Gene HRI (Sea Urchin)

HRI

Species: Sea Urchin
Alias: Spk184, HRI, SPU_009270
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: HRI

Sequence

Name Sequence Type Origin Length Description Download
HRI.AA Protein None 799 None Fasta, JSON
HRI.kin_dom Protein Kinase Domain None 549 None Fasta, JSON

Protein domain

Protein domains of HRI.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase HRI.AA HRI 152-760 74 0.0 1622.04 In-house 1-613 (613) Show / Hide 
Range on Protein: 152-760
Range on HMM: 1-613/613
Sequence Identity: 74% (454 aa)

FIQKEPIGEGGFGKVYKVQHKLDKEHYAIKKIKVTKRKSCSLQSMQREIKTLACLDHHNIVRYHQSWFGEEVQLLSQQRLMLGLGSFTDMGNGFEGEEDD
|.|||.||.||.|.||||.|||||.||||||||..||..||...||||.|.||||.|||||||||.|.....|...|||||||||||||||||||||||.
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIEHVHQIQPQQRLMLGLGSFTDMGNGFEGEEDR

EEEEEEEEEVEEEEEEGEEQEGTEKDEEDSFYEKSKNIYSCQENESISKLGSTSPIITELVETRSERHSQQTSMTVSMNPAETDPFDSNFTVSFEDERFD
||.||.|||||||.||..||.|..||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
EEIEEPEEEVEEEQEEDREQCGVKKDEEDSFYEKSKNIYSCQENESISKLGSTSPIITELVETRSERHSQQTSMTVSMNPAETDPFDSNFTVSFEDERFD

SGELVNKFFSQTSDNVDNIRPLAFNKKEEEFDGISDSLDSSGTSGSTIIFQNVDSDAKDCDEFNLPSLKEQNSSEFEFVRQSQRTEKHIGTSSKSDSYEK
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||..||||.||.|||.|.|.|..||||
SGELVNKFFSQTSDNVDNIRPLAFNKKEEEFDGISDSLDSSGTSGSTIIFQNVDSDAKDCDEFNLPSLKEQNSSEIIFVRQTQRKEKHFGESDKKNSYEK

IKITATTKSKKIVKSTLIPVTSATAALLSTITSSLSSSTRIHNRIRTAPFHSQQPIRNGKFRRSISWDGQESSPEVESGYWPRSRPSFKRHYYLYIQMEL
||||||||..||||.|..||....|.|.|||.......||||||||||.||.|||||..|.||||.||.|||||||||.||||....||.||.|.|||.|
IKITATTKNNKIVKYTTNPVIRNSAELESTIELQENGLTRIHNRIRTAIFHHQQPIRHNKHRRSIFWDTQESSPEVESNYWPRGQTEFKYHYMLHIQMQL

CSSTLRTWLSERNEK----ISKTENPFDVGNEKEIQNFFGQILEGMNYIHGRFILHRDVTPKNIFLSDKDDGHPLVKIGDFGLAREDVLTEPKTPMRFRR
|...|..|.||||..    ...||.|....|||.||..|.||.|||.|||..||.||||.|.||||.|.|.|||.|||||||||.||.|.||||||||||
CELSLWDWISERNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLACEDILQEPKTPMRFRR

DQDFDESSVDPCVSQTYTSGIGTETYAAPEQLDGTTYDNKSDMYSMGLILFELYHPFGTGMERHKCLQKLRKGNIPEELQKRWPVQHSAIQCLTRQDSQE
|||||.....|||.||.||..||.|||.||||||..|||||||||||.|||||. |||| ||| . |  .| | ||| |.|| |||   || |||  .  
DQDFDWTNRNPCVTQTHTSRVGTCTYASPEQLDGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQIPESLRKRCPVQAKYIQHLTRRNASQ

RPSASDLLSGDMF
||||  ||  ..|
RPSAIQLLQSELF
Kinase HRI.AA PEK 152-760 28 2.2e-235 788.27 In-house 1-655 (655) Show / Hide 
Range on Protein: 152-760
Range on HMM: 1-655/655
Sequence Identity: 28% (195 aa)

FIQKEPIGEGGF-GKVYKVQHKLDKEHYAIKKIKVTKRK---------------SCSLQSMQREIKTLACLDHHNIVRYHQSWFG-EEVQLLSQQRLMLG
|.... .| ||| | |||||.|||...||||.||. ...               ........||.||||.|.|.||||||..|.. .|.. ..||. |..
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

LGSFTDMGNG-----------FEGEEDDEEEEEEEEEVEEEEEEGEEQEGTEKDEEDSFYEKSKNIYSCQENESISKLGSTSP---------IITELVET
|.|.||..||           ||.|. |. ||..|..|..| .|..||.|..|....|....|||.|......|.|.....|.         |.. ..|.
LDSSTDWPNGKHKSKDYNFHPFEKEW-DD-EEAQESNVMSE-CEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINF-GTEN

RSERHSQQTSMTVSMNPAETDPFDSNFTVSFEDERFDSGELVNKFFSQTSDNVDNIRPLAFNKKEEEFDGISDSLDSSGTSGSTIIFQNVDSDAKDCDEF
..|.|....|..|.|......||||.|..|.....|...|....|............. .........||..|.......| ..  ....|.. |.||..
ENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSK

NLPSLKEQNSSEFEFVRQSQ-RTEKHIGTSSKSDSYEKIKITATTKSKKIVKSTLIPVTSATAALLSTITSSLSSSTRIHNRIRTAPFHSQQPIRNGKFR
| .. |.............. ....|||.||.|....... . .....|  ..|..                          .... .. |.   ..|..
NQSHKKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQ--------------------------YQCHYLYIQMEYCEKKTL

RSISWDGQESSPEVESGYWPRSRPSFKRHYYLYIQMELCSSTLRTWLSERNEKISKTENPFDVGNEKEIQNFFGQILEGMNYIHGRFILHRDVTPKNIFL
|....... . | |...|| | |.|.|.||..| .|..| ....||.. .. ... .||...  ........| |||||.||||.. . ||| .|.||||
RDWIDNNG-C-P-VQFNYW-R-RNSCKNHYNNY-IMNQC-CFQSTWSM-NM-RQW-DENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFL

SDKDDGHP-LVKIGDFGLAREDV--------------------LTEPKTPMRFRRDQDFD---------------ESSVDPCVSQTYTSGIGTETYAAPE
......|. .||||||||| ...                    ...... ..........               .| ...|.....|.|.|| .|..||
DCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTS-MFYCEHCHHTGGVGTCLYMSPE

QLDGT-----TYDNKSDMYSMGLILFELYHPFGTGM-ERHKCLQKLRK------GNIP-EELQKRWPVQHSAIQCLTRQDSQERPSASDLLSGDMF
||.|.      |..|.||||.|.|.||...|| | | || | |..||.      | .| . .... |.|.. || ..  | |.||||...|. . |
QLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase HRI.AA GCN2 544-760 32 2.2e-43 149.66 In-house 281-511 (511) Show / Hide 
Range on Protein: 544-760
Range on HMM: 281-511/511
Sequence Identity: 32% (80 aa)

YLYIQMELCS-STLRTWLSERNEKISKTENPFDVGNEKEIQNFFGQILEGMNYIHGRFILHRDVTPKNIFLSDKDDGHPLVKIGDFGLARE---------
||||||| |. .|||. ... .  . ..          |.   | |||||.||||   . |||  | ||||   ..    |||||||||           
YLYIQMEYCEGKTLRQYIDNHGWCMDHD----------ELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGN----VKIGDFGLATNNKMESQINR

-------------DVLTEPKTPMRFRRDQDFDESSVDPCVSQTYTSGIGTETYAAPEQLDGTTYDNKSDMYSM-GLILFELYHP-FGTGMERHKCLQKLR
               . | . .  |.  |.   ..  .  ....|...||  | .|||.    |. | ||||  |.|.||. .| | |.||| . | .||
KQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR

KGNIPEELQK----RWPVQHSAIQCLTRQDSQERPSASDLLSGDMF
. ..|. ..|    . . | . |. ..  |.|.||||..|| ..  
SCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase HRI.AA PEK 661-760 32 2.1e-34 111.47 In-house 642-758 (758) Show / Hide 
Range on Protein: 661-760
Range on HMM: 642-758/758
Sequence Identity: 32% (38 aa)

SQTYTSGIGTETYAAPEQLDGT----------------TYDNKSDMYSMGLILFELYHP-FGTGMERHKCLQKLRKGNIPEELQKRWPVQHSAIQCLTRQ
... | . || .|..|||. ..                 |..| | || |||.|||.|| | | ||| . . .||.| .|  ...  | ..  || ..  
CHRHTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSM

DSQERPSASDLLSGDMF
.  |||.|..... |.|
NPDERPTADQISMHDFF
Kinase HRI.AA Pkinase 538-701 28 1.4e-30 109.22 Pfam 68-206 (293) Show / Hide 
Range on Protein: 538-701
Range on HMM: 68-206/293
Sequence Identity: 28% (49 aa)

SFKRHYYLYIQMELCSS-----TLRTWLSERNEKISKTENPFDVGNEKEIQNFFGQILEGMNYIHGRFILHRDVTPKNIFLSDKDDGHPLVKIGDFGLAR
.| .. ..|. ||.|        | ...|       . ...|  . |.|..... |||.|..|.| . |.|||. | ||.......  . |||.|||||.
WFEDKDHIYMVMEYCEGGLYVMDLFDYIST------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK

E-DVLTEPKTPMRFRRDQDFDESSVDPCVSQTYTSGIGTETYAAPEQLD-GTTYDNKSDMYSMGLILFELY
  |                          .. .|.  ||  |.||| .  |. |. |.||.|.|.||.|..
QFD-----------------------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML
Kinase HRI.AA Ciliate-E2 538-760 19 3e-30 101.04 In-house 100-365 (365) Show / Hide 
Range on Protein: 538-760
Range on HMM: 100-365/365
Sequence Identity: 19% (57 aa)

SFK--RHYYLYIQMELCSS-TLRTWLSERNEKISKT--ENPFDVGNEKEIQNFFGQILE---------------GMNYIHGRF-ILHRDVTPKNIFLSDK
.|.     ..|. ||.|.  .|. .. ... |  .   .      .||||.... |||.               ...|.| .  |.|||  | ||..   
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

DDGHPLVKIGDFGLAREDVLTEPKTPMRFRRDQDFDESSVDPCVSQTYTSGI-----------GTETYAAPEQLDGTT---------YDNKSDMYSMGLI
      .|| ||||...    . .. . ... . . . ..|  ....| . .           ||  | ||| | |           || |.|..|.| |
------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMD-QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVI

LFEL---YHPFGTGMERHKCLQKLRKGNIP------------EELQKRW----PVQHSAIQCLTR-------QDSQERPS-ASDLLSGDMF
|.|.   ..||         .|.  ...|             . . . |     .  .... . .        | ..|.. ....|    |
LYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase HRI.AA S_TKc 152-760 11 8e-27 96.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 152-760
Range on HMM: 1-231/231
Sequence Identity: 11% (75 aa)

FIQKEPIGEGGFGKVYKVQHKLDKEHYAIKKIKVTKRKSCSLQSMQREIKTLACLDHHNIVRYHQSWFGEEVQLLSQQRLMLGLGSFTDMGNGFEGEEDD
.   ..||.|.||||||..|| .....|||.||                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

EEEEEEEEEVEEEEEEGEEQEGTEKDEEDSFYEKSKNIYSCQENESISKLGSTSPIITELVETRSERHSQQTSMTVSMNPAETDPFDSNFTVSFEDERFD
                                                                                                    
----------------------------------------------------------------------------------------------------

SGELVNKFFSQTSDNVDNIRPLAFNKKEEEFDGISDSLDSSGTSGSTIIFQNVDSDAKDCDEFNLPSLKEQNSSEFEFVRQSQRTEKHIGTSSKSDSYEK
                                                                                                    
----------------------------------------------------------------------------------------------------

IKITATTKSKKIVKSTLIPVTSATAALLSTITSSLSSSTRIHNRIRTAPFHSQQPIRNGKFRRSISWDGQESSPEVESGYWPRSRPSFKRHYYLYIQMEL
                                                           ..|| |.   .         .  .   .|    .||. ||.
----------------------------------------------------------EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEY

CSS---TLRTWLSERNEK-----ISKTENPFDVGNEKEIQNFFGQILEGMNYIHGRFILHRDVTPKNIFLSDKDDGHPLVKIGDFGLAREDVLTEPKTPM
|.    .|.. . .|. .     ..          | ... .. ||.....|.| . |.|||. | ||.|..       .||.||||||.          
CDGDLGDLFDYIKKRGRHGLRFPFP----------E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL---------

RFRRDQDFDESSVDPCVSQTYTSGIGTETYAAPEQLDGTTYDN-KSDMYSMGLILFELYH---PFGTGMERHKCLQKLRKGNIPEELQKRWPVQHSAIQC
                     |. .||  | ||| |    |.  |.|..| | ||.|..    ||    . .. ..|..            |   . |. 
---------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRK

LTRQDSQERPSASDLLS-------GDMF
. . | ..||.| ..|           |
CLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HRI.AA PEK 152-218 39 1.4e-26 84.75 In-house 1-74 (758) Show / Hide 
Range on Protein: 152-218
Range on HMM: 1-74/758
Sequence Identity: 39% (29 aa)

FIQKEPIGEGGFGKVYKVQHKLDKEHYAIKKIKVTK-------RKSCSLQSMQREIKTLACLDHHNIVRYHQSW
|  .. .| |||| |.... |.| . ||||.| .          .. ...   || .||| |||||||||. .|
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAW
Kinase HRI.AA CAMK 536-698 19 1.2e-23 72.44 In-house 117-325 (425) Show / Hide 
Range on Protein: 536-698
Range on HMM: 117-325/425
Sequence Identity: 19% (49 aa)

RPSF---------KRHYYLYI-QMELCSST-----LRTWLSER------NEKISKTENPFDV--------GNEKEIQNFFGQILEGMNYIHGRFILHRDV
.. .         ..|.|.   .||.||       |  .. |.      .          |.         .|.| . .| ||.....|.| . | ||| 
ND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF----------DQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDL

TPKNIFLSDKDDGHP-------------LVKIGDFGLA--RED------------------VLTEPKTPMRFRRDQDFDESSVDPCVSQTYTSG------
 | || |.|..|. .              .|| |||.|   ..                  .                             |..      
KPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQW-----------------------------TTPTEGQKM

---IGTETYAA-PEQLDG--------------TTYDNKSDMYSMGLILF
    ||  |.| || | |              . |. |.|| |.| ||.
KTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY
Kinase HRI.AA PEK 543-631 33 2.5e-23 73.7 In-house 412-513 (758) Show / Hide 
Range on Protein: 543-631
Range on HMM: 412-513/758
Sequence Identity: 33% (37 aa)

YYLYIQMELCSS-TLRTWLSERNEKISKTENPFDVGNEKEIQNFFGQILEGMNYIHGRFILHRDVTPKNIFLSDKDD--------------------GHP
.|.||||.|| . ||. |.. |         ...  .. .. . | ||.|| ||||.  . |||  | |||.|  ..                    || 
IYMYIQMQLCRKETLKDWMRNR--------CTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQ

LVKIGDFGLA
..|||||||.
IIKIGDFGLV
Kinase HRI.AA PEK-Unclassified 665-758 30 6.9e-21 69.18 In-house 731-835 (835) Show / Hide 
Range on Protein: 665-758
Range on HMM: 731-835/835
Sequence Identity: 30% (32 aa)

TSGIGTETYAAPEQL-----------DGTTYDNKSDMYSMGLILFELYHPFGTGMERHKCLQKLRKGNIPEELQKRWPVQHSAIQCLTRQDSQERPSASD
|| .|| ||. .||.            .  |. . |.||.| |.|.. |.. | ||| | .|...|| .|     ..|     |.     | | ||  | 
TSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQMFHQMNTTMERVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRPLLSK

LLSGD
.    
IEQTL
Kinase HRI.AA NEK 579-633 40 1.7e-19 65.63 In-house 113-172 (286) Show / Hide 
Range on Protein: 579-633
Range on HMM: 113-172/286
Sequence Identity: 40% (24 aa)

EKEIQNFFGQILEGMNYIHGR-----FILHRDVTPKNIFLSDKDDGHPLVKIGDFGLARE
|..| ..| |.. ...|.| |      |||||  |.||||.... . ..|||||||....
EEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKV
Kinase HRI.AA NEK1 579-632 43 2.7e-19 63.7 In-house 103-169 (276) Show / Hide 
Range on Protein: 579-632
Range on HMM: 103-169/276
Sequence Identity: 43% (29 aa)

EKEIQNFFGQILEGMNYIHGRFILHRDVTPKNIFLS--DKD-----------DGHPLVKIGDFGLAR
| .| ..| ||  ..|.|| | |||||  ..||||.  ...           |  ||||.|||| ||
EDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIAR
Kinase HRI.AA NEK 152-226 37 4.2e-19 64.24 In-house 1-81 (286) Show / Hide 
Range on Protein: 152-226
Range on HMM: 1-81/286
Sequence Identity: 37% (30 aa)

FIQKEPIGEGGFGKVYKVQHKLDKEH-----YAIKKIKVTKRKSCSLQSMQ-REIKTLACLDHHNIVRYHQSWFGEEVQLL
.   . ||.| |||||||..| |. |     |..|||.... ..   |  |  |.. |. |.| |||.|. |.. |. . |
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCL
Kinase HRI.AA CAMK 157-216 20 5.8e-18 53.8 In-house 1-105 (425) Show / Hide 
Range on Protein: 157-216
Range on HMM: 1-105/425
Sequence Identity: 20% (22 aa)

PIGEGGFGKVYKVQHKLDK------------EHYAIKKIKVTKRK--------------------------SCSLQSMQREIKTLAC-------LDHHNI
 .|.|.||||....||...            ...||| |. .| |                           .......|||. .         ||| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYHQ
.. ..
IKLYE
Kinase HRI.AA PEK-Unclassified 152-229 38 1.1e-17 57.63 In-house 1-83 (835) Show / Hide 
Range on Protein: 152-229
Range on HMM: 1-83/835
Sequence Identity: 38% (32 aa)

FIQKEPIGEGGFGKVYKVQHKLDKEHYAIKKIKVT-KRKSCSLQSMQ----REIKTLACLDHHNIVRYHQSWFGEEVQLLSQQ
|.|   || |||. ||.. ||.|   ||.|.|.|  |     ||       .|.  .| . | ||.||  ||  .|.   ||.
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIEVEIKKNSQK
Kinase HRI.AA Pkinase 152-218 37 1.4e-17 63.27 Pfam 1-69 (293) Show / Hide 
Range on Protein: 152-218
Range on HMM: 1-69/293
Sequence Identity: 37% (26 aa)

FIQKEPIGEGGFGKVYKVQHKLDKEHYAIKKIKVTKRKSCSLQSMQR--EIKTLACLDHHNIVRYHQSW
.  ...||.|.||.||| .|| . . .|.|.||. ..||. .|.  |  ||. .. |.| ||||.. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWF
Kinase HRI.AA GCN2 152-218 40 5.4e-17 55.68 In-house 1-70 (511) Show / Hide 
Range on Protein: 152-218
Range on HMM: 1-70/511
Sequence Identity: 40% (28 aa)

FIQKEPIGEGGFGKVYK-VQHKLDKEHYAIKKIKV--TKRKSCSLQSMQREIKTLACLDHHNIVRYHQSW
|   . .| ||||.|.| |. ..|   |||||...  ..||   . .. || |.|. | | ..|||.|.|
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAW
Kinase HRI.AA NEK1 152-217 40 5.8e-17 55.52 In-house 1-66 (276) Show / Hide 
Range on Protein: 152-217
Range on HMM: 1-66/276
Sequence Identity: 40% (27 aa)

FIQKEPIGEGGFGKVYKVQHKLDKEHYAIKKIKVTKRKSCSLQSMQREIKTLACLDHHNIVRYHQS
.. .  |||| |||...|.|| |  ||.|| |.|.| ..   .   .| . || ..| |||.|  |
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKES
Kinase HRI.AA PKR 152-220 43 1.2e-16 56.0 In-house 1-63 (272) Show / Hide 
Range on Protein: 152-220
Range on HMM: 1-63/272
Sequence Identity: 43% (30 aa)

FIQKEPIGEGGFGKVYKVQHKLDKEHYAIKKIKVTKRKSCSLQSMQREIKTLACLDHHNIVRYHQSWFG
| . | || ||||.|.| .|..|   |.||..|    |        .|.. || ||| |||.||  | |
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKYNNEK------AEHEVQALAKLDHVNIVHYHSCWDG
Kinase HRI.AA PKR 545-631 40 1.4e-14 48.52 In-house 96-170 (272) Show / Hide 
Range on Protein: 545-631
Range on HMM: 96-170/272
Sequence Identity: 40% (36 aa)

LYIQMELCS-STLRTWLSERN-EKISKTENPFDVGNEKEIQNFFGQILEGMNYIHGRFILHRDVTPKNIFLSDKDDGHPLVKIGDFGLA
|.|||| |   ||  |. .|. ||. |            | . . || .|..||| . ..|||. | |||| |.      .|||||||.
LFIQMEFCDKGTLEQWMRNRRQEKVDKV----------LILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVDERH----IKIGDFGLV
Kinase HRI.AA Ciliate-E2 152-215 20 4.8e-11 34.15 In-house 1-98 (365) Show / Hide 
Range on Protein: 152-215
Range on HMM: 1-98/365
Sequence Identity: 20% (20 aa)

FIQKEPIGEGGFGKVYKVQHKLDKEHYAIK---------------KIKVTKRKSCS---LQSMQREIKTLACLD----------------HHNIVRYH
..  . ||.|.||.|||........ .|||               |||    |. .   .... .||. . ...                | ||....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY
Kinase HRI.AA PEK-Unclassified 588-632 39 1e-10 32.67 In-house 621-663 (835) Show / Hide 
Range on Protein: 588-632
Range on HMM: 621-663/835
Sequence Identity: 39% (18 aa)

QILEGMNYIHGRF-ILHRDVTPKNIFLSDKDDGHPLVKIGDFGLAR
||. .. .||    . |||..| |||. .   .   .|||||||..
QIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQ---IKIGDFGLVK
Kinase HRI.AA PKR 669-758 31 2.3e-10 33.19 In-house 185-272 (272) Show / Hide 
Range on Protein: 669-758
Range on HMM: 185-272/272
Sequence Identity: 31% (28 aa)

GTETYAAPEQLDGTTYDNKSDMYSMGLILFELYHPFGTGMERHKCLQKLRKGNIPEELQKRWPVQHSAIQCLTRQDSQERPSASDLLSGD
||  | .|||.    |    |.| .|||| || |   | .|. |  . ||.| . ...  .     . .| |  .  ..||  |..|   
GTLQYMSPEQIFSQHYGKEVDIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDN--KEKTLLQKLLSKKPKDRPNTSEILRTL
Kinase HRI.AA TyrKc 152-760 10 7.9e-10 -63.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 152-760
Range on HMM: 1-280/280
Sequence Identity: 10% (65 aa)

FIQKEPIGEGGFGKVYKVQHKLDKEHYAIKKIKVTKRKSCSLQSMQREIKTLACL--DHHNIVRYHQSWFGE-------EVQLLSQQRLMLG-LGSFT-D
   .. .||| ||.||| . |   .  |.|..|  .     .. . ||.. .  |  .| |||| .     .       |  ..      .| | ..  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MGNGFEGEEDDEEEEEEEEEVEEEEEEGEEQEGTEKDEEDSFYEKSKNIYSCQENESISKLGSTSPIITELVETRSERHSQQTSMTVSMNPAETDPFDSN
 ..                                                                                                 
HRPK------------------------------------------------------------------------------------------------

FTVSFEDERFDSGELVNKFFSQTSDNVDNIRPLAFNKKEEEFDGISDSLDSSGTSGSTIIFQNVDSDAKDCDEFNLPSLKEQNSSEFEFVRQSQRTEKHI
                                                                                                    
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GTSSKSDSYEKIKITATTKSKKIVKSTLIPVTSATAALLSTITSSLSSSTRIHNRIRTAPFHSQQPIRNGKFRRSISWDGQESSPEVESGYWPRSRPSFK
                                                                                                    
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RHYYLYIQMELCSSTLRTWLSERNEKISKTENPFDVGNEKEIQNFFGQILEGMNYIHGRFILHRDVTPKNIFLSDKDDGHPLVKIGDFGLAREDVLT---
                                     . |.  .|  || .||.|.| . . |||    |. ....      |||.||||.|.       
------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQ

EPKTPMRFRRDQDFDESSVDPCVSQTYTS--GIGTET-----YAAPEQLDGTTYDNKSDMYSMGLILFELY----HPFGTG----MERHKCLQKLRKGNI
                       ...|..  . |. |       ||| ..  ..  ||| .| |  ..|..     |        |.    ......|. 
G--------------------ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR

PEELQK---------RWPVQHSAIQCLTRQDSQERPSASDLLSGDMF
..  .             .     ||  . |  .||. |..   . |
MPQPPNDYPMSFVCCPDEMYQIMKQCW-HEDPEDRPTFSEI--HECF
Kinase HRI.AA Pkinase_Tyr 591-632 38 5.5e-09 31.07 Pfam 122-159 (270) Show / Hide 
Range on Protein: 591-632
Range on HMM: 122-159/270
Sequence Identity: 38% (16 aa)

EGMNYIHGRFILHRDVTPKNIFLSDKDDGHPLVKIGDFGLAR
.||.| . . . |||.  .|. ...       |||.||||||
KGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLAR
Kinase HRI.AA Pkinase_Tyr 152-215 30 2e-06 22.66 Pfam 1-70 (270) Show / Hide 
Range on Protein: 152-215
Range on HMM: 1-70/270
Sequence Identity: 30% (22 aa)

FIQKEPIGEGGFGKVYKVQHK----LDKEHYAIKKIKVTKRKSCS---LQSMQREIKTLACL-DHHNIVRYH
 .  . .||| ||.|||   |     .| . |.|..|     . .   .... ||.|..  | .|.||||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK--EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase HRI.AA NEK 673-700 42 0.000133 12.58 In-house 190-217 (286) Show / Hide 
Range on Protein: 673-700
Range on HMM: 190-217/286
Sequence Identity: 42% (12 aa)

YAAPEQLDGTTYDNKSDMYSMGLILFEL
|..||.. .  |.||||. | | .|.|.
YMSPEVCQNKPYNNKSDIWSLGCVLYEM
Kinase HRI.AA NEK1 684-700 58 0.000644 9.67 In-house 198-214 (276) Show / Hide 
Range on Protein: 684-700
Range on HMM: 198-214/276
Sequence Identity: 58% (10 aa)

YDNKSDMYSMGLILFEL
|.||||. | | .| ||
YNNKSDIWSLGCVLYEL
Kinase HRI.AA PEK-Unclassified 545-567 47 0.003163 5.72 In-house 502-524 (835) Show / Hide 
Range on Protein: 545-567
Range on HMM: 502-524/835
Sequence Identity: 47% (11 aa)

LYIQMELCSSTLRTWLSERNEKI
.|||||||  |.   .  || |.
FYIQMELCHYTTARYIINRNKKL