Gene Gcy2 (Sea Urchin)

Gcy2

Species: Sea Urchin
Alias: SPU_009432, Spk216, Gcy2
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
Gcy2.AA Protein None 804 None Fasta, JSON
Gcy2.kin_dom Protein Kinase Domain None 178 None Fasta, JSON

Protein domain

Protein domains of Gcy2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Gcy2.AA RGC 163-342 48 1.8e-101 343.39 In-house 73-300 (300) Show / Hide 
Range on Protein: 163-342
Range on HMM: 73-300/300
Sequence Identity: 48% (111 aa)

DILENDDIKLDEMFIASLVSDIVKGMRHLHSTEIRTHGNLKSSNCVVDSRWVLKITDFGL-----VHFKVGQ-----------QPPDMGEHAYYQDLLWK
|||||||||.|.||..|.. ||||||..||. .|| ||||||.|||||||||.|||||||      .|| ||           .  . .||.||...||.
DILENDDIKMDWMFKYSFIRDIVKGMQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWT

APEVWE------PQG--------TQKGDVYSFGIILYEIAHRQG-----PF----GNCELSPKEIYEKVKTL---GETIPLRPNVMEIE-----NGHECL
|||..       ..|        ||||||||||||.|||..|.|     ||    |..||||.||.|.|| .   |.. |.|| . |.|       ..||
APEHLREWRMPHQWGPHRQTQRGTQKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCL

LTVMQECWVEDPEARPD-FKTIANKLKP
|..|..|| |||| ||| |..| ..|| 
LHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Gcy2.AA RGC 163-342 48 1.8e-101 343.39 In-house 73-300 (300) Show / Hide 
Range on Protein: 163-342
Range on HMM: 73-300/300
Sequence Identity: 48% (111 aa)

DILENDDIKLDEMFIASLVSDIVKGMRHLHSTEIRTHGNLKSSNCVVDSRWVLKITDFGL-----VHFKVGQ-----------QPPDMGEHAYYQDLLWK
|||||||||.|.||..|.. ||||||..||. .|| ||||||.|||||||||.|||||||      .|| ||           .  . .||.||...||.
DILENDDIKMDWMFKYSFIRDIVKGMQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWT

APEVWE------PQG--------TQKGDVYSFGIILYEIAHRQG-----PF----GNCELSPKEIYEKVKTL---GETIPLRPNVMEIE-----NGHECL
|||..       ..|        ||||||||||||.|||..|.|     ||    |..||||.||.|.|| .   |.. |.|| . |.|       ..||
APEHLREWRMPHQWGPHRQTQRGTQKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCL

LTVMQECWVEDPEARPD-FKTIANKLKP
|..|..|| |||| ||| |..| ..|| 
LHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Gcy2.AA TKL 179-340 24 3.9e-33 116.39 In-house 136-364 (364) Show / Hide 
Range on Protein: 179-340
Range on HMM: 136-364/364
Sequence Identity: 24% (56 aa)

SLVSDIVKGMRHLHSTEI-------RTHGNLKSSNCVVDSRWV--------------LKITDFGLVHFKVGQQPPDMGE--------------HAYYQD-
... || .|| .||| .          | .|||.|. ||. |               .||.||||  |. . .   ...              . . |  
RWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCG

-LLWKAPEVWEPQGTQKG-----------------DVYSFGIILYEIAHRQGPFGNCELSPKE------IYEKVKTLGETIPLRPNV-------MEIENG
 . | |||| . |.  .                  |||||||.|.||. |. |. .   .| .      .. ..  .    |..|..       .  .. 
TPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDC

HECLLTVMQECWVEDPEARPDFKTIANKL
 . .   ||.|| .|||.|| |..|  .|
PPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Gcy2.AA TKL-Unique 163-340 31 1.6e-29 101.36 In-house 89-290 (290) Show / Hide 
Range on Protein: 163-340
Range on HMM: 89-290/290
Sequence Identity: 31% (66 aa)

DILE---------NDDIKLDEMFIASLVSDIVKGMRHLHSTE--IRTHGNLKSSNCVVDSR-----WVLKITDFGLVHFKVGQQPPDMGEH------AYY
| |          |. .||.   . ... ||..|| .||..|  | .|..|||||  ||..     |  || ||||. |.        .||         
DVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPI-IHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRC

QDLLWKAPEVWEP---QGTQKGDVYSFGIILYEIAHRQG------PFGNCELSPKEIYEKVKT--LGETIPLRPNVMEI-ENGHECLLTVMQECWVEDPE
  ..| |||| .    | ..| |||||||.|.||| |.       |. ..  ......|.|..   .    .||   .| ..  . .   .|.||  ||.
GSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM--DQEQWCEMVHYMEEN----YRP---PIPNHCPKEYRDLIQQCWHHDPS

ARPDFKTIANKL
 || | .| ..|
QRPSFDEIIHRL
Kinase Gcy2.AA TK 183-340 20 3.9e-22 70.32 In-house 242-486 (486) Show / Hide 
Range on Protein: 183-340
Range on HMM: 242-486/486
Sequence Identity: 20% (50 aa)

DIVKGMRHLHSTEIR-----THGNLKSSNCVVDSRWV-----------LKITDFGLV--------------HFKVGQQPPDMG----------EHAYYQD
.| .||..|||  ..      |..|   || |... |            ||.||||               .  . ......|          ...|| .
QIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQ

-------LLWKAPEVWEPQG----------TQKGDVYSFGIILYEIAHRQ-GPFGNCELS--------PKEIYEKVKTL-----------GETIPLR--P
       . | |||... .           | | ||.|||. ..||  .  .|..    .        ..|..|....            |.  ..   |
QSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPP

NVME-------IENGHECLLTV-MQECWVEDPEARPDFKTIANKL
.  .       ...... ..   ||.|| .||| ||.|... ..|
HCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
S_TKc Gcy2.AA S_TKc 126-344 20 5.9e-11 -16.28 SMART 13-231 (231) Show / Hide 
Range on Protein: 126-344
Range on HMM: 13-231/231
Sequence Identity: 20% (52 aa)

GQVFTRVGRYNHTLVAIKPVHKKHIE----------------------------MSRCLR--KELKVDILENDDIK----LDEMFIASLVSDIVKGMRHL
|.|.  . .  . .|||| .. .||.                            |  |     .|.  | ..   .    ..|  .....  |.... ..
GKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYC

HSTEIRTHGNLKSSNCVVDSRWVLKITDFGLVHFKVGQQPPDMGEHAYYQDLLWKAPEVWEPQGTQKGDVYSFGIILYEIAHRQGPFGNCELSPKEIYEK
||     |  || .|  .|.  ..||.||||  .           . .   . . ||||  . |. | |..|.|.|||| . .. ||      ......|
HSH-GIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKK

VKTLGETIPLRPNVMEIENGHECLLTVMQECWVEDPEARPDFKTIAN-----KLKPLH
..                  .|..   .. |.. ||| ||    . .     |. |  
IG-----------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Gcy2.AA Dicty4 244-278 55 4e-10 30.13 In-house 182-217 (277) Show / Hide 
Range on Protein: 244-278
Range on HMM: 182-217/277
Sequence Identity: 55% (20 aa)

LWKAPEVWEPQG-TQKGDVYSFGIILYEIAHRQGPF
.| ||||   |. ..| |||||||.|.||. || |.
CWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPY
TyrKc Gcy2.AA TyrKc 127-340 23 1.1e-09 -66.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 127-340
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

QVFTRV-----------GRYNHTLVAIKPVHKKHIEM----SRCLRKE--------------LKV-----------------------DILENDDIKLDE
 .. ..           |... . ||.| ... ..|.     | ..|               ..                        | | .   ||  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

MFIASLVSDIVKGMRHLHSTEIRTHGNLKSSNCVVDSRWVLKITDFGLVHFKVGQ---QPPDMGEHAYYQ-----DLL------WKAPEVWEPQG--TQK
    |   .| .||..|||  .  |  |   || |... . ||.||||  .             .. ||      .        | |||..   |  | |
KDLLSFCWQIACGMEYLHSKNC-IHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTK

GDVYSFGIILYEIAHR-QGPFGN-CE--LSPKEIYEKVKTLGETIPLRPNVMEIEN----GHECLLTVMQECWVEDPEARPDFKTIANKL
 ||.|||. ..||  . | |  .  .  .|..|..|.||. |.  |  ||.   .      .. . ..|..|| |||| || |..|  ..
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-GYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Gcy2.AA Dicty4-Unclassified 167-222 41 1.7e-09 28.68 In-house 101-155 (263) Show / Hide 
Range on Protein: 167-222
Range on HMM: 101-155/263
Sequence Identity: 41% (23 aa)

NDDIKLDEMFIASLVSDIVKGMRHLHSTEIRTHGNLKSSNCVVDSRWVLKITDFGL
.  ||||.  |     || .|| |||. ..  |  .||||  .|     || |||.
QQPIKLDDTLIIKYAFDIAQGMQHLHTRNF-IHRDIKSSNILMDKHFNIKIADFGI
Kinase Gcy2.AA DRK 245-278 54 5.4e-09 26.65 In-house 168-202 (258) Show / Hide 
Range on Protein: 245-278
Range on HMM: 168-202/258
Sequence Identity: 54% (19 aa)

WKAPEVWEPQG-TQKGDVYSFGIILYEIAHRQGPF
| ||||   |. | | |||||.|.| |.. || |.
WTAPEVLRNQRYTEKADVYSFAIVLWECVTRQDPY
Kinase Gcy2.AA Dicty4 164-222 34 1.6e-08 24.74 In-house 92-160 (277) Show / Hide 
Range on Protein: 164-222
Range on HMM: 92-160/277
Sequence Identity: 34% (24 aa)

ILEN------DDIKLD-EMFIA--SLVSDIVKGMRHLHS--TEIRTHGNLKSSNCVVDSRWVLKITDFGL
.| .      . |||| . ...   .  |...|| .||.  . |  |  |||.|  ||  |. |..||||
LLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVI-IHRDLKSHNLLVDKNWRVKVCDFGL
Kinase Gcy2.AA DRK 164-222 40 2.6e-08 24.29 In-house 87-146 (258) Show / Hide 
Range on Protein: 164-222
Range on HMM: 87-146/258
Sequence Identity: 40% (24 aa)

ILENDDIKLDEMFIASLVSDIVKGMRHLHSTE-IRTHGNLKSSNCVVDSRWVLKITDFGL
|| .. |..|   . ..  |. |||  ||. . |  |  ||| |  ||  |  |. ||||
ILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGL
Kinase Gcy2.AA TK-Unique 172-222 28 4.1e-08 24.22 In-house 128-179 (294) Show / Hide 
Range on Protein: 172-222
Range on HMM: 128-179/294
Sequence Identity: 28% (15 aa)

LDEMFIASLVSDIVKGMRHLHS--TEIRTHGNLKSSNCVVDSRWVLKITDFGL
... . ..   .| .|| .|.|   .| .|..| ..|. . .. |.||.|||.
ISPKDLYHFAWQIACGMEYLASQRKKI-VHRDLCARNVLLTEDKVCKICDFGM
Kinase Gcy2.AA TK-Unique 318-340 43 4.4e-08 24.09 In-house 272-294 (294) Show / Hide 
Range on Protein: 318-340
Range on HMM: 272-294/294
Sequence Identity: 43% (10 aa)

VMQECWVEDPEARPDFKTIANKL
.|..|| ..|| ||.| .|...|
LMKSCWQWEPEERPSFRQIKHRL
Kinase Gcy2.AA Pkinase 163-340 19 5.5e-08 29.32 Pfam 93-293 (293) Show / Hide 
Range on Protein: 163-340
Range on HMM: 93-293/293
Sequence Identity: 19% (40 aa)

DILE-NDDIKL--DEMFIASLVSDIVKGMRHLHSTEIRTHGNLKSSNCVVDSRWVL----KITDFGL-VHFKVGQQPPDMGEHAYYQDLLWKAPEVWE--
|...  .. ..  .|  . . .  |..|. ..||  |  |  ||..|. .|.. ..    ||.||||  .|.     ..   . .   . . ||||    
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGI-IHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGG

PQGTQKGDVYSFGIILYEIAHRQGPFGNC--ELSPKEIYEKVKTLGETIPLRPNVMEIENG----------------HECLLTVMQECWVEDPEARPDFK
.  ..| |..|.|.|||| . .. || ..  . .  . .....  ..... ..   ....                 .| .. ..  |.  ||. || ..
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

TIANK--L
 | .   .
QILQHPWF
Kinase Gcy2.AA MLK 319-340 45 1.2e-07 22.69 In-house 270-291 (291) Show / Hide 
Range on Protein: 319-340
Range on HMM: 270-291/291
Sequence Identity: 45% (10 aa)

MQECWVEDPEARPDFKTIANKL
|..|| .||. ||.|. |  .|
MKQCWNQDPHKRPSFRQIVQHL
Kinase Gcy2.AA Pkinase_Tyr 317-340 45 1.9e-07 25.88 Pfam 247-270 (270) Show / Hide 
Range on Protein: 317-340
Range on HMM: 247-270/270
Sequence Identity: 45% (11 aa)

TVMQECWVEDPEARPDFKTIANKL
..|..|| .||| || |. | ..|
DLMKQCWHYDPEDRPTFSEIHEQL
Kinase Gcy2.AA MLK 245-278 36 2e-06 18.54 In-house 199-236 (291) Show / Hide 
Range on Protein: 245-278
Range on HMM: 199-236/291
Sequence Identity: 36% (14 aa)

WKAPEVW----EPQGTQKGDVYSFGIILYEIAHRQGPF
| ||||     . . . | ||.|.|..|.|.  |. |.
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPY
Kinase Gcy2.AA Dicty4-Unclassified 322-340 42 1.7e-05 14.73 In-house 245-263 (263) Show / Hide 
Range on Protein: 322-340
Range on HMM: 245-263/263
Sequence Identity: 42% (8 aa)

CWVEDPEARPDFKTIANKL
|| .||  || .  | ..|
CWHNDPNKRPTMNQIIQYL
Kinase Gcy2.AA Dicty4-Unclassified 245-278 40 3.2e-05 13.78 In-house 174-208 (263) Show / Hide 
Range on Protein: 245-278
Range on HMM: 174-208/263
Sequence Identity: 40% (14 aa)

WKAPEVWEPQG-TQKGDVYSFGIILYEIAHRQGPF
| .||.      .|| ||||....||| |    |.
WESPECLMHESYNQKSDVYSYAMMLYELATGDEPY
Kinase Gcy2.AA MLK 176-226 28 8.3e-05 12.75 In-house 125-183 (291) Show / Hide 
Range on Protein: 176-226
Range on HMM: 125-183/291
Sequence Identity: 28% (17 aa)

FIASLVSDIVKGMRHLHSTEIR--THGNLKSSNCVVDS------RWVLKITDFGLVHFK
....   .. .||  ||| .     |  |||.| ..|         .|||.|||.....
HAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDW
Kinase Gcy2.AA DRK 319-342 37 9.8e-05 12.0 In-house 235-258 (258) Show / Hide 
Range on Protein: 319-342
Range on HMM: 235-258/258
Sequence Identity: 37% (9 aa)

MQECWVEDPEARPDFKTIANKLKP
|..|| |||  || .  .   |  
MNDCWNEDPQHRPSMQECLERLEA
Kinase Gcy2.AA Dicty4 319-342 38 0.000353 10.03 In-house 252-277 (277) Show / Hide 
Range on Protein: 319-342
Range on HMM: 252-277/277
Sequence Identity: 38% (10 aa)

MQECWVEDPEARPDFKTIANK--LKP
.|.|| .||. || |. | ..  |  
IQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Gcy2.AA TK-Unique 256-272 52 0.000617 9.6 In-house 217-233 (294) Show / Hide 
Range on Protein: 256-272
Range on HMM: 217-233/294
Sequence Identity: 52% (9 aa)

TQKGDVYSFGIILYEIA
| |.||.|||....||.
TTKSDVWSFGVLMWEIF
Kinase Gcy2.AA RGC 136-161 26 0.009192 5.81 In-house 1-30 (300) Show / Hide 
Range on Protein: 136-161
Range on HMM: 1-30/300
Sequence Identity: 26% (8 aa)

NHTLVAIKPVHKK----HIEMSRCLRKELK
. ..|.|| ....    |.. .|  ..|||
EGDWVWIKKHNQRNLFRHWDFTRSMMRELK
Kinase Gcy2.AA RGC 136-161 26 0.009727 5.81 In-house 1-30 (300) Show / Hide 
Range on Protein: 136-161
Range on HMM: 1-30/300
Sequence Identity: 26% (8 aa)

NHTLVAIKPVHKK----HIEMSRCLRKELK
. ..|.|| ....    |.. .|  ..|||
EGDWVWIKKHNQRNLFRHWDFTRSMMRELK
Kinase Gcy2.AA Pkinase_Tyr 256-271 56 0.428587 4.33 Pfam 192-207 (270) Show / Hide 
Range on Protein: 256-271
Range on HMM: 192-207/270
Sequence Identity: 56% (9 aa)

TQKGDVYSFGIILYEI
| | ||.|||. ..||
TTKSDVWSFGVLMWEI
Kinase Gcy2.AA Pkinase_Tyr 206-222 58 1.221059 2.79 Pfam 141-157 (270) Show / Hide 
Range on Protein: 206-222
Range on HMM: 141-157/270
Sequence Identity: 58% (10 aa)

NCVVDSRWVLKITDFGL
|| |..  | ||.||||
NCLVTENNVVKICDFGL
CYCc Gcy2.AA CYCc 379-573 45 1.1e-99 338.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 379-573
Range on HMM: 1-231/231
Sequence Identity: 45% (106 aa)

EEKKKTENLLHRMLPKPVANQLKRGM-QVVPESFDCVTIFFSDIVGFTKLSSMSTPFQVVDLLNDLYTLFDDIISYYN-----VYKVETIGDAYMLVSGL
.||.|.. ||..|||. ||||||.|   |.|...||||| |.||||||.|.|..||.|||..|||.|| ||.||. .      .||||||||||| |||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PIRND-------------------NRHAAEIGSTALHLIDEVQKFKIRHR----PDDTLKLRVGIHSGPVVTGVVGLTMPRYCLFGDTVNTSSRMESNGE
| ||                     .|| .| . ||. ....  |...|.    |...|..|.|||.|||| ||||..|||||.||||||. |||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

ALKIHCSAECKAIL-------DEVGGYDVPE
. .||.| | . .|        . |.... .
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc Gcy2.AA Guanylate_cyc 406-592 40 5e-82 283.63 Pfam 1-214 (214) Show / Hide 
Range on Protein: 406-592
Range on HMM: 1-214/214
Sequence Identity: 40% (86 aa)

VVPESFDCVTIFFSDIVGFTKLSSMST----PFQVVDLLNDLYTLFDDIISYY--NVYKVETIGDAYMLVSGLPIR-----NDNRHAAEIGSTALHLIDE
|.....|||||.|.||||||...| ..    |.|.|..|||.|| ||.... .   .|||.||||.|| ||||| .     ..  ||. .   || ... 
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VQKFKIRHRP-DD----TLKLRVGIHSGPVVTGVVG--LTMPRYCLFGDTVNTSSRMESNGEAL--KIHCSAECKAILDEVGGYDVP----ERGIVAMKG
.|.. . | .  .    ....|.|||.|||| ||.|  . |||||..|||||. |||||.|...  ||| |.| ...| . ....      .||.. .||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGS---LLTYWLVD
||    . ||.|  
KGKMGEMETYFLHG
HNOBA Gcy2.AA HNOBA 374-400 59 1.9e-09 35.73 Pfam 208-234 (234) Show / Hide 
Range on Protein: 374-400
Range on HMM: 208-234/234
Sequence Identity: 59% (16 aa)

TQQLVEEKKKTENLLHRMLPKPVANQL
.. | ||||||. ||. |.||.|||.|
HRELEEEKKKTDDLLYSMFPKSVANRL