Gene Npr4 (Sea Urchin)
Npr4
Sequence
Protein domains of Npr4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Npr4.AA | RGC | 518-760 | 30 | 5.1e-100 | 338.6 | In-house | 1-300 (300) | Show / Hide |
Range on Protein: 518-760 Range on HMM: 1-300/300 Sequence Identity: 30% (90 aa) NGQTVAVKMIAKN----SFTLDKRIRKEVKQVRDLQHSNLCKFAGGCIEVP------NVSIITEYCPKGALSDVLLNEDVPLNWSFRFSFCMDVARGMHY .|..|..|.. .. . .... ...|.|| |.||| ||.|| | ||. | |..|..|||..| | |.| |.|... |.|..||..|...||.| EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY MHN-NKLYHGKLTSSNCVVDDRWVVKIADYGL-----TTFRNQ------------EGSQSNAGGYRSKAMQVY--LPPENRSNTYTLV-------TQATD .|. |||.|.|.|||||.||||||.|.|| ..|... . .|.. |..| .. . .|.|.. . ||. | LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD VYSYGVILVEIASRNE-----VIPE-----DDYPLDEAWRPPLPDLEIG---DTTDDERC------PCPADYLSLIERCWNINPAQRPH-FSQIRQTLHS |||.|.|. ||. | . . . . | ..... |... | . ... |. . |.|...||. .|..||. |.||| .| . VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT |
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| Kinase | Npr4.AA | RGC | 518-760 | 30 | 5.1e-100 | 338.6 | In-house | 1-300 (300) | Show / Hide |
Range on Protein: 518-760 Range on HMM: 1-300/300 Sequence Identity: 30% (90 aa) NGQTVAVKMIAKN----SFTLDKRIRKEVKQVRDLQHSNLCKFAGGCIEVP------NVSIITEYCPKGALSDVLLNEDVPLNWSFRFSFCMDVARGMHY .|..|..|.. .. . .... ...|.|| |.||| ||.|| | ||. | |..|..|||..| | |.| |.|... |.|..||..|...||.| EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY MHN-NKLYHGKLTSSNCVVDDRWVVKIADYGL-----TTFRNQ------------EGSQSNAGGYRSKAMQVY--LPPENRSNTYTLV-------TQATD .|. |||.|.|.|||||.||||||.|.|| ..|... . .|.. |..| .. . .|.|.. . ||. | LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD VYSYGVILVEIASRNE-----VIPE-----DDYPLDEAWRPPLPDLEIG---DTTDDERC------PCPADYLSLIERCWNINPAQRPH-FSQIRQTLHS |||.|.|. ||. | . . . . | ..... |... | . ... |. . |.|...||. .|..||. |.||| .| . VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT |
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| Kinase | Npr4.AA | TKL | 515-758 | 21 | 1.7e-62 | 213.98 | In-house | 12-364 (364) | Show / Hide |
Range on Protein: 515-758
Range on HMM: 12-364/364
Sequence Identity: 21% (77 aa)
GIYNG----------QTVAVKMIAKNSFTLD---------------------------KRIRKEVKQVRDLQHSNLCKFAGGCIEVPN------------
|...| ..||||.. ... .. .....|... . |.| |...| | |.. |.
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG
-VSIITEYCPKGALSDVLLNEDVPLNWSFRFSFCMDVARGMHYMHNNK--------LYHGKLTSSNCVVDDRWV--------------VKIADYGLTTFR
|..||||.| | ..|. |. |.....|.||||.|.|... . | |.|.|. ||. | .||.|.|| .|
QLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM
NQEGSQSNAG-----------GYRSKAMQV----YLPPENRSNT--YT------------LVTQATDVYSYGVILVEIASRNEVIPEDDYP---------
.|.|... . . . .|. ...|| .. || ....||||.|..| ||..| .. ...|.
SQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFE
------LDEAWRPPLP-----DLEIGDTTDDERCPCPADYLSLIERCWNINPAQRPHFSQIRQTL
|. |||.| . .|| .. .|...||. .| .|| |..| ..|
EMFMMVCDKGLRPPIPPIWQNHH---K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | Npr4.AA | TKL-Unique | 515-694 | 29 | 1e-36 | 127.04 | In-house | 16-224 (290) | Show / Hide |
Range on Protein: 515-694 Range on HMM: 16-224/290 Sequence Identity: 29% (62 aa) GIYNGQTVAVKMIAK-NSFTLDKRI--RKEVKQVRDLQ-HSNLCKFAGGCI----EVPNVSIITEYCPKGALSDVLL---------NEDVPLNWSFRFSF |...| ||.| ... ... .... ..||. |. | |. .. |.|. || .|..|||| | | ||| |. .||.. | .. GKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKM CMDVARGMHYMHNNK--LYHGKLTSSNCVVDDR-----WVVKIADYGLTTFRNQEGSQSNA---GGYRSKAMQV----YLPPENRSNTYTLVTQATDVYS |.|.||.| |... .|..|.||| || . | .||.| || .|.... .| |. .. . ...|| .. .. .. |||| AIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR--NQTRCGSFRWMAPEVLRMNFCQYSEKSDVYS YGVILVEIASR .|..| |||.| FGIVLWEIATR |
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| Kinase | Npr4.AA | TK | 508-758 | 15 | 6.7e-36 | 117.29 | In-house | 41-486 (486) | Show / Hide |
Range on Protein: 508-758
Range on HMM: 41-486/486
Sequence Identity: 15% (68 aa)
KQVFAQTGIYNGQTVAVKMIAKN-SFTLDKRIR----------------KEVKQVRD--LQHSNLCKFAGGCIEV------------PNVSIITEYCPKG
.. . . . . ..|||||. . . . . .. | |. . ..| |. .. | | .. . . |..||.|.|
TLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHG
A----LSDVLLNEDVP---------------------------------------------------------------------------LNWSFRFSF
| | | . . . |. . .
DMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-M
CMDVARGMHYMHNN------KLYHGKLTSSNCVVDDRWV-----------VKIADYGLT------TFRNQ---EGSQSNAGGYRSKAMQV----------
|...|.|| |.| . .. |. | || |... | .||||.||. | . . ...... |
CWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDY
------------YLPPENRSNT-------YTLVTQATDVYSYGVILVEIASRNEVIPEDDYPL------DEAWRPPLPDLEIGDTT---------DDERC
...|| | | ..||.|.|| . || .. .. . . . . . . |. | .. . |.
YRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRM
P----CP--------------ADYLSLIERCWNINPAQRPHFSQIRQTL
| || ..| |. .||. .|..|| |||... |
PQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | Npr4.AA | MLK | 515-696 | 24 | 1.5e-29 | 99.73 | In-house | 18-234 (291) | Show / Hide |
Range on Protein: 515-696 Range on HMM: 18-234/291 Sequence Identity: 24% (54 aa) GIYNGQT-----VAVKMIA---KNSFTL----DKRIRKEVKQVRDLQHSN----LCKFAGGCIEVPN-VSIITEYCPKGALSDVLLNED----------- | . ... ||||... . .. ...|....| |.| | ..| |.|.. |. . |..|||..| |..|| ... GRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQK --VPLNWSFRFSFCMDVARGMHYMHNNK---LYHGKLTSSNCVVDD------RWVVKIADYGLTTFRNQEGSQ---SNAGGYRSKAMQVYLPPENRSN-T . .. .......|||||| |... . | | |.| ..|. ..||.| |. .. .| . . |||| |. . || .. NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA------WMAPEVIQQFR YTLVTQATDVYSYGVILVEIASRNE . .. . ||.|.||.| |. .| . CEKYSEKCDVWSWGVVLWEMLTREV |
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| Kinase | Npr4.AA | DRK | 519-642 | 34 | 1.3e-28 | 94.0 | In-house | 22-151 (258) | Show / Hide |
Range on Protein: 519-642 Range on HMM: 22-151/258 Sequence Identity: 34% (45 aa) GQTVAVKMIAKNSFT-LD--KRIRKEVKQVRDLQHSNLCKFAGGCIEVPNVSIITEYCPKGALSDVLLNEDVPLNWSFRFSFCMDVARGMHYMHNNK--L | ||||| .. . ..|. | | | | | | | . | . |..|| |.| | .|..| . . |. . . .|.|.|| | |. GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPII YHGKLTSSNCVVDDRWVVKIADYGLTT-FR | | | | ||. | ||.||.|| | |. IHRDLKSHNLLVDEHWQVKVADFGLSTRFK |
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| Kinase | Npr4.AA | RIPK | 536-758 | 23 | 7.1e-28 | 92.05 | In-house | 41-290 (290) | Show / Hide |
Range on Protein: 536-758 Range on HMM: 41-290/290 Sequence Identity: 23% (61 aa) KRIRKEVKQVRDLQHSNLCKFAGGCIEV-----PN-VSIITEYCPKGALSDVLLNED----VPLNWSFRFSFCMDVARGMHYMHNNK--LYHGKLTSSNC . . |.| . |.... . | |... .. ..| .|| ..| |...| . |. |. |. ...||.| |... . | | .| MYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENI VVDDRWVVKIADYGLTTFRNQEGSQSNA--------GGYRSKA---MQVYLPPENRS--NTYTL--VTQATDVYSYGVILVEIASRNEVIPEDDYPL--- || ||||| || |. ...|.|. ...|| . |.|||. | . || . ||||..... |. .. .. .. .. LVDNNFHVKIADFGLATW--MMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIM ---DEAWRPPLPDLEIGDTTDDERCPCP---ADYLSLIERCWNINPAQRPHFSQIRQTL . ||.|... | .| | . .|..||| .| .|| | .. MCCKQGHRPCLQPVP-------EYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT |
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| Kinase | Npr4.AA | Dicty4 | 514-638 | 32 | 4e-24 | 77.48 | In-house | 17-160 (277) | Show / Hide |
Range on Protein: 514-638 Range on HMM: 17-160/277 Sequence Identity: 32% (47 aa) TGIYNGQTVAVKMI--AKN---SFTLDKRIRKEVKQVRDLQHSNLCKFAGGCI----EVPNVSIITEYCPKGALSDVLLN------EDVPLNWSFRFS-- .|. |. ||||. . ...| . ||||. ..| |.|.| | |. . . ..| |||.||| | .|.. . ..| |. . . KGTWRGKEVAVKKLNNHNQNFDENML-NEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAM -FCMDVARGMHYMHN-N-KLYHGKLTSSNCVVDDRWVVKIADYGL . |.|||| . |. | | | |.| ||. |.||..| || RMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGL |
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| Kinase | Npr4.AA | TK-Unique | 520-693 | 23 | 3.6e-21 | 69.82 | In-house | 31-234 (294) | Show / Hide |
Range on Protein: 520-693 Range on HMM: 31-234/294 Sequence Identity: 23% (48 aa) QTVAVKMIA-KNSFTLDKRIRKEVKQVRDLQ-HSNLCKFAGGCIEVP-NVSIITEYCPKGALSDVLL----------------------NEDVP---LNW . ||||| ....| .. || .. . | | |. .. | |.. .. || ||||.| | . | ..... .. KCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISP SFRFSFCMDVARGMHYMHN--NKLYHGKLTSSNCVVDDRWVVKIADYGLTTFRNQEGSQSNAGGYRSKAMQVYLPPENRSNTYTLV-TQATDVYSYGVIL . ..|. ..|.|| |.. | |. | ..|. . .. |.||.|.|... . .| .|. .. ... . ...|| . .. | .||.|.||.. KDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCS-QGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLM VEIAS ||.. WEIFT |
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| Kinase | Npr4.AA | Pkinase_Tyr | 515-639 | 29 | 7.5e-21 | 71.24 | Pfam | 18-158 (270) | Show / Hide |
Range on Protein: 515-639 Range on HMM: 18-158/270 Sequence Identity: 29% (42 aa) GIYN------GQTVAVKMIAKNSFTLD----KRIRKEVKQVRDL-QHSNLCKFAGGCI--EVP-NVSIITEYCPKGALSDVLLNE---DVPLNWSFRFSF |... ...|||||. |.. . . . .|.| . | .| |. .. | |. . | .. |..||.|.| | | | . . ||. . .. GTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQM CMDVARGMHYMHNNKLYHGKLTSSNCVVDDRWVVKIADYGLT |...|.|| | ..... | | || |.. ||||.| ||. CWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA |
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| Kinase | Npr4.AA | TyrKc | 515-758 | 23 | 1.1e-17 | 63.21 | SMART | 18-280 (280) | Show / Hide |
Range on Protein: 515-758 Range on HMM: 18-280/280 Sequence Identity: 23% (67 aa) GIYNGQTVAVKMIAKNSFTLDKRIRKEVKQVRDL--QHSNLCKFAGGCIEV-------PNVSIITEYCPKGALSDVLLNEDVPLNWSFRFSFCMDVARGM |... ..|||||. ... . ...| . . | .| |. .. | |.. . . |..||.|.|.| | | . |... ||| ..|.|| GTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGM HYMHNNKLYHGKLTSSNCVVDDRWVVKIADYGLTTFRNQEGS-------QSNAGGYRSKAMQV----YLPPENRSNTYTLVTQATDVYSYGVILVEIASR | | ... | | || |... .|||.| ||. |. . . .. . . ..|| | | ..||.|.|| . || .. EYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS--RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTY NEVIPEDD----YPLDEAW-------RPPLPDLEIGDTTDDERCP-----CPADYLSLIERCWNINPAQRPHFSQIRQTL . .... . .|. |.| |. | ||.. .....||. .|..|| ||.|.. . GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---------PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | Npr4.AA | Pkinase | 516-758 | 18 | 1.4e-17 | 63.26 | Pfam | 21-293 (293) | Show / Hide |
Range on Protein: 516-758
Range on HMM: 21-293/293
Sequence Identity: 18% (55 aa)
IYNGQTVAVKMIAKNSFTLDKRIRK----EVKQVRDLQHSNLCKFAGGCIEVPNVSIITEYCPKG----ALSDVLL-NEDVPL--NWSFRFSFCMDVARG
. .|..|||| | | . .|.... |.. . |.| | ... . . . ... ...|||..| |.|.. .. .. . ... ..||
KGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRG
MHYMHNNKLYHGKLTSSNCVVDDRWVV----KIADYGLTT---FRNQEGSQSNAGGYRSKAMQVYLPPENRSNTYTLVTQATDVYSYGVILVEIASRNEV
. |.|... | | ..|. .|.. .. ||.| || |.. .. .| .. |..|| .... ... |..|.|.|| | ....
LEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW------YMAPEV-IRGGQYYGPKVDMWSCGCILYEMLCGR--
IPEDDYPLDEAWRPPLPDL-------------EIGDTTDDERCPCP---------------------ADYLSLIERCWNINPAQRPHFSQIRQT--L
|| |. .|... .. .| . . ...|..|.. .|..|| . || | .
-------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| S_TKc | Npr4.AA | S_TKc | 499-762 | 17 | 3.9e-14 | 30.3 | SMART | 12-231 (231) | Show / Hide |
Range on Protein: 499-762
Range on HMM: 12-231/231
Sequence Identity: 17% (49 aa)
SGFVHTAHHKQVFAQTGIYNGQTVAVKMIAKNSFTLDKRIRKEVKQVRDLQHSNLCKFAGGCIEVPNVSIITEYCPK--GALSDVLLNEDVP-----LNW
| |. ..|| |. ||.|.| ..||.|.. . .| |..|. . . . .. ...|||. | | |.. . . ..
FGKVYKCRHKK--------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE
SFRFSFCMDVARGMHYMHNNKLYHGKLTSSNCVVDDRWVVKIADYGLTTFRNQEGSQSNAGGYRSKAMQV---YLPPENRSNTYTLVTQ-ATDVYSYGVI
... ..... |.|... | | .| .|. ..||.| || .. . . . |..|| . . |..| |.|
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCI
LVEIASRNEVIPEDDYPLDEAWRPPLPDLEIGDTTDDERCPCPADYLSLIERCWNINPAQRPHFSQIRQ-----TLHSIN
| | ... | ... .. . . . ...|..|.. .|..|| .. | .|
LYEMLCGYPPFP----QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | Npr4.AA | DRK | 729-760 | 34 | 3.6e-10 | 30.67 | In-house | 227-258 (258) | Show / Hide |
Range on Protein: 729-760 Range on HMM: 227-258/258 Sequence Identity: 34% (11 aa) CPADYLSLIERCWNINPAQRPHFSQIRQTLHS ||. | |. .||| .| .|| . .. . | . CPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
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| Kinase | Npr4.AA | MLK | 729-758 | 46 | 4.2e-10 | 31.38 | In-house | 262-291 (291) | Show / Hide |
Range on Protein: 729-758 Range on HMM: 262-291/291 Sequence Identity: 46% (14 aa) CPADYLSLIERCWNINPAQRPHFSQIRQTL ||. .|...||| .|..|| |.|| | | CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | Npr4.AA | Dicty4 | 729-760 | 38 | 2.4e-09 | 27.5 | In-house | 244-277 (277) | Show / Hide |
Range on Protein: 729-760 Range on HMM: 244-277/277 Sequence Identity: 38% (13 aa) CPADYLSLIERCWNINPAQRPHFSQIRQT--LHS ||. . .||..||. .| .|| |..| | | . CPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | Npr4.AA | TKL-Unique | 729-758 | 46 | 4.7e-09 | 28.26 | In-house | 261-290 (290) | Show / Hide |
Range on Protein: 729-758 Range on HMM: 261-290/290 Sequence Identity: 46% (14 aa) CPADYLSLIERCWNINPAQRPHFSQIRQTL || .| ||..||. .| ||| |..|. | CPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | Npr4.AA | TK-Unique | 729-758 | 35 | 2.2e-07 | 21.64 | In-house | 264-294 (294) | Show / Hide |
Range on Protein: 729-758 Range on HMM: 264-294/294 Sequence Identity: 35% (11 aa) C-PADYLSLIERCWNINPAQRPHFSQIRQTL | . . .|...||. .| .|| |.||.. | CCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | Npr4.AA | Pkinase_Tyr | 735-758 | 41 | 2.4e-07 | 25.48 | Pfam | 247-270 (270) | Show / Hide |
Range on Protein: 735-758 Range on HMM: 247-270/270 Sequence Identity: 41% (10 aa) SLIERCWNINPAQRPHFSQIRQTL .|. .||. .|..|| ||.|.. | DLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | Npr4.AA | Dicty4 | 676-696 | 47 | 0.002356 | 7.24 | In-house | 195-215 (277) | Show / Hide |
Range on Protein: 676-696 Range on HMM: 195-215/277 Sequence Identity: 47% (10 aa) TQATDVYSYGVILVEIASRNE ... ||||.| .| ||. | | NEKADVYSFGIVLWEILTRQE |
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| Kinase | Npr4.AA | DRK | 680-694 | 46 | 0.011458 | 4.9 | In-house | 184-198 (258) | Show / Hide |
Range on Protein: 680-694 Range on HMM: 184-198/258 Sequence Identity: 46% (7 aa) DVYSYGVILVEIASR ||||....| |.. | DVYSFAIVLWECVTR |
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| Kinase | Npr4.AA | Pkinase_Tyr | 676-694 | 42 | 0.417089 | 4.37 | Pfam | 192-210 (270) | Show / Hide |
Range on Protein: 676-694 Range on HMM: 192-210/270 Sequence Identity: 42% (8 aa) TQATDVYSYGVILVEIASR | ..||.|.|| . || .. TTKSDVWSFGVLMWEIFTY |
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| Guanylate_cyc | Npr4.AA | Guanylate_cyc | 823-877 | 37 | 5.3e-21 | 77.97 | Pfam | 1-61 (214) | Show / Hide |
Range on Protein: 823-877 Range on HMM: 1-61/214 Sequence Identity: 37% (23 aa) AKAEQYESCSIFFSDIVGFTSLSSTSS----PYEVVALLNKLYVTFDSIIDNY--DVYKVE .|..|....|.|.||||||...| .| | ..| .||..| .||...|.. ..|||. VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVK |
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| HNOBA | Npr4.AA | HNOBA | 797-817 | 66 | 2.5e-09 | 35.3 | Pfam | 214-234 (234) | Show / Hide |
Range on Protein: 797-817 Range on HMM: 214-234/234 Sequence Identity: 66% (14 aa) EKQKTDRLLYSMLPQPVADDL ||.|||.|||||.| .||. | EKKKTDDLLYSMFPKSVANRL |
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| CYCc | Npr4.AA | CYCc | 796-877 | 17 | 6.3e-05 | -36.51 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 796-877
Range on HMM: 1-231/231
Sequence Identity: 17% (41 aa)
LEKQKTDRLLYSMLPQPVADDLRQG-NIAKAEQYESCSIFFSDIVGFTSLSSTSSPYEVVALLNKLYVTFDSIIDNYD-----VYKV-------------
||||.||||..|||. ||..|.|| . . .. |....| |.||||||.|.|...|..|| .|| .| ||.|||... .|||
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC
----------------------------------------------------------------------------------------------------
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD
------------------------------E
.
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
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