Gene MST (Sea Urchin)

MST

Species: Sea Urchin
Alias: SPU_003403, MST, Spk235
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: MST

Sequence

Name Sequence Type Origin Length Description Download
MST.AA Protein None 597 None Fasta, JSON
MST.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of MST.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MST.AA MST 18-269 75 2.6e-233 749.08 In-house 1-254 (254) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-254/254
Sequence Identity: 75% (193 aa)

FDLLEKLGEGSYGSVFKAIHKESGQVLAIKQVPVDTDLQEIIKEISIMQQCDSTYVVKYYGSYF--KNTDLWIVMEYCGAGSVSDIMRRRNKTLNEAEIA
||..||||.||||||.|||||..|...|||.|||..|||||||||||||||.|.|.||||||||  ||...||||||||.|||.|||. ...||||..||
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVNEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIA

TILYSTLKGLEYLHFMRKIHRDIKAGNILLNNEGNAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYDCKADIWSLGITALEMAEGKPPYAEI
.|||.||.||.|||...||||||||||||||.||..|||||||.|||||||||||||||||.||||||||||.||||||||||||||.|||||.|||..|
CILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDI

HPMRAIFMIPTKPPPTFRDPEKWSQDFIDFTSKCLIKSPEDRATATDLLQHPFV
|||||.||||.||||||.|||.|||.|.|| .|||.|.||.|.||..||||||.
HPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase MST.AA STE20 18-269 54 3.8e-174 584.85 In-house 1-288 (288) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-288/288
Sequence Identity: 54% (156 aa)

FDLLEKLGEGSYGSVFKAIHKESGQV----LAIKQVPVDTD------LQEIIKEISIMQQCDSTYVVKYYGSYFKN----TDLWIVMEYCGAGSVSDIMR
..||||.|.||||.|.||.||..|..     |||.......      ...|.||||||.||.. ..|||||||.|.    ..|||||||||.||..|||.
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---RRNK-----TLNEAEIATILYSTLKGLEYLHFMRKIHRDIKAGNILLNNEGNAKLADFGVAGQLTD----TMA-KRNTVIGTPFWMAPEVIQE----
   ...|     ..||..||.|.. .|.||.||| ...|||||||.||||. .|..|||||||..|||.    ||. ||||..|||.||||||||.    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-IGYDCKADIWSLGITALEMAEGKPPYAEIHPMRAIFMIP--TKPPPTFRD--PEKWSQDFIDFTSKCLIKSPEDRATATDLLQHPFV
  |||.|.|||||||||.|||||.|||...|||||.||||  ..||||..|  |.|||..| || .||| | ||.|.||..||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MST.AA STE 18-269 39 5.9e-146 491.19 In-house 1-359 (359) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-359/359
Sequence Identity: 39% (143 aa)

FDLLEKLGEGSYGSVFKAIHK------ESGQV---------LAIKQVPVDTD-------------------LQEIIKEISIMQQCD--STYVVKYYGSYF
....||.|.|..|.|.||...      ..|.|          ||||......                   .|.|.|||.||..|.  . ..|||||.||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KN-------TDLWIVMEYCGAGSVSDIMR---RRNKTLN----------EAEIATILYSTLKG-LEYLHFMRKIHRDIKAGNILLNNEGNAKLADFGVAG
|.       ..|||.|||...||..||..    ..|.||          | .||.|....||| |.||| ...||||||..||||     .||.||||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLTDTMA----------------KRNTVIGTPFWMAPEVIQE------IGYDCKADIWSLGITALEMAEGKPPYAEIHPMRAIFMIPTK-----------
||||.||                ||||..||| ||||||||        |||.|.||||||.|..|||.||||... |||||.||||..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----PPPTFRD-----------------PEKWSQDFIDFTSKCLIKSPEDRATATDLLQ--HPFV
    |||.. |                 |.|||..|.|| .|||.| |..|.||..||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MST.AA YSK 18-269 52 1.2e-145 441.67 In-house 1-257 (257) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-257/257
Sequence Identity: 52% (136 aa)

FDLLEKLGEGSYGSVFKAIHKESGQVLAIKQVPVDTDLQEI---IKEISIMQQCDSTYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIMRRR--NKTLNEA
|  .|. | ||.| |.|.| .  ..| ||| .  . .  ||    .|| .  |||| |. |||||| | | |||.||||| ||..| |...  .. . | 
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQ-FDEK

EIATILYSTLKGLEYLHFMRKIHRDIKAGNILLNNEGNAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE--IGYDCKADIWSLGITALEMAEGKP
 ||.||   ||||.|||  ||||||||| |.||...|. ||.|||||||.|||. |||| .|||.|||||||..   .|| |||||||||||.||| | |
YIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEP

PYAEIHPMRAIFMIPTKPPPTFRDPEKWSQDFIDFTSKCLIKSPEDRATATDLLQHPFV
||.. ||||. | || ..||.  . ...|  |..|   || | ||.| .| .|| | |.
PYCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase MST.AA PAKL 18-269 51 4.8e-130 438.33 In-house 1-256 (256) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-256/256
Sequence Identity: 51% (133 aa)

FDLLEKLGEGSYGSVFKAIHKESGQVLAIKQVPV-DT-DLQEIIKEISIMQQCDSTYVVKYYGSYFKN-TDLWIVMEYCGAGSVSDIMRRRNKTLNEAEI
| . ||||.||||||.|||||... .||||  ..  . . ..| |||.|   | . ..| |.||     . .|| |.|| .||. |.|    |||||..|
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

ATILYSTLKGLEYLHFMRKIHRDIKAGNILLNNEGNAKLADFGVAGQLTDTMA-KRNTVIGTPFWMAPEVIQEIGYDCKADIWSLGITALEMAEGKPPYA
. ||  ||||| |||    ||||||| |||||  .  |.|||||  || |.     |  ||||.|||||.|    |. |.||||||||| |||.| ||  
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPHY

EIHPMRAIFMIPTKPPPTFRDPEKWSQDFIDFTSKCLIKSPEDRATATDLLQHPFV
.. ||||  ||| .||||| .| .||  | ||  .|. | || |. . ||| ||| 
DMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase MST.AA PAKA 18-269 43 1.3e-108 367.15 In-house 1-260 (260) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-260/260
Sequence Identity: 43% (114 aa)

FDLLEKLGEGSYGSVFKAIHKESGQV--LAIKQVPVDTDLQE--IIKEISIMQQCDSTYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIMRRRNK----TL
.. .||.|.|. |.|..|. .. .|    ||||  .... .   || ||..| .|    .|.|. ||  . .||.|||| ..|.  |.    ..    ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

NEAEIATILYSTLKGLEYLHFMRKIHRDIKAGNILLNNEGNAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYDCKADIWSLGITALEMAEGK
.|. || ..  .|.|||..|    ||||||  ||||. .|. |..||| . |||.   ||||. ||| |||||||.   || | ||||||| |.||.|| 
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPYAEIHPMRAIFMIPTKPPPTFRDPEKWSQDFIDFTSKCLIKSPEDRATATDLLQHPFV
||| .  | ||.. | |.  | ..||.||||.| || .||| . ...||.|..||.||| 
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase MST.AA S_TKc 18-269 33 1.1e-101 345.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-231/231
Sequence Identity: 33% (90 aa)

FDLLEKLGEGSYGSVFKAIHKESGQVLAIKQVPVDTDLQEIIKEISIMQQCDSTYVVKYYGSYFKNTDLWIVMEYCGA--GSVSDIMRRRNK-----TLN
...|.|.|.|..|.|.|..||..|.. |||...     . |..||.|... .  ..||.|...   ..|..|||||.   |.. |....|..      ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EAEIATILYSTLKGLEYLHFMRKIHRDIKAGNILLNNEGNAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYDC-KADIWSLGITALEMAEGK
| ... ..| ....|||.| .. ||||.|  ||||..  . |..|||.| ||       .|..|||..|||||.   ||.. |.|.||.|..  ||. |.
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

PPYAEIHPMRAIFMIPTKPPPTFRDPEKWSQDFIDFTSKCLIKSPEDRATATDLLQ-------HPFV
||.     | ..| .              |....|| .||| | ||.| || ..||       ||..
PPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MST.AA Ste20-DD1 18-269 47 6.5e-101 341.56 In-house 1-268 (268) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-268/268
Sequence Identity: 47% (128 aa)

FDLLEKLGEGSYGSVFKA-------IHKESGQVLAIKQVPVDT-DLQE---IIKEISIMQQC-DSTYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIMRRR
|  .|  | ||.| |          .     .| |.| | ..  |  |     ||| |.    |  |.||| | | |   | ||||||  ||. |||   
FQIVEVIGQGSFGVVCTCRWMKKKDRNTNNNRVIACKFVEMNADDVEENSNLKKEIDILKNTMDCPYIVKYHGCYIKENMLMIVMEYCDGGSILDIMQMC

NKTLNEAEIATILYSTLKGLEYLHFMRKIHRDIKAGNILLNNEGNAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE----IGYDCKADIWSLGIT
 |.| |..|| |.|   ||| |||  | .||||||||.|.| || .|||||||   .  .  | ||||| |.||.||.|       ||| ||||||||||
SKRLIEEQIAAICYQIVKGLVYLHSNRITHRDIKAGNVLVNKEGQPKLADFGVSTIAVNQGFKMNTVIGSPYWMSPEIIMPPKGSQGYDQKADIWSLGIT

ALEMAEGKPPYAEIHPMRAIFMIPTKPPPTFRDPEKWSQDFIDFTSKCLIKSPEDRATATDLLQHPFV
| |||| |||  .. | | || || ..||| . |  ||  | || . || . |. |  | .|| |||.
AIEMAESKPPRFNVNPVRVIFVIPHQQPPTLKIPSNWSPEFNDFIKQCLNMNPDKRPSAQQLLNHPFI
Kinase MST.AA NinaC 18-269 46 1e-99 337.55 In-house 1-267 (267) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-267/267
Sequence Identity: 46% (123 aa)

FDLLEKLGEGSYGSVFKAIHKESGQVLAIKQVPVDTDLQEII-KEISIMQQ-CDSTYVVKYYGSYFKNT-----DLWIVMEYCGAGSVSDIMR---RRNK
.   |  | | || |||.  |..||. |.|    . |..| |  |  |... ||   ||..|| |.|        ||.|||||  ||| |. .   .. .
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKCGR

TLNEAEIATILYSTLKGLEYLHFMRKIHRDIKAGNILLNNEGNAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYDCKADIWSLGITA
 ..|. || ||. .. ||  ||  . ||||.|  ||||  ||  || ||||  ||. |  .||| .|||.|||||||      .  ||  .|.|||||||
RMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGITA

LEMAEGKPPYAEIHPMRAIFMIPTKPPPTFRDPEKWSQDFIDFTSKCLIKSPEDRATATDLLQHPFV
 |.. |.|| |..|||||.| ||  |||| . ||.|.|.| || |.||.|  | | . ...|.|||.
IELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase MST.AA KHS 18-269 48 4.4e-99 333.92 In-house 1-258 (258) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-258/258
Sequence Identity: 48% (125 aa)

FDLLEKLGEGSYGSVFKAIHKESGQVLAIKQVPVDT--DLQEIIKEISIMQQCDSTYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIMRRRNKTLNEAEIA
..|| ..| | || |.|| ...|... |.| . ..   |.. | .|| .|..|  . .| |.|||...  |||.|||||.||. || .   . |.|  ||
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGP-LSELQIA

TILYSTLKGLEYLHFMRKIHRDIKAGNILLNNEGNAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---QEIGYDCKADIWSLGITALEMAEGKPPY
 .   ||.||.||| | |.|||||  ||||...|. |||||||..|.| |.|||   ||||.||||||    .. ||.   |||..||||.|.|| .|| 
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPM

AEIHPMRAIFMIPTKP---PPTFRDPEKWSQDFIDFTSKCLIKSPEDRATATDLLQHPFV
 ..|||||.|.. ||    ||. .| .|||| | .|   .|.|.|  | ||. |||||||
FDLHPMRALFLM-TKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase MST.AA MSN 18-269 45 2.7e-93 308.41 In-house 1-265 (265) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-265/265
Sequence Identity: 45% (122 aa)

FDLLEKLGEGSYGSVFKAIHKESGQVLAIKQVPVDTDLQEIIK-EISIMQQ-CDSTYVVKYYGSYFK------NTDLWIVMEYCGAGSVSDIMRR-RNKT
|.| | .| | || |.| .|.  ||. ||| . |  |  | || || ....      .. ||| ..|      .  ||.|||.|||||| |...  ....
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQS

LNEAEIATILYSTLKGLEYLHFMRKIHRDIKAGNILLNNEGNAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ-----EIGYDCKADIWSLGITAL
| |  || |    |.|| .||  . ||||||  |.|| .. . || ||||. ||  |. .||| ||||.|||||||.     .  || ..|.||.||||.
LKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITAI

EMAEGKPPYAEIHPMRAIFMIPTKPPPTFRDPEKWSQDFIDFTSKCLIKSPEDRATATDLLQHPFV
|||||.||  ..|||||.|.|| .|||. .  .|||. | .|  |||||  . | .. ..|.|||.
EMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase MST.AA Pkinase 18-269 30 5e-89 306.86 Pfam 1-293 (293) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

FDLLEKLGEGSYGSVFKAIHKESGQVLAIKQVPVDTDLQEIIK------EISIMQQCDSTYVVKYYGSYFKNTDLWIVMEYCGAG----SVSDIMR-RRN
. ...|.|.||.|.|.|..|| .|.. |.|.......  .  .      ||.||. ... ..|..|...  ......|||||. |    . .|... .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KTL--NEAEIATILYSTLKGLEYLHFMRKIHRDIKAGNILLNNEGNA----KLADFGVAGQL-TDTMAKRNTVIGTPFWMAPEVIQ-EIGYDCKADIWSL
...   | |.  ..| .|.||||.| |. ||||.|  |||..|.|.     |..|||.| |. .      .|. |||..||||||.   .|. |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GITALEMAEGKPPYAEI----HPMRAIFMIPTKPPPTFRDPEKWS---------------------QDFIDFTSKCLIKSPEDRATATDLLQHPFV
|..  ||. |.||. .     . .. ..||  . .| .. .. |.                     ....|| ..|| | |..| ||...||||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MST.AA Pkinase_Tyr 18-269 26 7e-34 115.37 Pfam 1-270 (270) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-270/270
Sequence Identity: 26% (73 aa)

FDLLEKLGEGSYGSVFKAIHK----ESGQVLAIKQVPVDTDLQE-----IIKEISIMQQC-DSTYVVKYYGSYF-KNTD--LWIVMEYCGAGSVSDIMRR
  ...|||||..|.|.|.. |    . ..  |.| .. ... ..      ..|..|| |  .   .|..||    .     ..|||||.  |.  |  |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---NKTLNEAEIATILYSTLKGLEYLHFMRKIHRDIKAGNILLNNEGNAKLADFGVAGQL--TDTM-AKRNTVIGTPFWMAPEVIQEIGYDCKADIWSL
.   .. |.  ..  . .   ||.|||. .. ||||. | |.|..... .| .||| |  .  .|.   ||       .|||||.|..  .  | |.|| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GITALEMAE-GKPP-YAEIHPMRAIFMI-PTKPPPTFRDPEKWSQDFIDFTSKCLIKSPEDRATATDLLQHPFV
|..  |.   |. | |... . . . .|           ||. ...  |   .|  . |||| | ...  | . 
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC--PENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
Kinase MST.AA TyrKc 18-269 25 1.2e-25 92.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-269
Range on HMM: 1-280/280
Sequence Identity: 25% (74 aa)

FDLLEKLGEGSYGSVFKAIHKESGQVLAIKQVPVDTDLQEIIKEISIMQQC--DSTYVVKYYGSYFKN-------TDLWIVMEYCGAGSVSDIMRRRNKT
  |..||||| .| |.|.. |   .  |.| .  |. ......|..|| .   .   .|. ||   .          |.|||||.  |.  |  |.. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LNEAEIATILYSTLKGLEYLHFMRKIHRDIKAGNILLNNEGNAKLADFGVAGQLTDT----MAKRNTVI----GTP-----FWMAPEVIQEIGYDCKADI
|. ..   . .   .| |||| .. ||||. | |.|..... .| .||| .  ..|      .|   .     |.       |||||.|..  .  | |.
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSLGITALEMAE-GKPPYAE-----IHPMRAIFMIPTK----PPPT-----FRDPEKWSQDFIDFTSKCLIKSPEDRATATDLLQHPFV
|| |..  |.   |..|| .     . . ..|  . .     .||      |      ...  .  ..|    |||| | ...  | . 
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Mst1_SARAH MST.AA Mst1_SARAH 542-590 67 3.8e-28 93.38 Pfam 1-49 (49) Show / Hide 
Range on Protein: 542-590
Range on HMM: 1-49/49
Sequence Identity: 67% (33 aa)

DFDFLKQLSIDELRERLTSLDPQMEAEIEELRKRYQEKRRPIIEAMEVK
||.||| .| .|| .|| ||||.|| ||||||.||| || ||..||| |
DFEFLKSWSYEELQQRLASLDPMMEQEIEELRQRYQAKRQPILDAMEAK