Gene Fused (Sea Urchin)

Fused

Species: Sea Urchin
Alias: SPU_008747, Fused, Spk201
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: Fused

Sequence

Name Sequence Type Origin Length Description Download
Fused.AA Protein None 974 None Fasta, JSON
Fused.kin_dom Protein Kinase Domain None 213 None Fasta, JSON

Protein domain

Protein domains of Fused.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Fused.AA Fused 174-386 71 1.3e-183 616.28 In-house 25-251 (251) Show / Hide 
Range on Protein: 174-386
Range on HMM: 25-251/251
Sequence Identity: 71% (163 aa)

KIVALKFIPKLGRSDKELDSLRKEIEIMKEMHHPNIIEMLDTFETDKEVVAVTDYAEGELFQILEDDGTLPEEQVKEIACQLLSALYYLHAHRILHRDMK
|.||.|||||.|||||||..||.|.|||..||||.||.|.|.||||||||.||||||.||.|.||.||..|||||..|||.|.|||||||.|||||||||
KVVAIKFIPKRGRSDKELKNLRRECEIMRRMHHPHIIHMIDSFETDKEVVVVTDYAEMELHQYLEYDGKMPEEQVRRIACHLVSALYYLHSHRILHRDMK

PQNILLGKGGVVKLCDFGFARAMSINTLVLTSIKGTPLYMAPELVEEKPYDHTADLWSLGCILYELFVGTPPFYTNSIFQLVSLIIKD------------
||||||.|....|||||||||.|||||.|||||||||||||||||||.||||.||.||||||||||.||.|||..||||.|||.|..|            
PQNILLDKNMHIKLCDFGFARNMSINTHVLTSIKGTPLYMAPELVEEQPYDHHADMWSLGCILYELMVGQPPFCANSIFHLVSMIKHDDVKWPSTITSCC

--FLQGLLTKSAKHRLTWPALLYHPFV
  ||||||||...||..||.||.||||
RNFLQGLLTKDPRHRISWPQLLCHPFV
Kinase Fused.AA Fused 1-173 74 3.1e-146 492.1 In-house 52-224 (251) Show / Hide 
Range on Protein: 1-173
Range on HMM: 52-224/251
Sequence Identity: 74% (129 aa)

MKEMHHPNIIEMLDTFETDKEVVAVTDYAEGELFQILEDDGTLPEEQVKEIACQLLSALYYLHAHRILHRDMKPQNILLGKGGVVKLCDFGFARAMSINT
|..||||.||.|.|.||||||||.||||||.||.|.||.||..|||||..|||.|.|||||||.|||||||||||||||.|....|||||||||.|||||
MRRMHHPHIIHMIDSFETDKEVVVVTDYAEMELHQYLEYDGKMPEEQVRRIACHLVSALYYLHSHRILHRDMKPQNILLDKNMHIKLCDFGFARNMSINT

LVLTSIKGTPLYMAPELVEEKPYDHTADLWSLGCILYELFVGTPPFYTNSIFQLVSLIIKDPVKWPKNMEPEF
.|||||||||||||||||||.||||.||.||||||||||.||.|||..||||.|||.|..|.||||  . ...
HVLTSIKGTPLYMAPELVEEQPYDHHADMWSLGCILYELMVGQPPFCANSIFHLVSMIKHDDVKWPSTITSCC
Kinase Fused.AA ULK 174-386 28 5e-88 298.76 In-house 29-329 (329) Show / Hide 
Range on Protein: 174-386
Range on HMM: 29-329/329
Sequence Identity: 28% (86 aa)

KIVALKFIPKLGRSDKELD--------SLRKEIEIMKEMH--------HPNIIEMLDTFETDKE--VVAVTDYAEG-ELFQILEDDGTLPEEQ-------
..|| | |.|   . |. .        .|..||.|||...        ||||....| |||...  .  ...| .|  |.|... ...|||..       
EKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLS

---VKEIACQLLSALYYLHAHRILHRDMKPQNILLGKG------------GVVKLCDFGFARAMSIN-----TLVLTS----IKGTPLYMAPELVE----
   .... .|.|... .|| |.| |||.||||||. .|            ||.|..|||||. .. .      .. ..    ..||||||||....    
EQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGE

EKPYD-HTADLWSLGCILYELFVGTPPFYTNSIFQLV-----SL-----------------------------IIKDFLQGLLTKSAKHRLTWPALLYHP
.|||. ...|.||||||.||. .| ||||.. .....     .|                              .||.....|..  | | .|. |. ||
QKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHP

FV
..
WF
Kinase Fused.AA ULK 174-386 27 2.6e-78 266.48 In-house 29-324 (324) Show / Hide 
Range on Protein: 174-386
Range on HMM: 29-324/324
Sequence Identity: 27% (82 aa)

KIVALKFIPKLGRSDKELD--------SLRKEIEIMKEMH---HPN--IIEMLDTFETD--KEVVAVTDYAEG-ELFQILEDDGT---------LPEEQV
..|| | |.| . ..|...        .|..||.|||...   |||  |....| |||.  . .  ...| .|  |.|... ...         |.|...
QYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEA

KEIACQLLSALYYLHAHRILHRDMKPQNILLGKG------------GVVKLCDFGFARAMSINTL---VLTSIK------GTPLYMAPELVE----EKPY
...  |..... .|| | | |||.||||||. .|            ||.|..|||||.    |..   ......      ||||||||....    .|||
IQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPY

D-HTADLWSLGCILYELFVGTPPFYTNSIFQLV---------------------------------SLIIKDFLQGLLTKSAKHRLTWPALLYHPFV
. . .|.||||||.||.  | .||... . ...                                 |  .||.....|..  | | .|. .. ||..
YDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase Fused.AA AGC 175-386 19 8e-78 199.95 In-house 32-395 (395) Show / Hide 
Range on Protein: 175-386
Range on HMM: 32-395/395
Sequence Identity: 19% (73 aa)

IVALKFIPKLG--------RSDKELDS--------LRKEIEIMKEMH----------HPNIIE-MLDTFETDKE--VVAVTDYAE----------G-ELF
. |.| . |            .. .          ...| .|.....          ||.|.  .  .|....   .  | .|..          | |||
YYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELF

QILE---DDGTLPEEQVKEIACQ-------LLSALYYLHA-HRILHRD-MKPQNILLGKGGVVKLCDFGFARAMSI------------------------
..|    . |...||... .|..       ...|| |||  . | ||| .|| |||| . | .||.|||..  .                          
LHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKS

--------------------------NTLVLTSIKG--TPLYMAPELVEEKPYDHTADLWS--LGCILYELFVGTPPFYTNS----------IFQLVSLI
                          ..   ... |  || ||||| .    |....| ||  |||..||. .| |||| ..           ...  .|
NMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKI

I------------------------------KDFLQGLLTKSAKHRLT----------WPALLYHPFV
.                              ||....||.|  ..||.             .  ||. 
MNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase Fused.AA Pkinase 174-386 31 3.2e-77 267.64 Pfam 25-293 (293) Show / Hide 
Range on Protein: 174-386
Range on HMM: 25-293/293
Sequence Identity: 31% (86 aa)

KIVALKFIPKLGRSDKELDSLRK--EIEIMKEMHHPNIIEMLDTFETDKEVVAVTDYAEG-----ELFQILE--DDGTL--PEEQVKEIACQLLSALYYL
||||.| |.| ....... ..|.  ||.|||...||||....|.||.....  |..|.||     .|| ...  ..|..  .|...| .. |.|..|.|.
KIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYC

HAHRILHRDMKPQNILLGKGGVV----KLCDFGFARAM-SINTLVLTSIKGTPLYMAPELVE-EKPYDHTADLWSLGCILYELFVGTPPFYTN------S
|...|.|||.||.|||. . |..    |.||||.|. .   |   .|.. ||| |||||..   ..|.. .| ||.||||||.. | |||.        .
HSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHD

IFQLVSLIIK-----------------------------------DFLQGLLTKSAKHRLTWPALLYHPFV
  |.. .| .                                   ||. ..|.|  | |.|.. .| ||..
QMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Fused.AA ULK 1-173 30 2.5e-74 253.24 In-house 64-289 (329) Show / Hide 
Range on Protein: 1-173
Range on HMM: 64-289/329
Sequence Identity: 30% (70 aa)

MKEMH--------HPNIIEMLDTFETDKE--VVAVTDYAEG-ELFQILEDDGTLPEEQ----------VKEIACQLLSALYYLHAHRILHRDMKPQNILL
||...        ||||....| |||...  .  ...| .|  |.|... ...|||..          .... .|.|... .|| |.| |||.||||||.
MKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILI

GKG------------GVVKLCDFGFARAMSIN-----TLVLTS----IKGTPLYMAPELVE----EKPYD-HTADLWSLGCILYELFVGTPPFYTNSIFQ
 .|            ||.|..|||||. .. .      .. ..    ..||||||||....    .|||. ...|.||||||.||. .| ||||.. ...
HNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FND

LVSLIIKDPVKWPKNME-------PEF
.. .||.. ...|....       ..|
QYLQIIQKLINNPPPWPQQIKKQPLQF
Kinase Fused.AA AGC 5-174 23 1.4e-73 188.72 In-house 88-359 (395) Show / Hide 
Range on Protein: 5-174
Range on HMM: 88-359/395
Sequence Identity: 23% (66 aa)

HHPNIIE-MLDTFETDKE--VVAVTDYAE----------G-ELFQILE---DDGTLPEEQVKEIACQ-------LLSALYYLHA-HRILHRD-MKPQNIL
|||.|.  .  .|....   .  | .|..          | |||..|    . |...||... .|..       ...|| |||  . | ||| .|| |||
HHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENIL

LGKGGVVKLCDFGFARAMSI--------------------------------------------------NTLVLTSIKG--TPLYMAPELVEEKPYDHT
| . | .||.|||..  .                                                    ..   ... |  || ||||| .    |...
LDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKA

ADLWS--LGCILYELFVGTPPFYTNS----------IFQLVSLII------KDPVKWP----------KNMEPEFK
.| ||  |||..||. .| |||| ..           ...  .|.      ...||.|          ... || |
CDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAK
Kinase Fused.AA S_TKc 167-386 34 2.9e-70 240.66 SMART 19-231 (231) Show / Hide 
Range on Protein: 167-386
Range on HMM: 19-231/231
Sequence Identity: 34% (82 aa)

KNMEPEFKIVALKFIPKLGRSDKELDSLRKEIEIMKEMHHPNIIEMLDTFETDKEVVAVTDYAEG---ELFQILEDDGT------LPEEQVKEIACQLLS
.. .   .|||.| |.         ...|.||.|.|. |||||. ..|.|.. ...  |..|..|   .||..... |.      .|| ... ...|...
RHKK-TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICC

ALYYLHAHRILHRDMKPQNILLGKGGVVKLCDFGFARAMSINTLVLTSIKGTPLYMAPELVEEKPYDH-TADLWSLGCILYELFVGTPPFYTNSIFQLVS
|| |.| |.|.||| ||.|||| .  ..|.||||.|| .       |.. ||| |||||..   .|..  .| ||.||||||...| |||.   ....  
ALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFK

LII----KDFLQGLLTKSAKHRLTWPALLY-------HPFV
.|     |||....|.|  ..|.|   .|        ||..
KIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Fused.AA CAMK 174-386 21 4e-69 221.65 In-house 32-425 (425) Show / Hide 
Range on Protein: 174-386
Range on HMM: 32-425/425
Sequence Identity: 21% (83 aa)

KIVALKFIPK--LGR------------------------SDKELDSLRKEIEIMKE-------MHHPNIIEMLDTFET-------------------DKE
. || |.|.|  |                          ..| ....|.||||||        ..||||| .....|.                   ||.
QKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKH

VVAVT---DYAEG-ELFQ--------------------ILEDDGTLPEEQVKEIACQLLSALYYLHAHRILHRDMKPQNILL-GKG--------------
.. |.   .|..| |||.                    |. ..| ..|.... .  |..||. |.| | | ||| || ||||  ..              
MYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDW

--GVVKLCDFGFARAMSIN-----------------------TLVLTSIKGTPLYMA-PELVE--------------EKPYDHTADLWSLGCILYELFVG
  . .|..|||||. .  .                       .  ..   ||| ||| ||...              ...|.  .| ||.|.||| . .|
NNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCG

TPPFYTN--------------------SIFQLV-SLI------------------------------IKDFLQGLLTKSAKHRLTWPALLYHPFV
.||||                       | .   . .                               ||.....|..  ..|.|    | ||..
YPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Fused.AA ULK 1-168 30 1.6e-64 220.63 In-house 64-287 (324) Show / Hide 
Range on Protein: 1-168
Range on HMM: 64-287/324
Sequence Identity: 30% (68 aa)

MKEMH---HPN--IIEMLDTFETD--KEVVAVTDYAEG-ELFQILEDDGT---------LPEEQVKEIACQLLSALYYLHAHRILHRDMKPQNILLGKG-
||...   |||  |....| |||.  . .  ...| .|  |.|... ...         |.|......  |..... .|| | | |||.||||||. .| 
MKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQ

-----------GVVKLCDFGFARAMSINTL---VLTSIK------GTPLYMAPELVE----EKPYD-HTADLWSLGCILYELFVGTPPFYTNSIFQLV--
           ||.|..|||||.    |..   ......      ||||||||....    .|||. . .|.||||||.||.  | .||... . ...  
PKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY

--SL----------IIKDPVKWPKN
  .|          | . |...||.
IQKLINNGKEQQIYIKNQPIQFPKP
Kinase Fused.AA Pkinase 1-166 35 1.8e-63 221.97 Pfam 54-238 (293) Show / Hide 
Range on Protein: 1-166
Range on HMM: 54-238/293
Sequence Identity: 35% (66 aa)

MKEMHHPNIIEMLDTFETDKEVVAVTDYAEG-----ELFQILE--DDGTL--PEEQVKEIACQLLSALYYLHAHRILHRDMKPQNILLGKGGVV----KL
||...||||....|.||.....  |..|.||     .|| ...  ..|..  .|...| .. |.|..|.|.|...|.|||.||.|||. . |..    |.
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKI

CDFGFARAM-SINTLVLTSIKGTPLYMAPELVE-EKPYDHTADLWSLGCILYELFVGTPPFYTN------SIFQLVSLIIKDPVKWP
||||.|. .   |   .|.. ||| |||||..   ..|.. .| ||.||||||.. | |||.        .  |.. .| . |....
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFD
Kinase Fused.AA MARK 176-346 39 1.2e-57 187.12 In-house 27-206 (262) Show / Hide 
Range on Protein: 176-346
Range on HMM: 27-206/262
Sequence Identity: 39% (71 aa)

VALKFIPKLGRSD-KELDSLRKEIEIMKEMHHPNIIEMLDTFE--TDKE-VVAVTDYAEG-ELFQILEDD--GTLPEEQVKEIACQLLSALYYLHAHRIL
||.|...|   .| ... ... |||||| ..|||||......|  | .  .. . .||.| ||.. ..    | |.||  . |  |..||..|.| ..| 
VAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIV

HRDMKPQNILLGKGG--VVKLCDFGFARAMSINTLVLTSIKGTPLYMAPELVEEKPYD-HTADLWSLGCILYELFVGTPPF
|||.||.|||. . |   .|..||||..    ... |..  ||| |||||... ||||   .| |||| .|| . .|. ||
HRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK-LNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPF
Kinase Fused.AA Ciliate-E2 176-386 24 3e-57 195.07 In-house 45-365 (365) Show / Hide 
Range on Protein: 176-386
Range on HMM: 45-365/365
Sequence Identity: 24% (80 aa)

VALKFIPKLGRSDKELDSLRKEIEIMKEMH----------------HPNIIEMLDTFE--TDKEVVAVTDYAEG-ELFQILE------------DDGTLP
|. |.. .   . ... .. .|| ||.|..                |||||.| ..|.  .|. .  |..|..| .||....            | . . 
VKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFT

EEQVKEIACQLLS---------------ALYYLHAHR-ILHRDMKPQNILLGKGGVVKLCDFGFAR---------------AMSINTL------------
|...|.|  |.|.               || |||    |.||| ||.|||.     .|..|||...                . ..              
EKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQ

-----VLTSIKGTPLYMAPELVEEKP---------YDHTADLWSLGCILYELFVGTPPFYTNSIFQL--------------------------VSLIIKD
     .  .| ||| ||||| .. |.         ||. .|.||||.||||.  | |||    . .                           .|.  ||
IIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKD

FLQG----LLTKSAKHRLT-WPALLYHPFV
...     .| |  . |.| |  .| ||. 
LIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Fused.AA CAMK 1-160 23 5.9e-57 181.71 In-house 85-361 (425) Show / Hide 
Range on Protein: 1-160
Range on HMM: 85-361/425
Sequence Identity: 23% (65 aa)

MKE-------MHHPNIIEMLDTFET-------------------DKEVVAVT---DYAEG-ELFQ--------------------ILEDDGTLPEEQVKE
||        ..||||| .....|.                   ||... |.   .|..| |||.                    |. ..| ..|.... 
MKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARR

IACQLLSALYYLHAHRILHRDMKPQNILL-GKG----------------GVVKLCDFGFARAMSIN-----------------------TLVLTSIKGTP
.  |..||. |.| | | ||| || ||||  ..                . .|..|||||. .  .                       .  ..   |||
YFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTP

LYMA-PELVE--------------EKPYDHTADLWSLGCILYELFVGTPPFYTN-------------SIFQLVSLIIK
 ||| ||...              ...|.  .| ||.|.||| . .|.||||               .. .|   |.|
EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMK
Kinase Fused.AA STE 175-386 24 7.9e-56 191.79 In-house 41-359 (359) Show / Hide 
Range on Protein: 175-386
Range on HMM: 41-359/359
Sequence Identity: 24% (81 aa)

IVALKFIPKLGRS---------------DKELDSLRKEIEIMKEMH--HPNIIEMLDTFETD-------KEVVAVTDYAE-GELFQILE--------DD-
|.| | ...   .               ..|.... |||.|||...  ||||.. ..... .        |.  .  | . | | .|..        .. 
IMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNH

-----GTLPEEQVKEIACQLLSA-LYYLHAHRILHRDMKPQNILLGKGGVVKLCDFGFARAMSI---------------NTL-VLTSIKGTPLYMAPELV
     ...||.|.. |..|.| . ||||| |.| ||| ||.||||     |||||||..  ..                ..    ... ||| .|||| .
NRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVI

EE------KPYDHTADLWSLGCILYELFVGTPPFYTNSIFQ-------------------------------------------------LVSLIIKDFL
.       |.||  .| ||||| . |.  | ||. . . ..                                                  .|   |||.
QQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFI

QGLLTKSAKHRLTWPALLY--HPFV
.  |.|  ..| |   ||   |||.
NKCLQKDPNKRPTASQLLKSEHPFI
Kinase Fused.AA NEK 174-360 32 7.6e-53 181.88 In-house 25-242 (286) Show / Hide 
Range on Protein: 174-360
Range on HMM: 25-242/286
Sequence Identity: 32% (72 aa)

KI-----VALKFIPKLGR-SDKELDSLR-KEIEIMKEMHHPNIIEMLDTFETDK--EVVAVTDYAE--GELFQI---LEDDG----TLPEEQVKEIACQL
|.     ...| |  .|. |.|| . .  .|. | |...||||..  | |. ..      | .|.|  | |.|    ..        ..|||. .. .|.
KHLVEKLYVWKKIN-MGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQM

LSALYYLHAH-----RILHRDMKPQNILLGK-GG---VVKLCDFGFARAMSINTLVLTS-IKGTPLYMAPELVEEKPYDHTADLWSLGCILYELFVG--T
..||.|.| .     .||||| ||||| | | .    .||. ||| .. .. .|  ...   ||| ||.||....|||.. .| |||||.|||.      
CLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPK

PPFYTN--SIFQLVSLIIK
.||. .  .. .|.  |.|
HPFEAWDMNMPSLYMKIMK
Kinase Fused.AA MARK 1-146 40 1.6e-49 160.17 In-house 53-206 (262) Show / Hide 
Range on Protein: 1-146
Range on HMM: 53-206/262
Sequence Identity: 40% (62 aa)

MKEMHHPNIIEMLDTFE--TDKE-VVAVTDYAEG-ELFQILEDD--GTLPEEQVKEIACQLLSALYYLHAHRILHRDMKPQNILLGKGG--VVKLCDFGF
|| ..|||||......|  | .  .. . .||.| ||.. ..    | |.||  . |  |..||..|.| ..| |||.||.|||. . |   .|..||||
MKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGF

ARAMSINTLVLTSIKGTPLYMAPELVEEKPYD-HTADLWSLGCILYELFVGTPPF
..    ... |..  ||| |||||... ||||   .| |||| .|| . .|. ||
SICIPPGQK-LNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPF
Kinase Fused.AA RSK 177-350 29 4.1e-49 169.5 In-house 28-219 (278) Show / Hide 
Range on Protein: 177-350
Range on HMM: 28-219/278
Sequence Identity: 29% (56 aa)

ALKFIPK--LGRSDKELDSLRKEIEIMKEMH-HPNIIEMLDTFETDKEVVAVTDYAEG-ELFQILEDDGT---LPEEQVKEIACQLLSALYYLHAHRILH
| | . |  . ...| .   ..|..|...   ||.|..  ..|.|....  ...| .| |||  |.  ..   . |. ..... .. .|. .|| . | |
AMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIH

RDMKPQNILLGK---GGVVKLCDFGFARAMSIN-TLVLTSIKGTPLYMAPELVE---EKP-YDHTADLWSLGCILYELFVGTPPFYT---NS
|| || |||.      | .||.||||.. .... .  . .  .|  |||||..     .  .|. .|.||||...||...| |||.    |.
RDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNN
Kinase Fused.AA NEK 2-160 34 5.8e-48 165.67 In-house 59-242 (286) Show / Hide 
Range on Protein: 2-160
Range on HMM: 59-242/286
Sequence Identity: 34% (63 aa)

KEMHHPNIIEMLDTFETDK--EVVAVTDYAE--GELFQI---LEDDG----TLPEEQVKEIACQLLSALYYLHAH-----RILHRDMKPQNILLGK-GG-
|...||||..  | |. ..      | .|.|  | |.|    ..        ..|||. .. .|...||.|.| .     .||||| ||||| | | .  
KQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNND

--VVKLCDFGFARAMSINTLVLTS-IKGTPLYMAPELVEEKPYDHTADLWSLGCILYELFVG--TPPFYTN--SIFQLVSLIIK
  .||. ||| .. .. .|  ...   ||| ||.||....|||.. .| |||||.|||.      .||. .  .. .|.  |.|
YHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMK
Kinase Fused.AA RSK 5-174 29 3.5e-47 163.08 In-house 59-247 (278) Show / Hide 
Range on Protein: 5-174
Range on HMM: 59-247/278
Sequence Identity: 29% (55 aa)

HHPNIIEMLDTFETDKEVVAVTDYAEG-ELFQILEDDGT---LPEEQVKEIACQLLSALYYLHAHRILHRDMKPQNILLGK---GGVVKLCDFGFARAMS
.||.|..  ..|.|....  ...| .| |||  |.  ..   . |. ..... .. .|. .|| . | ||| || |||.      | .||.||||.. ..
QHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFR

IN-TLVLTSIKGTPLYMAPELVE---EKP-YDHTADLWSLGCILYELFVGTPPFYT---NSIFQLVSLIIKDP--VKWP--KNMEPEFK
.. .  . .  .|  |||||..     .  .|. .|.||||...||...| |||.    |.  ..   | |    .. |  ... .|.|
CDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAK
Kinase Fused.AA Ciliate-E2 1-146 27 1.4e-46 157.91 In-house 70-296 (365) Show / Hide 
Range on Protein: 1-146
Range on HMM: 70-296/365
Sequence Identity: 27% (64 aa)

MKEMH----------------HPNIIEMLDTFE--TDKEVVAVTDYAEG-ELFQILE------------DDGTLPEEQVKEIACQLLS------------
|.|..                |||||.| ..|.  .|. .  |..|..| .||....            | . . |...|.|  |.|.            
MREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIAC

---ALYYLHAHR-ILHRDMKPQNILLGKGGVVKLCDFGFAR---------------AMSINTL-----------------VLTSIKGTPLYMAPELVEEK
   || |||    |.||| ||.|||.     .|..|||...                . ..                   .  .| ||| ||||| .. |
IILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGK

P---------YDHTADLWSLGCILYELFVGTPPF
.         ||. .|.||||.||||.  | |||
KYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase Fused.AA STE 1-174 26 2.8e-46 160.06 In-house 82-331 (359) Show / Hide 
Range on Protein: 1-174
Range on HMM: 82-331/359
Sequence Identity: 26% (67 aa)

MKEMH--HPNIIEMLDTFETD-------KEVVAVTDYAE-GELFQILE--------DD------GTLPEEQVKEIACQLLSA-LYYLHAHRILHRDMKPQ
||...  ||||.. ..... .        |.  .  | . | | .|..        ..      ...||.|.. |..|.| . ||||| |.| ||| ||.
MKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPA

NILLGKGGVVKLCDFGFARAMSI---------------NTL-VLTSIKGTPLYMAPELVEE------KPYDHTADLWSLGCILYELFVGTPPFYTNSIFQ
||||     |||||||..  ..                ..    ... ||| .|||| ..       |.||  .| ||||| . |.  | ||. . . ..
NILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMR

LVSLII----------------KDPVKWPKNME-------------------PEFK
   .|.                ..| . | . .                   ||||
AMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFK
Kinase Fused.AA S_TKc 1-164 27 3.4e-32 114.18 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-164
Range on HMM: 19-231/231
Sequence Identity: 27% (62 aa)

MKEM-----------------------HHPNIIEMLDTFETDKEVVAVTDYAEG---ELFQILEDDGT------LPEEQVKEIACQLLSALYYLHAHRIL
 .                         |||||. ..|.|.. ...  |..|..|   .||..... |.      .|| ... ...|...|| |.| |.|.
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGII

HRDMKPQNILLGKGGVVKLCDFGFARAMSINTLVLTSIKGTPLYMAPELVEEKPYDH-TADLWSLGCILYELFVGTPPFYTNSIFQ------------LV
||| ||.|||| .  ..|.||||.|| .       |.. ||| |||||..   .|..  .| ||.||||||...| |||.   ...            ..
HRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIGSPEAKDFI

SLIIK--------------------DPVK
. . .                    .|  
RKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase Fused.AA TyrKc 178-385 18 5.4e-12 -28.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 178-385
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

LKFIPKLG---------------------RSDKELDSLRKEIEIMKEM--HHPNIIEMLDTFETD-------KEVVAVTDYAE-GELFQILEDDGT-LPE
.... |||                     ..|. .  ...|..||..   |||||. ..    ..       . .  |. |.. | | . | . .  |. 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

EQVKEIACQLLSALYYLHAHRILHRDMKPQNILLGKGGVVKLCDFGFARAMSIN--------TLVLTSIKGTP--L---YMAPELVEEKPYDHTADLWSL
..  ... |  .   ||| ... |||    |.|.|....|| .||| .|.            . . .. ||.   |    ||||   .. . .  | || 
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF

GCILYELF-VGTPPFYT-----NSIFQLVSLIIKDFLQGLLTK-----------------------SAKHRLTWPALLYHPF
|  ..|.|  | .| .       | .... .. . .                               .. | |  .. .. |
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase Fused.AA Pkinase_Tyr 38-140 29 1.5e-10 36.39 Pfam 159-264 (270) Show / Hide 
Range on Protein: 38-140
Range on HMM: 159-264/270
Sequence Identity: 29% (32 aa)

EDDGTLPEEQVKEIACQLLSALYYLHAHRILHRDMKPQNILLGKGGVVKLCDFGFARAM-SINTLVLTSIKGTPL---YMAPELVEEKPYDHTADLWSLG
||.. |. ..  ... |  ... ||..... |||    |.|.....||| |||| ||.. .  .  ... .|..|    ||||   .. . .  | || |
EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG

CILYELF
  ..|.|
VLMWEIF
Kinase Fused.AA Pkinase_Tyr 238-340 29 1.5e-10 36.39 Pfam 103-208 (270) Show / Hide 
Range on Protein: 238-340
Range on HMM: 103-208/270
Sequence Identity: 29% (32 aa)

EDDGTLPEEQVKEIACQLLSALYYLHAHRILHRDMKPQNILLGKGGVVKLCDFGFARAM-SINTLVLTSIKGTPL---YMAPELVEEKPYDHTADLWSLG
||.. |. ..  ... |  ... ||..... |||    |.|.....||| |||| ||.. .  .  ... .|..|    ||||   .. . .  | || |
EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG

CILYELF
  ..|.|
VLMWEIF
Kinase Fused.AA RSK 360-386 21 8.2e-05 13.94 In-house 247-278 (278) Show / Hide 
Range on Protein: 360-386
Range on HMM: 247-278/278
Sequence Identity: 21% (7 aa)

KDFLQGLLTKSAKHRLT-----WPALLYHPFV
||.....|..  . ||.        .. ||. 
KDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase Fused.AA Pkinase_Tyr 176-213 34 0.000141 16.13 Pfam 31-70 (270) Show / Hide 
Range on Protein: 176-213
Range on HMM: 31-70/270
Sequence Identity: 34% (14 aa)

VALKFIPKLGRSDKE--LDSLRKEIEIMKEM-HHPNIIEML
|| | . | | ....  .... .|..|||.. |||||. ..
VAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY