequence Identity: 27% (183 aa)

FEFLAFLGKGGF-GNVIKVRNKLDGNLYAIKKILLNPKSRE---------------LNKKITREVKLLSRLNHENVVRYYNSWIEVAEEPPTTDTDESRT
|| .. |||||| | |.||.|||||..||||.| ||.|.|.               ...|..||||.|.||||.|.|||.|.|||. ||......||...
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

TGTGETSPDTN-------------------------------GVGRGAREVPLAVNSLSLSDNIEEQALKLSIRNSLE----------------------
... ...|...                               .. .|....   .|| | ..|.||.  .  .. | .                      
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENES

----WSSSGNIGLIGD-----------------------------------------------------------SDDSSSDDEGVFGRSFLPRSDDSS-
    ||||.. .   |                                                           ..|.....|.....|....|...| 
HISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQSH

------SDGIDFEGSDRGEESDISLSISNRVKESKGNRGKSKEEDISEDNPVFSPVQYLYIQMEFCEKSTLRTAIDAG----------------------
      .. .|.| ... ..|....| |.  .|.. |  ..|... ...|.......|||||||.|||.|||. || .                      
KKCMEMTWIQDQEDNKN-NCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYI

----------------------MYEDKRRLWTHFREIIEGLAHIHLQGMIHRDLKPVNIFLDSNDF-----VKIGDFGLATS----------------EQ
                      |..|| ..| .||.|.|||..|| ||||||||||.|||||....     ||||||||||.                ..
MNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSY

MAGALTSEVSCHNRLTDSSHSGEATPG-----------------NHLTGKVGTALYVAPELC---KARIGHYNQKVDLYSLGIIFFEMCYRSLSTGMERV
.. .....  ..|. ...|..|  |..                 .|.||.|||.||..||..   ... .|||.|||.||||||||||.|.  .|.||||
WKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERV

KILGQIRQESIQLPEDFD----EVRNTNENAIVHWLLNHDPKERPTSQELLESKLL
|.| ..|.||||.|.||.    ... ...  ...|.|.|||..||..|..|.....
KTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase GCN2.AA S_TKc 443-870 16 9e-45 155.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 443-870
Range on HMM: 1-231/231
Sequence Identity: 16% (73 aa)

FEFLAFLGKGGFGNVIKVRNKLDGNLYAIKKILLNPKSRELNKKITREVKLLSRLNHENVVRYYNSWIEVAEEPPTTDTDESRTTGTGETSPDTNGVGRG
.|.|  .|||.|| | |.|.| .| ..|||.|                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

AREVPLAVNSLSLSDNIEEQALKLSIRNSLEWSSSGNIGLIGDSDDSSSDDEGVFGRSFLPRSDDSSSDGIDFEGSDRGEESDISLSISNRVKESKGNRG
                                                                                         .  .| .  . 
----------------------------------------------------------------------------------------EHIRREIQILKK

KSKEEDISEDNPVFSPVQYLYIQMEFCEK--STLRTAIDAGMY------EDKRRLWTHFREIIEGLAHIHLQGMIHRDLKPVNIFLDSNDFVKIGDFGLA
  . . |     ||   ..||. ||.|.    .|.. |.   .       .  . .  ...|...|...| .| ||||||| ||.||.   .||.|||||
--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLA

TSEQMAGALTSEVSCHNRLTDSSHSGEATPGNHLTGKVGTALYVAPELCKARIGHYNQ-KVDLYSLGIIFFEMCYRSLSTGMERVKILGQIRQESIQLPE
.                                 |  .||  |.|||..     .|.  |.| .|.|.|..||...      .  ... .|.        
RQL-------------------------------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------

DFDEVRNTNENAIVHWLLNHDPKERPTSQELLE-------SKLL
            ..  .|. ||..|||  |.|.          .
------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GCN2.AA STE 443-807 15 1.2e-41 144.7 In-house 1-262 (359) Show / Hide 
Range on Protein: 443-807
Range on HMM: 1-262/359
Sequence Identity: 15% (68 aa)

FEFLAFLGKGGFGNVIKVRNKL---------------DGNLYAIKKILLNPKS---------------RELNKKITREVKLLSRLN--HENVVRYYNSWI
.|.. ..|||.|| | | .|.                 |...|||.. |....                |  ..| .|.|.....|  |.|.|.|| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EVAEEPPTTDTDESRTTGTGETSPDTNGVGRGAREVPLAVNSLSLSDNIEEQALKLSIRNSLEWSSSGNIGLIGDSDDSSSDDEGVFGRSFLPRSDDSSS
   ..                                                                                               
KEGHN-----------------------------------------------------------------------------------------------

DGIDFEGSDRGEESDISLSISNRVKESKGNRGKSKEEDISEDNPVFSPVQY---LYIQMEFCEKSTLRTAID-AGMY---------------EDKRRLWT
                                                 .    |.| ||...  .|.  |.  ..                |.  .  .
------------------------------------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYIC

HFREIIEG-LAHIHLQGMIHRDLKPVNIFLDSNDFVKIGDFGLAT--SEQMAGALTSEVSCHNRLTDSSHSGEATPGNHL-----TGK------VGTALY
  |.|..| |...| .. ||||.|| ||.|     ||. |||...  .. ||.    .                  .|       |..      |||  .
--RQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANI-Q-S------------------NN-IIDCIETMQQKRNTFVGTP-W

VAPELCKARI----GHYNQKVDLYSLGIIFFEMC
 |||  . .     ..|. |.| .|||.   ||.
MAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase GCN2.AA Ciliate-E2 660-870 21 1.3e-31 105.72 In-house 107-365 (365) Show / Hide 
Range on Protein: 660-870
Range on HMM: 107-365/365
Sequence Identity: 21% (59 aa)

QYLYIQMEFCEKSTLRTAIDAG---------------MYEDKRRLWTHFR-----------EIIEGLAHIHLQG-MIHRDLKPVNIFLDSNDFVKIGDFG
...|. ||.|.  .|.  |                  ..| |.  .  ..           .||..| ..| ..  ||||.|| ||..     .|| |||
NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFG

LATSEQ-MAGALTSEVSCHNRLTDSSHSGEATPG--------NHLTGKVGTALYVAPELCKARI------GH-YNQKVDLYSLGIIFFEMCYRSLSTGME
|..  .      |   . .. ... .   . |||        |     .||. |.|||  .         .. |. |.|..|||.|..||..  .     
LSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---

RVKILGQIRQESIQLPEDFDEVRNTNENAIVHW--------------------LLNHDPKERPT-SQELLESKLL
    . || |  |..|. . . . |... .. |                    .|. ||..|.|  ...|. . .
----QQQIKQCKIDFPCPEWQKD-TQCI-QCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GCN2.AA Pkinase 660-870 23 4.5e-31 110.94 Pfam 73-293 (293) Show / Hide 
Range on Protein: 660-870
Range on HMM: 73-293/293
Sequence Identity: 23% (60 aa)

QYLYIQMEFCEKS----TLRTAID-------AGMYEDKRRLWTHFREIIEGLAHIHLQGMIHRDLKPVNIFLDSNDFV----KIGDFGLATSEQMAGALT
...|. ||.||.      | . |          . |.  . .  ...|..||...| .| ||||||| ||..|.|. .    ||.|||||   .      
DHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFY--MYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------

SEVSCHNRLTDSSHSGEATPGNHLTGKVGTALYVAPELCKARIGHYNQKVDLYSLGIIFFEMCY-RSLSTGM----ERVKILGQIRQESI-QLPEDFDEV
                   ..  .|. .||  |.|||... . ..  .||| .|.|.|..||.  | .  |     . .  .  |..    .|..|... 
-----------------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG-PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWW

RN-------------------TNENAIVHWLLNHDPKERPTSQELLESKLL
..                    .   .. |.|. |||.||| ...|... .
CSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GCN2.AA HRI 443-511 50 9.7e-28 94.54 In-house 1-69 (613) Show / Hide 
Range on Protein: 443-511
Range on HMM: 1-69/613
Sequence Identity: 50% (35 aa)

FEFLAFLGKGGFGNVIKVRNKLDGNLYAIKKILLNPKSRELNKKITREVKLLSRLNHENVVRYYNSWIE
|| .. .||||.| | |||.|||.  ||||||.   . .    |. |||| |  |.| |.|||  .|||
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIE
Kinase GCN2.AA STE-Unique 662-807 29 2.1e-27 94.03 In-house 369-547 (616) Show / Hide 
Range on Protein: 662-807
Range on HMM: 369-547/616
Sequence Identity: 29% (54 aa)

LYIQMEFCEKSTLRTAIDA-GM---------YEDKRRLWTHFREIIEGLAHIHLQG--MIHRDLKPVNIFLDSND-----FVKIGDFGLATSEQMA--GA
..|.||.||..||.. |.. |           .  . .|   ..| ||| ..| |.   ||||||| |||... .      |||.|||.||. |    . 
VWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWY-TYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEK

LTSEVSCHNRLTDSSHS------GEATPG-------NHLTGKVGTALYVAPELCKAR---IGHYNQKVDLYSLGIIFFEMC
. .  .  |    .  .         ||          ... .||  | .||    |     .|. ||| .|||...|.||
DNN-SKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMC
Kinase GCN2.AA PEK 769-870 31 9.8e-27 85.33 In-house 646-758 (758) Show / Hide 
Range on Protein: 769-870
Range on HMM: 646-758/758
Sequence Identity: 31% (37 aa)

TGKVGTALYVAPELCKAR--------------IGHYNQKVDLYSLGIIFFEMCYRSLSTGMERVKILGQIRQESIQLPEDFDE-VRNTNENAIVHWLLNH
|. ||| || .|| |.                 ..|| ||| ||||.||||. .   || |||....  .|  . |.| .|.  .    |   . ... .
TVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLR--NGQWPKWFTQKY--PQEYEFIQQMMSM

DPKERPTSQELLESKLL
.| ||||. ..... . 
NPDERPTADQISMHDFF
Kinase GCN2.AA HRI 693-870 33 1.4e-24 83.16 In-house 439-613 (613) Show / Hide 
Range on Protein: 693-870
Range on HMM: 439-613/613
Sequence Identity: 33% (61 aa)

FREIIEGLAHIHLQGMIHRDLKPVNIFLDSNDF----VKIGDFGLATSEQMAGALTSEVSCHNRLTD-SSHSGEATPGNHLTGKVGTALYVAPELCKARI
| .|.||.  ||  . .|||.|| ||||   |     |||||||||    .    |       . .| ..  .  |.    | .||| .| .||      
FQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLACEDILQEPKTPMRFRRDQDFDWTNRNPCVTQT--HTSRVGTCTYASPEQLDG--

GHYNQKVDLYSLGIIFFEMCYRSLSTGMERVKILGQIRQESIQLPEDFDEVRNTNENAIVHWLLNHDPKERPTSQELLESKLL
  |  | |.||.|.| ||. .    | ||| ..|  .|    |.||     |       .  |       ||    || | | 
SQYDNKSDMYSMGVILFEL-FQPFGTEMERAEVLTGVR--TGQIPESLRK-RCPVQAKYIQHLTRRNASQRPSAIQLLQSELF
Kinase GCN2.AA PEK 443-511 47 2.6e-23 73.66 In-house 1-76 (758) Show / Hide 
Range on Protein: 443-511
Range on HMM: 1-76/758
Sequence Identity: 47% (36 aa)

FEFLAFLGKGGFGNVIKVRNKLDGNLYAIKKILL-N-----PKSRELNK-KITREVKLLSRLNHENVVRYYNSWIE
||    ||.|||| | .. ||.|.|.||||.| . |     |  ||.   |  |||. |  |.| | |||.|.| |
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLE
Kinase GCN2.AA WEE 443-511 35 2.5e-22 71.77 In-house 1-76 (297) Show / Hide 
Range on Protein: 443-511
Range on HMM: 1-76/297
Sequence Identity: 35% (27 aa)

FEFLAFLGKGGFGNVIKVRNKLDGNLYAIKKILLNPKSRELNKKITREVKLLSRLN-------HENVVRYYNSWIE
|...  .|.| || | |.|...||..|||||.   ..     | . |||. .. |        |...||||..|.|
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEE
Kinase GCN2.AA PEK 586-735 24 2.6e-22 70.25 In-house 318-514 (758) Show / Hide 
Range on Protein: 586-735
Range on HMM: 318-514/758
Sequence Identity: 24% (49 aa)

SDDSSSDDEGVFGRSFLPRSDDSSSDGIDFEGSDRGEESDISLSISNRVKESKGNRGKSKEEDI--------------SEDNPVFSPVQ------YLYIQ
....|.. .|.|. .. . ..|||...    .  ..  .... . .| ... |    ||  | .                 |  .. ..      |.|||
PSEASDYYSGSFSNNSSIIFEDSSCEDNKPKEYSMSTKQHQQQQCQNQQTNQKCSSSKSCMENNWLLTSHHNNNNNNNNNNNNKNWKMHPTGNCIYMYIQ

MEFCEKSTLRTAIDA--GMYEDKRRLWTH-FREIIEGLAHIHLQGMIHRDLKPVNIFLDSNDF------------------------VKIGDFGLAT
|. |.| ||.  .     | .  . .  | |  |.||.  ||. ||||||||| |||. . .                         .|||||||.|
MQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGLVT
Kinase GCN2.AA WEE 662-736 29 4.5e-21 67.49 In-house 80-181 (297) Show / Hide 
Range on Protein: 662-736
Range on HMM: 80-181/297
Sequence Identity: 29% (30 aa)

LYIQMEFCEKS-TLRTAIDAGMYEDKR-----RLWTHFREIIEGLAHIHLQ-GMIHRDLKPVNIFLDSND--------------------FVKIGDFGLA
.|||||.|...  |. .. .  .  ..     ..|  ...|..||.||| . ||.| |.|| |||. ...                      ||||||..
MYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHV

TS
|.
TD
Kinase GCN2.AA PEK-Unclassified 443-514 35 1.3e-20 68.23 In-house 1-77 (835) Show / Hide 
Range on Protein: 443-514
Range on HMM: 1-77/835
Sequence Identity: 35% (27 aa)

FEFLAFLGKGGFGNVIKVRNKLDGNLYAIKKILLN-----PKSRELNKKITREVKLLSRLNHENVVRYYNSWIEVAE
|  .  .|.|||. | .. .|.|   ||.|.| .|             |  .||  . ..|| |..||| ||||| .
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIEVEI
Kinase GCN2.AA NEK 443-511 38 5e-20 67.52 In-house 1-75 (286) Show / Hide 
Range on Protein: 443-511
Range on HMM: 1-75/286
Sequence Identity: 38% (29 aa)

FEFLAFLGKGGFGNVIKVRNKLDGNL-----YAIKKILLNPKSRELNKKIT-REVKLLSRLNHENVVRYYNSWIE
.| .  .|.| || | ||| | ||.      |..||| ..  |..  ..    ||..|..|.|.|.|.||.|.||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIE
Kinase GCN2.AA STE-Unique 444-511 33 1e-18 62.63 In-house 1-72 (616) Show / Hide 
Range on Protein: 444-511
Range on HMM: 1-72/616
Sequence Identity: 33% (24 aa)

EFLAFLGKGGFGNVIKVRNKLDGNLYAIKKILLNPKSRE----LNKKITREVKLLSRLNHENVVRYYNSWIE
.   ..|.|.|||| . .|| |.. .|||.| |. .. .    | ..| .|. ....|.|.|.|.|| .|..
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLW
Kinase GCN2.AA NEK 660-734 32 1e-18 62.86 In-house 79-170 (286) Show / Hide 
Range on Protein: 660-734
Range on HMM: 79-170/286
Sequence Identity: 32% (30 aa)

QYLYIQMEFCE-KSTLRTA---IDAGM----YEDKRRLWTHFREIIEGLAHIHLQ-----GMIHRDLKPVNIFLDSND----FVKIGDFGLA
..|.| ||.|| . .|      |  .     | . .  |  |  .. .| ..| .       .|||.|| ||||..|.    .|||||||..
NCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGIS
Kinase GCN2.AA PEK-Unclassified 694-735 56 4.8e-17 55.38 In-house 620-663 (835) Show / Hide 
Range on Protein: 694-735
Range on HMM: 620-663/835
Sequence Identity: 56% (25 aa)

REIIEGLAHIHLQG-MIHRDLKPVNIFLDSNDF-VKIGDFGLAT
|.|| .| ||| |. |.|||.|| |||.  | . .|||||||..
RQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVK
Kinase GCN2.AA Pkinase 443-511 29 2.4e-16 58.85 Pfam 1-71 (293) Show / Hide 
Range on Protein: 443-511
Range on HMM: 1-71/293
Sequence Identity: 29% (21 aa)

FEFLAFLGKGGFGNVIKVRNKLDGNLYAIKKILLNPKSRELNKKITR--EVKLLSRLNHENVVRYYNSWIE
....  .|.|.|| | | ..| .| ..|.|.| .  .. . ..  .|  |.... ||||.|.||.| .. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED
Kinase GCN2.AA Ciliate-E2 443-511 25 1.6e-12 39.26 In-house 1-103 (365) Show / Hide 
Range on Protein: 443-511
Range on HMM: 1-103/365
Sequence Identity: 25% (26 aa)

FEFLAFLGKGGFG-----NVIKVRN------------------KLDGNLYAIKKI-------LLNPKS--RELN---KKITREVKLLSRLNHENVVRYYN
..|.  .|.|.||     .|.||..                  | ....||.| .       ... ..  ||.|   |||  | ..|..||| |....| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

SWIE
...|
CFQE
Kinase GCN2.AA PEK-Unclassified 764-821 38 6.7e-11 33.3 In-house 726-791 (835) Show / Hide 
Range on Protein: 764-821
Range on HMM: 726-791/835
Sequence Identity: 38% (26 aa)

PGNHLTGKVGTALYVAPELC---KARI------GHYNQKVDLYSLGIIFFEMCYRSLSTGMERVKIL
|   .|  .||..|  .|     | ||        ||.. |.||.|||||.|    . | ||||| .
PKEEITSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQM-FHQMNTTMERVKTI
Kinase GCN2.AA TyrKc 443-869 13 7.1e-09 -79.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 443-869
Range on HMM: 1-280/280
Sequence Identity: 13% (63 aa)

FEFLAFLGKGGFGNVIKVRNKLDGNLYAIKKILLNPKSRELNKKITREVKLLSRL--NHENVVRYYNSWIEV---------------------------A
 ...  || | || | | . |      |.|..  .       . . || .....|  .|.|.|| |   ..                            .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

EEPPTTDTDESRTTGTGETSPDTNGVGRGAREVPLAVNSLSLSDNIEEQALKLSIRNSLEWSSSGNIGLIGDSDDSSSDDEGVFGRSFLPRSDDSSSDGI
 .|                                                                                                 
HRPK------------------------------------------------------------------------------------------------

DFEGSDRGEESDISLSISNRVKESKGNRGKSKEEDISEDNPVFSPVQYLYIQMEFCEKSTLRTAIDAGMYEDKRRLWTHFREIIEGLAHIHLQGMIHRDL
                                                                         . |      | .| ...| .. |||||
----------------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDL

KPVNIFLDSNDFVKIGDFGLATSEQMA---GALTSEVSCHNRLTDSSHSGEATPGNHL----TGK-VGTALYVAPELCKARIGHYNQKVDLYSLGIIFFE
   |. ...|  |||.||||.         |                   |..   .      || .      |||    . | .. | | .| |.  .|
AARNCLVGENHTVKISDFGLSRDIYDDDQQG-------------------ESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWE

MCYR--SLSTG-----MERVKILGQIRQE-SIQLPED---------FDEVRNTNENAIVHWLLNHDPKERPTSQELLESKL
.. .  .   |     |.   .. ...|      |..          ||.       |  .  ..||..||| .|.  ...
IFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMY-----QIMKQCWHEDPEDRPTFSEI-HECF
Kinase GCN2.AA Pkinase_Tyr 698-734 43 3e-06 21.8 Pfam 122-158 (270) Show / Hide 
Range on Protein: 698-734
Range on HMM: 122-158/270
Sequence Identity: 43% (16 aa)

EGLAHIHLQGMIHRDLKPVNIFLDSNDFVKIGDFGLA
.|... . ...|||||   |. ...| .|||.|||||
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase GCN2.AA WEE 846-870 40 1.2e-05 14.98 In-house 273-297 (297) Show / Hide 
Range on Protein: 846-870
Range on HMM: 273-297/297
Sequence Identity: 40% (10 aa)

IVHWLLNHDPKERPTSQELLESKLL
.. | .. ||. |||.|.||.. .|
LIKWMMHPDPEQRPTCQQLLQHPVL
Kinase GCN2.AA NEK 772-807 47 5.6e-05 13.91 In-house 185-218 (286) Show / Hide 
Range on Protein: 772-807
Range on HMM: 185-218/286
Sequence Identity: 47% (17 aa)

VGTALYVAPELCKARIGHYNQKVDLYSLGIIFFEMC
|||  | .||.|. .   ||.|.|  ||| . .|||
VGTPYYMSPEVCQNK--PYNNKSDIWSLGCVLYEMC
Kinase GCN2.AA STE 851-870 36 0.000276 11.18 In-house 338-359 (359) Show / Hide 
Range on Protein: 851-870
Range on HMM: 338-359/359
Sequence Identity: 36% (8 aa)

LNHDPKERPTSQELLE--SKLL
|. ||..|||...||.   . .
LQKDPNKRPTASQLLKSEHPFI
Kinase GCN2.AA NEK 844-870 25 0.000465 10.64 In-house 260-286 (286) Show / Hide 
Range on Protein: 844-870
Range on HMM: 260-286/286
Sequence Identity: 25% (7 aa)

NAIVHWLLNHDPKERPTSQELLESKLL
. ... .|. ||..||. ...||  ..
QNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GCN2.AA Pkinase_Tyr 443-506 29 0.001141 13.05 Pfam 1-70 (270) Show / Hide 
Range on Protein: 443-506
Range on HMM: 1-70/270
Sequence Identity: 29% (21 aa)

FEFLAFLGKGGFGNVIKVRNK----LDGNLYAIKKILLNPKSREL--NKKITREVKLLSRL-NHENVVRYY
 .|.  ||.| ||.| | . |     ..   |.|..  .  . |    ..  ||.|... | .|.|.||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase GCN2.AA HRI 661-676 43 0.00572 5.25 In-house 393-407 (613) Show / Hide 
Range on Protein: 661-676
Range on HMM: 393-407/613
Sequence Identity: 43% (7 aa)

YLYIQMEFCEKSTLRT
.|.|||. || ..|..
MLHIQMQLCE-LSLWD
Kinase GCN2.AA STE-Unique 850-870 33 0.040789 2.63 In-house 596-616 (616) Show / Hide 
Range on Protein: 850-870
Range on HMM: 596-616/616
Sequence Identity: 33% (7 aa)

LLNHDPKERPTSQELLESKLL
.|. .|  ||.  .||.. .|
CLERNPHHRPSAHQLLHHFWL
Kinase GCN2.AA PEK-Unclassified 662-675 57 0.04636 1.53 In-house 502-515 (835) Show / Hide 
Range on Protein: 662-675
Range on HMM: 502-515/835
Sequence Identity: 57% (8 aa)

LYIQMEFCEKSTLR
.||||| |  .|.|
FYIQMELCHYTTAR