JAK2

Species: Sea Urchin
Alias: Spk276, JAK2, SPU_020082
External Links: Sea Urchin Project Link ,
Annotation: Secondary Group: TK, Secondary Family: JakB

Classification

Group: TK
Family: Jak

Sequence

Name Sequence Type Origin Length Description Download
JAK2.kin_dom2 Protein Kinase Domain None 268 None Fasta, JSON
JAK2.AA Protein None 829 None Fasta, JSON
JAK2.kin_dom Protein Kinase Domain None 157 None Fasta, JSON

Protein domain

Protein domains of JAK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B41 JAK2.AA B41 31-248 15 2e-06 21.7 SMART 1-232 (232) Show / Hide
Range on Protein: 31-248
Range on HMM: 1-232/232
Sequence Identity: 15% (37 aa)

GMEPDIVEVRTYMCGNLVLPWRERLTVEQVCIKAAKLCGIPRLTSNLFALYDKTN---KKWLCPKAQVFSRRQR----KSEQLEYRVRFHTAT-MCPSGD
  .|  . |...  . | .    . |....| .... ||| .. ...|.|. .     ..|| . . ..  . .     ...| .||.| . . ..    
SPKPRFCRVYFMDGTTLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHEDRHWLDHWKTIMKQDVKWHKSEPWTLHFRVKFYPPDWHG----

AQGFMLLEENVVN-YMFCQYRESFLNDEFMGLSTEESLGLMVLDFMQHVKEDGTS-------LTNLNGRLRFGRFLPKSLNE------GLSWWDKRKLRR
    .| |....  |...| |. .|....   ..||.|.| .|... . ...  .       .. . . ..  |||||....      . .   . ..|.
-FPNQLQEDPTRYNYFYLQCRHDILQGRHPCPHEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWIDSIKQSFMHYQMHHKEWRK

KVRTALTDFRDDPRETFAFRVMFLVSLSEEMKQEWGTEQF
... .  ...   .|   .. . ..   .   .. |.| |
RIMEWHKNHCGMTPEEAKLKYLQIC---QRWPPMYGVEHF

SH2 JAK2.AA SH2 357-445 24 8.4e-12 46.46 SMART 1-87 (87) Show / Hide
Range on Protein: 357-445
Range on HMM: 1-87/87
Sequence Identity: 24% (22 aa)

KNRCHGPIPLSKAKQKIEETGRQEGVYLIRQNPEDHYSYCLTVRIHANQELKNFKINCYEDDDQVGLDN--QRRFNCLRSFVEFYRSRENS
 . .||.|. ..| |.    | ..| .|.|.   . ..|.|.|| .  .. |...|.. .| ... .|    |.|..|   |..|.    .
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK--GKVKHYRIRRNDD-GKYYIDETWRRKFPSL-ELVNHYQHNPLG

Kinase JAK2.AA Jak 498-761 28 7.8e-87 294.79 In-house 2-299 (299) Show / Hide
Range on Protein: 498-761
Range on HMM: 2-299/299
Sequence Identity: 28% (86 aa)

TNWRHLDDGDFTEVWAADLRKKV------GNRPRKMRVAIKCPKMDAPQSVQQKFSQSVDLMSSWVHKHIIRFEG-----IGAGYMLVMEYASEGPLDHY
.  .||  |.|. |    ..  .      ..  ..  |..|  ....  .....|......||.|.||||....|     ....|..||||...||||.|
KWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDDY

LRSLLENERKRLGL--NSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLVLRPAPN-----MHIKLADPMLGVYYHSLEMTSRPKLERVRWTAPELLAT-
|....|........  ..... |.|......|||..|..||.|.|.|.|| |....     ...||.||. .......||..|   ||..|.|||.|.. 
LHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDR--DERIPWYAPECLTNC

NSEPTLAGDKFSYA-ITLWQIM----------------SHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDVNS
....|||.||.|.. .|||.|.                . | .|   .        |  | || .|. |..|.  .|  ||. .|..||| | ..||.|.
KFYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ





Kinase JAK2.AA TK 506-759 15 6e-52 172.04 In-house 10-486 (486) Show / Hide
Range on Protein: 506-759
Range on HMM: 10-486/486
Sequence Identity: 15% (75 aa)

GDFT---EVWAADLRKKVGNRPRK-------------------MRVAIKCPKMDAPQSVQQKFS----------------QSVDLMSS--WVHKHIIRFE
| |    ||. . .| . ......                   ..||.|. | ....| ...|                 .   .|..    |..|.|. 
GQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLY

G---IGAG------------YMLVMEYASEGP----LDHYLRSLLENERK--------------------------------------------------
|    |..            .|.||||.. |     |..|||.  .....                                                  
GVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHP

---------------------RLGLNSQLHAAFQLIDALEYLESR------RIVHGNVSAHNTLVLRPAPN--------MHIKLADPMLG----------
                     .| .  .|  ..|. ...|||.|.      ..||... |.| || .  ..        ...|.||  |           
PPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARD

-----VYYHSL-EMTSR------------------PKLERVRWTAPELLATNS--------EPTLAGDKFSYAITLWQIMSHG-AIPAENLSD-------
      || .  . |.|                       .||.||| |...           | . | .|. ...| |...| . .....|.       
IYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG

--EXXXXXYRHG--------------VRLDAPPGCP--------------QELLKIMEACWSHNPRNRPSCRGVLRDV
  .      | |               |. .||.||              .|.  .|  ||...|. ||. . ...  
DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase JAK2.AA Pkinase_Tyr 506-759 25 3e-38 130.16 Pfam 10-270 (270) Show / Hide
Range on Protein: 506-759
Range on HMM: 10-270/270
Sequence Identity: 25% (67 aa)

GDFTEVWAADLRKKVGNRPRKMRVAIKCPKMDAPQSV--QQKFSQSVDLMSSW-VHKHIIRFEGIGA----G--YMLVMEYASEGPLDHYLRSLLENERK
| | ||. . ..        |. ||.|. | .| ..   ...| . . .|..   |..|.|. |.         ...||||.  | |..|||.   ....
GAFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-EDKQ

RLGLNSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLVLRPAPNMHIKLADP--MLGVYYHSLE-MTSRPKLERVRWTAPELLATNSEPTLAGDKFSYAI
.| .   |. ..|  ...|||||....|  . | | || .   |...| .|   .  .|  .    ..      ..|.||| ....   | . |  |. .
PLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGV

TLWQIMSHGAIP-AENLSDEXXXXXY-RHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDV
..| |.. |..|  ...|.|       ..| |...|..||.|. ..|  || ..| .||. . .... 
LMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase JAK2.AA TK-Unique 497-759 23 1.2e-34 116.93 In-house 1-294 (294) Show / Hide
Range on Protein: 497-759
Range on HMM: 1-294/294
Sequence Identity: 23% (71 aa)

RTNWRHLDDGDFTEVWAADLRKKVGNRPRKMRVAIKCPKMDAPQSVQQKFSQSVDLMSSWV-HKHIIRFEGIGA--G--YMLVMEYASEGPLDHYLRSLL
 .. . ...| | .|| ...... ... .. .||.|  | .| .  .|.| .   .|..   |..|....|.    .   |..|||.. | |.||||.  
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-E-----------------NERKR---LGLNSQLHAAFQLIDALEYLES--RRIVHGNVSAHNTLVLRPAPNMHIKLADPMLGVYY-----HSLEMTSRP
 .                 ....|   . . . .| |.|.  ..|||.|  ..|||....|.| |. .   .  .|..|  .|  .     . ..|. . 
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE---DKVCKICD--FGMARDVYTNGVYSMMCSQ

KLERVRWTAPELLA-TNSEP-TLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGC-PQELLKIMEACWSHNPRNRPSCRGVLRDV
.   .|| ||| |  .     |  .|  |.....| |.. || |  .....      | |.|.. |..| ..|. ..|. ||...|  |||.| ..   
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase JAK2.AA TKL 503-759 18 3.6e-27 94.9 In-house 1-364 (364) Show / Hide
Range on Protein: 503-759
Range on HMM: 1-364/364
Sequence Identity: 18% (68 aa)

LDDGDFTEVWAADLRKKVGNRPRK----MRVAIKCPKMDA--------------------------PQSVQQKFSQSVDLMSSWVHKHIIRFEG--IGAG
.  | | ||. . .|   | .  .      ||.|  |..                           ..  .... . . .||.  | .|..| |  .  .
IGSGGFGEVYKGKWRGWGG-KC-PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

--------------YMLVMEYASEGPLDHYLRSLLENERKRLGLNSQLHAAFQLIDALEYLESRR--------IVHGNVSAHNTLVL-----------RP
              ...||||.. | | |||            ..  .. | .   ...|| |..        |.| .   .| ||            .|
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP

APNMHIKLADPMLGVYYH---SLEMTSRP-------------KLERV---RWTAPELLATN---------------SEPTLAGDKFSYAITLWQIMSHGA
. . ..|..|  |    .   . ..|.               .  ..   || |||.|  .               .| . . | .|..| || |..   
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR

IPAENLSDEXX---------XXXYRHGVRLDAP------------PGCPQELLKIMEACWSHNPRNRPSCRGVLRDV
  ... ...              . .| |.  |            | ||... |.|. ||.|.|..|||.  .|   
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase JAK2.AA UTK 668-759 26 1.2e-24 81.21 In-house 203-296 (296) Show / Hide
Range on Protein: 668-759
Range on HMM: 203-296/296
Sequence Identity: 26% (25 aa)

VRWTAPELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHG--VRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDV
.||.||| |. .. .|.. | .|. ...| |...|. | ...|..      . |   |. .|..|| .. ..| .||  .|..||... ..  .
IRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM

Kinase JAK2.AA Abl 571-759 27 1.5e-20 64.87 In-house 70-252 (252) Show / Hide
Range on Protein: 571-759
Range on HMM: 70-252/252
Sequence Identity: 27% (52 aa)

YMLVMEYASEGPLDHYLRSLLENERKRLGLNSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLVLRPAPNMHIKLADPMLGVYYHSLEMTSRPKLE-RVR
. .. |. . | |  |||   |..|. |     |. | |.  ...|||.|  .|  . | | ||   . .  .|.||  |    .    | .      ..
FYIITEFMCYGNLLDYLR---ECDREELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLV---GEHHIVKVADFGLARMMKDDTYTAHAGAKFPIK

WTAPELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDV
||||| || | .     | . . . || |   |  |   .  .       .| |.. |.|||..  ..| .||  ..  ||| . . . .
WTAPESLAYN-KFSSKSDVWAFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM

Kinase JAK2.AA Frk 572-763 27 4.2e-19 62.55 In-house 70-260 (260) Show / Hide
Range on Protein: 572-763
Range on HMM: 70-260/260
Sequence Identity: 27% (54 aa)

MLVMEYASEGPLDHYLRSLLENERKRLGLNSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLVLRPAPNMHIKLADPMLGV-YYHSLE--MTSRPKLE-R
... |   .| | .||... .. |. . .. ..  | |.   . ||||.  .|  . | | ||     .  .|.||  |        |    ||      
YIITELMRHGSLQEYLQAINDKGRQ-CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLV---GEHNICKIADFGLARVLMKDNEDIYESRHGARFP

VRWTAPELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDVNSFL
..|||||   .|.  |.  | .|. | |  |. .| .|   . .        || |.  ||.|||.| .||  || ..|..||    .   .. ..
IKWTAPEAANYNKF-TIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF

Kinase JAK2.AA TyrKc 497-759 23 1.2e-17 62.66 SMART 1-280 (280) Show / Hide
Range on Protein: 497-759
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

RTNWRHLDDGDFTEVWAADLRKKVGNRPRKMRVAIKCPKMDAPQSVQQKFSQSVDLMSSW--VHKHIIRFEGIGAG----------YMLVMEYASEGPLD
 |  . |  | | ||. . ..         . ||.|. | ||    .. | .   .|..    |..|.|. |.             .|.||||.. | |.
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

HYLRSLLENERKRLGLNSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLVLRPAPNMHIKLADPMLGVYYHSL-------EMTSR--PKLER----VRWT
.|||.  ..    | .   |. ..|  .  |||.|....|    | | || ..    ..| .|  |  . ..        .. .    | ..    .||.
DYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAEN-----LSDEXXXXXYRHGVRLDAPPG--------CPQELLKIMEACWSHNPRNRPSCRGVLRD
||| .   .. | . | .|. ...| |.. |. | ..     .|..      ..| |.. ||         ||.|. .||. || ..| .||. . . ..
APECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

V
 
F

Kinase JAK2.AA Musk 668-759 30 5.3e-17 52.51 In-house 192-282 (282) Show / Hide
Range on Protein: 668-759
Range on HMM: 192-282/282
Sequence Identity: 30% (28 aa)

VRWTAPELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDV
.||..|| .  |   |.. |  .| . || | | .  |  ... |      | | .|  |  |||.. ..|  ||. || .||.   . . .
IRWMPPESIWYN-QFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI

Kinase JAK2.AA FAK 523-647 32 3.2e-16 50.68 In-house 48-167 (285) Show / Hide
Range on Protein: 523-647
Range on HMM: 48-167/285
Sequence Identity: 32% (41 aa)

RPRKMRVAIKCPKMDAPQSVQQKFSQSVDLMSSWVHKHIIRFEGI--GAGYMLVMEYASEGPLDHYLRSLLENERKRLGLNSQLHAAFQLIDALEYLESR
|| |. ||||  | .  .... || |    |    | ||..  ||       ..|| .  | | ||    |. ....| . . .  ..||  |. ||||.
RPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWIIMELCKYGELRHY----LQRNKNSLKHATLILYCYQLCMAMAYLESK

RIVHGNVSAHNTLVLRPAPNMHIKLAD
. ||  . | | ||   . .  .||.|
KFVHRDIAARNVLV---SSPDCVKLGD

Kinase JAK2.AA Eph 668-763 34 3e-13 40.72 In-house 174-264 (264) Show / Hide
Range on Protein: 668-763
Range on HMM: 174-264/264
Sequence Identity: 34% (33 aa)

VRWTAPELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDVNSFL
.|||||| .|     | | |  || | .| .|| |  |  ..|.         | || .|..||. | ..|  ||   . .||       .. |.|
IRWTAPEAIAYR-KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPH----FQQIVSIL

Kinase JAK2.AA S_TKc 497-763 17 9.5e-11 -19.28 SMART 1-231 (231) Show / Hide
Range on Protein: 497-763
Range on HMM: 1-231/231
Sequence Identity: 17% (50 aa)

RTNWRHLDDGDFTEVWAADLRKKVGNRPRKMRVAIKCPKMDAPQSVQQKFSQSVDLMSSWVHKHIIRFEGIGA--GYMLVMEYASE--GPLDHYLRSLLE
 .  |..  | | .|. .  .|       . .||||. |        ... . ......  |..|... ..     . .||||..   | | .|...   
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGR

-NERKRLGLNSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLVLRPAPNMHIKLADPMLGVYYHSLEMTSRPKLERV---RWTAPELLATNSEPTL-AGD
   |...      . . |...||||. |..|.|  .   | |. .     |||..|   |.  .            .    . |||.|      .  . |
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICD--FGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCD

KFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLR-----DVNSFL
  |  ..|.  .. |  | .          ... .        ..|.. ... |.  .|..||..  .|.         ..
WWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase JAK2.AA UTK 572-634 33 2.9e-09 27.84 In-house 86-151 (296) Show / Hide
Range on Protein: 572-634
Range on HMM: 86-151/296
Sequence Identity: 33% (22 aa)

MLVMEYASEGPLDHYLRSLLEN---ERKRLGLNSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLV
|.|.||...| |..|||.  ..   ..  | | ..|. | .  ....||.|...||... | | ||
MIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLV

Kinase JAK2.AA Eph 506-588 33 1e-06 18.21 In-house 10-96 (264) Show / Hide
Range on Protein: 506-588
Range on HMM: 10-96/264
Sequence Identity: 33% (29 aa)

GDFTEVWAADLRKKVGNRPRKMR-VAIKCPKMDAPQSVQQKFSQSVDLMSSWVHKHIIRFEGI---GAGYMLVMEYASEGPLDHYLR
|.| ||    |... | |  ..  ||||  |  .. . .  |     .|    | .||| ||.   .   | | ||   |.|| .||
GEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLR

Kinase JAK2.AA FAK 683-750 30 1e-06 18.38 In-house 204-271 (285) Show / Hide
Range on Protein: 683-750
Range on HMM: 204-271/285
Sequence Identity: 30% (21 aa)

TLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRP
| | |   ... .| |...|  |   .  .        | ||  || ||  |  .|  ||. .|  ||
TTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRP

Kinase JAK2.AA Musk 529-589 31 0.000428 9.17 In-house 32-95 (282) Show / Hide
Range on Protein: 529-589
Range on HMM: 32-95/282
Sequence Identity: 31% (20 aa)

VAIKCPKMDAPQSVQQKFSQSVDLMSSWVHKHIIRFEG---IGAGYMLVMEYASEGPLDHYLRS
||.|  | || . .|. |     .|    |  |..  |   .|    | .|| ..| |. .|.|
VAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHS

Kinase JAK2.AA Pkinase 669-759 10 0.003224 12.46 Pfam 176-293 (293) Show / Hide
Range on Protein: 669-759
Range on HMM: 176-293/293
Sequence Identity: 10% (13 aa)

RWTAPELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAENL----SDEXXXXXYRHGVRLDAPPGCP-----------------------QELLKIMEAC
.. |||.. .... . . | .|. ..|.. ..   .   .     .       ..   . . .  .|                       .|...... |
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

WSHNPRNRPSCRGVLRD--V
.  .|  ||... .| .  .
LCKDPKKRPTAEQILQHPWF

Kinase JAK2.AA Pkinase 573-624 24 0.025408 9.29 Pfam 77-131 (293) Show / Hide
Range on Protein: 573-624
Range on HMM: 77-131/293
Sequence Identity: 24% (14 aa)

LVMEYASEG----PLDHYLRSLLENERKRL--GLNSQLHAAFQLIDALEYLESRRIVH
.||||.  |     | .|..     .....    .   . . |.. .|||. |..|.|
MVMEYCEGGLYVMDLFDYIST---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH