Gene MKK4 (Sea Urchin)

MKK4

Species: Sea Urchin
Alias: Spk243, MKK4, SPU_012098
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: MEK4

Sequence

Name Sequence Type Origin Length Description Download
MKK4.AA Protein None 368 None Fasta, JSON
MKK4.kin_dom Protein Kinase Domain None 266 None Fasta, JSON

Protein domain

Protein domains of MKK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MKK4.AA MEK4 77-342 68 1e-223 737.39 In-house 1-275 (275) Show / Hide 
Range on Protein: 77-342
Range on HMM: 1-275/275
Sequence Identity: 68% (189 aa)

LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIR-STVD-----EKDQKQLLMDLDVVKRSANCVYIIKFFGALFKEGDCWICMELMDSSLDKFYRFVHEV
|.|.||||.||||.|||||||.|..|||||||| ..||     .|.||.|||..|||..|.||.||.||.||.||||||||||||||.|.||||..|..|
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

QNTYIPENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISGQLVDSIARTMDAGCKPYMAPERIDPFQSRPGYDIRSDVWSLGI
|...|||||||.....||.||||||||.||||||||||||||||.|..|||||||.||||||||.|.||||.||||||||||.|...|||||||||||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

TMYEVATGEFPYPKWN--SVFEQLSQVVKGDPPRLKHNDF-YSYSEDFISFVNKCLTKDEKYRPKYKNLLEYKFI
||||||||.|||.|||  |||.|...|||||||.|.|... ..||.....|.|.|||||...||||.||....|.
TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase MKK4.AA STE7 77-342 52 3.8e-184 618.04 In-house 1-288 (288) Show / Hide 
Range on Protein: 77-342
Range on HMM: 1-288/288
Sequence Identity: 52% (154 aa)

LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRSTVDE-KDQKQLLMDLDVVKRSANCVYIIKFFGALFKEGD--CWICMELMD-SSLDKFYRFVHEV--
||..||.|.|..|.|.||.||.|. ||||||||.|... ..|||.||.|||......| ||..|.||...|||  .|||||.|| ..|||||. |..|  
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--QNTYIPENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISGQLVDSI-ARTMDAGCKPYMAPERIDPFQSRPGYDIRSDVWS
  ... |||.|.||.|.|..|.|.||.|..|||||||||||||... |..|||||||.||||||. |.|...||.|||||||||.  ....||.||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG--NKQHYDVRSDVWS

LGITM-YEVATGEFPYPKWNS-----------------VFEQLSQVVKG-DPPRLKHNDFYSYSEDFISFVNKCLTKDEKYRPKYKNLLE-YKFI
||||| .|.|||..|||.||.                 .||||...|.. .||||.     ..|..|..||||||.||.. ||||..|..   ||
LGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP-----KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase MKK4.AA MEK3 77-342 55 2.6e-162 545.51 In-house 1-264 (264) Show / Hide 
Range on Protein: 77-342
Range on HMM: 1-264/264
Sequence Identity: 55% (149 aa)

LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRSTVDEKDQKQLLMDLDVVKRSANCVYIIKFFGALFKEGDCWICMELMDSSLDKFYRFVHEVQNTYIP
.. . | ||||.| | || |.|| .||||||||.||  ..||..|||.|.  ||  |.| ..|.||.|.||| |||||.|| .|||||| | . ..  ||
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

ENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISGQLVDSIARTMDAGCKPYMAPERIDPFQSRPGYDIRSDVWSLGITMYEVA
|.|.||.|   |.||.|..| ||.|||||||||.|. . | .|.|||||||.||||.| |.|||||||||||||||  .  |||..|||||||||| |.|
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA

TGEFPYPKWNSVFEQLSQVVKGDPPRLKHND-FYSYSEDFISFVNKCLTKDEKYRPKYKNLLEYKFI
.| .|| .|   |.|| |||.. ||.|     |   |.|.  |.|.|| |. . ||.|. |.|  |.
IGRYPYDNWHTPFQQLKQVVEEPPPQLPMEKGF---SPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase MKK4.AA MEK7 77-342 50 3.9e-127 428.66 In-house 1-269 (269) Show / Hide 
Range on Protein: 77-342
Range on HMM: 1-269/269
Sequence Identity: 50% (137 aa)

LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRSTVDEKDQKQLLMDLDVVKRSANCVYIIKFFGALFKEGDCWICMELMDSSLDKFYRFVHEVQNTYIP
|.  |..| |  | | || ||.|  |||||  | |    . |  ||||||.  . .| ||.. ||..  . | |||||.|   .||  . . . .  .||
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP

ENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISGQLVDSIARTMDAGCKPYMAPERIDP-FQSRPGYDIRSDVWSLGITMYEV
| |.||. .|...||.||||   |.||||||||||||  |||||||||||| .||| |.|  ||| .|||||||||     | ||||.||||||||..| 
EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVEL

ATGEFPYPKWNSVFEQLSQVVKG--DPPRLKHNDFYSYSEDFISFVNKCLTKDEKYRPKYKNLLEYKFI
||| .|||  .  || .. .     .||.|.    |..| ||..||.|||.|| . ||||. |..  ||
ATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MKK4.AA STE 77-342 29 2.5e-108 366.18 In-house 1-359 (359) Show / Hide 
Range on Protein: 77-342
Range on HMM: 1-359/359
Sequence Identity: 29% (107 aa)

LEDMGEIGRGAFG-SVNKMWHKQS--------------QSIMAVKRIR----------------STVDEKDQKQLLMDLDVVKRSAN-CVYIIKFFGALF
.|....||.||||  . .| ||..              . |||.|...                .........|.|..... |.. . . .|.|..|. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KEG-------DCWICMELMD-SSLDKFYRFVHEVQN---------TYIPENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISG
|||       ..|||||.||  |||.... ......         ...||.. ........|.| |... ..|||||.||.||||     .||||||..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLVDSIA-----------------RTMDAGCKPYMAPERIDPFQSR--PGYDIRSDVWSLGITMYEVATGEFPYPKWNSV---------------FEQLS
||.||.|                 |. ..|.  .||||.|.. ..   .|||...|.||||.|. | |||. |. . .                 |||| 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

QVVKGDPPRLKHNDF---------------YSYSEDFISFVNKCLTKDEKYRPKYKNLLE--YKFI
..|.|.||.|...                  ..|..|. |.||||.|| . ||... ||.   .||
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MKK4.AA STE7-Unclassified 77-342 35 2.7e-92 312.95 In-house 1-301 (301) Show / Hide 
Range on Protein: 77-342
Range on HMM: 1-301/301
Sequence Identity: 35% (107 aa)

LEDMGEIGRGAFGSVNKMWHKQ------SQSIMAVKRIR-STVDEKDQKQLLMDLDVVKRSANCVYIIKFFGALFKEGD---CWICMELMD-SSLDKFYR
||  ...|.|..|.| |  ||       .  ||| | |.    |....||.|. | ...  . . ||....|| . |.      ||||.|| .|||.   
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

FVHEV------QNTYIPENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISGQLVDSI--ARTMDAGCKPYMAPERIDPF-QSR
 . ..        . ||| . ||.||.  ..| ||.| ..|||||.||.|||..  |..|.||||..|||....  | |. .||  ||.||||      |
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTW-VGCQMYMSPERIQGQMPHR

PGYDIRSDVWSLGITMYEVATGEFPYP------KWNSVFE-------QLSQVVKGDP-PRLKHND-FYSYSEDFISFVNKCLTKDEKYRPKYKNLLE-YK
|.| ..||.||||.|  |.|||..||.      . |  |.       .|.. . . | |||. .    ..|..|..|..||. |... || . .||.   
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP

FI
.|
WI
Kinase MKK4.AA MEK5 77-342 43 8e-69 234.96 In-house 1-254 (254) Show / Hide 
Range on Protein: 77-342
Range on HMM: 1-254/254
Sequence Identity: 43% (119 aa)

LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRSTVDEKDQKQLLMDLDVVKRSANCVYIIKFFGALFKEGDCWICMELMDSSLDKFYRFVHEVQNTYIP
.     .| |  |.| | .|  |  |.||| |   .  . |||.. .|... .     ||| |.|| | |    || | ||      ||         ||
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYK-CDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYR--------CIP

ENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISGQLVDSIARTMDAGCKPYMAPERIDPFQSRPGYDIRSDVWSLGITMYEVA
| |.|... | || |||| . |||.||||||||.|   .|.|||||||.| |||.||.||   |   |||||||   |    | | |||||||| . |.|
EHILGRMTVAIVKGLNYLWN-LKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERISGDQ----YGIHSDVWSLGIFFMEMA

TGEFPYPKWNSVF------EQLSQVVKGDPPRLKHNDFYSYSEDFISFVNKCLTKDEKYRPKYKNLLEYKFI
|| ||||. .         . |  .|  .||||  ..|   || |. |.|.|. |  | ||| ..|..  ||
TGRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDKF---SEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MKK4.AA S_TKc 77-342 27 1.9e-68 234.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 77-342
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRSTVDEKDQKQLLMDLDVVKRSANCVYIIKFFGALFKEGDCWICMELMDS---SLDKFYRFVHE-VQN
 | . .||.||||.| | .|| .. |.|.|.|.        ....  ... |.  .. .|.|....    .. ...||..|    .| .. .       .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

TYIPENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISGQLVDSIARTMDAGCKPYMAPERIDPFQSRPGYDI-RSDVWSLGIT
 ..||    ...| ...||.|. .  .|||||.||.|||||.  .||.||||.. ||      |   |   ||||| .       ||.  ..|.||.|..
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCI

MYEVATGEFPYPKWNSVFEQLSQVVKGDPPRLKHNDFYSYSEDFISFVNKCLTKDEKYRPKYKNLLE-------YKFI
.|| ..|. |.|      ... ....              |.....|..|||.|| . ||    .|.         ..
LYEMLCGYPPFP----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MKK4.AA MEK1 77-283 42 2e-61 208.59 In-house 1-197 (297) Show / Hide 
Range on Protein: 77-283
Range on HMM: 1-197/297
Sequence Identity: 42% (88 aa)

LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRSTVDEKDQKQLLMDLDVVKRSANCVYIIKFFGALFKEGDCWICMELMD-SSLDKFYRFVHEVQNTYI
.| .||.| |  | |.|. |...  ||| | |.  .    ..|.. .| |. .  |  ||. |.|| . .|.  |||| ||  |||   . .       |
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-----GRI

PENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISGQLVDSIARTMDAGCKPYMAPERIDPFQSRPGYDIRSDVWSLGITMYEV
||.|.|||. | .. | ||..  ||.||||||||||    | |||||||.||||.||.|     | . ||.|||.        | ..||.||.|. . |.
PEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTH----YTVQSDIWSMGLSLVEM

ATGEFPYP
| | .| |
AIGRYPIP
Kinase MKK4.AA Pkinase 77-342 25 2.2e-55 195.11 Pfam 1-293 (293) Show / Hide 
Range on Protein: 77-342
Range on HMM: 1-293/293
Sequence Identity: 25% (77 aa)

LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRSTVDEKDQKQLL---MDLDVVKRSANCVYIIKFFGALFKEGDCWICMELMDS-----SLDKFYRFVH
..  . ||.|.||.| |  || .. | |||.|.   ......| .   . . . ||  |. .|......   .......||...      .|    ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF---DYIS

EVQNTYI--PENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNI----KLCDFGISGQ--LVDSIARTMDAGCKPYMAPERIDPFQSRPGYD
  ... .  .|.   ...| ....|.|. .  .|||||.||.|||.|. |.|    |.||||.. |  .  .   |  .|  .||||| |    ....|.
TWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYG

IRSDVWSLGITMYEVATGEFPYPKWN----SVFEQLSQVVKGDPPRLKHNDFYSYS-------------------EDFISFVNKCLTKDEKYRPKYKNLL
 ..|.||.|...||...|..|.|       .  .|.  ...  .|.|. . ....|                   |....|...||.|| | ||  . .|
PKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

EYKFI
. ...
QHPWF
Kinase MKK4.AA STE20 77-342 29 2e-48 167.23 In-house 1-288 (288) Show / Hide 
Range on Protein: 77-342
Range on HMM: 1-288/288
Sequence Identity: 29% (87 aa)

LEDMGEIGRGAFGSVNKMWHKQSQSI----MAVKRIRSTVDE---KDQKQLLMDLDVVKRSANCVYIIKFFGALFKE----GDCWICMELMDS-SLDKFY
 |.. .||.|..|.| |  ||... .     |.|..    ..   .... ..   .. |..  . .|.|..|. .|.     . ||.||...  ||   .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

RFVHEVQN----TYIPENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISGQLVD----SIA---RTMDAGCKPYMAPERIDPF
... . ..    . . |     . . ....|.|| .  .|||||.|  ||||.  |..||.||| ..|| .    ...    |.  |   .|||| |   
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHS-NHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTF-VGTPYWMAPEVIQCM

QS-RPGYDIRSDVWSLGITMYEVATGEFPYPKWNSVFEQLSQVVKG--DPPRLKHNDF-YSYSEDFISFVNKCLTKDEKYRPKYKNLLEYKFI
.. . ||| ..|.||||||  | |.|| || . . .   . .. |.  .||.||.     ..| .|  ||.|||.|| . ||  . ||. .||
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPM-RAMFMIPKNQNPPPTLKDD-KPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MKK4.AA SLK 78-342 30 1.6e-42 141.21 In-house 2-259 (259) Show / Hide 
Range on Protein: 78-342
Range on HMM: 2-259/259
Sequence Identity: 30% (82 aa)

EDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRSTVDEKDQKQLLMDLDVVKRSANCVYIIKFFGALFKEGDCWICMELMDSSLDKFYRFVHEVQNTYIPE
| .||.| |||| | |  ||  |...|  ..  . || . .  ....|..       .|.| ..| . ... |. .|  |         . |.. . . |
EIIGELGDGAFGKVYKAQHK-EQKVFAAAKMIEIKDEEELEDYMVEIDILSECK-HPNIVKLYEAYYYDNKLWMMIEFCDGGA--VDNIMVELEHP-LTE

NIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISGQLVDSIARTMDAGCKPY-MAPERI--DPFQSRPGYDIRSDVWSLGITMYE
. .  |.. .. |||.| .  |.||||.|  |||.   |...| |||.| ..   . .       || |||| .  . |. .| || ..|.||||||. |
DQIQYVCKHMCEALNWLHSN-KVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQP-YDYKADIWSLGITLIE

VATGEFPYPKWNSVFEQLSQVVKGDPPRLKHNDFYSYSEDFISFVNKCLTKDEKYRPKYKNLLEYKFI
.| .| |.   | .   | .. | .||.|.      .|..|  |. ||| || . |.  ..|......
MAQMEPPHHEMN-PMRVLLKIQKSEPPTLEQPS--HWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase MKK4.AA TyrKc 77-342 19 2.6e-14 8.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 77-342
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRSTVDEKDQKQLLMDLDVVKRS-ANCVYIIKFFGALFKE-------GDCWICMELMDS-SLDKFYRFV
..   ..|.|||| | |   |      ||| ...      .. ..  . . ..   .   |....|.  ..       .  .| ||.|.  .|... |  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

HEVQNTYIPENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISGQLVDS-IA----RTMDA----GCKP-----YMAPERIDPF
..     ..   . . ..   .  .|| .  ..||||    |.|..... .| .||| |  . |   .     . ..    |.|       |||| |  .
RPK----LCMKDLLSFCWQIACGMEYL-HSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--N

QSRPGYDIRSDVWSLGITMYEVATGEFPYPKW-----NSVFEQLSQVVKGDPPRLKHNDFYS-----YSEDFISFVNKCLTKDEKYRPKYKNLLEYKFI
 ..  . . ||||| |..|.|. |   . .        | .| . .| .|. ..  .||         ...  .   .|   | . ||  ...  ....
YGK--FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MKK4.AA Pkinase_Tyr 209-298 31 5.6e-13 44.59 Pfam 141-232 (270) Show / Hide 
Range on Protein: 209-298
Range on HMM: 141-232/270
Sequence Identity: 31% (31 aa)

NILLDRGGNIKLCDFGISGQL-VDS---IARTMDAGCKPYMAPERIDPFQSRPGYDIRSDVWSLGITMYEVAT-GEFP-YPKWNSVFEQLSQV-VKG
|.|..... .| |||| .  .  |.    .|.      . |||| |        . . ||||| |..|.|. | || | || . | .| . ..  .|
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK----FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDG
Kinase MKK4.AA MEK1 288-342 41 1.1e-10 32.28 In-house 246-297 (297) Show / Hide 
Range on Protein: 288-342
Range on HMM: 246-297/297
Sequence Identity: 41% (23 aa)

VFEQLSQVVKGDPPRLKHNDFYSYSEDFISFVNKCLTKDEKYRPKYKNLLEYKFI
.|| |  .|.. ||.|.|  |   ||.|. ||.||| |  . |   |.|.   ||
IFEMLDYIVNEPPPKLPHRVF---SEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MKK4.AA Pkinase_Tyr 77-163 19 0.458739 4.23 Pfam 1-97 (270) Show / Hide 
Range on Protein: 77-163
Range on HMM: 1-97/270
Sequence Identity: 19% (19 aa)

LEDMGEIGRGAFGSVNKMWHK----QSQSIMAVKRIRSTVDEKD--QKQLLMDLDVVKRSANCVYIIKFFGALF-KEGD--CWICMELMDS-SLDKF
.. . ..|.||||.| |   |    . .   ||| .. . ....  .. ..  . . |   ..  |... |.   ...    .| ||.|   .|...
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY