Spk401

Species: Sea Urchin
Alias: Spk401
External Links:
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urchC

Sequence

Name Sequence Type Origin Length Description Download
Spk401.AA Protein None 339 None Fasta, JSON
Spk401.kin_dom Protein Kinase Domain None 216 None Fasta, JSON

Protein domain

Protein domains of Spk401.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk401.AA urchC 50-267 56 5e-167 545.16 In-house 1-223 (223) Show / Hide
Range on Protein: 50-267
Range on HMM: 1-223/223
Sequence Identity: 56% (127 aa)

KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVSAITMGRELCVVTEFVGSGQTGRPYR
...|.|||.||.|.|.||.|.|...||||||||||.|...|..|.|||.|.||..||..|......||||..|..........|.||||.|..|.|..|.
QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVYM

LHDALQ---VIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYT-EQRSFSDLIPESQRLK-FPHIAP
||||..   ..|||.|...|||||||||..|||...|||||||||||.||.|||||.|||||.|||||.|.||||. .||.|.|..|..|.|. |.||||
LHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAP

ELLDIAGSQVSASTDIFAVGVQL
|.|||.|.|||...||..||| |
EVLDIDGCQVSVASDIYSVGVIL

Kinase Spk401.AA urch 56-264 39 1.6e-109 370.17 In-house 1-217 (217) Show / Hide
Range on Protein: 56-264
Range on HMM: 1-217/217
Sequence Identity: 39% (87 aa)

IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLK--GEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVSAITMGRELCVVTEFVGSGQTGRPYRLHDA
||.|..| |.|..... ..|||||.|..| ...  .|....|||||..|..||..|..|. |.||| ..   ......||.|.||.|. .||..|.||..
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC

LQ---VIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE-RWHGVIIDMGLVTTMAYT-EQRSF-SDLIPESQRLK-FPHIAPEL
..   ...|....|.||...|||| |.|.. .||.|.||||.|.||.|||.||. |||.||||.|.|.||... ....| .....|..... ..|||||.
IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC

LDIAGSQVSASTDIFAVG
.. .|...|...|...||
VL-DGQPCSIASDVYSVG

Kinase Spk401.AA urch-unclassified 56-264 30 1.5e-41 144.35 In-house 1-215 (215) Show / Hide
Range on Protein: 56-264
Range on HMM: 1-215/215
Sequence Identity: 30% (68 aa)

IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWK---ANQGRTRKESLVLELLKGCPYFAQMVSAITMGRELCVVTEFVGSGQTGRPYRLHD
|| |.|| | .. . .   ||..|  ... | . .  | . .   ..  |. ||..|  |. . |||  .    . .  .|.| || |  ||.. | | .
IGKGTFGKVFMMRHQREAVPVKVK--MIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQ

ALQVID---PILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE--RWHGVIIDMGLVTTMAY-TEQRSFSDLIPESQRL--KFPHIAP
..       | |  |. ..  |..| . |    |. .|||||.|..||||. ...  |||  |||.|...||..   ||.|||   .  ..     |.||
WIHERHKSNPAL--SKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAP

ELLDIAGSQVSASTDIFAVG
|     |   |  .||.  |
EIV-LYGQPTSVYSDIYSLG

Kinase Spk401.AA urchB 51-218 39 7.8e-36 125.37 In-house 2-164 (212) Show / Hide
Range on Protein: 51-218
Range on HMM: 2-164/212
Sequence Identity: 39% (68 aa)

LELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPA--HLKGEAAENEWK-ANQGRTRKESLVLELLKGCPYFAQMVSAITMGRELCVVTEFVGSGQTGRP
 .|  || |..| |..        | ||| |       . .|  . | . |   | .|| ..  |. . ||| .      ....||   ||||   ||  
NDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVD-ELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIG

YRLHDALQVIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTT
| ||       | |  |. | | |||| |.|.  .|| |||||| | ||.||| || |.| |||| |.| |
YPLHEP-----PPL--SMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVST

Kinase Spk401.AA urchA 137-215 30 1.1e-12 37.26 In-house 77-158 (208) Show / Hide
Range on Protein: 137-215
Range on HMM: 77-158/208
Sequence Identity: 30% (26 aa)

EFVGSGQTGRPYRLHDALQV----IDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEH-RGERWHGVIIDMGL
||.|.  ||. | . . |.       | |  .   . ... |   |   .|. | | || | ||.|.    . || ..|||.|.
EFCGDEMTGESYTITWCLDKAMEMRQPAL--TRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGW

Kinase Spk401.AA TKL 56-265 16 8.6e-12 38.74 In-house 1-277 (364) Show / Hide
Range on Protein: 56-265
Range on HMM: 1-277/364
Sequence Identity: 16% (48 aa)

IGNGSFGIVLLGHLDGLS--------KPVAIKRPYVPAHLKGEAAENE-------------WKANQGRTRKESLVLELLKG--CPYFAQMVSAITMGRE-
|| |.||.|  |.. | .        |.||.|.  .    . .  ..|             .. ..    .|  .. ...   .|   |.. . . ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCVVTEFVGSGQ-TGRPYRLHDALQVIDPILYPSIWNM-VAIAEDLVRGVSIIHDFG--------LLHNDIKGDNILLEHRGE-----
            || |.|..  |    .                   |.  . .| |  ||..  |  .        ..| |.| .|||.   ..     
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNY

------RWHGVIIDMGLVTTMAYTEQRSFSDL-------------IPESQRLKFPHIAPELLD--------------IAGSQVSASTDIFAVGV
       |.  | |.|| ..|  ... . .                  .|.  . . |||.|.              . |.. | ..|... |.
MYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI

Kinase Spk401.AA S_TKc 50-306 17 2.3e-11 -10.34 SMART 1-231 (231) Show / Hide
Range on Protein: 50-306
Range on HMM: 1-231/231
Sequence Identity: 17% (50 aa)

KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVSAITMGRELCVVTEFVGS--GQTGRP
   |. || |.|| | ...  .  . ||||.                     ..|.|  .|.   ..|.  ..  ..    .|..|.|...   |     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGD----

YRLHDALQVIDPILYP---SIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYTEQRSFSDLIPESQRLKFPHIAP
  |.| ..   .  ..   .      ..  .....  .|. | .| |.| .|||| .     |  |.| || . .              ..      .||
--LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAP

ELLDIAGSQVSA-STDIFAVGV-------------QLNMIGQFIDDDELVMVGEHCCENEPHLRPKALDDIV-------PKLV
|.|     . .  . |. ..|.             |..|. . | ..|.    ..|.. .|  || | .             .
EVL-----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Spk401.AA Pkinase 56-204 23 4.1e-09 33.32 Pfam 7-146 (293) Show / Hide
Range on Protein: 56-204
Range on HMM: 7-146/293
Sequence Identity: 23% (36 aa)

IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVSAITMGRELCVVTEFVGSGQTGRPYRLHDALQ
|| |||| | ..|  | .| ||.|.  .. | | .  .. ...       |  ..  | ..|.  ..  . . ......|.|... | .     |.| ..
IGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY--VMDLFDYIS

--VIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE
     ...  | |    ..  ..||.  .|. | .| |.| .|||. ..|.
TWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH

Kinase Spk401.AA TKL-ciliate1 174-265 28 3.1e-07 20.8 In-house 111-207 (279) Show / Hide
Range on Protein: 174-265
Range on HMM: 111-207/279
Sequence Identity: 28% (28 aa)

DLVRGVSIIHDFG--LLHNDIKGDNILLEHRGERWHGVIIDMGLVTT--MAYTEQRSFSDLIPESQRLKFPH-IAPELLD---IAGSQVSASTDIFAVGV
|. .|.. .|     | | |.|  |||.   .|     | . . |..     .   || |.  |.||.  .|  ||| .|     . ...   ||.|.|.
DIAQGMQYLHMRQNPLIHRDLKMQNILY---DEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGI





Kinase Spk401.AA TyrKc 50-305 16 2e-06 -117.69 SMART 1-280 (280) Show / Hide
Range on Protein: 50-305
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLVLELL-KGCPYFAQMVSAITMG-------RELCVVTEFVGS
   ....|.| ||.| .|...    .||.|     |              .   ..|  ..  | .  |   ... ..| .         |..|.|..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

GQTGRPYRLHDALQVIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYT-EQRSFSDLIPESQ--RLK
|       |.| |.   |    .   .. .. .  .| . .|. .. | |.   |.|. ...   .  | | ||        .|   .| .  ..    |
G------DLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

--FP--HIAPELLDIA---------------------GSQVSAS--------TDIFAVGVQLNMIGQFID---------DDELVMVGEHCCENEPHLRPK
  .|    ||| ..                       | |            .....   | ..  |  .          ||. .. . |.. .|. || 
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

ALDDIVPKL
   .|. ..
FS-EIHECF

Kinase Spk401.AA Ciliate-B3 168-214 31 7e-06 17.95 In-house 2-49 (69) Show / Hide
Range on Protein: 168-214
Range on HMM: 2-49/69
Sequence Identity: 31% (15 aa)

MVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE-RWHGVIIDMG
 .   . .|  . |.|.  . | ||| ||||... ..  .  .||| |
ALKHFHQVVEKIKILHEKNICHCDIKVDNILVNQQDKENYKVIIIDFG

Kinase Spk401.AA Dicty3 171-199 46 7e-06 15.27 In-house 116-145 (351) Show / Hide
Range on Protein: 171-199
Range on HMM: 116-145/351
Sequence Identity: 46% (14 aa)

IAEDLVRGVSIIHDFG-LLHNDIKGDNILL
|..||| . . ||. . ..| |||.|||.|
IICDLVKTLNYIHKNCHIIHRDIKCDNIML

Kinase Spk401.AA Ciliate-E1 162-204 27 8e-06 15.38 In-house 105-147 (202) Show / Hide
Range on Protein: 162-204
Range on HMM: 105-147/202
Sequence Identity: 27% (12 aa)

YPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE
. .......|. .|. |....|.....| ||| .||| .. |.
QFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGN

Kinase Spk401.AA urchA 241-261 38 0.008342 4.96 In-house 189-208 (208) Show / Hide
Range on Protein: 241-261
Range on HMM: 189-208/208
Sequence Identity: 38% (8 aa)

HIAPELLDIAGSQVSASTDIF
|||||.  . ..  | | |..
HIAPECA-LDAQPCSTSSDVY

Kinase Spk401.AA urchB 242-264 47 0.05021 3.46 In-house 191-212 (212) Show / Hide
Range on Protein: 242-264
Range on HMM: 191-212/212
Sequence Identity: 47% (11 aa)

IAPELLDIAGSQVSASTDIFAVG
|||| . . |   | | |.| ||
IAPEVI-LHGQSTSISSDVFSVG

Kinase Spk401.AA Ciliate-E1 56-67 66 0.216423 0.87 In-house 1-12 (202) Show / Hide
Range on Protein: 56-67
Range on HMM: 1-12/202
Sequence Identity: 66% (8 aa)

IGNGSFGIVLLG
||||||.||. .
IGNGSFSIVFKA