Gene SLK (Sea Urchin)

SLK

Species: Sea Urchin
Alias: Spk231, SPU_014726, SLK
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: SLK

Sequence

Name Sequence Type Origin Length Description Download
SLK.AA Protein None 209 None Fasta, JSON
SLK.kin_dom Protein Kinase Domain None 73 None Fasta, JSON

Protein domain

Protein domains of SLK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SLK.AA SLK 3-209 64 1.6e-117 396.75 In-house 18-228 (259) Show / Hide 
Range on Protein: 3-209
Range on HMM: 18-228/259
Sequence Identity: 64% (136 aa)

ARNKHNGVTVAAKIIEIKEHDDLNDFRVEIDILTECKHPNIVGLEETFLHQSKLWMMLEFCEGGALDDIVLEVEKPLTEAQIKVVCRQTLEALVYLHEHN
|..| ..|  |||.||||. ..|.|. ||||||.||||||||.| |.. .. |||||.|||.|||.| |..|.|.|||| ||..||....||| .||...
AQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQYVCKHMCEALNWLHSNK

IIHRDLKAGNILLKMDGNVRL----VSAKNTSPLQRRDSFIGTPYWMAPEVVICETLKDNPYDYKADIWSLGITLIELAEMEPPYHDLNPMRVLIKIPKA
.|||||||||||. |||.|||    |||||....|.||.|||||||||||||.|||.||.|||||||||||||||||.|.||||.|..||||||.|| |.
VIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPPHHEMNPMRVLLKIQKS

PPPRLQQKKRW
 ||.|.|  .|
EPPTLEQPSHW
Kinase SLK.AA STE20 3-209 43 1.7e-102 346.85 In-house 18-257 (288) Show / Hide 
Range on Protein: 3-209
Range on HMM: 18-257/288
Sequence Identity: 43% (104 aa)

ARNKHNGVT----VAAKIIEIKEH----DDLNDFRVEIDILTECKHPNIVGLEETFLHQ----SKLWMMLEFCEGGALDDIVL---EVEK-----PLTEA
|..|..|      || |......     |...|   ||.|. .|||||||   ...|      ..||.  |.|.|| | ||.    . .|     |..|.
AYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEE

QIKVVCRQTLEALVYLHEHNIIHRDLKAGNILLKMDGNVRL----VSAKNTS----PLQ-RRDSFIGTPYWMAPEVVICETLKDNPYDYKADIWSLGITL
|| ..||..|..| |||...|||||.||.|||| .||.| |    |.|. |.      | .|..|.||||||||||. |.. .|..||||.||||||||.
QIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITA

IELAEMEPPYHDLNPMRVLIKIP--KAPPPRLQQ--KKRW
||.|| ||||.|..|||.. .||  . |||.|..  ...|
IEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKW
Kinase SLK.AA STE 5-209 30 7.8e-82 278.18 In-house 35-326 (359) Show / Hide 
Range on Protein: 5-209
Range on HMM: 35-326/359
Sequence Identity: 30% (91 aa)

NKHNGVTVAAKIIEIKE-----------------HDDLNDFRVEIDILTECK--HPNIVGLEETFLHQ-------SKLWMMLEFCEGGALDDIVL---EV
|...|. .| |......                 |......  ||.|. .|.  |||||    ....        ..||. .|...|| ||||.    ..
NGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGC

EKPLT----------EAQIKVVCRQTLEA-LVYLHEHNIIHRDLKAGNILLKMDGNVRLV----SAKNTS---------------PLQ-RRDSFIGTPYW
 |||.          | ||...|||.|.. | |||.|.|||||.|..||||     | |.    ... |.                 | .|..|.||| |
GKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-W

MAPEVVICETLK-DNPYDYKADIWSLGITLIELAEMEPPYHDLNPMRVLIKIPKA---------------PPPRLQQ-----------------KKRW
|||||. ... . |..||.|.||||||.|.||.|. .||.||..|||..  ||.                |||.|..                 ...|
MAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKW
Kinase SLK.AA MST 5-209 41 1.5e-75 239.6 In-house 20-223 (254) Show / Hide 
Range on Protein: 5-209
Range on HMM: 20-223/254
Sequence Identity: 41% (87 aa)

NKHNGVTVAAKIIEIKEHDDLNDFRVEIDILTECKHPNIVGLEETFL--HQSKLWMMLEFCEGGALDDIVLEVEKPLTEAQIKVVCRQTLEALVYLHEHN
.| .|  || |.. .    ||..   || |. .|| ..||..   ..   .. .|   |.|..| . ||.    ..|.|.|| .....||  | |||   
HKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIACILYDTLQGLQYLHDNK

IIHRDLKAGNILLKMDGNVRL----VSAKNTSPLQRRDSFIGTPYWMAPEVVICETLKDNPYDYKADIWSLGITLIELAEMEPPYHDLNPMRVLIKIPKA
.||||.|||||||  .|.  |    ||.  |     |...|||||||||||     .  . ||.|||||||||| ||.|| .|||.|. |||....||. 
KIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEV-----IQEIKYDCKADIWSLGITAIEMAEGMPPYSDIHPMRAMFMIPQK

PPPRLQQKKRW
||| ..   .|
PPPTFKDPEQW
Kinase SLK.AA YSK 5-204 41 4.7e-72 216.13 In-house 20-222 (257) Show / Hide 
Range on Protein: 5-204
Range on HMM: 20-222/257
Sequence Identity: 41% (86 aa)

NKHNGVTVAAKIIEIKE-HDDLNDFRVEIDILTECKHPNIVGLEETFLHQSKLWMMLEFCEGGALDDIVLE-VEKPLTEAQIKVVCRQTLEALVYLHEHN
... . .|| |||.  .  |.  |   || .| .|. |.|     ..|  .|||   |.| || . |        .. | .| .. |  | .| |||. .
DNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYIAIILREILKGLDYLHSER

IIHRDLKAGNILLKMDGNVRL----VSAKNTSPLQRRDSFIGTPYWMAPEVVICETLKDNPYDYKADIWSLGITLIELAEMEPPYHDLNPMRVLIKIPKA
 |||| || |.||  .|.| |    |... |   ..|. |.||||||||||. .|      ||.|||||||||| .|.|  |||| |. ||||.  ||| 
KIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEV---SYYDFKADIWSLGITAYEMAKGEPPYCDYHPMRVMFLIPKN

PPPRLQ
.||.|.
NPPKLE
Kinase SLK.AA KHS 3-209 45 6e-70 234.43 In-house 18-227 (258) Show / Hide 
Range on Protein: 3-209
Range on HMM: 18-227/258
Sequence Identity: 45% (97 aa)

ARNKHNGVTVAAKIIEIKEHDDLNDFRVEIDILTECKHPNIVGLEETFLHQSKLWMMLEFCEGGALDDIVLEVEKPLTEAQIKVVCRQTLEALVYLHEHN
||... .  .| |.| .   ||.     || .. .|.|||||.    .|.. |||...|.| ||.| ||  .|  ||.| ||  |||.||..| ||| . 
ARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDI-YHVTGPLSELQIAYVCRETLQGLHYLHSMG

IIHRDLKAGNILLKMDGNVRL----VSAKNTSPLQRRDSFIGTPYWMAPEVVICETLKDNPYDYKADIWSLGITLIELAEMEPPYHDLNPMRVLIKIPKA
 .|||.|  ||||  .|.|.|    |||. |  . .| |||||||||||||   |  .   |.   |||..||| |||||. ||  || |||.|. . |.
KMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE--RKGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMTKS

P--PPRLQQKKRW
   ||.|..|..|
NFQPPKLKDKHKW
Kinase SLK.AA PAKL 6-209 41 5.2e-65 222.3 In-house 21-225 (256) Show / Hide 
Range on Protein: 6-209
Range on HMM: 21-225/256
Sequence Identity: 41% (88 aa)

KHNGVTVAAKIIEIKEHDDLNDFRVEIDILTECKHPNIVGLEETFLHQ-SKLWMMLEFCEGGALDDIVLEVEKPLTEAQIKVVCRQTLEALVYLHEHNII
|  . . | | |||||  .  |   ||.||  || ||||          ...|  ...|  |   |.   ..| |.|.|| |. .|||  |.|||  |||
KDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQISVILQQTLKGLHYLHSKNII

HRDLKAGNILLKMDGNVRL----VSAKNTSPLQ-RRDSFIGTPYWMAPEVVICETLKDNPYDYKADIWSLGITLIELAEMEPPYHDLNPMRVLIKIPKAP
||| || ||||  |. | .    || .  . .     . ||||||||||.     ..  .|..|.||||||||.||.|. .||  |..||| .  ||  |
HRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEI-----INKQNYNNKCDIWSLGITAIEMADGFPPHYDMPPMRAMYMIPNWP

PPRLQQKKRW
|| .   | |
PPTFSNPKHW
Kinase SLK.AA PAKA 3-209 37 4.8e-59 202.49 In-house 18-229 (260) Show / Hide 
Range on Protein: 3-209
Range on HMM: 18-229/260
Sequence Identity: 37% (82 aa)

ARNKHNGVT--VAAKIIEIKEHDDLNDFRVEIDILTECKHPNIVGLEETFLHQSKLWMMLEFCEGGALDDIVLEVEK----PLTEAQIKVVCRQTLEALV
| |.... .  || | ...|. .  .    || .. ||||.|||   ...| ...||. .|. ||| | |.. ....    ...|.||  |||..| .| 
ATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMDEGQIAYVCRECLQGLE

YLHEHNIIHRDLKAGNILLKMDGNVRLV----SAKNTSPLQRRDSFIGTPYWMAPEVVICETLKDNPYDYKADIWSLGITLIELAEMEPPYHDLNPMRVL
..|....||||.|  |||| |||.| .      |  |   |.|..  ||||||||||.     . . ||.| ||||||| .||..| |||| . .| | .
FIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVI-----RRKQYDEKVDIWSLGIMAIEMIEGEPPYLNEPPLRAM

IKIPKAPPPRLQQKKRW
  | .   | .... .|
YLIATNGKPDIKDPDKW
Kinase SLK.AA Pkinase 3-202 30 4e-57 200.88 Pfam 18-237 (293) Show / Hide 
Range on Protein: 3-202
Range on HMM: 18-237/293
Sequence Identity: 30% (69 aa)

ARNKHNGVTVAAKIIEIKEHDDLND--FRV--EIDILTECKHPNIVGLEETFLHQSKLWMMLEFCEGG----ALDDIVL-EVEKPL--TEAQIKVVCRQT
...| .| .|| |||. .. ..  |   |   || |. ...||||| | ..|   ....| .|.||||     | |..  . ....  .| ..| ...|.
CHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQI

LEALVYLHEHNIIHRDLKAGNILLKMDGNV----RLV---SAKN--TSPLQRRDSFIGTPYWMAPEVVICETLKDNPYDYKADIWSLGITLIELAEMEPP
|..| |.|...|||||||  |||.. .|..    ..    .||   . . .  ..| |||..|||||.     ....|..|.|.||.|..|.|..  .||
LRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILYEMLCGRPP

YHDL------NPMRVLIKIPKAPPPR
. .       ..| .. .| ..|...
FPGHCWHDNHDQMQMICRIMGPPLHF
Kinase SLK.AA MSN 4-207 41 8.9e-57 185.91 In-house 19-233 (265) Show / Hide 
Range on Protein: 4-207
Range on HMM: 19-233/265
Sequence Identity: 41% (90 aa)

RNKHNGVTVAAKIIEIKEHDDLNDFRVEIDILTE-CKHPNIVGLEETFL------HQSKLWMMLEFCEGGALDDIVLEV-EKPLTEAQIKVVCRQTLEAL
| .  |  .| |.....| |. .. . ||..|     | ||.     |.      |. .|||..|||  |.. |.| .  .. | |  |  .||  |  |
RHVKTGQLAAIKVMDVRE-DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQSLKEDWIAYICREILRGL

VYLHEHNIIHRDLKAGNILLKMDGNVRLV----SAKNTSPLQRRDSFIGTPYWMAPEVVICETLKDNPYDYKADIWSLGITLIELAEMEPPYHDLNPMRV
 .||.| .||||.|  |.||. . .|.||    ||.      || .||||||||||||. |.   |  |||..|.||.||| ||.|| .||  |. ||| 
AHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITAIEMAEGQPPLCDMHPMRA

LIKIPKAPPPRLQQKK
|. ||. |||.|. ||
LFLIPRNPPPKLKSKK
Kinase SLK.AA TAO 3-209 41 6e-56 181.11 In-house 18-223 (254) Show / Hide 
Range on Protein: 3-209
Range on HMM: 18-223/254
Sequence Identity: 41% (87 aa)

ARNKHNGVTVAAKIIEI---KEHDDLNDFRVEIDILTECKHPNIVGLEETFLHQSKLWMMLEFCEGGALDDIVLEV-EKPLTEAQIKVVCRQTLEALVYL
||.||.  .|| | ..    . |.  .|   |.  | . ||||..     .|...  |...|.| | | |  .|.|  ||. |  |  .|...|..| ||
ARDKHTEEVVAIKKMSYSGKQSHEKWQDIIKEVRFLQQVKHPNCIEYKGCYLREHTCWLVMEYCLGSASD--ILDVHKKPMQEVEIAAICHGALQGLRYL

HEHNIIHRDLKAGNILLKMDGNVRLVSAKNTSPLQRRDSFIGTPYWMAPEVVICETLKDNPYDYKADIWSLGITLIELAEMEPPYHDLNPMRVLIKIPKA
|.|. ||||.|||||||  .| |.|      |  .  .||.||||||||||..   . .  || |.|.|||||| |||||  ||. ..| |  |  | . 
HSHKMIHRDIKAGNILLTEHGQVKLADFGSASMVCPANSFVGTPYWMAPEVILA--MDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN

PPPRLQQKKRW
 .| || .. |
DSPTLQ-QNEW
S_TKc SLK.AA S_TKc 1-208 29 1.8e-40 141.68 SMART 16-220 (231) Show / Hide 
Range on Protein: 1-208
Range on HMM: 16-220/231
Sequence Identity: 29% (69 aa)

MAARNKHNGVTVAAKIIEIKEHDDLNDFRVEIDILTECKHPNIVGLEETFLHQSKLWMMLEFCEG--GALDDIVLEVEKP-----LTEAQIKVVCRQTLE
. .|.|. |  || |||        ...| ||.|| . .||||| | ..| . ..|.| .|.|.|  | | |.  .  ..     ..| ... ...|...
YKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICC

ALVYLHEHNIIHRDLKAGNILLKMDGNVRLV---SAKNTSPLQRRDSFIGTPYWMAPEVVICETLKDNPYDY-KADIWSLGITLIELAEMEPPYHDLNPM
|| |.|.|.|||||||  ||||    .. .    .|.        ..|.|||..|||||.        .|.. |.|.||.|..|.|..  .||..    |
ALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYPPFP---QM

RVLIKIPKAPPPRLQ-----------------QKKR
 ...|. .  .| .                  .  .
QMMFKKIG--SPEAKDFIRKCLQKDPEKRPTAEALQ
Kinase SLK.AA Pkinase_Tyr 8-122 28 9.1e-13 43.87 Pfam 27-151 (270) Show / Hide 
Range on Protein: 8-122
Range on HMM: 27-151/270
Sequence Identity: 28% (36 aa)

NGVTVAAKII-EIKEHDD--LNDFRVEIDILTEC-KHPNIVGLEETFL-HQSK--LWMMLEFCEGGALDDIVLEV---EKPLTEAQIKVVCRQTLEALVY
....|| |.. |   |..  . ||  |. |...  .||||| |    . ..    ... .|....| |.|   .    ..|||  ..   |.|  ... |
TKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEY

LHEHNIIHRDLKAGNILLKMDGNVR
|...|.||||| | |.|.. .. |.
LESKNCIHRDLAARNCLVTENNVVK
TyrKc SLK.AA TyrKc 1-209 19 5.8e-12 -29.24 SMART 16-280 (280) Show / Hide 
Range on Protein: 1-209
Range on HMM: 16-280/280
Sequence Identity: 19% (55 aa)

MAARNKHNGVTVAAKIIEIKEHDDLNDFRVEIDILTEC--KHPNIVGLEETFLHQ-------SKLWMMLEFCEGGALDDIVLEVEKPLTEAQIKVVCRQT
. .. |   ..|| | .       . ||. |. |...   .||||| |    ..|         |.. .|....|.|.|   . .. |. ..    | | 
YKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQI

LEALVYLHEHNIIHRDLKAGNILLKMDGNV--------RLVSAK----NTSPLQRRDSFIGTP-----YWMAPEVVICETLKDNPYDYKADIWSLGITLI
 .   |||..|.||||| | |.|.. .. |        | .  .      .   |  .  |.       |||||.      ... .  | |.|| |... 
ACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYGKFTTKSDVWSFGVCMW

ELAEM-EPPYHD-----LNPMRVLIKIPKA---PPPRL--------------------------------QQKKRW
|.    ..|| .     ... .|. .. .    |.|                                  . ....
EIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SLK.AA Pkinase_Tyr 144-192 27 0.007401 10.3 Pfam 180-225 (270) Show / Hide 
Range on Protein: 144-192
Range on HMM: 180-225/270
Sequence Identity: 27% (14 aa)

WMAPEVVICETLKDNPYDYKADIWSLGITLIELAEME-PP-YHDLNPMRVL
|||||.     .... .  | |.|| |... |.      | | .. . .|.
WMAPEC-----INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVY