Wee1a

Species: Sea Urchin
Alias: SPU_014185, Spk209, Wee1a
External Links: Sea Urchin Project Link ,
Annotation:

Classification

Group: Other
Family: WEE
Subfamily: WEE1

Sequence

Name Sequence Type Origin Length Description Download
Wee1a.AA Protein None 313 None Fasta, JSON
Wee1a.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of Wee1a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Wee1a.AA WEE 48-249 43 6.9e-115 386.73 In-house 37-297 (297) Show / Hide
Range on Protein: 48-249
Range on HMM: 37-297/297
Sequence Identity: 43% (113 aa)

QDTPFRQMALNEVYAHAVLG------THIHVVRYYSAWSEAGHMIIQNEYCNGGS--LADIISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSE-GLVHM
... .|..||.|||||.|||      .|.|.|||||||.|..||.||.|||||||  |...|......||...|....|.||.|.|||..|||. |.|||
RGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEEDDHMYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHM

DIKPG---------------------------------DLGHVTSIS----NPKVE-EGDVRFLPVEILQE--EHTHLTKADIFALALTAYLAAGGESLP
||||.                                 |.||||...    ||..| ||| |... ||||.  ..|||.|||||.|..| | .|....||
DIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNSNNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYELACNMDLP

KNGDDWHRIRQG-------HFP-P--LLHISTDLVDLLQTMIDPDPSQRPSASALVQHPLL
||||.||.||||       ..| |  .  ||..| .|.. |..|||.|||....|.|||.|
KNGDWWHQIRQGDLSFDKNQIPFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL

Kinase Wee1a.AA Pkinase 52-142 32 1.2e-20 74.04 Pfam 41-136 (293) Show / Hide
Range on Protein: 52-142
Range on HMM: 41-136/293
Sequence Identity: 32% (32 aa)

FRQMALN--EVYAHAVLGTHIHVVRYYSAWSEAGHMIIQNEYCNGG----SLADIIS-SNKQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKP
..| ...  |.. .. |  | ..||.| .. . .|. .  |||.||    .|.|.|| ... .   ..| |.| .. ||..||.|.||.| .| |.||
KDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKP

Kinase Wee1a.AA STE 69-143 34 3.6e-17 57.27 In-house 89-181 (359) Show / Hide
Range on Protein: 69-143
Range on HMM: 89-181/359
Sequence Identity: 34% (32 aa)

HIHVVRYYSAWSEAG-------HMIIQNEYCNGGSLADIISSN----KQNN------HRMTEIELKQVLVQIAQG-LKYIHSEGLVHMDIKPG
| ..|.|| .    |       .  |  ||..|||| ||| ..    |..|      ||. | ... ...|| .| |.|.|| . .| ||||.
HPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPA

Kinase Wee1a.AA Ciliate-E2 69-142 28 5.3e-17 54.89 In-house 91-189 (365) Show / Hide
Range on Protein: 69-142
Range on HMM: 91-189/365
Sequence Identity: 28% (28 aa)

HIHVVRYYSAWS--EAGHMIIQNEYCNGGSLADIISSNKQNN-------HRMTEIELKQVLVQIAQ---------------GLKYIHSEG-LVHMDIKP
| .....| ..      .. .  |||.||.| |.| .||..        ...|| | |..  ||.|               .|.|.||..  .| ||||
HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP

Kinase Wee1a.AA ULK 90-142 40 7.5e-17 55.44 In-house 100-158 (329) Show / Hide
Range on Protein: 90-142
Range on HMM: 100-158/329
Sequence Identity: 40% (24 aa)

EYCNGGSLADIISSNKQ------NNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKP
|||||| | ..|. ||       .. | .| | .|.. ||..|.|..|... .| ||||
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKP

Kinase Wee1a.AA ULK 90-142 41 1.8e-16 55.03 In-house 97-154 (324) Show / Hide
Range on Protein: 90-142
Range on HMM: 97-154/324
Sequence Identity: 41% (24 aa)

EYCNGGSLADIISSNKQ-----NNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKP
|||||| | ..|  ||      .. | .| | .|.. ||..|.|..|... .| ||||
EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKP

Kinase Wee1a.AA Ciliate-E2-Unclassified 69-142 27 7.2e-16 51.55 In-house 80-172 (352) Show / Hide
Range on Protein: 69-142
Range on HMM: 80-172/352
Sequence Identity: 27% (26 aa)

HIHVVRYYSAWSEAGHMIIQNEYCNGGSLADIISS-------------NKQNNHRMTEIELK-----QVLVQIAQGLKYIHSEG-LVHMDIKP
|...|... .     ...|  |||.||.| ..|..             |...... || . |     . . || |||.|.|...  .| ||||
HPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKP

Kinase Wee1a.AA CAMK 53-142 21 4.6e-14 41.01 In-house 75-207 (425) Show / Hide
Range on Protein: 53-142
Range on HMM: 75-207/425
Sequence Identity: 21% (28 aa)

RQMALNEVYAHAVLGT------HIHVVRYYSAWSEAGH-------------------MIIQN---EYCNGG----SLADIISSNKQNN-----------H
|.. ..|.  .  |        | .... | ..  . .                   |..     ||| ||     | | | .....            .
RKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERG

RMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKP
|.|| | ...  ||.....|.|| . || |.||
RFTEREARRYFRQICSAVHYCHSHNIVHRDLKP

S_TKc Wee1a.AA S_TKc 35-249 19 1.7e-13 20.84 SMART 1-231 (231) Show / Hide
Range on Protein: 35-249
Range on HMM: 1-231/231
Sequence Identity: 19% (49 aa)

YGFKPQCSTGVPG-----QDTP----------FRQMALNEVYAHAVLGTHIHVVRYYSAWSEAGHMIIQNEYCNG--GSLADIISSNKQNNHR--MTEIE
| .  .   |  |     ...             .....|.  .     | ..|..| .. . .|. .  |||.|  |.| |.| ... .  |  ..| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

LKQVLVQIAQGLKYIHSEGLVHMDIKP-----------GDLGHVTSISNPKVEEGDVRFLPVEILQEEHTHLT-KADIFALALTAYLAAGGES-LPKNGD
 . .. ||...|.|.|| | .| |.||           .| |  . .   .   |   ... |.|     . . |.|. ..  . |  . |.   | . .
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL---TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQ

DWHRIRQGHFPPLLHISTDLVDLLQTMIDPDPSQRPSASALVQ-------HPLL
   ..           | .. |... . . ||..||.|  . |       || .
MMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Wee1a.AA GCN2 87-142 41 1.3e-12 40.13 In-house 284-336 (511) Show / Hide
Range on Protein: 87-142
Range on HMM: 284-336/511
Sequence Identity: 41% (23 aa)

IQNEYCNGGSLADIISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKP
|| ||| |..|...|.... .. .    ||.... ||  ||.|||| | .| |.||
IQMEYCEGKTLRQYIDNHGWCMDHD---ELWRYFRQILEGLNYIHSQGMIHRDLKP

Kinase Wee1a.AA PEK 87-143 23 2e-12 38.82 In-house 360-456 (655) Show / Hide
Range on Protein: 87-143
Range on HMM: 360-456/655
Sequence Identity: 23% (23 aa)

IQNEYCNGGSLADIISSNK--------------------QNN--------------------HRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKPG
|| |||....| |.|..|.                    ..|                    .   . .... . ||. ||.|||| |..| |.||.
IQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPS

Kinase Wee1a.AA NEK 69-142 30 2e-11 36.9 In-house 63-147 (286) Show / Hide
Range on Protein: 69-142
Range on HMM: 63-147/286
Sequence Identity: 30% (26 aa)

HIHVVRYYSAWSEAG--HMIIQNEYCN-GGSLADI---ISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSE-----GLVHMDIKP
| ..|.|| .. | .  ...|  |||. || |..    |  .|| .. . | .   ...|.. .|||.|..       .| ||||
HPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKP

Kinase Wee1a.AA NEK 206-249 35 9e-11 34.56 In-house 239-286 (286) Show / Hide
Range on Protein: 206-249
Range on HMM: 239-286/286
Sequence Identity: 35% (17 aa)

RIRQG-HFPPLL-H--ISTDLVDLLQTMIDPDPSQRPSASALVQHPLL
.|..| ..||.  |   |.|| .|.. |. .||.||||.. . ..|..
KIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase Wee1a.AA PEK 207-249 31 3.1e-09 27.52 In-house 605-655 (655) Show / Hide
Range on Protein: 207-249
Range on HMM: 605-655/655
Sequence Identity: 31% (16 aa)

IRQ------GHFP-PLLHI-STDLVDLLQTMIDPDPSQRPSASALVQHPLL
.|.      | || ...    ... |..| |...||.|||||. . ||...
LRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF

Kinase Wee1a.AA Pkinase 143-249 16 4e-09 33.35 Pfam 154-293 (293) Show / Hide
Range on Protein: 143-249
Range on HMM: 154-293/293
Sequence Identity: 16% (23 aa)

GDLGH-----VTSISNPKVEEGDVRFLPVEILQEEHTHLTKADIFALALTAYLAAGGESLPKNG------DDWHRIRQGHFPPLLHIS------------
.| |        . | ...  |  .... |....   . .|.|.... .. |  . |. . ..       |. ..|..   |||   .            
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFR

------------TDLVDLLQTMIDPDPSQRPSASALVQHPLL
             .. |..  ....||..||.|  ..||| .
HWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase Wee1a.AA STE 167-249 19 1.1e-08 26.92 In-house 232-359 (359) Show / Hide
Range on Protein: 167-249
Range on HMM: 232-359/359
Sequence Identity: 19% (25 aa)

EILQE-----EHTHLTKADIFALALTAYLAAGGESL----PKNGDDWHRIRQ--------------GHFPPLL--------------------HISTDLV
|..|      .. . ||.||  | .|.   | |.      .     .. ..               |. |||                     . | .. 
EVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFK

DLLQTMIDPDPSQRPSASALVQ--HPLL
| ..   . ||..||.|| | .  || .
DFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase Wee1a.AA GCN2 219-249 38 1.4e-08 25.68 In-house 481-511 (511) Show / Hide
Range on Protein: 219-249
Range on HMM: 481-511/511
Sequence Identity: 38% (12 aa)

STDLVDLLQTMIDPDPSQRPSASALVQHPLL
..|  |... ....||..||||. | ||..|
HKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL

Kinase Wee1a.AA CAMK 204-249 17 1.7e-08 22.75 In-house 356-425 (425) Show / Hide
Range on Protein: 204-249
Range on HMM: 356-425/425
Sequence Identity: 17% (12 aa)

WHRIRQGHFP-PLLHIST-----------------------DLVDLLQTMIDPDPSQRPSASALVQHPLL
...|..| .  |  ..|.                       .  ||.. |  .||..|....   .|| .
FEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase Wee1a.AA Ciliate-E2 216-249 23 2.5e-08 24.68 In-house 327-365 (365) Show / Hide
Range on Protein: 216-249
Range on HMM: 327-365/365
Sequence Identity: 23% (9 aa)

LHISTDLVDLLQT----MIDPDPSQRPS-ASALVQHPLL
...| .  ||..     |.. ||..|.. .. . .|| .
KKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

TyrKc Wee1a.AA TyrKc 35-249 14 2.8e-08 -88.74 SMART 1-280 (280) Show / Hide
Range on Protein: 35-249
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)

YGFKPQCSTG-----------------VPGQDTPFRQMALNEVYAHAVLG-THIHVVRYYSAWSEA-------GHMIIQNEYCNGGSLADIISSNKQNNH
  .. .   |                 .   |.  |.. ..|      ||  | ..|| | . ..        . . |  ||. .|.| | . ... .  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

RMTEIELKQVLVQIAQGLKYIHSEGLVHMDI--------KPG-----------DLGHV------TSISNPK---VEE--GDVRFLPVEILQEEHTHLTKA
  .  .| .  .|||.|  |.|| ...| |.        ...           |...       ..   .|    .     .| .. | .  ...  || 
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKS

DIFALALTAY-LAAGGESLP-------KNGDD-WHRIRQGHFPPLLHI---------STDLVDLLQTMIDPDPSQRPSASALVQHPLL
|...   . . .   |.. .       .. ..  ....||. .|  .          .... .. ..  . ||..||. |..  | ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase Wee1a.AA Pkinase_Tyr 66-137 28 2.9e-07 25.25 Pfam 60-134 (270) Show / Hide
Range on Protein: 66-137
Range on HMM: 60-134/270
Sequence Identity: 28% (22 aa)

LGTHIHVVRYYSAWS-EAGH---MIIQNEYCNGGSLADIISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVH
|| | ..||.| . . . ..   .|.  ||. .|.| |   ... .... |  .| |  .|||.|. | .| ...|
LGHHPNIVRLYGVCTDQGEPNQIYIVM-EYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH

Kinase Wee1a.AA Ciliate-E2-Unclassified 224-249 34 2e-06 18.12 In-house 327-352 (352) Show / Hide
Range on Protein: 224-249
Range on HMM: 327-352/352
Sequence Identity: 34% (9 aa)

DLLQTMIDPDPSQRPSASALVQHPLL
|||| |.. .|..|.... . .||..
DLLQKMLKKNPNKRITFEQILNHPWF

Kinase Wee1a.AA ULK 212-249 31 0.000361 10.55 In-house 289-329 (329) Show / Hide
Range on Protein: 212-249
Range on HMM: 289-329/329
Sequence Identity: 31% (13 aa)

FP---PLLHISTDLVDLLQTMIDPDPSQRPSASALVQHPLL
||   .  .|| .. ||.. |.  |...| |   | .||..
FPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF

Kinase Wee1a.AA ULK 212-249 29 0.000842 9.44 In-house 284-324 (324) Show / Hide
Range on Protein: 212-249
Range on HMM: 284-324/324
Sequence Identity: 29% (12 aa)

FP---PLLHISTDLVDLLQTMIDPDPSQRPSASALVQHPLL
||   .  .|| .. ||.. |.  |...| |   . .||..
FPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF

Kinase Wee1a.AA PEK 69-81 53 0.025491 3.01 In-house 73-85 (655) Show / Hide
Range on Protein: 69-81
Range on HMM: 73-85/655
Sequence Identity: 53% (7 aa)

HIHVVRYYSAWSE
|...|||..|| |
HPNIVRYHNAWIE

Kinase Wee1a.AA GCN2 69-81 76 0.066367 1.95 In-house 60-72 (511) Show / Hide
Range on Protein: 69-81
Range on HMM: 60-72/511
Sequence Identity: 76% (10 aa)

HIHVVRYYSAWSE
|.|||||| || |
HQHVVRYYQAWIE