PAK4

Species: Sea Urchin
Alias: PAK4, SPU_010141, Spk234
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: PAKB

Sequence

Name Sequence Type Origin Length Description Download
PAK4.AA Protein None 693 None Fasta, JSON
PAK4.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of PAK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD PAK4.AA PBD 17-74 30 2.8e-16 59.44 Pfam 1-60 (60) Show / Hide
Range on Protein: 17-74
Range on HMM: 1-60/60
Sequence Identity: 30% (18 aa)

KISTP-SNFEHRVHTGYDRRLGKYVGLPPQWASIIGAE-ETRPKPIVDPSCITQTEAFEL
 |||| .||.|..| |.|.  |...|.||.|...  .   ..|.. ..|.....   |. 
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ

PBD PAK4.AA PBD 18-53 44 2e-12 48.55 SMART 1-38 (38) Show / Hide
Range on Protein: 18-53
Range on HMM: 1-38/38
Sequence Identity: 44% (17 aa)

ISTPS-NFEHRVHTG-YDRRLGKYVGLPPQWASIIGAE
||||. ||.|.|| |  |.. |...|||.||.....  
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC

Kinase PAK4.AA PAKB 422-674 83 7.50000000001e-226 756.6 In-house 1-252 (252) Show / Hide
Range on Protein: 422-674
Range on HMM: 1-252/252
Sequence Identity: 83% (212 aa)

LENFVKIGEGSTGIVCIATEASSGRQVAVKKMDLRKQQRRELLFNEVVIMRDYKHPNIVEMYDSFLVGDELWVVMEFLEGGALTDIVTHTGRMQEEQVAY
|.|.||||||||||||||||...||||||||||||||||||||||||||||||.||||||||.|.||||||||||||.|||||||||||| ||.|||.|.
LDNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHT-RMNEEQIAT

VCQAILKALAFLHSQGVIHRDIKSDSILLTHDGNVKLSDFGFCAQISSDTPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVMEMVDGEPPFFNEP
||...|.|||.||.|||||||||||||||||||.|||||||||||.|...||||||||||||||||||||||||||||||||||||.||||||||.||||
VCRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEP

PLQAMRRIRDMPPPKLKNTHKASPRLLGFIERLLVRDPSQRASAFELLEHPFL
|||||.|||||.||.|||.||.|||| .|..|.|||||.||..|.|||.||||
PLQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL

Kinase PAK4.AA STE20 422-674 45 5e-153 514.68 In-house 1-288 (288) Show / Hide
Range on Protein: 422-674
Range on HMM: 1-288/288
Sequence Identity: 45% (131 aa)

LENFVKIGEGSTGIVCIATEASSGRQ----VAVKKMDLRKQ----QRRELLFNEVVIMRDYKHPNIVEMYDSFLVG----DELWVVMEFLEGGALTDIVT
 |.. |||.||.| |. |.. ..|..    ||.|||.|.|.    ...|....|..||...||||||..|.|.|..    ||||.|||...|| ||||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---HTG------RMQEEQVAYVCQAILKALAFLHSQGVIHRDIKSDSILLTHDGNVKLSDFGFCAQISS-----DTPKRKSLVGTPYWMAPEVISR----
    .|      .|.|||.||.|. .|..|..|||...||||||.| ||||.||.|||.|||.|||...     . .||...||||||||||||..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-LPYGTEVDIWSLGIMVMEMVDGEPPFFNEPPLQAMRRIR--DMPPPKLKN--THKASPRLLGFIERLLVRDPSQRASAFELLEHPFL
  .|.. .|||||||. .||..||||.|...|..|| .|   ..|||.||.  .|| || .  |... |..||..|..| .||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI

Kinase PAK4.AA PAKA 423-674 51 1.1e-133 450.43 In-house 2-260 (260) Show / Hide
Range on Protein: 423-674
Range on HMM: 2-260/260
Sequence Identity: 51% (133 aa)

ENFVKIGEGSTGIVCIATEASSGRQ--VAVKKMDLRKQQRRELLFNEVVIMRDYKHPNIVEMYDSFLVGDELWVVMEFLEGGALTDIVTHTGR-----MQ
... |||.|..| | .||... . .  ||.|.|.. .| . ||. ||  .|...||.|||  .||.|| ||||||||..||| |||..|.. .     |.
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

EEQVAYVCQAILKALAFLHSQGVIHRDIKSDSILLTHDGNVKLSDFGFCAQISSDTPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVMEMVDGEP
|.|.||||. .|..| |.||...|||||||| |||  ||.||. |||||||..    ||.. ||||||||||||.|  |.  |||||||||..||..|||
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEP

PFFNEPPLQAMRRIRDMPPPKLKNTHKASPRLLGFIERLLVRDPSQRASAFELLEHPFL
|. ||||| ||  |     |..|...| |. .  | .. |  |. .|||| |||.||||
PYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL

Kinase PAK4.AA STE 422-674 31 2.8e-122 412.53 In-house 1-359 (359) Show / Hide
Range on Protein: 422-674
Range on HMM: 1-359/359
Sequence Identity: 31% (114 aa)

LENFVKIGEGSTGIVCIATEA------SSGRQ---------VAVKKMDLRKQ-----------------QRRELLFNEVVIMRDYK--HPNIVEMYDSFL
.|.  |||.|..| |. |         ..|..         .|.|.|.|...                 . .. . .|. ||....  |||||. |....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG-------DELWVVMEFLEGGALTDIVTHT--------------GRMQEEQVAYVCQAILKA-LAFLHSQGVIHRDIKSDSILLTHDGNVKLSDFGFCA
..       ||||..||...|| |.||. |.              .|..|.|.||.|..|||. |..|||...||||||.. |||     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QISSDTP----------------KRKSLVGTPYWMAPEVISR------LPYGTEVDIWSLGIMVMEMVDGEPPFFNEPPLQAMRRIRDM-----------
|.... .                ||...|||| |||||||..       .|.| .||||||....||..|.||.....|..|| .| ..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----PPPKLKN-----------------THKASPRLLGFIERLLVRDPSQRASAFELLE--HPFL
    |||.|..                 .|| || .  ||.. |..||..|..| .||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase PAK4.AA S_TKc 422-674 32 9.5e-101 341.92 SMART 1-231 (231) Show / Hide
Range on Protein: 422-674
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

LENFVKIGEGSTGIVCIATEASSGRQVAVKKMDLRKQQRRELLFNEVVIMRDYKHPNIVEMYDSFLVGDELWVVMEFLEG--GALTDIVTHTGR------
 |   |||.|. | |. ... ..||.||.|...       | . .|. |..  .||||| .||.|   |.|..|||...|  | | |.  . ||      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MQEEQVAYVCQAILKALAFLHSQGVIHRDIKSDSILLTHDGNVKLSDFGFCAQISSDTPKRKSLVGTPYWMAPEVISRLPYGT-EVDIWSLGIMVMEMVD
. | ....... |..||...||.|.||||.| . |||..  ..|..|||...|.       ....|||..|||||.   .||. ..|.||.|... ||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPFFNEPPLQAMRRIRDMPPPKLKNTHKASPRLLGFIERLLVRDPSQRASAFELLE-------HPFL
|.|||    . . ...|.             || .. ||...|..||..| .| |.|.       ||..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase PAK4.AA Pkinase 422-674 30 9.1e-93 319.29 Pfam 1-293 (293) Show / Hide
Range on Protein: 422-674
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

LENFVKIGEGSTGIVCIATEASSGRQVAVKKMDLRKQQRREL--LFN--EVVIMRDYKHPNIVEMYDSFLVGDELWVVMEFLEGG----ALTDIVT--HT
..   |||.|| | |..... ..|..||||....|..   ..  ...  |. ||.  .|||||..||.|  .|....|||..|||     | |...    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRM--QEEQVAYVCQAILKALAFLHSQGVIHRDIKSDSILLTHDGNV----KLSDFGFCAQI-SSDTPKRKSLVGTPYWMAPEVIS-RLPYGTEVDIWSL
|..  .|...  ..  ||..|...||.|.||||.|.. ||. ..|..    |..|||...|.     .  ....|||..||||||  . .||..||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMVMEMVDGEPPFFNE----PPLQAMRRIRDMPPPKLKNTHKAS---------------------PRLLGFIERLLVRDPSQRASAFELLEHPFL
|... ||. |.||| ..    . .  | .|.   .|.|.     .                     . .. ||...| .||..| .| ..|.||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase PAK4.AA YSK 425-674 40 7.9e-80 239.97 In-house 1-257 (257) Show / Hide
Range on Protein: 425-674
Range on HMM: 1-257/257
Sequence Identity: 40% (105 aa)

FVK---IGEGSTGIVCIATEASSGRQVAVKKMDLRKQQRR-ELLFNEVVIMRDYKHPNIVEMYDSFLVGDELWVVMEFLEGGALTDIVTHT--GRMQEEQ
|.|   || || | |  . .   .| ||.|  || .     |..  |. .  . . |.|   | |.| .  ||..||.. || . |       | ..|..
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

VAYVCQAILKALAFLHSQGVIHRDIKSDSILLTHDGNVKLSDFGFCAQISSDTPKRKSLVGTPYWMAPEVISR--LPYGTEVDIWSLGIMVMEMVDGEPP
.| .   |||.| .|||. .||||||.  .||. .|.||| |||  .||   . ||   ||||||||||||      | . .|||||||   ||  ||||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

FFNEPPLQAMRRIRDMPPPKLKN-THKASPRLLGFIERLLVRDPSQRASAFELLEHPFL
     |. .| .|   .||||.  ..  |  .  |.|  |. ||.|| || ||| | | 
YCDYHPMRVMFLIPKNNPPKLEGRSY--SKMFKEFVECCLNKDPEQRPSAKELLKHKFI

Kinase PAK4.AA CAMK 427-674 19 1.2e-78 252.87 In-house 1-425 (425) Show / Hide
Range on Protein: 427-674
Range on HMM: 1-425/425
Sequence Identity: 19% (83 aa)

KIGEGSTGIVCIATEASSG------------RQVAVKKMDLRKQQR----------------------------RELLFNEVVIMRD-------YKHPNI
..|.|| |.|  ... ...            ..||.| .| .| .                             |. ...|. ||.         .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VEMYDSFL------------VGDE--------LWVVM---EFLEGGAL--------------------TDIVTHTGRMQEEQVAYVCQAILKALAFLHSQ
. .|. .               .         .. ||   |. .|| |                     |||  .||..|...... . |. |....||.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

GVIHRDIKSDSILLTHD-----------------GNVKLSDFGFCAQISS-----------------------DTPKRKSLVGTPYWMA-PEVISR----
...|||.| . |||...                 .|.|..|||| ... .                       ...| |  .|||. || |||...    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------LPYGTEVDIWSLGIMVMEMVDGEPPFFNEPPLQAMR-------------RIR----DMPPPKLKN------------------THKASPR
           .|| ..|.||.|..   |. |.|||  .   . .              .|.    |.|||....                    . |. 
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQE

LLGFIERLLVRDPSQRASAFELLEHPFL
   .| ..|..||..|... . |.||..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase PAK4.AA KHS 423-674 41 3.6e-78 262.49 In-house 2-258 (258) Show / Hide
Range on Protein: 423-674
Range on HMM: 2-258/258
Sequence Identity: 41% (107 aa)

ENFVKIGEGSTGIVCIATEASSGRQVAVKKMDLRKQQRRELLFNEVVIMRDYKHPNIVEMYDSFLVGDELWVVMEFLEGGALTDIVTHTGRMQEEQVAYV
|   ..| |  | |  | .  |.  .||| . .  ..  ...  |...|.| .|||||  . |.|  | ||..||.  ||.| ||   || ..| |.|||
ELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV

CQAILKALAFLHSQGVIHRDIKSDSILLTHDGNVKLSDFGFCAQISSDTPKRKSLVGTPYWMAPEVIS---RLPYGTEVDIWSLGIMVMEMVDGEPPFFN
|. .|..|..|||.| .|||||   ||||..|.||| |||  |||.    |||| .|||||||||| .   .  |.   |||..||  .|. .  ||.|.
CRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFD

EPPLQAMRRIR--DMPPPKLKNTHKASPRLLGFIERLLVRDPSQRASAFELLEHPFL
  |..|.  .   .  |||||. || |.    |.   |...| .| .|  ||.|||.
LHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV

Kinase PAK4.AA MST 423-674 38 3e-77 245.07 In-house 2-254 (254) Show / Hide
Range on Protein: 423-674
Range on HMM: 2-254/254
Sequence Identity: 38% (98 aa)

ENFVKIGEGSTGIVCIATEASSGRQVAVKKMDLRKQQRRELLFNEVVIMRDYKHPNIVEMYDSFL--VGDELWVVMEFLEGGALTDIVTHTGR-MQEEQV
.   |.|.|| | |  |.  ..|  ||.|..        . . .|  || . | ..||  |.|..     ..| |||. ..| . ||.  |.|   |.| 
DIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQI

AYVCQAILKALAFLHSQGVIHRDIKSDSILLTHDGNVKLSDFGFCAQISSDTPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVMEMVDGEPPFFN
| ...  |. |. ||.   ||||||.  ||| |.|. ||.|||  .| .  . || ...|||||||||||  . | . .|||||||   ||  |.||...
ACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSD

EPPLQAMRRIRDMPPPKLKNTHKASPRLLGFIERLLVRDPSQRASAFELLEHPFL
  |  ||  |   |||..|. .. |. .  |. . |...|.||..| .||.||| 
IHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI

Kinase PAK4.AA SLK 423-674 36 2.1e-70 236.72 In-house 2-259 (259) Show / Hide
Range on Protein: 423-674
Range on HMM: 2-259/259
Sequence Identity: 36% (93 aa)

ENFVKIGEGSTGIVCIATEASSGRQVAVKKMDLRKQQRRELLFNEVVIMRDYKHPNIVEMYDSFLVGDELWVVMEFLEGGALTDIVTHTGR-MQEEQVAY
|    .|.|  | |  | .   ..  | | ......   |  . |. |. . ||||||..|... . ..||...|| .|||.  |.   .. ..|.|..|
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQY

VCQAILKALAFLHSQGVIHRDIKSDSILLTHDGNVKLSDFGFCAQISSDTPKRKSLVGTPYWMAPEVI-----SRLPYGTEVDIWSLGIMVMEMVDGEPP
||. .. || .|||. |||||.|   ||.| ||.|.| |||  |.  ..  || . .||||||||||.        ||   .||||||| ..|| ..|||
VCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPP

FFNEPPLQAMRRIRDMPPPKLKNTHKASPRLLGFIERLLVRDPSQRASAFELLEHPFL
  .  |.  . .|.   ||.|..  . |     |... ||.|| .| .. .|..|...
HHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV

Kinase PAK4.AA PAKL 427-674 36 2.7e-69 236.51 In-house 6-256 (256) Show / Hide
Range on Protein: 427-674
Range on HMM: 6-256/256
Sequence Identity: 36% (92 aa)

KIGEGSTGIVCIATEASSGRQVAVKKMDLRKQQRRELLFNEVVIMRDYKHPNIVEMYDSFLVG-DELWVVMEFLEGGALTDIVTHTGR-MQEEQVAYVCQ
| |.|| | |  |.  ...   |.| . .    . . . .|. |    | ||||  . |   . ...|. |..   |   |.   ..  ..|.|.. . |
KLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQISVILQ

AILKALAFLHSQGVIHRDIKSDSILLTHDGNVKLSDFGFCAQISSDTP-KRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVMEMVDGEPPFFNEPPL
  || |  |||...||||||.  |||. |. ||. |||   |. .      ....|||||||||.| . .|   .||||||| . || ||.||    || 
QTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPHYDMPPM

QAMRRIRDMPPPKLKNTHKASPRLLGFIERLLVRDPSQRASAFELLEHPFL
 ||  |  .|||...| .. || .  |. . .| || .|.|. .|| |||.
RAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI

Kinase PAK4.AA Pkinase_Tyr 422-631 28 6e-28 95.28 Pfam 1-231 (270) Show / Hide
Range on Protein: 422-631
Range on HMM: 1-231/270
Sequence Identity: 28% (65 aa)

LENFVKIGEGSTGIVCIATEA----SSGRQVAVKKM--DLRKQQ--RRELLFNEVVIMRDY-KHPNIVEMYDSFL-VGDE--LWVVMEFLEGGALTDIVT
..   |.|||. | |. .|      . . .||||..  .  ..|  |....  |. ||. . .||||| .|   .  |.   ...|||. ..| | |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

H----TGRMQEEQVAYVCQAILKALAFLHSQGVIHRDIKSDSILLTHDGNVKLSDFGFCAQI--SSDT-PKRKSLVGTPYWMAPEVISRLPYGTEVDIWS
      ..   ..    |. | |....|.|.. ||||.    .|.|... || .||| .  |   .    ||..      |||||.|.   . |. |.||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

LGIMVMEMVD-GEPP-FFNEPPLQAMRRI-RD
 |.   |..  || | . . .. . ...| .|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED

Kinase PAK4.AA TyrKc 422-674 25 4.7e-20 73.88 SMART 1-280 (280) Show / Hide
Range on Protein: 422-674
Range on HMM: 1-280/280
Sequence Identity: 25% (73 aa)

LENFVKIGEGSTGIVCIATEASSGRQVAVKKMDLRKQQRRELLFNEVVIMRDY--KHPNIVEMYDSFLVG-------DELWVVMEFLEGGALTDIV-THT
..   |.|||  |.|. .|     .|||||..   .   || . .|  ||. .  .||||| .|   . .       . |..|||. ..|.| |    | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

GRMQEEQVAYVCQAILKALAFLHSQGVIHRDIKSDSILLTHDGNVKLSDFGFCAQISSD-------TPKRKSL-VGTP-----YWMAPEVISRLPYGTEV
.. . ..  . |  | .  ..|||...||||.    .|..... || |||| .  | .|         .||.   |.       |||||.|    . |. 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSLGIMVMEMV-DGEPPFFN-----EPPLQAMRRIRDM---PPPKL-----KNTHKASPRLLGFIERLLVRDPSQRASAFELLEHPFL
|.|| |..  |.  .|..|  .      .. ........    |.|.           ... .   ...   .||..| .  |.  | ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF