Spk370

Species: Sea Urchin
Alias: SPU_010456, Spk370
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urchC

Sequence

Name Sequence Type Origin Length Description Download
Spk370.AA Protein None 497 None Fasta, JSON
Spk370.kin_dom Protein Kinase Domain None 216 None Fasta, JSON

Protein domain

Protein domains of Spk370.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk370.AA urchC 208-425 57 9.1e-168 547.6 In-house 1-223 (223) Show / Hide
Range on Protein: 208-425
Range on HMM: 1-223/223
Sequence Identity: 57% (129 aa)

KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHQKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYR
...|.|||.||.|.|.||.|.|...||||||||||.|...|..|.|||.|.||..||..|......||||..|.||..|....|.||||.|..|.|..|.
QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVYM

LHDALQ---VIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYT-EQRSFSDLIPESQRLK-FPHIAP
||||..   ..|||.|...|||||||||..|||...|||||||||||.||.|||||.|||||.|||||.|.||||. .||.|.|..|..|.|. |.||||
LHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAP

ELLDSAGSQVSASTDIFAVGVQL
|.||..|.|||...||..||| |
EVLDIDGCQVSVASDIYSVGVIL

Kinase Spk370.AA urch 214-422 40 1.4e-112 380.31 In-house 1-217 (217) Show / Hide
Range on Protein: 214-422
Range on HMM: 1-217/217
Sequence Identity: 40% (89 aa)

IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHQK--GEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYRLHDA
||.|..| |.|..... ..|||||.|..| . .  .|....|||||..|..||..|..|. |.||| .. |...|...||.|.||.|. .||..|.||..
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC

LQ---VIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE-RWHGVIIDMGLVTTMAYT-EQRSF-SDLIPESQRLK-FPHIAPEL
..   ...|....|.||...|||| |.|.. .||.|.||||.|.||.|||.||. |||.||||.|.|.||... ....| .....|..... ..|||||.
IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC

LDSAGSQVSASTDIFAVG
.. .|...|...|...||
VL-DGQPCSIASDVYSVG

Kinase Spk370.AA urch-unclassified 214-422 31 2.5e-45 156.9 In-house 1-215 (215) Show / Hide
Range on Protein: 214-422
Range on HMM: 1-215/215
Sequence Identity: 31% (69 aa)

IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHQKGEAAENEWK---ANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYRLHD
|| |.|| | .. . .   ||..|  ... |.. .  | . .   ..  |. ||..|  |. . |||  . |  ...  .|.| || |  ||.. | | .
IGKGTFGKVFMMRHQREAVPVKVK--MIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQ

ALQVID---PILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE--RWHGVIIDMGLVTTMAY-TEQRSFSDLIPESQRL--KFPHIAP
..       | |  |. ..  |..| . |    |. .|||||.|..||||. ...  |||  |||.|...||..   ||.|||   .  ..     |.||
WIHERHKSNPAL--SKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAP

ELLDSAGSQVSASTDIFAVG
|     |   |  .||.  |
EIV-LYGQPTSVYSDIYSLG

Kinase Spk370.AA urchB 209-376 41 8.2e-39 135.27 In-house 2-164 (212) Show / Hide
Range on Protein: 209-376
Range on HMM: 2-164/212
Sequence Identity: 41% (71 aa)

LELDMIGNGSFGIVLLGHLDGLSKPVAIKRP-YVPAHQKGEAAENEWK-ANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPY
 .|  || |..| |..        | ||| |      |      .| . |   | .|| ..  |. . ||| .  ||  |...||   ||||   ||  |
NDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIGY

RLHDALQVIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTT
 ||       | |  |. | | |||| |.|.  .|| |||||| | ||.||| || |.| |||| |.| |
PLHEP-----PPL--SMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVST

Kinase Spk370.AA TKL 214-423 16 2.7e-15 51.56 In-house 1-277 (364) Show / Hide
Range on Protein: 214-423
Range on HMM: 1-277/364
Sequence Identity: 16% (49 aa)

IGNGSFGIVLLGHLDGLS--------KPVAIKRPYVPAHQKGEAAENE-------------WKANQGRTRKESLVLELLKG--CPYFAQMVGTITIGRE-
|| |.||.|  |.. | .        |.||.|.  .   .. .  ..|             .. ..    .|  .. ...   .|   |..|  . ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCVVTEFVGSGQ-TGRPYRLHDALQVIDPILYPSIWNM-VAIAEDLVRGVSIIHDFG--------LLHNDIKGDNILLEHRGE-----
            || |.|..  |    .                   |.  . .| |  ||..  |  .        ..| |.| .|||.   ..     
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNY

------RWHGVIIDMGLVTTMAYTEQRSFSDL-------------IPESQRLKFPHIAPELLDSA--------------GSQVSASTDIFAVGV
       |.  | |.|| ..|  ... . .                  .|.  . . |||.|. .              |.. | ..|... |.
MYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI

Kinase Spk370.AA urchA 262-373 27 4.3e-13 38.65 In-house 43-158 (208) Show / Hide
Range on Protein: 262-373
Range on HMM: 43-158/208
Sequence Identity: 27% (32 aa)

RKESLVLELLKGCPYFAQMVGTITIGRELCVVT-EFVGSGQTGRPYRLHDALQV----IDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNIL
..|  ....| . |.| .. |   |     .   ||.|.  ||. | . . |.       | |  .   . ... |   |   .|. | | || | ||.|
QNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEMRQPAL--TRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCL

LEH-RGERWHGVIIDMGL
.    . || ..|||.|.
VRKTEFGRWRAKIIDFGW

Kinase Spk370.AA S_TKc 208-464 17 2.2e-11 -10.08 SMART 1-231 (231) Show / Hide
Range on Protein: 208-464
Range on HMM: 1-231/231
Sequence Identity: 17% (50 aa)

KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHQKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGS--GQTGRP
   |. || |.|| | ...  .  . ||||.                     ..|.|  .|.   ..|.  .. ...    .|..|.|...   |     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGD----

YRLHDALQVIDPILYP---SIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYTEQRSFSDLIPESQRLKFPHIAP
  |.| ..   .  ..   .      ..  .....  .|. | .| |.| .|||| .     |  |.| || . .              ..      .||
--LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAP

ELLDSAGSQVSA-STDIFAVGV-------------QLNMIGQFIDDDELVTVGEHCCENEPHLRPKALDDIV-------PKLV
|.|     . .  . |. ..|.             |..|. . | ..|.    ..|.. .|  || | .             .
EVL-----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Spk370.AA Pkinase 214-362 23 1.1e-09 35.28 Pfam 7-146 (293) Show / Hide
Range on Protein: 214-362
Range on HMM: 7-146/293
Sequence Identity: 23% (36 aa)

IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHQKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYRLHDALQ
|| |||| | ..|  | .| ||.|.  .. |.| .  .. ...       |  ..  | ..|.  .. .. . ......|.|... | .     |.| ..
IGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY--VMDLFDYIS

--VIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE
     ...  | |    ..  ..||.  .|. | .| |.| .|||. ..|.
TWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH

Kinase Spk370.AA TKL-ciliate1 332-423 28 4e-07 20.42 In-house 111-207 (279) Show / Hide
Range on Protein: 332-423
Range on HMM: 111-207/279
Sequence Identity: 28% (28 aa)

DLVRGVSIIHDFG--LLHNDIKGDNILLEHRGERWHGVIIDMGLVTT--MAYTEQRSFSDLIPESQRLKFPH-IAPELLD---SAGSQVSASTDIFAVGV
|. .|.. .|     | | |.|  |||.   .|     | . . |..     .   || |.  |.||.  .|  ||| .|     . ...   ||.|.|.
DIAQGMQYLHMRQNPLIHRDLKMQNILY---DEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGI





Kinase Spk370.AA TyrKc 208-463 16 9.3e-07 -113.39 SMART 1-280 (280) Show / Hide
Range on Protein: 208-463
Range on HMM: 1-280/280
Sequence Identity: 16% (51 aa)

KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHQKGEAAENEWKANQGRTRKESLVLELL-KGCPYFAQMVGTITIG-------RELCVVTEFVGS
   ....|.| ||.| .|...    .||.|     |              .   ..|  ..  | .  |   ...| .| .         |..|.|..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

GQTGRPYRLHDALQVIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYT-EQRSFSDLIPESQ--RLK
|       |.| |.   |    .   .. .. .  .| . .|. .. | |.   |.|. ...   .  | | ||        .|   .| .  ..    |
G------DLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

--FP--HIAPELLDSA---------------------GSQVSAS--------TDIFAVGVQLNMIGQFID---------DDELVTVGEHCCENEPHLRPK
  .|    ||| ..                       | |            .....   | ..  |  .          ||. .. . |.. .|. || 
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

ALDDIVPKL
   .|. ..
FS-EIHECF

Kinase Spk370.AA Ciliate-B3 326-372 31 7e-06 17.95 In-house 2-49 (69) Show / Hide
Range on Protein: 326-372
Range on HMM: 2-49/69
Sequence Identity: 31% (15 aa)

MVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE-RWHGVIIDMG
 .   . .|  . |.|.  . | ||| ||||... ..  .  .||| |
ALKHFHQVVEKIKILHEKNICHCDIKVDNILVNQQDKENYKVIIIDFG

Kinase Spk370.AA Dicty3 329-357 46 7e-06 15.27 In-house 116-145 (351) Show / Hide
Range on Protein: 329-357
Range on HMM: 116-145/351
Sequence Identity: 46% (14 aa)

IAEDLVRGVSIIHDFG-LLHNDIKGDNILL
|..||| . . ||. . ..| |||.|||.|
IICDLVKTLNYIHKNCHIIHRDIKCDNIML

Kinase Spk370.AA Ciliate-E1 320-362 27 8e-06 15.38 In-house 105-147 (202) Show / Hide
Range on Protein: 320-362
Range on HMM: 105-147/202
Sequence Identity: 27% (12 aa)

YPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE
. .......|. .|. |....|.....| ||| .||| .. |.
QFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGN

Kinase Spk370.AA urchA 399-419 42 0.064097 2.06 In-house 189-208 (208) Show / Hide
Range on Protein: 399-419
Range on HMM: 189-208/208
Sequence Identity: 42% (9 aa)

HIAPELLDSAGSQVSASTDIF
|||||.  .| .  | | |..
HIAPECALDAQP-CSTSSDVY

Kinase Spk370.AA Ciliate-E1 214-225 66 0.216423 0.87 In-house 1-12 (202) Show / Hide
Range on Protein: 214-225
Range on HMM: 1-12/202
Sequence Identity: 66% (8 aa)

IGNGSFGIVLLG
||||||.||. .
IGNGSFSIVFKA

Kinase Spk370.AA urchB 400-422 47 0.293643 0.68 In-house 191-212 (212) Show / Hide
Range on Protein: 400-422
Range on HMM: 191-212/212
Sequence Identity: 47% (11 aa)

IAPELLDSAGSQVSASTDIFAVG
|||| .   |   | | |.| ||
IAPEVI-LHGQSTSISSDVFSVG