Gene Npr5 (Sea Urchin)

Npr5

Species: Sea Urchin
Alias: SPU_027510, Spk218, Npr5
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
Npr5.AA Protein None 796 None Fasta, JSON
Npr5.kin_dom Protein Kinase Domain None 238 None Fasta, JSON

Protein domain

Protein domains of Npr5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Npr5.AA RGC 34-291 38 6e-118 398.15 In-house 1-300 (300) Show / Hide 
Range on Protein: 34-291
Range on HMM: 1-300/300
Sequence Identity: 38% (116 aa)

NSHTVVLRKVEVH----DFNLTKAIKRELKEMRWLVHDNINRFLGLCFPSTSGD---MFYHVSEFSPKGSLKSILANDDVNLDLSFKASFIRDLARGMQF
.  .|...|..      . ..|....||||.|| |.|||.|.|.|.|. ...     ... |.|. ..|||. ||.|||...| .||.|||||...|||.
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHASEIKNHGVLSSSTCYVDSRWVLKISGFGLLS--FNILKED------------VMKQKDPEVKFSKMLWTAPEHLRGE-MLPSKG--------SQKGD
||.|.|. || |.|..|.||||||.||..||| .  .. .|..             ..|.|.. ...|||||||||||.. | ...|        .||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFAIILQEIVTRSH-----PFYLS----GYTSREIIRRVIRRDE----PPCRPKINEDEFETSDMATIFTAIYELMKVCWEELPEDRPD-FTAIRAKL
||||.||..||.||..     ||..       . .|||..|.. ..    .|.||.|.||| . . |...  ....||. ||.| ||.||| |  || .|
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEG-H-MIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQL

RG
..
KT
Kinase Npr5.AA RGC 34-291 38 6e-118 398.15 In-house 1-300 (300) Show / Hide 
Range on Protein: 34-291
Range on HMM: 1-300/300
Sequence Identity: 38% (116 aa)

NSHTVVLRKVEVH----DFNLTKAIKRELKEMRWLVHDNINRFLGLCFPSTSGD---MFYHVSEFSPKGSLKSILANDDVNLDLSFKASFIRDLARGMQF
.  .|...|..      . ..|....||||.|| |.|||.|.|.|.|. ...     ... |.|. ..|||. ||.|||...| .||.|||||...|||.
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHASEIKNHGVLSSSTCYVDSRWVLKISGFGLLS--FNILKED------------VMKQKDPEVKFSKMLWTAPEHLRGE-MLPSKG--------SQKGD
||.|.|. || |.|..|.||||||.||..||| .  .. .|..             ..|.|.. ...|||||||||||.. | ...|        .||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFAIILQEIVTRSH-----PFYLS----GYTSREIIRRVIRRDE----PPCRPKINEDEFETSDMATIFTAIYELMKVCWEELPEDRPD-FTAIRAKL
||||.||..||.||..     ||..       . .|||..|.. ..    .|.||.|.||| . . |...  ....||. ||.| ||.||| |  || .|
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEG-H-MIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQL

RG
..
KT
Kinase Npr5.AA TKL 31-289 20 2e-32 114.02 In-house 12-364 (364) Show / Hide 
Range on Protein: 31-289
Range on HMM: 12-364/364
Sequence Identity: 20% (76 aa)

ATYNSHT----------VVLRKVEVHDFNLT------------------------KAIKRELKEMRWLV---HDNINRFLGLCFPSTSGD----------
.... ..          |.  |  .|. ...                        .. ..| .|.. .    |.|| .|.| |. ...|           
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

MFYHVSEFSPKGS-LKSILANDDVNLDLSFKASFIRDLARGMQFLHASEI-------KNHGVLSSSTCYVDSRWV--------------LKISGFGLLSF
 .. | |. |.|| |  ..        .. . ....| ||||..||...          |  | |. . ||. |               .||. |||  |
QLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRF

NILKEDVMKQKDPEV--------------KFSKMLWTAPEHLRGEMLPS------------KGSQKGDVYSFAIILQEIVTRSHPFY-LSGYTSR-----
.  ...  ...  .               .     | ||| |||.|  .            . |.| |||||.|.| ||.|| .|.| .  ..       
MSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPF

-EIIRRVIRRDEPPCRPKINED--EFETSDMATIFTAIYELMKVCWEELPEDRPDFTAIRAKL
 |..  |. . ..| .| | ..  .   ..  .. . . .||. ||.. ||.|| |. |  .|
EEMFMMVCDKGLRPPIPPIWQNHHK-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Npr5.AA TK 56-289 17 1.3e-26 85.61 In-house 87-486 (486) Show / Hide 
Range on Protein: 56-289
Range on HMM: 87-486/486
Sequence Identity: 17% (69 aa)

RELKEMRWLV-----HDNINRFLGLCFPSTS---------GDMFYHVSEFSPKGS----LKSILANDDVN------------------------------
.|. ||  .      |.|| |..| |. . .         .  .. | |. |.|.    |.. | . . .                              
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

---------------------------------------------LDLSFKASFIRDLARGMQFLHASEIK-----NHGVLSSSTCYVDSRWV-------
                                             |..  .  . ...|.||..||.  ..      |. |    | |... |       
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDG

----LKISGFG-------LLSFNILKEDVMKQKDPEVKFSKMLW-----------------------TAPEHLRGEML-----PSKGSQKGDVYSFAIIL
     ||. ||       .|.  | ..|    |... .   | |                       .||| |..          | . | ||.|| . .
CGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM

QEIVTRS-HPFY--LS-------GYTSREIIRRVIRR-------------DEPPCRPKINED----EFETSDMATIFTAIYELMKVCWEELPEDRPDFTA
 ||.|.   |.|  .|       | . .|..... |                .. .|.   |    ..   .  .  ...|.||. ||.. |||||.|..
WEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQ

IRAKL
.. .|
LHEQL
Kinase Npr5.AA TKL-Unique 55-221 31 2e-23 79.59 In-house 43-234 (290) Show / Hide 
Range on Protein: 55-221
Range on HMM: 43-234/290
Sequence Identity: 31% (61 aa)

KRELKEMRWLV-HDNINRFLGLCF-PSTSGDMFYHVSEFSPKGSLKSILA---------NDDVNLDLSFKASFIRDLARGMQFLHASE--IKNHGVLSSS
..|.. |  |  |.|| .. | |.    .   .. |.|. | ||| . |.         |.  .|... . ....| |.|| .|| .|  |  |. | ||
ENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPI-IHRDLKSS

TCYVDSR-----WVLKISGFGLLSFNILKEDVMKQKDP-----EVKFSKMLWTAPEHLRGEMLPSKGSQKGDVYSFAIILQEIVTRSH------PF
  .||..     |  ||..|||  ||  |.. |. . .     ... .  .| ||| ||..   .. |.| |||||.|.| ||.||        |.
NFLVDNNSNIAEWNIKICDFGLSKFNS-KINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF--CQYSEKSDVYSFGIVLWEIATRKITKTYKKPY
Kinase Npr5.AA RIPK 185-289 28 4.1e-15 47.91 In-house 190-290 (290) Show / Hide 
Range on Protein: 185-289
Range on HMM: 190-290/290
Sequence Identity: 28% (31 aa)

APEHLRGEMLPSK---GSQKGDVYSFAIILQEIVTRSHPFYLSGYTSREIIRRVIRRDEPPCRPKINEDEFETSDMATIFTAIYELMKVCWEELPEDRPD
.|||.| . ...     . | |||||||.. |. |. ||.  .. .  ..|  .. ..  || . ..|   |.  .. .     |||. ||.  |.||| 
PPEHFR-TDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPY--EDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMI----ELMQRCWQQDPNDRPC

FTAIRAKL
|  .. . 
FQECEEWT
TyrKc Npr5.AA TyrKc 30-289 24 8.7e-13 -15.91 SMART 17-280 (280) Show / Hide 
Range on Protein: 30-289
Range on HMM: 17-280/280
Sequence Identity: 24% (74 aa)

FATYNSHTVVLRKVEVHDFNLTKAIKRELKEMRWL--VHDNINRFLGLCFPS----TSGDMFYHVSEFSPKGSLKSILANDDVNLDLSFKASFIRDLARG
 .|..  . |  |.  .|    ... ||.. |. |   |.|| |..| |  .     . .  . | |. |.|.||. | .   .| .. . ||  . |.|
KGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACG

MQFLHASEI-------------KNHGVLSSSTCYVDSRWVLKISGFGLLSFNILKE-------DVMKQK---DPE----VKFSKMLWTAPEHLRGEMLPS
|..||   .             .||              . ||| || || .|  .       |. ..|   .      ..     |.||| .       
MEYLHSKNCIHRDLAARNCLVGENH--------------TVKISDFG-LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR-----WMAPECI------N

KG--SQKGDVYSFAIILQEIVTRSHPFYLSG----YTSREIIRRVIRRDEPPCRPK---INEDEFETSDMATIFTAIYELMKVCWEELPEDRPDFTAIRA
.|  . | ||.|| . . || |.  . |        . .|.|..| ... .|. |    .    |      .  ...|..|| ||.| ||||| |..|. 
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---F-----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

KL
..
CF
Kinase Npr5.AA MLK 31-133 22 5.7e-11 34.43 In-house 18-146 (291) Show / Hide 
Range on Protein: 31-133
Range on HMM: 18-146/291
Sequence Identity: 22% (29 aa)

ATYNSHTVVLRKVEVHDFN-------LT----KAIKRELKEMRWLVHDN----INRFLGLCFPSTSGDMFYHVSEFSPKGSLKSILAN------------
...   ..| . | |  ..        |    .....| .. | | | |    | .|.| |  . ..  |. |.|. ..||| ..|..            
GRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVC--LQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQ

-DDVNLDLSFKASFIRDLARGMQFLHASEIK
  |.. |.......  . ||||..||. . |
KNDRVYDHDHAMNWALQCARGMHYLHSMAPK
Kinase Npr5.AA TK-Unique 263-289 48 1.1e-10 33.13 In-house 268-294 (294) Show / Hide 
Range on Protein: 263-289
Range on HMM: 268-294/294
Sequence Identity: 48% (13 aa)

AIYELMKVCWEELPEDRPDFTAIRAKL
..|.||| || . ||.||.|..|. .|
EMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase Npr5.AA Pkinase_Tyr 264-289 57 1.7e-10 36.13 Pfam 245-270 (270) Show / Hide 
Range on Protein: 264-289
Range on HMM: 245-270/270
Sequence Identity: 57% (15 aa)

IYELMKVCWEELPEDRPDFTAIRAKL
||.||| ||.. ||||| |..|. .|
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Npr5.AA Dicty4 182-221 42 7.2e-09 25.9 In-house 182-217 (277) Show / Hide 
Range on Protein: 182-221
Range on HMM: 182-217/277
Sequence Identity: 42% (17 aa)

LWTAPEHLRGEMLPSKGSQKGDVYSFAIILQEIVTRSHPF
.|.||| ....       .| |||||.|.| ||.||  |.
CWMAPEVMMHQPY----NEKADVYSFGIVLWEILTRQEPY
S_TKc Npr5.AA S_TKc 5-287 12 7.3e-09 -46.9 SMART 1-220 (231) Show / Hide 
Range on Protein: 5-287
Range on HMM: 1-220/231
Sequence Identity: 12% (39 aa)

MSKQSLLST----VSVKGKDANKKGKNFAFATYNSHTVVLRKVEVHDFNLTKAIKRELKEMRWLVHDNINRFLGLCFPSTSGDMFYHVSEFSPK--GSLK
  .  ..      .  |... .             . | . ..        . |.||.. ..   |.|| .... .      | .| | |. .   |.|.
YEILRKIGKGAFGKVYKCRHKK-----------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLF

SILANDDVN-----LDLSFKASFIRDLARGMQFLHASEI------------KNHGVLSSSTCYVDSRWVLKISGFGLLSFNILKEDVMKQKDPEVKFSKM
... .   .     ..    ..... ........|   |             .               ..||. |||  .                    
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------HIKICDFGLARQL------------TTFCGTP

LWTAPEHLRGEMLPSKGSQKGDVYSFAIILQEIVTRSHPFYLSGYTSREIIRRVIRRDEPPCRPKINEDEFETSDMATIFTAIYELMKVCWEELPEDRPD
 . ||| |      . |  | |..|. .|| | ...  ||.    .  ......                              .... |..  ||.|| 
WYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPT

FTAIRA
   . .
A-EALQ
Kinase Npr5.AA DRK 47-158 32 8.8e-09 25.91 In-house 37-146 (258) Show / Hide 
Range on Protein: 47-158
Range on HMM: 37-146/258
Sequence Identity: 32% (37 aa)

DFNLTKAIKRELKEMRWLVHDNINRFLGLCFPSTSGDMFYHVSEFSPKGSLKSILANDDVNLDLSFKASFIRDLARGMQFLHASE-IKNHGVLSSSTCYV
| |. .  .||   |  | | ||  |.| |  . .      . |. |.||| .|| .. . .| .   .   | |.|| .|| .. |  |  | |    |
DENFLNEFHREINLMCQLRHPNICQFMGTCNNPPD---ICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLV

DSRWVLKISGFGL
|  |  |.. |||
DEHWQVKVADFGL
Kinase Npr5.AA DRK 183-221 53 1.2e-08 25.46 In-house 168-202 (258) Show / Hide 
Range on Protein: 183-221
Range on HMM: 168-202/258
Sequence Identity: 53% (21 aa)

WTAPEHLRGEMLPSKGSQKGDVYSFAIILQEIVTRSHPF
||||| || .        | |||||||.| |.|||  |.
WTAPEVLRNQRY----TEKADVYSFAIVLWECVTRQDPY
Kinase Npr5.AA MLK 266-289 45 3.2e-07 21.26 In-house 268-291 (291) Show / Hide 
Range on Protein: 266-289
Range on HMM: 268-291/291
Sequence Identity: 45% (11 aa)

ELMKVCWEELPEDRPDFTAIRAKL
.||| ||.. |..||.|  |  .|
KLMKQCWNQDPHKRPSFRQIVQHL
Kinase Npr5.AA Dicty4 68-130 33 7.6e-07 19.05 In-house 59-131 (277) Show / Hide 
Range on Protein: 68-130
Range on HMM: 59-131/277
Sequence Identity: 33% (25 aa)

NINRFLGLCF--PSTSGDMFYHVSEFSPKGSLKSILAN------DDVNLDLSFKAS---FIRDLARGMQFLHAS
||  |.| |    |..|.|   |.|. |||.| |.| .      . . ||..   .     .| ||||. ||..
NICLFMGACTAPRSHPGKMCI-VTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCC
Kinase Npr5.AA TKL-Unique 266-289 37 2e-06 19.18 In-house 267-290 (290) Show / Hide 
Range on Protein: 266-289
Range on HMM: 267-290/290
Sequence Identity: 37% (9 aa)

ELMKVCWEELPEDRPDFTAIRAKL
.|.. ||   |..|| |. |. .|
DLIQQCWHHDPSQRPSFDEIIHRL
Kinase Npr5.AA MLK 183-221 38 4e-06 17.22 In-house 199-236 (291) Show / Hide 
Range on Protein: 183-221
Range on HMM: 199-236/291
Sequence Identity: 38% (16 aa)

WTAPEHL---RGEMLPSKGSQKGDVYSFAIILQEIVTRSHPF
| ||| .   |.|.     | | ||.|....| |..|| .|.
WMAPEVIQQFRCEKY----SEKCDVWSWGVVLWEMLTREVPY
Kinase Npr5.AA TK-Unique 52-158 21 8e-06 16.27 In-house 48-179 (294) Show / Hide 
Range on Protein: 52-158
Range on HMM: 48-179/294
Sequence Identity: 21% (29 aa)

KAIKRELKEMRWLV-HDNINRFLGLCFPSTSGDMFYHVSEFSPKGSLKSILA----------------------NDDVN---LDLSFKASFIRDLARGMQ
.. ..|.. |. |  | || ..|| |  |.  . .... |. |.|.| . |                       .|...   ... . ..|. ..|.||.
QDFLKEIQMMKELGDHPNIVQCLGCCTKSD--EPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGME

FLHA--SEIKNHGVLSSSTCYVDSRWVLKISGFGL
.|.    .|  |. |... . . .. |.||..||.
YLASQRKKI-VHRDLCARNVLLTEDKVCKICDFGM
Kinase Npr5.AA Pkinase_Tyr 49-129 27 0.000285 15.09 Pfam 45-129 (270) Show / Hide 
Range on Protein: 49-129
Range on HMM: 45-129/270
Sequence Identity: 27% (24 aa)

NLTKAIKRELKEMRWL-VHDNINRFLGLCF-PSTSGDMFYHVSEFSPKGSLKSILAND---DVNLDLSFKASFIRDLARGMQFLHA
|. ..  ||.| |. |  |.|| |..| |   . ..   | | |. |.|.|.. | .    . .|... . .. .. |.||..|..
NCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase Npr5.AA DRK 267-291 36 0.001755 7.7 In-house 234-258 (258) Show / Hide 
Range on Protein: 267-291
Range on HMM: 234-258/258
Sequence Identity: 36% (9 aa)

LMKVCWEELPEDRPDFTAIRAKLRG
||. ||.| |  || .  .   |  
LMNDCWNEDPQHRPSMQECLERLEA
Kinase Npr5.AA TK-Unique 199-216 44 0.017311 4.54 In-house 217-234 (294) Show / Hide 
Range on Protein: 199-216
Range on HMM: 217-234/294
Sequence Identity: 44% (8 aa)

SQKGDVYSFAIILQEIVT
. |.||.||.... ||.|
TTKSDVWSFGVLMWEIFT
Kinase Npr5.AA Dicty4 266-291 32 0.072314 2.21 In-house 250-277 (277) Show / Hide 
Range on Protein: 266-291
Range on HMM: 250-277/277
Sequence Identity: 32% (9 aa)

ELMKVCWEELPEDRPDFTAIRAK--LRG
.|.. ||.. |. || |  |  .  |  
HLIQWCWDHDPQHRPSFEEIIQRRILEH
CYCc Npr5.AA CYCc 329-523 43 1.5e-99 337.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 329-523
Range on HMM: 1-231/231
Sequence Identity: 43% (100 aa)

EEKKKTDALLFRMLPEVVAEELKKG-NQFPGEFFDHVTVYFSDVVGFTDISAQSTPMQVVDLLNDLYTCFDAVLERFD-----VYKVETIGDAYMVVSGL
.||.|.| || .|||. ||..|| | .  . . .| ||..|.|.||||......||||||..|||.||.|| ...|..     .|||||||||||||||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PRRNG-------------------NRHAGEIACVALELLTGARQFRIRHK----PDHQLQIRIGINTGPVAAGVVGLTMPRFCLFGDTVNTASRMESNSL
|.||.                    .|| .|| .||. .  ...| ..|.    |...|..||||.||||..||||..||| |.||||||.||||||...
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PQKIHCSSDSAAVL-------KELGGYVLEK
| .||.|..   .|       .. |....| 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc Npr5.AA Guanylate_cyc 356-542 42 1.9e-87 301.64 Pfam 1-214 (214) Show / Hide 
Range on Protein: 356-542
Range on HMM: 1-214/214
Sequence Identity: 42% (90 aa)

FPGEFFDHVTVYFSDVVGFTDISAQST----PMQVVDLLNDLYTCFDAVLERF--DVYKVETIGDAYMVVSGLPRR-----NGNRHAGEIACVALELLTG
.. . .| ||..|.|.||||.......    |||.|..|||.||||| .....  ..|||.||||.||.||||| .     ..  ||  .|  ||...  
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

ARQFRIRHKPDHQ-----LQIRIGINTGPVAAGVVG--LTMPRFCLFGDTVNTASRMESNSLPQ--KIHCSSDSAAVLKELGGYVLEK----RGLITIKG
..|... |..  .     .|.||||.|||| |||.|  . |||.|..|||||.||||||...|   ||| |   ...||...... |.    || | .||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGQ---MTTYWLLG
||.   |.||.| |
KGKMGEMETYFLHG
HNOBA Npr5.AA HNOBA 308-350 43 2.7e-08 31.54 Pfam 195-234 (234) Show / Hide 
Range on Protein: 308-350
Range on HMM: 195-234/234
Sequence Identity: 43% (19 aa)

KME-KYTENLEKVVADRTGQLLEEKKKTDALLFRMLPEVVAEEL
.|| . ...||.  ..    | |||||||.||. |.|  ||..|
RMEQQLKDKLEQMHRE----LEEEKKKTDDLLYSMFPKSVANRL