Gene PLK1 (Sea Urchin)

PLK1

Species: Sea Urchin
Alias: PLK1, Spk187, SPU_017949
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK1

Sequence

Name Sequence Type Origin Length Description Download
PLK1.AA Protein None 587 None Fasta, JSON
PLK1.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of PLK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PLK1.AA PLK 27-279 62 3.1e-197 647.7 In-house 1-258 (258) Show / Hide 
Range on Protein: 27-279
Range on HMM: 1-258/258
Sequence Identity: 62% (162 aa)

YTKGRFLGKGGFAKCYELTDDATKQIFAGKVVSKALLVKPHQKDKMTMEIHIHKSLHHRHVVGFHSFFEDKENVYVLLELCRRRSLMELHKRR-KAITEP
|..|.||||||||||||.||..|||..|.|||.|.|..||||..||..||.||..|||...|.||.||||.||||..||.|..||||..|||| |..|||
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

ETRYFMRQCILACQYLSKTKVIHRDLKLGNLFIDDNMELKVGDFGLATKVDFSGERKKTLCGTPNYIAPEVL--SKKGHSYEVDLWSLGCIMYTLLVGKP
|.||.|.|.. ...|| . ..|||||||||||..|||..|.|||||||.... ||||||.||||||||||||  .|.||||||| |||||||||||.|||
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFETQSLKDTYQRIKRNEYRVPSH--VSTPARNLIVKLLKNDPTQRPHIDILLQDEFF
||||...|.||.||| |.|..|.|  .| .|..||.|.|...|..||.|| .||..||
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase PLK1.AA PLK1 27-279 71 7.70000000001e-178 589.44 In-house 1-253 (253) Show / Hide 
Range on Protein: 27-279
Range on HMM: 1-253/253
Sequence Identity: 71% (181 aa)

YTKGRFLGKGGFAKCYELTDDATKQIFAGKVVSKALLVKPHQKDKMTMEIHIHKSLHHRHVVGFHSFFEDKENVYVLLELCRRRSLMELHKRRKAITEPE
|.|||||||||||.|||..|..||..||||||.|.||.|.||.||||.||.||..|||||.|.||.|||||.|||..|||||||||||||||||||||||
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

TRYFMRQCILACQYLSKTKVIHRDLKLGNLFIDDNMELKVGDFGLATKVDFSGERKKTLCGTPNYIAPEVLSKKGHSYEVDLWSLGCIMYTLLVGKPPFE
.||.|.|....||||...|.|||||||||||..|....|.||||||||....|||||||||||||||||||.|||||.|||.||.|||||.||.|.||||
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFE

TQSLKDTYQRIKRNEYRVPSHVSTPARNLIVKLLKNDPTQRPHIDILLQDEFF
|..||.||.|||.||||.|||.|.||..||.|.|..|||.||.|...|.||||
TKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase PLK1.AA PLK2 27-279 52 1.8e-159 517.44 In-house 1-257 (257) Show / Hide 
Range on Protein: 27-279
Range on HMM: 1-257/257
Sequence Identity: 52% (136 aa)

YTKGRFLGKGGFAKCYELTDDATKQIFAGKVVSKALLVKPHQKDKMTMEIHIHKSLHHRHVVGFHSFFEDKENVYVLLELCRR----RSLMELHKRRKAI
|..|. |||||||.|||.||  |  ..|.|.| .    ||||  ||  || .|  |.|||.|.|| .|||..|.|.|||.|.|    .|.    | |.  
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHL

TEPETRYFMRQCILACQYLSKTKVIHRDLKLGNLFIDDNMELKVGDFGLATKVDFSGERKKTLCGTPNYIAPEVLSKKGHSYEVDLWSLGCIMYTLLVGK
|||| ||.||| .    ||   ..|||||||||.|| ||||.|.|||||| .. . .....|.||||||||||||...||| | | |.|||||||.|.| 
TEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVLNRQGHSCESDIWALGCIMYTMLCGR

PPFETQSLKDTYQRIKRNEYRVPSHVSTPARNLIVKLLKNDPTQRPHIDILLQDEFF
||||| .|| ||..|. | |  |.| | ||| || ..|  ||  || .| .....||
PPFETANLKETYRCIRHNHYHMPTHLSPPARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase PLK1.AA PLK-Unclassified 27-279 53 2.7e-145 488.97 In-house 1-264 (264) Show / Hide 
Range on Protein: 27-279
Range on HMM: 1-264/264
Sequence Identity: 53% (141 aa)

YTKGRFLGKGGFAKCYELTDDATKQIFAGKVVSKALLVKPHQKDKMTMEIHIHKSLHHRHVVGFHSFFEDKENVYVLLELCRRRSLMELHKRR-------
| .|.|||||||||||. ... ||.|.| |.. |. | |  .. |   || |||||||...| |  .||| |||| |||.|   .|||..|||       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

KAITEPETRYFMRQCILACQYLSKTKVIHRDLKLGNLFIDDNMELKVGDFGLATKVDFSGERKKTLCGTPNYIAPEVL-SKK-GHSYEVDLWSLGCIMYT
| .||.|....  | . | .|| . ..|||||||||.|..||||.| .|||||||. . ||.||| ||||||||||.|  |. ||||||| ||.||| ||
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLVGKPPFETQSLKDTYQRIKRNEYRVP--SHVSTPARNLIVKLLKNDPTQRPHIDILLQDEFF
||.|||||||.. | ||..|| |.| .|  .|.|  |..||.. |. .| ||| || .... |.
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase PLK1.AA S_TKc 27-279 31 6.6e-84 285.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-279
Range on HMM: 1-231/231
Sequence Identity: 31% (84 aa)

YTKGRFLGKGGFAKCYELTDDATKQIFAGKVVSKALLVKPHQKDKMTMEIHIHKSLHHRHVVGFHSFFEDKENVYVLLELCRR--RSLMELHKRRKA---
|...| .|||.|.|.|  ..  |..|.| |...          ...  || |.|. || ..| .. .|.| ...|. .|.|     .|... |.|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ITEPETRYFMRQCILACQYLSKTKVIHRDLKLGNLFIDDNMELKVGDFGLATKVDFSGERKKTLCGTPNYIAPEVLSKKGHSY-EVDLWSLGCIMYT
   ..| ..|..|.| ..| .|. . ..||||||  |...|.  ..|..|||||...       .|.||||.|.|||||   |... ..| ||.|||.| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLVGKPPFETQSLKDTYQRIKRNEYRVPSHVSTPARNLIVKLLKNDPTQRPHIDILLQ-------DEFF
.|.|.|||.   .. ....|.          | .|...| |.|. ||..|| .  .||       ...|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PLK1.AA CAMK 32-279 20 6.7e-84 270.13 In-house 1-425 (425) Show / Hide 
Range on Protein: 32-279
Range on HMM: 1-425/425
Sequence Identity: 20% (86 aa)

FLGKGGFAKCYELTDDATK------------QIFAGKVVSKALLVK-------------------------PHQKDKMTMEIHIHKS-------LHHRHV
 ||.|.|.| .. ..  |.            | .| |...|  | .                         |. ....  ||.|.|.       |.|...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGFHSFFED-------------------KENVYVLL---ELCRRR----SLMELHKRR---------------KAITEPETRYFMRQCILACQYLSKTKV
. .. ..||                   ....|  .   |.|        | .  ...               . .|| |.|...|| . | .|. . ..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKLGNLFIDDNM-----------------ELKVGDFGLATKVDFS-----------------------GERKKTLCGTPNYIA-PEVLSK------
.|||||. |. .|||.                  .|. |||.|.|.| .                       |.  || |||| |.| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KGHSYEVDLWSLGCIMYTLLVGKPPFETQ-------------SLKDTYQRIKRNEYR-VPSH-----------------------VSTPARN
        .......| ||.|.|.|..|.|.|||.               ........|.. .|.  |..                       ||. ...
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIVKLLKNDPTQRPHIDILLQDEFF
|| |.|. ||..|. |.  |.....
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PLK1.AA SAK 27-279 37 6.8e-76 257.93 In-house 1-254 (254) Show / Hide 
Range on Protein: 27-279
Range on HMM: 1-254/254
Sequence Identity: 37% (96 aa)

YTKGRFLGKGGFAKCYELTDDATKQIFAGKVVSKALLVKPHQKDKMTMEIHIHKSLHHRHVVGFHSFFEDKENVYVLLELCRRRSLME-LHKRRKAITEP
|  .  |||||||  |      | |  | |.. | |. |    ...  |..||  | |  ..   ..|||   ||. ||.|.   .   ...| .  || 
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEE

ETRYFMRQCILACQYLSKTKVIHRDLKLGNLFIDDNMELKVGDFGLATKVDFSGERKKTLCGTPNYIAPEVLSKKGHSYEVDLWSLGCIMYTLLVGKPPF
| | ||.| .    ||    ..|||| | |. .  .|..|. ||||||..    |.  |.|||||||.||. ..  |  . |.|||||..||||.|.|||
EARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPF

ETQSLKDTYQRIKRNEYRVPSHVSTPARNLIVKLLKNDPTQRPHIDILLQDEFF
.|.. | |  ..   || .|.|.|  |. || |.|. .|..|  ..  |   | 
DTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase PLK1.AA CAMKL 27-279 25 7.6e-75 238.24 In-house 1-297 (297) Show / Hide 
Range on Protein: 27-279
Range on HMM: 1-297/297
Sequence Identity: 25% (77 aa)

YTKGRFLGKGGFAKCYELTD-DATKQIFAGKVVSKALLVKPHQKDKMTM------------EIHIHKSLH---HRHVVGFHSFFEDKEN------VYVLL
|. |. ||||.|.|    |.   |..  | |.. |  . .  ...|.              ||.|.|.|.   | ... ..  .|..|.      .|  .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCRRRS--LMELHKRR----KAITEPETRYFMRQCILACQYLSKTKVIHRDLKLGNLFIDDNM--ELKVGDFGLATKVD-F---SGERKKTLCGTPNYI
|.|   .  |..  ...    . ..|.|.| . || . | .|. . ...|||.|. |. .|.|.   .|. |||.... .     .|.  || ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLSK--KGHS-YEVDLWSLGCIMYTLLVGKPPFETQSLK---------DTYQRIKRNEYRVPSHVSTPARNLIVKLLKNDPTQRPHIDILLQDEFF
|||....  | .  ..|| ||.| |.|....|. ||. ....            ...   ......||| ..|.|| |.|. .|..|| |. .......
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase PLK1.AA Pkinase 27-279 28 2.4e-73 254.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 27-279
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

YTKGRFLGKGGFAKCYELTDDATKQIFAGKVVSKALLVKPHQKDKMT---MEIHIHKSLHHRHVVGFHSFFEDKENVYVLLELCRRR----SLMELHK--
|..|| .|.|.|...|. ..  | .|.| |...|    . ..||.     .||.|.|.|.| ..| .. .|||| ..|. .|.|.      .|... .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

RRKAI--TEPETRYFMRQCILACQYLSKTKVIHRDLKLGNLFIDDNMEL----KVGDFGLATKV-DFSGERKKTLCGTPNYIAPEVLS-KKGHSYEVDLW
|....  .| | . .|.| . . .|. . ..||||||. |..||.|...    |..||||| ..   ...  .|.||||.|.||||.   ......|| |
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGCIMYTLLVGKPPFETQ------SLKDTYQRIKRNEYRVPSHVS---------------------TPARNLIVKLLKNDPTQRPHIDILLQDEFF
|.|||.| .| |.|||  .      . .  ..||.. ... ..  .                      ... .| ..|. ||..|| .. .||...|
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PLK1.AA MARK 27-279 31 1.4e-70 229.97 In-house 1-262 (262) Show / Hide 
Range on Protein: 27-279
Range on HMM: 1-262/262
Sequence Identity: 31% (84 aa)

YTKGRFLGKGGFAKCYELTDDATKQIFAGKVVSKALLVKPHQKDKMTMEIHIHKSLHHRHVVGFHSFFE--DKEN-VYVLLELCRRRSLMELHKRR--KA
|  .. .|.|..|| .  ..  |.. .| |.. |  | .|... .   ||.|.|.|.| ... ..  .|  .... .|. .|.. . .|..  | .    
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

ITEPETRYFMRQCILACQYLSKTKVIHRDLKLGNLFIDDNM--ELKVGDFGLATKVDFSGERKKTLCGTPNYIAPEVLSKKGHS-YEVDLWSLGCIMYTL
..|.|.| . || . | .|. .  ..|||.|. |. ||.|.    |  |||.....  .|.. .| |||| | |||...||    ..|| |||| ..|..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIP-PGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

LVGKPPFE--TQSLKDTYQRIKRNEYRVPSHVSTPARNLIVKLLKNDPTQRPHIDILLQDEFF
..|. ||.  ||..|. |..| | .|..|.|||. .|||| .||. .| .|| |. .......
VCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase PLK1.AA ULK 27-279 26 4e-68 232.63 In-house 1-329 (329) Show / Hide 
Range on Protein: 27-279
Range on HMM: 1-329/329
Sequence Identity: 26% (89 aa)

YTKGRFLGKGGFAKCYELTDDATK----QIFAGKVVSKA-LLVKPHQ------KDKMTMEIHIHKSLH--------HRHVVGFHSFFEDK--ENVYVLLE
| . . |||| |.| |. ..  ||    ...| |...|  .  |...      ..  . || | | |.        | ..| .. .||..   |.|  .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCRRRSLMELHKRRKA----------ITEPETRYFMRQCILACQYLSKTKVIHRDLKLGNLFIDDN------------MELKVGDFGLATKVDFSG----
.|    |... |..|           ..|.|.. |..| . ....| | ..||||.|. |  |...            . ||..|||.| .|| ..    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-ERKKT----LCGTPNYIAPEVLS----KKGHS-YEVDLWSLGCIMYTLLVGKPPFETQSLKDTY-----QR----------IKRNEYRVP-----SHVS
 .   .    ||||| | ||..|.    .| .. |..|.||||||.| .|.|||||...   |.|     .           || .  . |      ..|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

TPARNLIVKLLKNDPTQRPHIDILLQDEFF
   ..|| ..|. |...|  .. |.. ..|
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase PLK1.AA ULK 27-279 26 6.8e-67 228.54 In-house 1-324 (324) Show / Hide 
Range on Protein: 27-279
Range on HMM: 1-324/324
Sequence Identity: 26% (87 aa)

YTKGRFLGKGGFA-KCYELTDDAT---KQIFAGKVVSKALLVK-PHQ------KDKMTMEIHIHKSLH------HRHVVGFHSFFEDK--ENVYVLLELC
| . . |||| |. | |. ..  |   .|..| |...|  . | ...      ...   || | | |.      | |.| .. .||..   |.|  .|.|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

RRRSLMELHKRRKA---------ITEPETRYFMRQCILACQYLSKTKVIHRDLKLGNLFIDDN------------MELKVGDFGLATKVDFSG---ERKK
    | .. |..|          ..|.|.. |..| . ....| | ..||||.|. |. | ..              ||..|||.| .||  .      .
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TLC------GTPNYIAPEVLS----KKGHS-YEVDLWSLGCIMYTLLVGKPPFETQSLKDTYQR--------------IKRNEYRVP-----SHVSTPAR
|..      ||| | ||..|.    .| .. |..|.||||||.| .| ||.||...   |.|..              || .  . |      ..|   .
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

NLIVKLLKNDPTQRPHIDILLQDEFF
.|| ..|. |...|  .. ... ..|
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase PLK1.AA TyrKc 27-278 20 1.4e-14 12.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YTKGRFLGKGGFAKCY--ELTDDATKQIFAGKVVSKALLVKPHQKDKMTMEIHIHKSL--HHRHVVGFHSFFEDK-------ENVYVLLELCRRRSLME-
 |.|. || | | . |  ...     .  | |.. .        .  .  |. | ..|  || ..| ..    ..       | .....|..   .| . 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LHKRRKAITEPETRYFMRQCILACQYLSKTKVIHRDLKLGNLFIDDNMELKVGDFGLATKV---DFSGERKKTLC-----GTP-----NYIAPEVLSKKG
|.|.|. .. ..  .|. |    ..||.. ..|||||   |  ...|   |..||||. ..   | .||.|..       |.         |||.. .. 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HSYEVDLWSLGCIMY---TLLVGKPPFET-----QSLKDTYQRIKRNEYRVPSHV---------STPARNLIVKLLKNDPTQRPHIDILLQDEF
 . . | || |  |.   |.  |..| .       | .. ....|. ... . .          ..   ... .  . || .||    .  ..|
FTTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase PLK1.AA Pkinase_Tyr 66-245 25 3.6e-10 35.07 Pfam 42-236 (270) Show / Hide 
Range on Protein: 66-245
Range on HMM: 42-236/270
Sequence Identity: 25% (50 aa)

PHQ--KDKMTMEIHIHKSL-HHRHVVGFHSFFE-DKEN--VYVLLELCRRRSLME-LHKR---RKAITEPETRYFMRQCILACQYLSKTKVIHRDLKLGN
..|  ....  |. | |.| || ..| ..     ..|   .|. .|..   .| . |.|.   ....| ..   . .|   ...||.  . |||||   |
HEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARN

LFIDDNMELKVGDFGLATKVDFSGE---RKKTLCGTP-NYIAPEVLSKKGHSYEVDLWSLGCIMYTLLV-GKPP-FETQSLKDTYQRIKRNEYRVP
  ...|.  |..|||||  . .. .   ||.. .  |    |||... .  . . | || |  |. ..  |. | ..  |  . |..|... || |
CLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMP
POLO_box PLK1.AA POLO_box 398-461 35 4.1e-28 104.52 Pfam 1-74 (74) Show / Hide 
Range on Protein: 398-461
Range on HMM: 1-74/74
Sequence Identity: 35% (26 aa)

YSDKYGLGYQLCDGSVGVL-FNDSTRLLLHANAD-TLEYIE--RDGNEKYCRLGS------YDSTLHKKVTLLK
|..|||..|||..|.|.|. |||.|...|..|.. ...||.  ....... .| .      | . |.||.|.||
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box PLK1.AA POLO_box 496-565 48 2.9e-29 108.33 Pfam 1-74 (74) Show / Hide 
Range on Protein: 496-565
Range on HMM: 1-74/74
Sequence Identity: 48% (36 aa)

FRTKSAIVLHLSNGTVQINFFEDHTKLIVCPMMG-AATYID--AKRNFRTFRLNLIEKHGC-TPDLYDRIKYAN
.|||..|. .|||||||.||| ||||.|.|| |. | ||||   .....|..|. |..|||  .||. ...|. 
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK