Gene CSK1 (Sea Urchin)

CSK1

Species: Sea Urchin
Alias: SPU_022112, CSK1, Spk258, SpCSK
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Csk

Sequence

Name Sequence Type Origin Length Description Download
CSK1.AA Protein None 763 None Fasta, JSON
CSK1.kin_dom Protein Kinase Domain None 243 None Fasta, JSON

Protein domain

Protein domains of CSK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
7tm_1 CSK1.AA 7tm_1 49-335 18 1.6e-34 108.41 Pfam 1-263 (263) Show / Hide 
Range on Protein: 49-335
Range on HMM: 1-263/263
Sequence Identity: 18% (56 aa)

GNSLVVLAVAMSRRLQTPTNVFVVSLSLSDFLTCLGLPFQAVAILSE-HGWPLNSGLCAMVGGSAILSLTCGVLSLALIAINRFTLITRSKRTYIRVFSK
||.||..... ..|..||||.|...|...|.| || .|. .. ..   | ||. . .|  .... ..........|..|.| |.  |..  |.. |. ..
GNILVIWVICRHKRMRTPTNYFICNLAVADLLFCLTCPPWMLYYFHWGHHWPFGRAMCKIWTYFFYMCCYASIFFLCCISIDRYWAICHPMRYRRRMTPP

KRNLLYAVISWVVPLFAFVVPQLVGFGRLGYDPY---FRLCVWDTSDDHAH----IYEILAAITIFIATTIITTSYITIYIFIRLHVSVMKNHVNGSRAG
.. ..  .. ||.  |.. .|.|.....          . |  |   . ..    .| ..  .. .|  ......|  ||. .. |.. |.         
RHAWVMCLVIWVL-AFLWSLPPLMFWWCYTHECPNWNHCWCYIDYPHVMWTWWRSYYICSCIVGFYIPLLVMCFCYCRIYRTLWKHRRQMA---------

PSGKVNQVEAVAHSLNHTNNDVNTMETGAPAGGRHKIKVTKREIDITKNLFYIVCFFFLCIIPYGFALALNNLGVYPW---------------YAGIMFV
                                     .  ..|  ..| |. .|. ||.|  ||  .. .. .   .|               ..    .
------------------------------------KRNSRKERKAAKMLCVVVVVFFVCWLPYHIFMFMDTFC-MHWWWNCEMECVIPWAYQICVWLAY

ANSAINPFIY
.|...||.||
VNCCLNPIIY
SH2 CSK1.AA SH2 398-472 46 9e-38 112.72 Pfam 1-81 (81) Show / Hide 
Range on Protein: 398-472
Range on HMM: 1-81/81
Sequence Identity: 46% (38 aa)

WFHGKITREQAEDLLQP--REDGLFLVRESTNYPGDYTLCVAFLT---KVEHYRVIYEKNK-LTIDSEEFFENLTKLVEHY
|.||||.|..||.||.    .|| |||||| ..||||||.| .     .|.|||.  ..|. . |  .. |..|  |||||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 CSK1.AA SH2 396-478 45 9.9e-35 122.62 SMART 1-87 (87) Show / Hide 
Range on Protein: 396-478
Range on HMM: 1-87/87
Sequence Identity: 45% (40 aa)

MPWFHGKITREQAEDLLQP--REDGLFLVRESTNYPGDYTLCVAFLTKVEHYRVIYEK-NKLTIDS--EEFFENLTKLVEHYQSEADG
.||.||.|.||.||.||.    .|| ||||.| . ||||.|.| .  || |||.  .. .|  ||   .. |..|  ||.|||  ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase CSK1.AA Csk 515-757 69 3.6e-197 661.32 In-house 1-251 (251) Show / Hide 
Range on Protein: 515-757
Range on HMM: 1-251/251
Sequence Identity: 69% (175 aa)

IHLGSCIGAGNFGDVLQGTYQGRKVAIKQVKDNS-TAAQAFLAEASVMTTLKHPNLVQLLGVVLGNP--LYIVLEFMSKGNLVDYLRSREXNVFXGRHLL
.|||.|||.|.||||.||.||.||||.|..|... ..||||||||||||.|.|||||||.||.|...  ||||.|.|||||||||||||. .|. .|.||
LHLGECIGHGEFGDVMQGEYQNRKVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQLL

KF--DVCNGMAYLEEKEFVHRDLAARNILVSEQDIAKVSDFGLSQEATLNQE---GGKFPIKWTSPEALRKKEFSSMSDVWSYGIFMWELYSFGRVPYPR
||  |||.||.|||.|.|||||||||||||||...||||||||..|....|.   .||||||||.|||||.|.||..|||||.||..||.||||||||||
KFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGRVPYPR

VPLSEVVAHVEKGYRMESPEGCPDHVYKVMKDCWDINPKKRPTFKHVRSQL
.||..||.|||||||||.|||||.|||||||.||..||.|||||..||.||
IPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase CSK1.AA Pkinase_Tyr 515-757 40 3.3e-127 431.45 Pfam 1-270 (270) Show / Hide 
Range on Protein: 515-757
Range on HMM: 1-270/270
Sequence Identity: 40% (109 aa)

IHLGSCIGAGNFGDVLQGTYQ------GRKVAIKQVKDNSTAA----QAFLAEASVMTTL-KHPNLVQLLGVVL--GNP--LYIVLEFMSKGNLVDYLRS
|..|  .|.|.||.| .||.       . .||.| .|....      ..|..||..|..| .|||.|.|.||..  | |  .|||.|.| .|.| ||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R--EXNVFXGRHLLKF--DVCNGMAYLEEKEFVHRDLAARNILVSEQDIAKVSDFGLSQEA-----T-LNQEGGKFPIKWTSPEALRKKEFSSMSDVWSY
.  . . .   .||..  ....||.|||.| ..||||||||.||.|. ..|..||||.            ..|||.||||..||... ..|.. |||||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GIFMWELYSFGRVP-YPRVPLSEVVAHV-EKGYRMESPEGCPDHVYKVMKDCWDINPKKRPTFKHVRSQL
|. |||....|. | || .. .||.... |.||||. ||.||| .|..||.||. .|..||||. ...||
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase CSK1.AA TyrKc 515-757 38 2.4e-119 403.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 515-757
Range on HMM: 1-280/280
Sequence Identity: 38% (108 aa)

IHLGSCIGAGNFGDVLQGTYQGRKVAIKQVKDNSTAAQAFLAEASVMTTL--KHPNLVQLLGVVLG--------NPLYIVLEFMSKGNLVDYLRSREXNV
|.||  .| |.|| | .||.  ..||.| .|...   ..|. ||..|. |  .|||.|.|.||..          ||.||.|.|..|.| ||||... . 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

FXGRHLLKF--DVCNGMAYLEEKEFVHRDLAARNILVSEQDIAKVSDFGLSQEATLN------------QE--GGK--FPIKWTSPEALRKKEFSSMSDV
.  ..||.|  ....||.||..| ..||||||||.||.|. ..|.|||||| . .              .|  |||  .||.|..||......|.. |||
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSYGIFMWELYSFGRVPYPR-----VPLSEVVAHVEKGYRMESPEG--------CPDHVYKVMKDCWDINPKKRPTFKHVRSQL
||.|. |||....|  |||      .. .||...|..||||. |.         ||| .|..||.||. .|..||||. .....
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CSK1.AA TK 515-757 21 7.4e-110 369.6 In-house 1-486 (486) Show / Hide 
Range on Protein: 515-757
Range on HMM: 1-486/486
Sequence Identity: 21% (106 aa)

IHLGSCIGAGNFG---DVLQGTYQGR---------------------------KVAIKQVKDN-STAAQAFLA--------------EASVMTTLK----
|.||  .|.|.||   .| .|...||                           .||.|..|.  ......|..              ||..|  ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVQLLGVVLGN-------------PLYIVLEFMSKGN----LVDYLRSREXNVFX-----------------------------------------
 |||.|.|.||.. .             |..||.|.|..|.    | ||||..  . .                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------GRHLLK---------------------FDVCNGMAYLEEK------EFVHRDLAARNILVSEQDI-----------AKVSDFGLS--
              ..||                      .....||.||..|       ||||||||||.||.|...           .|..|||||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

-----------------------------------QEATLNQEGGKFPIKWTSPEALRKKE---------FSSMSDVWSYGIFMWELYSFGRVPYPR-VP
                                   |. .. | |||.||.|..||.|....         |.. |||||.|..|||....|..||.  ..
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

L---------SEVVAHVEKG--------------YRMESPEGCP--------------DHVYKVMKDCWDINPKKRPTFKHVRSQL
           ||. ....|              .||. |..||              . .| .|..||. .|..||||. ...||
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CSK1.AA Src 515-757 44 8.4e-108 364.44 In-house 1-255 (255) Show / Hide 
Range on Protein: 515-757
Range on HMM: 1-255/255
Sequence Identity: 44% (113 aa)

IHLGSCIGAGNFGDVLQGTYQG-RKVAIKQVKDNSTAAQAFLAEASVMTTLKHPNLVQLLGVVLGN-PLYIVLEFMSKGNLVDYLR-SREXNVFXGRHLL
|.|   .|.|.||.| .|...|  |||.|  |  . . .|||.|| .|..|.|..||||. |.    | ||| |.||.|.| |||. ..|      ..|.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

KF--DVCNGMAYLEEKEFVHRDLAARNILVSEQDIAKVSDFGLSQEAT------LNQEGGKFPIKWTSPEALRKKEFSSMSDVWSYGIFMWELYSFGRVP
 .   | .||||||.. ..||||||||.||.|. ..|| |||| .           ..| ||||||| |||..   |.  |||||.|| ..|. ..||||
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPRVPLSEVVAHVEKGYRMESPEGCPDHVYK-VMKDCWDINPKKRPTFKHVRSQL
||     ||. .||.||||  |..||| .|. .|. ||.  |..||||.  .. |
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase CSK1.AA SFK-Src 515-761 45 9.20000000001e-107 317.49 In-house 1-259 (259) Show / Hide 
Range on Protein: 515-761
Range on HMM: 1-259/259
Sequence Identity: 45% (117 aa)

IHLGSCIGAGNFGDVLQGTYQGR-KVAIKQVKDNSTAAQAFLAEASVMTTLKHPNLVQLLGV-VLGNPLYIVLEFMSKGNLVDYLRSREXNVFXGRHLLK
| | .  |.| |||| .|.  .   ||.|  |  .. |. ||.|| ||  |.||||.||  |   | |.||. | |  | | |||.. .        |  
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

F--DVCNGMAYLEEKEFVHRDLAARNILVSEQDIAKVSDFGLSQEATLNQE------GGKFPIKWTSPEALRKKEFSSMSDVWSYGIFMWELYSFGRVPY
   .|  ||||||.. ||||||||||.|| .  . || |||.|     ..|      | ||||||| |||     ||  |||||.|| | |.  .||.||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PRVPLSEVVAHVEK--GYRMESPEGCPDHVYKVMKDCWDINPKKRPTFKHVRSQLNLFM
|     ||.  |..  ||||. | .|||  ||.| |||  .|  ||||   . |.  | 
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase CSK1.AA UTK 515-757 31 3.4e-94 319.23 In-house 1-296 (296) Show / Hide 
Range on Protein: 515-757
Range on HMM: 1-296/296
Sequence Identity: 31% (93 aa)

IHLGSCIGAGNFGDVLQGTYQG----RKVAIKQVKDNS-----TAAQA----FLAEAS---VMTTLK-HPNLVQLLGVVL-GNPLYIVLEFMSKGNLVDY
..|| ..|.|.||.|  ....     ...... ||...     . ...    |. ||    .|  .. |||...|.||.. . |..||.|.|..|.|..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSREXNVF------XGRHLLKF--DVCNGMAYLEEKEFVHRDLAARNILVSEQ-------DIAKVSDFG---LSQEAT--------------LNQEGGK
||.   ...        ...|..  |. .||.||... ||||||||||.|| ..        ..|..|||   .| ..                 |. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPIKWTSPEALRKK-EFSSMSDVWSYGIFMWELYSFGRVPYPRVPLSEVVAHVEKG--YRMESPEGCPDHVYKVMKDCWDINPKKRPTFKHVRSQL
 ||.|..|||| .   |.. |||||.|...||....||.|||     .|.. |..|  |||..|..||. ||..|..||  .| .||.|. ...|.
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase CSK1.AA Tec 515-759 43 2.2e-93 316.57 In-house 1-254 (254) Show / Hide 
Range on Protein: 515-759
Range on HMM: 1-254/254
Sequence Identity: 43% (110 aa)

IHLGSCIGAGNFGDVLQGTYQG-RKVAIKQVKDNSTAAQAFLAEASVMTTLKHPNLVQLLGVVLGN-PLYIVLEFMSKGNLVDYLRSREXNVFXGRH--L
. .   .| | || |  | ... ..|||| .|  |     |. || ||. | ||.|||| || .   |.||| |.|..| | .|||...   | .    |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHH-FQKNMAIL

LKF--DVCNGMAYLEEKEFVHRDLAARNILVSEQDIAKVSDFGLSQ----EATLNQEGGKFPIKWTSPEALRKKEFSSMSDVWSYGIFMWELYSFGRVPY
|.   ||| ||||||.. |.|||||||| ||..| . ||||||..            | |||.|| .|| .    .|| ||||..|. ||| .| |..||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PRVPLSEVVAHVEKGYRMESPEGCPDHVYKVMKDCWDINPKKRPTFKHVRSQLNL
..   |||| || .|.|.. |. |..|.|..|..||   |..||||..  .|.  
ENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase CSK1.AA Abl 515-757 45 3.4e-92 307.88 In-house 1-252 (252) Show / Hide 
Range on Protein: 515-757
Range on HMM: 1-252/252
Sequence Identity: 45% (114 aa)

IHLGSCIGAGNFGDVLQGTYQ--GRKVAIKQVKDNSTAAQAFLAEASVMTTLKHPNLVQLLGV-VLGNPLYIVLEFMSKGNLVDYLRSREXNVFXGRHLL
| .   .| | .|.| .| ..  .  ||.| .|... . . ||.|| .|  .|||||||||||     | ||. |||..|||.||||. . .      ||
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

KF--DVCNGMAYLEEKEFVHRDLAARNILVSEQDIAKVSDFGLS----QEATLNQEGGKFPIKWTSPEALRKKEFSSMSDVWSYGIFMWELYSFGRVPYP
     .  || |||...|.|||||||| ||.|..| || ||||.    ..    . | ||||||| ||.|  ..||| |||| .|. .||.  .|  |||
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

RVPLSEVVAHVEKGYRMESPEGCPDHVYKVMKDCWDINPKKRPTFKHVRSQL
 . ||.|   .||||||| |||||..||..|. ||. ..  ||.||..  ..
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase CSK1.AA Fer 515-758 31 1.8e-87 296.87 In-house 1-283 (283) Show / Hide 
Range on Protein: 515-758
Range on HMM: 1-283/283
Sequence Identity: 31% (89 aa)

IHLGSCIGAGNFGDVLQGT-----YQG-----RKVAIKQVKD--N-STAA--QAFLAEASVMTT-LKHPNLVQLLGV-VLGNPLYIVLEFMSKGNLVDYL
..||  .| |.||.| .|.     . |     .|||.|..|   . .|..  . |..|| .| . ..||| |.. || |.  |..||.||.. |.| .||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RSREX-NVFX-GRHLLKFDVCNGMAYLEEKEFVHRDLAARNILVSE-QDIAK--VSDFGLSQE----ATLNQEG---GKFPIKWTSPEALRKKEFSSMSD
.  .  .|    ..   .....||.||..|  .|||.||||.|... ..  |  .||||.| .     .  ...    | ||.|..||.......|...|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSYGIFMWELYSFGRVPYPR----VPLSEV----VAH-VEKGYRMESPEGCPDHVYKVMK-DCWDINPKKRPTFKHVRSQLN
|||.|. .|| .. |  |||     . . .|    ..  ..|||.|  |...|. ....|. .||. .|..|||.|... .|.
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase CSK1.AA SrcB 515-758 43 3.1e-87 295.15 In-house 1-251 (251) Show / Hide 
Range on Protein: 515-758
Range on HMM: 1-251/251
Sequence Identity: 43% (110 aa)

IHLGSCIGAGNFGDVLQGTYQGR-KVAIKQVKDNSTAAQAFLAEASVMTTLKHPNLVQLLGVVLGNPLYIVLEFMSKGNLVDYLRSREXNVFXGRHLLKF
..|   .||| ||.|  |.|..  |||.| .|. . . .|||||| || ||.|  ||.|  ||   |.||. |.| || |.|.|.. |       .|. .
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

--DVCNGMAYLEEKEFVHRDLAARNILVSEQDIAKVSDFGLSQEATL----NQEGGKFPIKWTSPEALRKKEFSSMSDVWSYGIFMWELYSFGRVPYPRV
   .  ||||.|.. ..|||| | ||||||  . |. ||||           .|| ||||||| |||.    |   |||||.|| . |.  .||.|||  
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

PLSEVVAHVEKGYRMESPEGCPDHVYKVMKDCWDINPKKRPTFKHVRSQLN
  .||.  .|.||||  |. ||. .|..|. ||   |  |||| ...| |.
TNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase CSK1.AA Syk 515-751 38 7.1e-86 291.61 In-house 1-257 (257) Show / Hide 
Range on Protein: 515-751
Range on HMM: 1-257/257
Sequence Identity: 38% (99 aa)

IHLGSCIGAGNFGDVLQGTYQGR---------KVAIKQVKDNSTA---AQAFLAEASVMTTLKHPNLVQLLGVVLGNPLYIVLEFMSKGNLVDYLRSR--
. ..  || |||| |..|.|. .         |||||  |.  .     | |..||.||  | ||  | ..|. .. ..  |.|  . | . .||     
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

EXNVFXGRHLLKFDVCNGMAYLEEKEFVHRDLAARNILVSEQDIAKVSDFGLSQEATLN------QEGGKFPIKWTSPEALRKKEFSSMSDVWSYGIFMW
|  .     |.   |  || ||||| ||||||||||.|   .  ||.||||.|    ..      . .|| |.||  ||   .  ||. |||||.|. ||
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW

ELYSFGRVPYPRVPLSEVVAHVEKGYRMESPEGCPDHVYKVMKDCWDINPKKRPTFK
| .| |  ||     .||.. .|.| ||. |.|||. .| .|..||   .. |||| 
EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase CSK1.AA S_TKc 515-760 23 7.8e-40 139.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 515-760
Range on HMM: 1-231/231
Sequence Identity: 23% (62 aa)

IHLGSCIGAGNFGDVLQGTYQG--RKVAIKQVKDNSTAAQAFLAEASVMTTLKHPNLVQLLGVVLGNPLYIVLEFMSK--GNLVDYLRSRE-------XN
 ...  || | || | ...  .  |.||||..|      . .. | ...   .|||.|.|..|   . ||.|.|...   |.| ||...|         .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

VFXGRHLLKFDVCNGMAYLEEKEFVHRDLAARNILVSEQDIAKVSDFGLSQEATLNQEGGKFPIKWTSPEALRKKEFSS-MSDVWSYGIFMWELYSFGRV
    |....  .|....|. .. ..||||   |||..|    |..||||. .             . .|| |    ..   .|.|| |. ..|... |. 
E-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYP

PYPRVPLSEVVAHVEKGYRMESPEGCPDHVYKVMKDCWDINPKKRPTFKHVRS------QLNLF
|.|   . ..  ..            .. .   .. |.. .|.||||   .        .   |
PFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CSK1.AA Pkinase 515-757 22 6.7e-36 128.01 Pfam 1-293 (293) Show / Hide 
Range on Protein: 515-757
Range on HMM: 1-293/293
Sequence Identity: 22% (66 aa)

IHLGSCIGAGNFGDVLQGTYQGRK--VAIKQVKDNSTAA----QAFL-AEASVMTTLKHPNLVQLLGVVL-GNPLYIVLEFMSKG----NLVDYLRSREX
.|.|..||.|.|| | ... .|    ||.|..|  ..      .... .|...|  |.||| |.|....  .. .|.|.|.. .|     | ||.. .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NVF--XGRHLLKF--DVCNGMAYLEEKEFVHRDLAARNILVSEQDIA----KVSDFGLSQEA-TLNQEGGKFP---IKWTSPEALR-KKEFSSMSDVWSY
..|    ... ..   .. |..|. .. ..||||   |||.....      |..||||.  . . |..  . .   . . .|| .|  .. .. .|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIFMWELYSFGRVPYPRV-------PLSEVVAHVEKGYRMESPEGCP-------------------DHVYKVMKDCWDINPKKRPTFKHVRSQ--L
|. ..|... || |.|         ..  ..   .. .. ..|. |.                   .   ...|.|.. .||||||....     .
GCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF