Gene YSK (Sea Urchin)

YSK

Species: Sea Urchin
Alias: YSK, Spk232, SPU_018724
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: YSK

Sequence

Name Sequence Type Origin Length Description Download
YSK.AA Protein None 340 None Fasta, JSON
YSK.kin_dom Protein Kinase Domain None 189 None Fasta, JSON

Protein domain

Protein domains of YSK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase YSK.AA YSK 5-193 76 3e-175 532.44 In-house 63-257 (257) Show / Hide 
Range on Protein: 5-193
Range on HMM: 63-257/257
Sequence Identity: 76% (149 aa)

LGATMQGTKLWIIMEYLGGGSALDLLKS---GAMDEIYIATILREVIKGLDYLHCERKIHRDIKAANVLLSENGDVKLADFGVAGQLTETQIKRNTFVGT
.|.....|||||||||.||||.|||.|.   |..||.|||.||||..|||||||.|||||||||||||||||.|||||.|||||||.|.|||||||||||
YGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGT

PFWMAPEVIKQ--SAYDSKADMWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPKLEG-SYTKNFKDFVEVCLNKDPRHRPTAKELLKHRFI
|.|||||||.|  |.||.|||.|||||||.|.||||||..|.|||||.||||||||||||| ||.|.||.|||.||||||..||.|||||||.||
PYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPYCDYHPMRVMFLIPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase YSK.AA STE20 5-193 52 8.20000000001e-124 417.63 In-house 70-288 (288) Show / Hide 
Range on Protein: 5-193
Range on HMM: 70-288/288
Sequence Identity: 52% (116 aa)

LGATMQG----TKLWIIMEYLGGGSALDLLK-----SG-----AMDEIYIATILREVIKGLDYLHCERKIHRDIKAANVLLSENGDVKLADFGVAGQLTE
.|. . .    ..|||.|||.||||..|..|      .      |.| .||.|.||| .|||||| ...|||||||.|.||.|.|.||||||||..|||.
YGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTK

----TQI-KRNTFVGTPFWMAPEVIKQ-----SAYDSKADMWSLGITAIELAKGEPPNSDLHPMRVLFLIP--KNNPPKLEG----SYTKNFKDFVEVCL
    |.  |||||||||.|||||||..     . ||.|.| |||||||||.|.||||..|.||||..|.||  .| ||.|..    .....|.|||..||
HGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCL

NKDPRHRPTAKELLKHRFI
.|||  ||||..|||| ||
QKDPEKRPTASQLLKHPFI
Kinase YSK.AA MST 12-193 55 5.1e-106 337.99 In-house 69-254 (254) Show / Hide 
Range on Protein: 12-193
Range on HMM: 69-254/254
Sequence Identity: 55% (103 aa)

TKLWIIMEYLGGGSALDLLK--SGAMDEIYIATILREVIKGLDYLHCERKIHRDIKAANVLLSENGDVKLADFGVAGQLTETQIKRNTFVGTPFWMAPEV
. .||.||| |.||..|. |       |  ||.||. . .||.|||  .||||||||.| ||.. |  |||||||.||||.|. ||||..|||.||||||
NHCWIVMEYCGMGSVCDIMKITQRTLNEQQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEV

IKQSAYDSKADMWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPKLE--GSYTKNFKDFVEVCLNKDPRHRPTAKELLKHRFI
| .. ||.||| |||||||||.| |.|| ||.||||..|.||.. ||..     .  .| |||  || |.|  |.||..||.| ||
IQEIKYDCKADIWSLGITAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase YSK.AA STE 5-193 40 4.5e-103 348.72 In-house 96-359 (359) Show / Hide 
Range on Protein: 5-193
Range on HMM: 96-359/359
Sequence Identity: 40% (108 aa)

LGATMQG-------TKLWIIMEYLGGGSALDLLKS---------------GAMDEIYIATILREVIKG-LDYLHCERKIHRDIKAANVLLSENGDVKLAD
.|. ...       ..|||.|||..|||. |..|.               . ..|  ||.|.|...|| |.|||  ..||||||.||.||     |||.|
YGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCD

FGVAGQLTE---------------TQI-KRNTFVGTPFWMAPEVIKQ------SAYDSKADMWSLGITAIELAKGEPPNSDLHPMRVLFLIPKN------
|||.||||.               |.  ||||||||| |||||||.|      . || |.|.||||.|.||.| |.|| .|.||||..|.||.|      
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ

---------NPPKLEG-------------------SYTKNFKDFVEVCLNKDPRHRPTAKELLK--HRFI
         .||.|.                    .....||||.. ||.|||..||||..|||  | ||
FEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase YSK.AA FRAY 14-193 49 3.3e-92 286.68 In-house 73-277 (277) Show / Hide 
Range on Protein: 14-193
Range on HMM: 73-277/277
Sequence Identity: 49% (102 aa)

LWIIMEYLGGGSALDLLK----SGA------MDEIYIATILREVIKGLDYLHCERKIHRDIKAANVLLSENGDVKLADFGVAGQLTE-----TQIKRNTF
||..| ||..|| ||..|     |       .||  |||||.|| |||.|.|   .||||||| |.|. |.| . .||||| . | .     ..  | ||
LWLVMRYLECGSCLDIMKFKMPQGEPHKQGVFDEHVIATILKEVLKGLCYFHKNGQIHRDIKAGNILIGEDGTIQIADFGVSAWLATGGDLSRCCVRHTF

VGTPFWMAPEVIKQSA-YDSKADMWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPKLEGS---------YTKNFKDFVEVCLNKDPRHRPTAKELL
|||| ||||||. |   || |||.||.||||||||.| .|  .. || || |.  |.|| ||.          | . ||. .| || |||. |||| |||
VGTPCWMAPEVMEQVHGYDFKADIWSFGITAIELATGKAPYHKYPPMKVLMLTLQNDPPSLETDEDDKDMYKKYGHSFKKMIEKCLQKDPSKRPTASELL

KHRFI
||.| 
KHKFF
Kinase YSK.AA PAKA 13-193 46 6.4e-85 288.42 In-house 72-260 (260) Show / Hide 
Range on Protein: 13-193
Range on HMM: 72-260/260
Sequence Identity: 46% (87 aa)

KLWIIMEYLGGGSALDLLKSGA------MDEIYIATILREVIKGLDYLHCERKIHRDIKAANVLLSENGDVKLADFGVAGQLTETQIKRNTFVGTPFWMA
.||..|||..||.  |...  .      |||  || ..||...||...| .  ||||||  |.||  .|.||..||| . |||. | |||| |||| |||
ELWVVMEYMEGGCLTDVITQCCNIQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMA

PEVIKQSAYDSKADMWSLGITAIELAKGEPPNSDLHPMRVLFLIPKN-NPPKLE-GSYTKNFKDFVEVCLNKDPRHRPTAKELLKHRFI
||||..  || | | ||||| |||.. ||||  .  | | ..|| .|  |....  . ...|.||.. ||..|.. |..|.|||.| |.
PEVIRRKQYDEKVDIWSLGIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase YSK.AA PAKL 6-193 45 3e-78 266.28 In-house 63-256 (256) Show / Hide 
Range on Protein: 6-193
Range on HMM: 63-256/256
Sequence Identity: 45% (88 aa)

GATMQG-TKLWIIMEYLGGGSALDLLKS--GAMDEIYIATILREVIKGLDYLHCERKIHRDIKAANVLLSENGDVKLADFGVAGQLTETQI-KRNTFVGT
|  .|. ...|| |.|   ||  |...|    ..|  |. ||. . ||| |||    |||||||||.||.| ..||.|||||  ||  .     |  .||
GSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGT

PFWMAPEVIKQSAYDSKADMWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPKLEG--SYTKNFKDFVEVCLNKDPRHRPTAKELLKHRFI
|.|||||.|..  |..|.| |||||||||.| |.||..|. ||| .  ||   ||..     . . | ||.  |. |||  |. . .|| | ||
PYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPHYDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase YSK.AA KHS 6-193 51 3.2e-77 259.25 In-house 63-258 (258) Show / Hide 
Range on Protein: 6-193
Range on HMM: 63-258/258
Sequence Identity: 51% (101 aa)

GATMQGTKLWIIMEYLGGGSALDLLK-SGAMDEIYIATILREVIKGLDYLHCERKIHRDIKAANVLLSENGDVKLADFGVAGQLTETQIKRNTFVGTPFW
|. ..  ||||.||| ||||  |. .  | . |. || . ||...||.||| . |.||||| ||.||...||||||||||..|.| |  ||  |.|||.|
GSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYW

MAPEVI---KQSAYDSKADMWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNN--PPKLE--GSYTKNFKDFVEVCLNKDPRHRPTAKELLKHRFI
|||||    ..  |.   |.|..||||||||   ||  ||||||.|||. | |  ||||.    ....| .|| ..| |.|. ||||. ||.| |.
MAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase YSK.AA MSN 13-193 52 5e-77 253.85 In-house 76-265 (265) Show / Hide 
Range on Protein: 13-193
Range on HMM: 76-265/265
Sequence Identity: 52% (99 aa)

KLWIIMEYLGGGSALDLLKS---GAMDEIYIATILREVIKGLDYLHCERKIHRDIKAANVLLSENGDVKLADFGVAGQLTETQIKRNTFVGTPFWMAPEV
.||..||. | ||  ||.|.    .. | .|| | ||...|| .|| .. ||||||  |||| .| .||| ||||. ||  |  .||||.|||.||||||
QLWMVMEFCGAGSVTDLVKMTKGQSLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV

IK-----QSAYDSKADMWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPKLEGS-YTKNFKDFVEVCLNKDPRHRPTAKELLKHRFI
|.     . .||...|.||.||||||.| |.||  |.|||| |||||.| ||||  . ..| |..|.| || |.  .||.....||| ||
IACDENPDATYDYRSDLWSVGITAIEMAEGQPPLCDMHPMRALFLIPRNPPPKLKSKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase YSK.AA NinaC 11-193 51 3.4e-76 259.45 In-house 73-267 (267) Show / Hide 
Range on Protein: 11-193
Range on HMM: 73-267/267
Sequence Identity: 51% (100 aa)

GTKLWIIMEYLGGGSALD----LLKSGA-MDEIYIATILREVIKGLDYLHCERKIHRDIKAANVLLSENGDVKLADFGVAGQLTETQIKRNTFVGTPFWM
| .||..|||  |||. |    ||| |  |.|  || ||.| . ||  |||.. ||||.|  |.||  .| ||| ||||  ||. |  .||| ||||.||
GDQLWFVMEYCNGGSVTDMVKGLLKCGRRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWM

APEVI-----KQSAYDSKADMWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPKLE--GSYTKNFKDFVEVCLNKDPRHRPTAKELLKHRFI
|||||       . ||  .| ||||||||||. |.||  |.|||| .| || | ||.|    .  . | ||.  || ||   ||.  ..|.|.||
APEVIACMQQYDPDYDARCDVWSLGITAIELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase YSK.AA Pkinase 11-193 29 5.6e-68 236.95 Pfam 72-293 (293) Show / Hide 
Range on Protein: 11-193
Range on HMM: 72-293/293
Sequence Identity: 29% (66 aa)

GTKLWIIMEYLGGG----SALDLLK---SGAM--DEIYIATILREVIKGLDYLHCERKIHRDIKAANVLLSENGDV----KLADFGVAGQL-TETQIKRN
.......|||..||    .  |...   .|..  .|  .  .......||.|.| .. ||||.| .|.|...||..    |..|||.| |. .  .   .
KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT

TFVGTPFWMAPEVIK-QSAYDSKADMWSLGITAIELAKGEPPNSDL----HPMRVLFLIPKNNPPKLEGSYT-----------------------KNFKD
||.|||..||||||. .. |..|.||||.|.. .|.. |.|| ..     . .. ...| .. .|.|. ..                        ...||
TFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKD

FVEVCLNKDPRHRPTAKELLKHRFI
|.. ||.|||  ||||...|.| ..
FIKWCLCKDPKKRPTAEQILQHPWF
S_TKc YSK.AA S_TKc 3-193 24 4e-44 153.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 3-193
Range on HMM: 1-231/231
Sequence Identity: 24% (64 aa)

MTLG-------------ATMQG-------------------------------------TKLWIIMEYLGG--GSALDLLKSGA-------MDEIYIATI
 ...             ..  .                                     ..|...|||..|  |. .|..|.         ..|  .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

LREVIKGLDYLHCERKIHRDIKAANVLLSENGDVKLADFGVAGQLTETQIKRNTFVGTPFWMAPEVIKQSAYDS-KADMWSLGITAIELAKGEPPNSDLH
.......|.|.|  . ||||.| .|.||.|   .|..|||.| ||       .||.|||..|||||.    |.  |.|.||.|.. .|.. |.|| .  .
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--Q

PMRVLFLIPKNNPPKLEGSYTKNFKDFVEVCLNKDPRHRPTAKELLK-------HRFI
..... .|            .. .|||.. ||.|||..|||| |.|.       | ..
MQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase YSK.AA Pkinase_Tyr 5-127 32 1.8e-15 53.03 Pfam 70-203 (270) Show / Hide 
Range on Protein: 5-127
Range on HMM: 70-203/270
Sequence Identity: 32% (43 aa)

LGATM-QGTK--LWIIMEYLGGGSALDLLKSG-----AMDEIYIATILREVIKGLDYLHCERKIHRDIKAANVLLSENGDVKLADFGVAGQL--TETQ-I
.|. . ||    ..|.|||  .|. || |..      . .   .  . ... ||..||.  . ||||. | |.|..||. || .||| |  .  ...   
YGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYR

KRNTFVGTPFWMAPEVIKQSAYDSKADMWSLGIT
||       .|||||.|. . . .| | || |..
KRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVL
TyrKc YSK.AA TyrKc 3-192 19 6.7e-12 -30.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 3-192
Range on HMM: 1-280/280
Sequence Identity: 19% (55 aa)

MT--------------------------------------------L-----------GATMQG-------TKLWIIMEYLGGGSALDLLKSGA--MDEI
 |                                            |           |. .|.         |.|.|||  .|. .| |..        
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

YIATILREVIKGLDYLHCERKIHRDIKAANVLLSENGDVKLADFGVAGQLTET-------QIKRNTF-VGTP-----FWMAPEVIKQSAYDSKADMWSLG
    .   . .| .|||  . ||||. | |.|..||. || .||| .  ...        . .| .   |.       |||||.|. . . .| | || |
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG

ITAIELA-KGEPPNSD-----LHPMRVLFLIPKNNPPKLEGS--------YTKNFKDFVEVCLNKDPRHRPTAKELLKHRF
..  |.   |..| ..     . . .|. .. . . ..   .         ..   .  . | . ||  ||| .|. ...|
VCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase YSK.AA Pkinase_Tyr 173-193 38 0.558716 3.94 Pfam 252-270 (270) Show / Hide 
Range on Protein: 173-193
Range on HMM: 252-270/270
Sequence Identity: 38% (8 aa)

CLNKDPRHRPTAKELLKHRFI
| ..|| .||| .|.  |...
CWHYDPEDRPTFSEI--HEQL