Gene PEK (Sea Urchin)

PEK

Species: Sea Urchin
Alias: Spk185, SPU_026724, PEK
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: PEK

Sequence

Name Sequence Type Origin Length Description Download
PEK.AA Protein None 1108 None Fasta, JSON
PEK.kin_dom Protein Kinase Domain None 526 None Fasta, JSON

Protein domain

Protein domains of PEK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PQQ PEK.AA PQQ 74-112 25 0.002678 14.19 Pfam 1-37 (37) Show / Hide 
Range on Protein: 74-112
Range on HMM: 1-37/37
Sequence Identity: 25% (10 aa)

PMMIVSTVDGKVLALDIQNAGQQQWSMDAGVGPLLSSSI
....| | ||.. |||. . |.  |. ..| ..   .  
GDVYVHTWDGYIYALDADT-GKVKWKFKTGPPDWW-PMT
PQQ PEK.AA PQQ 204-241 21 0.003341 13.87 Pfam 1-37 (37) Show / Hide 
Range on Protein: 204-241
Range on HMM: 1-37/37
Sequence Identity: 21% (8 aa)

DIIVIQHTRQTVRAVDQRNGMEKWNFSVGQHDVTFLKG
.....   . ...|.| ..| .|| | .|..|.   ..
GDVYVHTWDGYIYALDADTGKVKWKFKTGPPDWW-PMT
Kinase PEK.AA PEK 556-1081 32 0.0 1048.33 In-house 1-758 (758) Show / Hide 
Range on Protein: 556-1081
Range on HMM: 1-758/758
Sequence Identity: 32% (246 aa)

FEHTECLGKGGFGIVFRAKNKVDENNYAVKRITLPN--------REEARDKVLREARTLAILDHSGIVRYFNSWLEEP----------------------
|||..|||.||||.|||||||||.||||.||||.||        ||.||.||.||.||||.|||..||||||.|||.|                      
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLETPELLPPNNKMRSTSFSTVNGKQI

-------------------------------------------PLGWQDIQDKKFVGESSLGGNDGLTSLDTPAFFNKNSELIRNHDQLMQQTGGRSSMG
                                           |..||...||......|......|..|..|.........|||.||.||....|..|.
DSNNDNDIYNNHFFFDGNWGQDEDEDEYENEDDNPCNRFVNKIPKKWQEKMDKCWNNNISNNWKKKLHQLKYPFKMDDDISFIRNMDQTMQNDQSRYKMQ

PSYVPFSKTRESPILKFDLSDDSNVSSEGRVDQKGDNKRAGVESDILFPGAVCEFEESGSFSIVFQGTEEENSQNMSVISDTGEETPQNLATFDESISNR
.|..||.|.....|........|..|.|...||...|.....|.|..|....|.|.||......|.||..|....|....||.....|...|........
YSHDPFFKKFNKQIIIREPMRNSSFSKESYCDQDDSNDIYSNEVDFFFTPKKCYFSESQFMPSEFSGTDDEEQSWMDSNNDTMYNAQQKCMTKCFGHHKH

STDTSLDNTMDVPFKHYANDAKDIRDLDRSESFQIVFEDSGCTDQPRYSDSESTQSDTSKSSKNSST----PSSAPCMEGHWRETSSHHATDPSQTPTTT
..|.|.||.....|......|.|......|....|.||||.|.|......|.||.........|..|    .||..|||..|..||.|............
MMDFSKDNKEEHTFFDCPSEASDYYSGSFSNNSSIIFEDSSCEDNKPKEYSMSTKQHQQQQCQNQQTNQKCSSSKSCMENNWLLTSHHNNNNNNNNNNNN

SLAVMK--VQKIYLYIQMQLCRKETLKDWLST--NTLSRDRNKVLHIFHQILEAVNYIHGCGMIHRDLKPSNIFFSVDGK--------------------
....|.  ...||.|||||||||||||||...  .. ||.....||.||||.|.|||||..|||||||||||||||.|..                    
KNWKMHPTGNCIYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDG

----IKVGDFGLVT--------------------------------------------------------------------------------------
    ||.|||||||                                                                                      
GHQIIKIGDFGLVTDHTIVTPTPTPTPNNTPSTTPINTHITPIDQIININQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTITTISVSPSKPSSIS

------------------------AIDTSMEGAEDSVDGAAGHLHTGRVGTQLYMCPEQVSGQ----------------NYDHKVDIFSLGLIFFELFHP
                        |||..||...........| ||..|||.|||.|||...|                .|.|||||.|||||||||.||
TPPISSMQHQHQQQPCPIQTTSPTAIDQQMEWCTPQMSMPSCHRHTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHP

-FSTQMERITVMCKAKRQDFPKRFTKELPLEAKFAKWLLSHDPDLRPDTDEISESDSD
 ||||||||..||.......||.||...| |..|.....|..|| ||..|.||..|..
GFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNPDERPTADQISMHDFF
Kinase PEK.AA PEK 556-1081 27 1.4e-226 759.05 In-house 1-655 (655) Show / Hide 
Range on Protein: 556-1081
Range on HMM: 1-655/655
Sequence Identity: 27% (188 aa)

FEHTECLGKGGF-GIVFRAKNKVDENNYAVKRITLPNRE----------------EARDKVLREARTLAILDHSGIVRYFNSWLEEPPLGWQDIQDKKFV
||. .||||||| |.|....||.|...||.|||.|....                ....|||||..|||.|.| .||||.|.|.|.|. .||. ||... 
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

GESSLGGNDGLTSLDTPAFFNKNSELIRNHDQLMQQTGGRSSMGP--SYVPFSKTRESPILKFDLSDDSNVSSEGRVDQKGDNKRAGVESDILFPGAVCE
..||.. ..|.. ......|. ..| .. .|  ..|.....|. .  .. ...|...|.. ... .. ...|.| ......|......            
LDSSTDWPNGKH-KSKDYNFH-PFEKEW-DD-EEAQESNVMSE-CEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPN------------

FEESGSFSIVFQGTEEENSQNMSVISDTGEETPQNLATFDESISNRSTDTSLDNTMDVPFKHYANDAKDIRDLDRSESFQIVFEDSGCTDQPRYSDSEST
 .|.... |.| |||.||....|..|......... ..||.|.||....|. ....|..|... .......|.|.|........|.||.....| .|...
-IENQFS-INF-GTENENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQD

QSDTSKSSKNSST----PSSAPCMEGHW----------------RETSSHHATDPSQTPTTTSLAVMK----VQKIYLYIQMQLCRKETLKDWLSTNT--
... .. ......    .|...|||..|                ....|....  ... ...... |.     |..||||||..|.|.||.||.. |.  
DEHEQNDCQSKQCDSKNQSHKKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCP

-----------------------------------------LSRDRNKVLHIFHQILEAVNYIHGCGMIHRDLKPSNIFFSVDGK-----IKVGDFGLVT
                                         ...|.. ...||.||||..||||..|||||||||||||...||.     .|.|||||.|
VQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLAT

-----------------------AIDTSMEGAEDSVDGAAGHL----------------------HTGRVGTQLYMCPEQVSGQ-----NYDHKVDIFSL
                       |.| ...  ....   .|.                       |||.|||.|||.||| |||     .|.||||..||
NHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSL

GLIFFELFHPFSTQM-ERITVMCKAKR------QDFP-KRFTKELPLEAKFAKWLLSHDPDLRPDTDEISESDSD
|.||||...||.|.| ||...... .       .||| |.|... | .|.| .|.|||||. || ...|....  
GIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase PEK.AA GCN2 888-1082 34 1.4e-58 200.95 In-house 280-511 (511) Show / Hide 
Range on Protein: 888-1082
Range on HMM: 280-511/511
Sequence Identity: 34% (81 aa)

IYLYIQMQLCRKETLKDWLSTNTLSRDRNKVLHIFHQILEAVNYIHGCGMIHRDLKPSNIFFSVDGKIKVGDFGLVTAIDTSM-----------------
.||||||  | . ||.. .. ... .|.  .  .| ||||..||||  |||||||||||||.  .| .|.|||||.| . ..                  
HYLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHW

---------EGAEDSVDGAAGH-------LHTGRVGTQLYMCPEQVSGQNYDHKVDIFSL-GLIFFELFHP-FSTQMERITVMCKAKRQDFPKRFTK---
         .  .. .... .         |||.|||..||||||     |. |||..|| |.||||...| |.|||||. .  . . . ||. | |   
AIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVD

-ELPLEAKFAKWLLSHDPDLRPDTDEISESDSDI
 . . .... .|.|.|||. || .... ... ..
NHHKDQQDMIRWCLNHDPQKRPSAQQLLQHE-FL
Kinase PEK.AA HRI 889-1083 35 1.1e-44 154.8 In-house 393-613 (613) Show / Hide 
Range on Protein: 889-1083
Range on HMM: 393-613/613
Sequence Identity: 35% (80 aa)

YLYIQMQLCRKETLKDWLST-NTLSRDR-----------N--KVLHIFHQILEAVNYIHGCGMIHRDLKPSNIFFS-VDG---KIKVGDFGLVTAIDTSM
.|.||||||   .|.||.|  |  ||.            |   .  || ||.| ..|||. . .|||.|| ||| .  |     .|.|||||  . |   
MLHIQMQLC-ELSLWDWISERNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLACE-DILQ

E------------GAEDSVDGAAGHLHTGRVGTQLYMCPEQVSGQNYDHKVDIFSLGLIFFELFHPFSTQMERITVMCKAKRQDFPKRFTKELPLEAKFA
|              . ....     || |||| .|  |||  | .|| | | .|.|.| |||| || | ||| .|.   .    |    |  |  ||. 
EPKTPMRFRRDQDFDWTNRNPCVTQTHTSRVGTCTYASPEQLDGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQIPESLRKRCPVQAKYI

KWLLSHDPDLRPDTDEISESDSDIF
. |       ||    |    |..|
QHLTRRNASQRPSA--IQLLQSELF
Kinase PEK.AA PKR 890-1079 39 3.1e-40 140.0 In-house 96-272 (272) Show / Hide 
Range on Protein: 890-1079
Range on HMM: 96-272/272
Sequence Identity: 39% (76 aa)

LYIQMQLCRKETLKDWLSTNTLSR-DRNKVLHIFHQILEAVNYIHGCGMIHRDLKPSNIFFSVDGKIKVGDFGLVTAIDTSMEGAEDSVDGAAGHLHTGR
|.|||  | | ||  |.     .. |.  .| .. || . |.|||  ..|||||||||||   . .||.||||||||..              |   | |
LFIQMEFCDKGTLEQWMRNRRQEKVDKVLILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVDERHIKIGDFGLVTALK------------NDGKSRTRR

VGTQLYMCPEQVSGQNYDHKVDIFSLGLIFFELFHPFSTQMERITVMCKAKRQDFP-KRFTKELPLEAKFAKWLLSHDPDLRPDTDEISESD
 ||  || |||.. |.|   |||. ||||  || |   |..|.|      .  ||    | .    |    . |||. |. ||.| ||    
KGTLQYMSPEQIFSQHYGKEVDIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDNK---EKTLLQKLLSKKPKDRPNTSEILRTL
Kinase PEK.AA STE 556-1021 12 1e-37 130.74 In-house 1-261 (359) Show / Hide 
Range on Protein: 556-1021
Range on HMM: 1-261/359
Sequence Identity: 12% (66 aa)

FEHTECLGKGGFGIVFRAKNK------VDENN---------YAVKRITLPNRE----------------EARDKVLREARTLAILD--HSGIVRYFNSWL
.|. |..|||.|| |..|.|.         ..         .|.|.. | | .                | ....|.| ...  ..  |  ||.|. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EEPPLGWQDIQDKKFVGESSLGGNDGLTSLDTPAFFNKNSELIRNHDQLMQQTGGRSSMGPSYVPFSKTRESPILKFDLSDDSNVSSEGRVDQKGDNKRA
 | .                                                                                                
KEGHN-----------------------------------------------------------------------------------------------

GVESDILFPGAVCEFEESGSFSIVFQGTEEENSQNMSVISDTGEETPQNLATFDESISNRSTDTSLDNTMDVPFKHYANDAKDIRDLDRSESFQIVFEDS
                                                                                                    
----------------------------------------------------------------------------------------------------

GCTDQPRYSDSESTQSDTSKSSKNSSTPSSAPCMEGHWRETSSHHATDPSQTPTTTSLAVMKVQKI--YLYIQMQLCRKETLKDWLSTN-----TLSRDR
                                                               .|   .|.| | ..   .| | . ..     .|.  |
---------------------------------------------------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNR

-------NKVL-HIFHQILEA-VNYIHGCGMIHRDLKPSNIFFSVDGKIKVGDFGLVTAIDTSM-EGAEDSVDGAAGHL-----HTG-----RVGTQLYM
        ... .| .|||..  .|.|  . ||||.||.||..     .|  |||. . .. || .. . |    ..        ..      |||. .|
QHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANI-Q-S----NN-IIDCIETMQQKRNTFVGTP-WM

CPEQVSG------QNYDHKVDIFSLGLIFFEL
 || ...      . || |.|| |||.   |.
APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase PEK.AA Pkinase 889-1078 26 1.9e-36 129.95 Pfam 74-290 (293) Show / Hide 
Range on Protein: 889-1078
Range on HMM: 74-290/293
Sequence Identity: 26% (60 aa)

YLYIQMQLCRKE----TLKDWLS---TNTLSRDRNKVLHIFHQILEAVNYIHGCGMIHRDLKPSNIFFSVDGKI----KVGDFGLVTAIDTSMEGAEDSV
..|. | .|..      |.|..|    .... . . . ... |||....|.| .| |||||||.||... .| |    |..||||   .|          
HIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------

DGAAGHLHTGRVGTQLYMCPEQVS-GQNYDHKVDIFSLGLIFFELFH---PFSTQ-----MERITVMCKAKRQDFPKRFTKELP----------------
    ..  |...||  || || .  || |..|||..|.|.|..|..    ||. .     .. . ..|. .. ...  . .. .                
-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFH

---LEAK-FAKWLLSHDPDLRPDTDEISES
    |.| | ||.|  ||  ||  ..| ..
NWSEECKDFIKWCLCKDPKKRPTAEQILQH
Kinase PEK.AA S_TKc 556-1083 13 7.3e-36 126.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 556-1083
Range on HMM: 1-231/231
Sequence Identity: 13% (71 aa)

FEHTECLGKGGFGIVFRAKNKVDENNYAVKRITLPNREEARDKVLREARTLAILDHSGIVRYFNSWLEEPPLGWQDIQDKKFVGESSLGGNDGLTSLDTP
.|  . .|||.|| |.....| .   .|.|.|                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

AFFNKNSELIRNHDQLMQQTGGRSSMGPSYVPFSKTRESPILKFDLSDDSNVSSEGRVDQKGDNKRAGVESDILFPGAVCEFEESGSFSIVFQGTEEENS
                                                                                                    
----------------------------------------------------------------------------------------------------

QNMSVISDTGEETPQNLATFDESISNRSTDTSLDNTMDVPFKHYANDAKDIRDLDRSESFQIVFEDSGCTDQPRYSDSESTQSDTSKSSKNSSTPSSAPC
                                                                                                    
----------------------------------------------------------------------------------------------------

MEGHWRETSSHHATDPSQTPTTTSLAVMKVQKIYLYIQMQLCRK--ETLKDWLSTNTLS-----RDRNKVLHIFHQILEAVNYIHGCGMIHRDLKPSNIF
 |  .|| . ..          . . |.     .||. | .|     .|.| .  .         .   . ....||..|..|.|  | |||||||.||.
-EHIRREIQILKK---HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENIL

FSVDGKIKVGDFGLVTAIDTSMEGAEDSVDGAAGHLHTGRVGTQLYMCPEQVSGQNYDH-KVDIFSLGLIFFELFH---PFSTQMERITVMCKAKRQDFP
..    ||..|||| . .                   |  .||  || || .    |.. |.|. |.| |..|..    ||. ||...  ...       
LDE--HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------

KRFTKELPLEAK-FAKWLLSHDPDLRPDTDEISESD-----SDIF
       . ||| | . .|  ||. ||   |. ...        |
-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PEK.AA Ciliate-E2 886-1021 25 2.9e-34 115.03 In-house 105-289 (365) Show / Hide 
Range on Protein: 886-1021
Range on HMM: 105-289/365
Sequence Identity: 25% (48 aa)

QKIYLYIQMQLCRKETLKDWLSTNTLSR----------DRNKVLHIFHQILE---------------AVNYIHGCG-MIHRDLKPSNIFFSVDGKIKVGD
.. ..|. | .|   .|.|..  | ..|          . .....|. |||.               |..|.|  .  ||||.||.||.|     ||. |
DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIID

FGLVTAIDTS---------MEGAEDSV---DGAAG--------HLHTGRVGTQLYMCPEQVSGQN---------YDHKVDIFSLGLIFFEL
||| . .|..         ..   .     ..  |        ...   .||  ||.|| ..|..         ||.|.||.||| |..|.
FGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase PEK.AA STE-Unique 890-1031 26 2.4e-25 86.59 In-house 369-556 (616) Show / Hide 
Range on Protein: 890-1031
Range on HMM: 369-556/616
Sequence Identity: 26% (51 aa)

LYIQMQLCRKETLKDWLSTNTLS--------RDRNKVLHIFHQILEAVNYIHGCG--MIHRDLKPSNIFFSVDG-----KIKVGDFGLVTAIDTSMEGAE
..|.| .| . ||.. .  .                |. .  ||||. .|.|  .   |||||||.|||.. ||     |.|..|||.  |.  .  . |
VWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGH--ATCCQPDHFE

D-----------------SVDGAAG-----------HLHTGRVGTQLYMCPEQVSGQ-----NYDHKVDIFSLGLIFFELFHPFSTQMER
.                 | .  |               .. .||  ||||| ....      ||.||||.||| ..|..   . ....|
KDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQR
Kinase PEK.AA WEE 890-1021 26 1.6e-23 75.85 In-house 80-229 (297) Show / Hide 
Range on Protein: 890-1021
Range on HMM: 80-229/297
Sequence Identity: 26% (43 aa)

LYIQMQLCRK--ETLKDWLSTNTLSRD---RNKVLHIFHQILEAVNYIHGC-GMIHRDLKPSNIFFSVDG--------------------KIKVGDFGLV
.|||| .|..    | .|.. .. . .    ... .|. .|......||   ||.| |.||.|||.| ..                    ..| ||||.|
MYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHV

TAIDTSMEGAEDSVDGAAGHLHTGRV---GTQLYMCPEQVSG--QNYDH-KVDIFSLGLIFFEL
| ...                .   .   | . || || ..|  .. .. | ||||||. ..||
TDMNS--------------NNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYEL
Kinase PEK.AA PEK-Unclassified 986-1079 33 2.8e-23 77.77 In-house 731-835 (835) Show / Hide 
Range on Protein: 986-1079
Range on HMM: 731-835/835
Sequence Identity: 33% (35 aa)

TGRVGTQLYMCPEQV-----------SGQNYDHKVDIFSLGLIFFELFHPFSTQMERITVMCKAKRQDFPKRFTKELPLEAKFAKWLLSHDPDLRPDTDE
|  .|| .|  .||             . .|.|. ||.|.| |||..||.. | ||| . . . |. . || |    |  |   |  || ||  ||    
TSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQMFHQMNTTMERVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRPLLSK

ISESD
|    
IEQTL
Kinase PEK.AA GCN2 556-627 36 3.4e-23 77.76 In-house 1-79 (511) Show / Hide 
Range on Protein: 556-627
Range on HMM: 1-79/511
Sequence Identity: 36% (29 aa)

FEHTECLGKGGFGIVFR-AKNKVDENNYAVKRITLP-NREEARDK--VLREARTLAILDHSGIVRYFNSWLE---EPPL
||  .|||||||| |   ..|..|...||.|.. .. . .. . |   .||. .|..| |...|||...|.|   ||..
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMV
Kinase PEK.AA PEK-Unclassified 556-624 33 3.6e-22 73.78 In-house 1-75 (835) Show / Hide 
Range on Protein: 556-624
Range on HMM: 1-75/835
Sequence Identity: 33% (25 aa)

FEHTECLGKGGFGIVFRAKNKVDENNYAVKRITLP------NREEARDKVLREARTLAILDHSGIVRYFNSWLEE
|     .|.|||.||..  .|.|.  ||||.| .             .| ..|.| .| . |  |.||. || |.
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIEV
Kinase PEK.AA HRI 556-624 41 3.2e-21 71.03 In-house 1-70 (613) Show / Hide 
Range on Protein: 556-624
Range on HMM: 1-70/613
Sequence Identity: 41% (29 aa)

FEHTECLGKGGFGIVFRAKNKVDENNYAVKRITLPNREEAR-DKVLREARTLAILDHSGIVRYFNSWLEE
||  | .||||.| |.. ..| |   ||.|.|    |      |..|| ..|| |.|  ||||  .|.|.
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIEH
Kinase PEK.AA WEE 556-623 31 3.1e-17 54.44 In-house 1-76 (297) Show / Hide 
Range on Protein: 556-623
Range on HMM: 1-76/297
Sequence Identity: 31% (24 aa)

FEHTECLGKGGFGIVFRAKNKVDENNYAVKRITLPNREEA-RDKVLREARTLAILD-------HSGIVRYFNSWLE
|.  . .|.| || |. .....| . ||.|..  | |..  |.  |||.. .. |        |  ||||...| |
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEE
Kinase PEK.AA PEK-Unclassified 912-967 41 1e-14 46.99 In-house 609-666 (835) Show / Hide 
Range on Protein: 912-967
Range on HMM: 609-666/835
Sequence Identity: 41% (24 aa)

SRDRNKVLHIFHQILEAVNYIHGCG-MIHRDLKPSNIFFSVD-GKIKVGDFGLVTAID
. .      |  ||. |  .||  . |.|||.|| |||       ||.||||||. |.
FEYKQQCREITRQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVKKIE
Kinase PEK.AA STE-Unique 557-624 27 1.6e-14 47.5 In-house 1-73 (616) Show / Hide 
Range on Protein: 557-624
Range on HMM: 1-73/616
Sequence Identity: 27% (20 aa)

EHTECLGKGGFGIVFRAKNKVDENNYAVKRITLPNREEAR-----DKVLREARTLAILDHSGIVRYFNSWLEE
.. . .|.|.|| |....||.| ...|.| | | ..   .      . ..|  ... | |..||.|  .||..
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWG
Kinase PEK.AA PKR 556-621 42 3.1e-14 47.28 In-house 1-61 (272) Show / Hide 
Range on Protein: 556-621
Range on HMM: 1-61/272
Sequence Identity: 42% (28 aa)

FEHTECLGKGGFGIVFRAKNKVDENNYAVKRITLPNREEARDKVLREARTLAILDHSGIVRYFNSW
|.  | .| |||| ||.|| ..|   |..||.   | | |     .| . || |||  ||.|   |
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKY-NNEKAE----HEVQALAKLDHVNIVHYHSCW
Kinase PEK.AA Pkinase 556-625 24 9.5e-11 39.09 Pfam 1-73 (293) Show / Hide 
Range on Protein: 556-625
Range on HMM: 1-73/293
Sequence Identity: 24% (18 aa)

FEHTECLGKGGFGIVFRAKNKVDENNYAVKRITLPNREEARDKVLR---EARTLAILDHSGIVRYFNSWLEEP
..  ...|.|.|| |.....| ..  .|||.| ......  |. .|   |.. .. |.|  |||.. .. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKD
Kinase PEK.AA TyrKc 556-1083 11 2.5e-09 -71.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 556-1083
Range on HMM: 1-280/280
Sequence Identity: 11% (63 aa)

FEHTECLGKGGFGIVFRAKNKVDENNYAVKRITLPNREEARDKVLREARTLAIL--DHSGIVRYFNSWLE--------EPPLGWQDIQD----KKFVGES
 .  . || | ||.|.... |    . ||| .        |   .|||| .  |  .|  ||| .   ..        ||..      .    |..  ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

SLGGNDGLTSLDTPAFFNKNSELIRNHDQLMQQTGGRSSMGPSYVPFSKTRESPILKFDLSDDSNVSSEGRVDQKGDNKRAGVESDILFPGAVCEFEESG
                                                                                                    
RPK-------------------------------------------------------------------------------------------------

SFSIVFQGTEEENSQNMSVISDTGEETPQNLATFDESISNRSTDTSLDNTMDVPFKHYANDAKDIRDLDRSESFQIVFEDSGCTDQPRYSDSESTQSDTS
                                                                                                    
----------------------------------------------------------------------------------------------------

KSSKNSSTPSSAPCMEGHWRETSSHHATDPSQTPTTTSLAVMKVQKIYLYIQMQLCRKETLKDWLSTNTLSRDRNKVLHIFHQILEAVNYIHGCGMIHRD
                                                                           . |.. .|| .  .|.|  . ||||
-----------------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRD

LKPSNIFFSVDGKIKVGDFGLVTAIDTS-MEGAEDSVDGAAGHLHTGRVGTQLYMCPEQVSGQNYDHKVDIFSLGLIFFELF----HPFSTQ----MERI
|   |.  . .. .|..||||  .|.   ..|.....  ...| ..  .     | ||      . .| |..| |   .|.|     | . .    |. .
LAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ

TVMCKAKRQDFPKRFTK---------ELPLEAKFAKWLLSHDPDLRPDTDEISESDSDIF
 |. . |. . ...               .     |.   .||. ||   ||     ..|
EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI----HECF
Kinase PEK.AA Ciliate-E2 556-621 16 1.2e-08 25.81 In-house 1-101 (365) Show / Hide 
Range on Protein: 556-621
Range on HMM: 1-101/365
Sequence Identity: 16% (17 aa)

FEHTECLGKGGFGIVFRAKN-----------------------KVDENNYAVKRI--TLPNREEARDKVLREAR----------TLAILDHSGIVRYFNS
..  ...|.|.||.|...|.                       ||. . ||.|..     .  .  ....|| .           | .|.|  |.... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

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