Ack2

Species: Sea Urchin
Alias: SPU_024332, Spk255, Ack2
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Ack

Sequence

Name Sequence Type Origin Length Description Download
Ack2.AA Protein None 235 None Fasta, JSON
Ack2.kin_dom Protein Kinase Domain None 148 None Fasta, JSON

Protein domain

Protein domains of Ack2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Ack2.AA Ack 65-235 61 1.3e-118 400.37 In-house 1-177 (266) Show / Hide
Range on Protein: 65-235
Range on HMM: 1-177/266
Sequence Identity: 61% (108 aa)

LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSSPL-KMVTELAPLGALVDRLREDPS--
.||.||||.|.||||.||.|..|.||...||||||||....||....||..||..|| ||||||||||||||..|. .|||||||.|.|.|.||....  
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRTA

KFLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASM-QKVKIGDFGLMRALPSATNYYIMTEHN--QVPYAW
.|||.||..|..|||.||..||.||.||||||||||||.|. .||||.||||||||. . .|| | .|    ||.||
FFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAW

Kinase Ack2.AA Pkinase_Tyr 65-235 39 1.3e-68 233.01 Pfam 1-180 (270) Show / Hide
Range on Protein: 65-235
Range on HMM: 1-180/270
Sequence Identity: 39% (71 aa)

LTLHEKLGNGSFGVVRRGDWK-TPRGKRVEVAVKCLRSEMVNQ-PGFFEDFVKEVNTMHLL-DHPHLVRLYGVVL--SSP--LKMVTELAPLGALVDRLR
.|. .||| |.||.|..| ||  | .....||||.|.     .   . ||| .|...|. | .||..||||||..  . |  . .|.|..|.| | | ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

ED---PSKFLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSATNYY-IMTEHNQVPYAW
.    . .. ...|  ...|||.||..|| |..|||||||||.|...  .|||.||||.|..   . ||  ....  .|  |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKW

Kinase Ack2.AA TK 65-235 19 3.2e-58 193.45 In-house 1-351 (486) Show / Hide
Range on Protein: 65-235
Range on HMM: 1-351/486
Sequence Identity: 19% (70 aa)

LTLHEKLGNGSFG---VVRRGDWKT----------------------PRGKRVEVAVKCLRSEMVNQPG-FFE-------------DFVKEVNTMH--LL
.|| .||| | ||   .|..| |..                      ..|....||||.|...  ...  ||.              .. |   |.  |.
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHPHLVRLYGVVLSS-------------PLKMVTELAPLGA----LVDRLREDPSK--------------------------------------------
.||..||||||.. .             |. .|.|..|.|     | | ||. . |                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FLISTLSAFALQIASGMSFLEYK------RFIHRDLAARNILLASMQK-----------VKIGDFG---
                               .   .|  ...|||.||..|. |      .|.||||||||.|...  .           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LMRALPSATNYYIMTEHN-----------------------QVPYAW
     | |...| ..|| ....                        ..|  |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRW

Kinase Ack2.AA Src 65-235 35 6.3e-47 157.45 In-house 1-166 (255) Show / Hide
Range on Protein: 65-235
Range on HMM: 1-166/255
Sequence Identity: 35% (61 aa)

LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSS-PLKMVTELAPLGALVDRLR--EDPS
..| .|||.| || |  | |.    ....|||| |..    .    |.| .| ..|  |.|..||.|| |.    |   |||.   | | | |.  .. .
IKLCRKLGQGQFGEVWMGYWN----GNTKVAVKTLKPGTMSP----EAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGR

KFLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSATNYYIMTEHNQVPYAW
.  . .|  .| |.|.||..|| ...|||||||||.|      .|..|||| | .    . | . . . .|. |
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKW

Kinase Ack2.AA UTK 65-235 27 2.6e-43 146.04 In-house 1-205 (296) Show / Hide
Range on Protein: 65-235
Range on HMM: 1-205/296
Sequence Identity: 27% (56 aa)

LTLHEKLGNGSFGVVRRGDWKTPR--GKRVEVAVKCLRSEMVNQPGFFED----FVKEVN---TMHLLD-HPHLVRLYGVVLSS-PLKMVTELAPLGALV
. | ..|| | ||.|.........  .. . |||| .... . |  ....    | .| .    |  .. ||...||.||.... |. .|||... | |.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQ--QEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

DRLR-------EDPSKFLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASM-------QKVKIGDFG---LMRALPS--------ATNYYIMTEH
. ||       ..|  .   ..  .|..||.||..|. ..|.||||||||.|...        ...||.|||   . |....         ..|| ... 
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

NQVPYAW
...| .|
DRWPIRW

Kinase Ack2.AA EGFR 65-223 41 8.1e-43 139.89 In-house 1-158 (258) Show / Hide
Range on Protein: 65-223
Range on HMM: 1-158/258
Sequence Identity: 41% (67 aa)

LTLHEKLGNGSFGVVRRGDWKTPRGKRVE--VAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSSPLKMVTELAPLGALVDRLREDPSK
| .  .|| | || | .| |  | |. |   ||.| || .    |  .|... |   |  .|||||||| || ..| ...|| . |.|.| | .|.   .
LKKVKVLGSGAFGTVYKGIW-IPEGENVKIPVAIKVLREQT--GPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDN

FLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSATNYY
     |  ...|||.||..|| .| .||||||||.|. | ..||| |||| . |..  . |
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEY

Kinase Ack2.AA Syk 65-228 36 8.2e-43 145.2 In-house 1-168 (257) Show / Hide
Range on Protein: 65-228
Range on HMM: 1-168/257
Sequence Identity: 36% (61 aa)

LTLHEKLGNGSFGVVRRGDWKTP----RGKRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSSPLKMVTELAPLGALVDRLREDP
| . . .| | || |. |  .       .....||.| |. .  |||.  . |. | . |. ||||. ||. |. .  .. || |.|.||.. . | .. 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADH-NQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHR

SKFLI-STLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSATNYYIMTEH
      . |   . |.|.||  || | |.||||||||.||      || |||. .||    .||  | |
HEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTH

Kinase Ack2.AA Tec 65-214 40 4.3e-37 127.15 In-house 1-145 (254) Show / Hide
Range on Protein: 65-214
Range on HMM: 1-145/254
Sequence Identity: 40% (63 aa)

LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLR----SEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSS-PLKMVTELAPLGALVDRLRED
||. . ||.| ||||..| |   |.   .||.| ..    ||        |||. |  .|  | || ||.|||| .   |. .|||    | | . ||| 
LTFMKELGSGQFGVVHLGKW---RH-QYDVAIKMIKEGSMSE--------EDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREH

PSKFLIST--LSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMR
  .|  ..  |    ...  || .|| . |||||||||| |  . . ||. |||. |
KHHFQKNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTR

Kinase Ack2.AA FAK 65-235 29 6.8e-37 121.05 In-house 1-192 (285) Show / Hide
Range on Protein: 65-235
Range on HMM: 1-192/285
Sequence Identity: 29% (57 aa)

LTLHEKLGNGSFGVVRRGDWKTPRG------------------------KRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSSPL
 ||  ..| | || |  | .  ...                          ..||.|  . .   ..   | |..|  .|. .||||.|.| |..   | 
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCC--DDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPI

KMVTELAPLGALVDRLREDPSKFLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSATNYYIMTEHNQVPYAW
 .. ||...| |   |.    .  . ||  ...|..  |..|| |.|.||| ||||.| .| . || ||||| | . .   ||  .   . |  |
WIIMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWM-HDHSYYKASPKGKLPIKW

Kinase Ack2.AA Abl 65-214 42 1e-35 116.31 In-house 1-145 (252) Show / Hide
Range on Protein: 65-214
Range on HMM: 1-145/252
Sequence Identity: 42% (64 aa)

LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGV-VLSSPLKMVTELAPLGALVDRLREDPSKF
.....||| | .| |  | ||        |||| |. . ..     ..|.||   |  . || ||.| ||    .|  ..||  . | |.| |||   . 
IMMKHKLGGGQYGEVYEGVWKR---HDCTVAVKTLKEDTME----VHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREE

LIS-TLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMR
| . .|   | |||||||.|| . |||||||||| |..  . ||. |||| |
LPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLAR

Kinase Ack2.AA Fer 65-212 34 4.5e-35 116.95 In-house 1-160 (283) Show / Hide
Range on Protein: 65-212
Range on HMM: 1-160/283
Sequence Identity: 34% (56 aa)

LTLHEKLGNGSFGVVRRG--DWKTPRGKRVE-----VAVKCLRSEMVNQPGFFEDFVKEVNTMHL-LDHPHLVRLYGV-VLSSPLKMVTELAPLGALVDR
 ||..|||.| || |..|  . |  .||...     |.|| ...|...     ..| .| . |   .|||. |..||| |.  |.  | |... |.| ..
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQ-IKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY

LREDPSK-FLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLAS-MQKVK--IGDFGL
|.. ..|   . ..  ...|.|.|| .|. |  ||||.||||.|.     |.|  | |||.
LKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGM

Kinase Ack2.AA TyrKc 65-235 25 1.5e-26 95.41 SMART 1-280 (280) Show / Hide
Range on Protein: 65-235
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLL--DHPHLVRLYGVVLS--------SPLKMVTELAPLGALVD
.|| .|||.| ||.|..| ||      ..||||.|...        ||| .| . |. |  .||..||||||...         || .|.|..|.|.| |
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

RLREDPSKFLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSA------TNYYIMTE---HN----------------
.||.   |.  ..|  |..|||.||..|. |..|||||||||.|... . |||.||||.|.. .       . || ..|    .                
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

----------------------QVPYA----------------------------------------------------------------W
                      | ||                                                                 .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase Ack2.AA Pkinase 65-212 27 4.9e-20 71.92 Pfam 1-158 (293) Show / Hide
Range on Protein: 65-212
Range on HMM: 1-158/293
Sequence Identity: 27% (45 aa)

LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLRSEMVNQPGFFEDFVK--EVNTMHLLDHPHLVRLYGVVL-SSPLKMVTELAPLG----ALVDRLR
.....|.| ||||.|... .|  .    .||||... .  . ... .  ..  |.  |. |.||. ||||...  .. . ||.|... |     | |...
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

-EDPSKF--LISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKV----KIGDFGL
 ..  .|     ..  ...||..|. ..  ...|||||   |||. .   .    ||.||||
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGL

Kinase Ack2.AA S_TKc 65-234 20 2.6e-12 3.73 SMART 1-231 (231) Show / Hide
Range on Protein: 65-234
Range on HMM: 1-231/231
Sequence Identity: 20% (50 aa)

LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSSPLKMVTELAPL--GALVDRLREDPSK
 ....|.| |.||.|... .|       .||.|...          |.. .|.. ..  .||..|.||.|  .. | ||.|...   | | |.... ...
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSAT---------------NY------------YIMTE---
     |   .   .. ||.... ..  ...|||||   |||| .   .||.|||| | |   |               ..            |.|     
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYP

--------------------------HN----------Q-------VPYA
                           .          |        |. 
PFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF