Gene ROR (Sea Urchin)

ROR

Species: Sea Urchin
Alias: SPU_020646, ROR, Spk286
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Ror

Sequence

Name Sequence Type Origin Length Description Download
ROR.AA Protein None 1076 None Fasta, JSON
ROR.kin_dom Protein Kinase Domain None 280 None Fasta, JSON

Protein domain

Protein domains of ROR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 ROR.AA IGc2 50-118 34 8.4e-15 56.41 SMART 1-56 (56) Show / Hide 
Range on Protein: 50-118
Range on HMM: 1-56/56
Sequence Identity: 34% (24 aa)

IPGDSVTLNCRIRGYPKPTYWWYRNDAIIRDDIGRNVVREFKGGSTLTINNVGTLDTGSYKCIAANDNG
..|.||||.|. .|.| |.  ||. .  .             ...|||| ||   | | | |.| | .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set ROR.AA I-set 38-115 27 6.4e-14 49.76 Pfam 1-79 (92) Show / Hide 
Range on Protein: 38-115
Range on HMM: 1-79/92
Sequence Identity: 27% (22 aa)

IAIDAPMNNETVIPGDSVTLNCRIRGYPKPTYWWYRNDAIIR--DDIGRNVVREFKGGSTLTINNVGTLDTGSYKCIAAN
  .. .  . .|  |......|...|.|.|.  |..... .|  .|  . . .. .| .|||| ||   |.|.|.|.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDG-DGTYTLTISNVQPDDEGKYTCVATN
IG ROR.AA IG 44-131 23 1.5e-12 48.91 SMART 1-58 (58) Show / Hide 
Range on Protein: 44-131
Range on HMM: 1-58/58
Sequence Identity: 23% (22 aa)

MNNETVIPGDSVTLNCRIRGYPKPTYWWYRNDAIIRDDIGRNVVREFKGGSTLTINNVGTLDT---GSYKCIAANDNGTKSVQG--SITLNAN
    || .|..|||.| .      ..|||                       ||| ||   |.   | | | |      .....  ..||   
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ
V-set ROR.AA V-set 25-111 26 4.4e-05 19.37 Pfam 1-110 (128) Show / Hide 
Range on Protein: 25-111
Range on HMM: 1-110/128
Sequence Identity: 26% (31 aa)

LSDSTT-PPPGTPYIAIDAPMNNETVIPGDSVTLNCRIR-GY----PKPTYWWYR-NDA------II-------RDDIGRNVVREFKGGST---------
 |. |. ||.|   .         || .|.||||.|  . .|    .  .. |||  ..      ||       ... . ..  .|||  |         
QSQVTQHPPRGC-PW-------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKND

--LTINNVGTLDTGSYKC
  |||.|.   |.| | |
FSLTISNLQPSDSGTYYC
Fz ROR.AA Fz 154-238 17 0.202272 5.63 Pfam 1-94 (143) Show / Hide 
Range on Protein: 154-238
Range on HMM: 1-94/143
Sequence Identity: 17% (17 aa)

CEPYR--GSVCSPHIANSQV--YIPAGQT--QADIEAA----LGAAIQQINNDLPIT---LNQRCTKYLKPSMCLTAFPLCRERPRLA-VHRMCYDECR
|.|.|  ...|   . |...  .     |  |...|..    . .    ..     |   |  .|  ....  |  .|| | ....   .   |.. |.
CQPIRNDIPMCHGMPYNMTWMPNLLHHETGTQKEAELQWEMMIHQWWPLVH-----TSTHLSPKCHPHIQFFLCSMYFPMCTDGFHHPPPIPPCRSMCE
IGc2 ROR.AA IGc2 323-393 35 6.3e-17 63.47 SMART 1-56 (56) Show / Hide 
Range on Protein: 323-393
Range on HMM: 1-56/56
Sequence Identity: 35% (25 aa)

HTGDKATLRCRIIGDPTPHYKWYKNDALLTEERRDRRITTKEYEWGSKLSIRNVDTTDTGYYKCVAENRAG
| |. .||.|.  |.|.|  .||| .  |               |.. |.|.||   | ||| |.|.|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set ROR.AA I-set 321-397 30 1.4e-15 55.39 Pfam 11-86 (92) Show / Hide 
Range on Protein: 321-397
Range on HMM: 11-86/92
Sequence Identity: 30% (24 aa)

ELHTGDKATLRCRIIGDPTPHYKWYKNDALLTEERRDRRITTKEYE-WGSKLSIRNVDTTDTGYYKCVAENRAGVRST
|   |. |.. |...|||.|   |.|... |..  ...|.  .. .   ..| |.||.  |.| |.|||.|..|  ..
EVQEGETARFECQVTGDPPPQVSWFKDGQPLRP--DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAEC
IG ROR.AA IG 317-405 18 3.2e-08 34.58 SMART 1-58 (58) Show / Hide 
Range on Protein: 317-405
Range on HMM: 1-58/58
Sequence Identity: 18% (17 aa)

NNETELHTGDKATLRCRIIGDPTPHYKWYKNDALLTEERRDRRITTKEYEWGSKLSIRNVDTTDT---GYYKCVAENRAGVRST-MGILFARI
   ..   |. .||.| .      ...||                         | | ||   |.   | | |.|.  .|. .   |.     
PP-VTVKEGETVTLTC-VS-----QIWWY-------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set ROR.AA V-set 300-390 14 0.014633 10.66 Pfam 1-114 (128) Show / Hide 
Range on Protein: 300-390
Range on HMM: 1-114/128
Sequence Identity: 14% (17 aa)

PFGVPT--ARYFIIMERPMNNETELHTGDKATLRCRIIGDP----TP-HYKWYK-NDA-----------LLTEERRDRRITTKEYEWGSK----------
.. | .   | . .       . .  .|...||.|    |.    .. .. ||.  ..                . ..  .. ..               
QSQVTQHPPRGC-PW------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDF

-LSIRNVDTTDTGYYKCVAEN
 |.|.|.   |.| | |.. |
SLTISNLQPSDSGTYYCAVWN
Fz ROR.AA Fz 422-543 20 3.5e-23 72.26 Pfam 1-143 (143) Show / Hide 
Range on Protein: 422-543
Range on HMM: 1-143/143
Sequence Identity: 20% (29 aa)

CQPYR--GMTCSNFISNHSIYVTDFQA----QKLIDER----LTQAFLLMAR--DLSPQCQQYAIPSLCFFAFPFCDETRQEPRGRELCRDECEILEQDI
|||.|  .  | ... |. ..    .     || . .     ..| . |..    |||.| ..... || ..|| |... ..| .. .||. ||..... 
CQPIRNDIPMCHGMPYNMTWMPNLLHHETGTQKEAELQWEMMIHQWWPLVHTSTHLSPKCHPHIQFFLCSMYFPMCTDGFHHPPPIPPCRSMCEAVKEQG

CKTEYQI----------AKEMPNVILPDCSRLPAIGTNANANCI
|  ..|.             ..   ...|...|  .   ...|.
CEPVMQMMEDKKHRRMYPFGFHWPEMLNCNKFPHHHD-DRHMCM
KR ROR.AA KR 556-638 44 4.8e-38 133.64 SMART 1-90 (90) Show / Hide 
Range on Protein: 556-638
Range on HMM: 1-90/90
Sequence Identity: 44% (40 aa)

HKCYND--TGEDYRGRINTTKSGFACQSWDKQEPHEHALWPSHYRELA----GGHNFCRNPGNGLDKPWCFTTNPDVR-AEKCDIPRCDE
. ||..  .||.||| .|||.||  ||.|| | || |   |......     ..||.||||..   .|||.|..|.||  | ||||.|..
RDCYWGDDNGESYRGTVNTTWSGHPCQRWDSQYPHLHWFYPEWFPCAGQLGLLEHNYCRNPDGDSEGPWCYTMDPNVRDWEYCDIPQCED
Kringle ROR.AA Kringle 558-636 50 1.6e-30 106.94 Pfam 1-85 (85) Show / Hide 
Range on Protein: 558-636
Range on HMM: 1-85/85
Sequence Identity: 50% (43 aa)

CYNDTGEDYRGRINTTKSGFACQSWDKQEPHEHAL-WPSHYREL---AGGHNFCRNPGNGLDK-PWCFT-TNPDVRAEKC-DIPRC
|| . || |||  .||.||  || ||.| ||.|    |. .       |.||.|||| .|  . |||.| |.| || | | |||||
CYHGNGENYRGTWSTTESGRPCQRWDSQTPHRHPFYTPENFPCKGLGEGKHNYCRNP-DGDERGPWCYTQTDPRVRWEYCSDIPRC
Kinase ROR.AA Ror 712-995 63 2.3e-237 794.85 In-house 1-285 (308) Show / Hide 
Range on Protein: 712-995
Range on HMM: 1-285/308
Sequence Identity: 63% (182 aa)

IKFSEALGDGTFGKVWRGELMGLNNQYSCTSIVIKTLDKEASPALQQDYRNETSVMASLNHPNIITLLGVCTKEKPNCMLFEFLPHGDLHEFLVRHSPNS
..|.|.||...||||..|.|||.|..|.|....|||....||||..||.|.|...||.|.||||..||||||...|.|||||...||||||||...||.|
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHS

DVGFGSGDD-DTQSSLDASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMVGEHHQIKITDFGLARDIYSGDYYRMPSQAVLPIRWMSPEAIMFGRFTV
|.|..|.|| ...||||..|||.|||||..||.||||.||||||||||||.|||||..||.||||.|||||.|||||......|||||||||||.|.|..
DHGCSSDDDRMVKSSLDHPDFLHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAIMYGKFSE

ESDIWSFGVVLWEIYSYGLQPFYGYNNNEVIEMIRTRHILPSPSGCPQYIYALMTECWSEIPARRPPFKVISTRLRALDTVPMHT
.|||||||||||||.|||.||.|||.|.|||||||.||.||.|..||..||.||.|||.|||.|||.||.|..|||..|..  |.
DSDIWSFGVVLWEIWSYGMQPYYGYSNQEVIEMIRNRHLLPCPHNCPTWIYSLMIECWHEIPSRRPRFKDIHSRLRSWDNLSNHN
Kinase ROR.AA Pkinase_Tyr 712-985 41 3.4e-129 438.19 Pfam 1-270 (270) Show / Hide 
Range on Protein: 712-985
Range on HMM: 1-270/270
Sequence Identity: 41% (118 aa)

IKFSEALGDGTFGKVWRGELMGLNNQYSCTSIVIKTLDKEASPAL--QQDYRNETSVMASL-NHPNIITLLGVCT-KEKP--NCMLFEFLPHGDLHEFLV
|.| . || | ||.|..|.. |   .  ..   .|.|   |..    ..|  .| ..| .| .||||. |.|||| ...|   .. .|. |||||...| 
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RHSPNSDVGFGSGDDDTQSSLDASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMVGEHHQIKITDFGLARDIYSGDYY-RMPSQAVLPIRWMSPEAIM
.|.            . . .|. .| |....|| .||.||.|....|||||||||.|.| ...||.|||||||||. ||| |. . . |||.||.||.|.
KHR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECIN

FGRFTVESDIWSFGVVLWEIYSYGLQP-FYGYNNNEVIEMI-RTRHILPSPSGCPQYIYALMTECWSEIPARRPPFKVISTRL
.|.||..||.|||||..|||..|| || ..|  |.||.|.| . .. .| | .||. || ||..|| . |..|| |. |  .|
YGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ROR.AA TyrKc 712-985 38 8.3e-124 418.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 712-985
Range on HMM: 1-280/280
Sequence Identity: 38% (117 aa)

IKFSEALGDGTFGKVWRGELMGLNNQYSCTSIVIKTLDKEASPALQQDYRNETSVMASL--NHPNIITLLGVCTKE-------KPNCMLFEFLPHGDLHE
|.. . || | ||.|..|..         .   .|.| ..|    ..| ..| ..| .|  .||||. |.||||..       .| ....|. |||||..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLVRHSPNSDVGFGSGDDDTQSSLDASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMVGEHHQIKITDFGLARDIYSG-------DYYRM----PSQA
.| .| |.               |  .|.|....|| .||.||.|....|||||||||.||| |..||.||||.||||..       ||||.     . .
YLRKHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

VLPIRWMSPEAIMFGRFTVESDIWSFGVVLWEIYSYGLQPFYG-----YNNNEVIEMIRTRHILPSPSG--------CPQYIYALMTECWSEIPARRPPF
.||||||.||.|..|.|| .||.|||||..|||..|| || .|      .| |||| ..... .| |          ||. .| .|..|| | |. || |
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

KVISTRL
. |  ..
SEIHECF
Kinase ROR.AA TK 712-985 25 6.9e-114 383.34 In-house 1-486 (486) Show / Hide 
Range on Protein: 712-985
Range on HMM: 1-486/486
Sequence Identity: 25% (122 aa)

IKFSEALGDGTFG---KVWRGELMGLN----------------------NQYSCTSIVIKTLDKEASPALQQD--------------YRNETSVMAS--L
|.. . || | ||   .|..||. |.|                      ..   . . ..... ..|.. ..|                .| ..| .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHPNIITLLGVCTKE------------KPNCMLFEFLPHGD----LHEFLVRHSPNSDVGFGSGDD----------------------------------
.||||. |.||||..            .| ... |. ||||    |...| ...|.      ..|.                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------DTQSSLDASDFLN-------------------IAIQIVSGMDYLSSR------HFVHRDLAARNCMVGEHHQ-----------IKITDFG----
      |  ..|. .|.|.                   .. || .|| ||.|.      .|||||||||||.|||...           .||.|||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LARDIYSG-DYYRMP-----------------------SQAVLPIRWMSPEAIM---------FGRFTVESDIWSFGVVLWEIYSYGLQPFYG-YN
    |||||||. ||||.                        |.. ||||||.||...         .|.|| .||.|||||..|||..|| .|.||  .
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------NEVIEMIRT--------------RHILPSPSGCP--------------QYIYALMTECWSEIPARRPPFKVISTRL
|          ||.|..|.              |. .| | .||              . .| ||..||.. |..|| |. .  .|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ROR.AA Trk 712-985 43 6.9e-109 368.04 In-house 1-275 (275) Show / Hide 
Range on Protein: 712-985
Range on HMM: 1-275/275
Sequence Identity: 43% (119 aa)

IKFSEALGDGTFGKVWRGELMGLNNQYSCTSIVIKTLDKEASPALQQDYRNETSVMASLNHPNIITLLGVCTKEKPNCMLFEFLPHGDLHEFLVRHSPNS
| .   ||.| ||||  .|   | ..   . . .||| |.|| .  .|.. |  ..  | |..|. . |||| ..|  | ||.. |||| ..|  | |  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTL-KDASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

DVGFGSGDDDTQSSLDASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMVGEHHQIKITDFGLARDIYS-GDYYRMPSQAVLPIRWMSPEAIMFGRFTV
..  .  .   .  |  .. | || || ||| |. | ||||||.|.|||.||.   .|| |||. ||.||  ||||.  .  |||||| ||.||. .||.
MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTY

ESDIWSFGVVLWEIYSYGLQPFYGYNNNEVIEMIRTRHI-LPSPSGCPQYIYALMTECWSEIPARRPPFKVISTRL
|||.||||||.||...|| ||.|.  |.|||| |      |  | .||| .|..|  ||   | .|   | | ...
ESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase ROR.AA Musk 712-985 43 4.4e-105 348.24 In-house 1-282 (282) Show / Hide 
Range on Protein: 712-985
Range on HMM: 1-282/282
Sequence Identity: 43% (124 aa)

IKFSEALGDGTFGKVWRGELMGLNNQYSCTSIVIKTLDKEASPALQQDYRNETSVMASLNHPNIITLLGVCTKEKPNCMLFEFLPHGDLHEFLVRHSPNS
| .   .|.| || |      ||  .   |.. .| |  .||  .|.|.  |   ||   ||||. |||||   .| |.|||..  ||| |||   ||  
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

DVGFGSGDDD--------TQSSLDASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMVGEHHQIKITDFGLARDIYSGDYYRMPSQAVLPIRWMSPEAI
     . |            . |   . |..| ||  || ||| . ||||||| |||...||  .|| ||||.| ||. |||.       ||||| ||.|
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

MFGRFTVESDIWSFGVVLWEIYSYGLQPFYGYNNNEVIEMIRTRHILPSPSGCPQYIYALMTECWSEIPARRPPFKVISTRL
.  .||.|||.|..||.||||.||.|||.||    |||  ||   || .|  ||| .|.|| .||.  || || |. |   .
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase ROR.AA TK-Unique 712-985 36 1.5e-96 327.1 In-house 1-294 (294) Show / Hide 
Range on Protein: 712-985
Range on HMM: 1-294/294
Sequence Identity: 36% (108 aa)

IKFSEALGDGTFGKVWRGELMGLN-NQYSCTSIVIKTLDKEASPALQQDYRNETSVMASLN-HPNIITLLGVCTKEK-PNCMLFEFLPHGDLHEFLVRHS
... . .|.| || |||||. |.. ..   .....|.| ..|..  .||. .| ..| .|  ||||...||.|||   | ....|..| |.|  .| .  
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PN--SD-------VGFGSGDDDTQSS-LDASDFLNIAIQIVSGMDYLSS--RHFVHRDLAARNCMVGEHHQIKITDFGLARDIY-SGDYYRMPSQAVLPI
|.  .         .|..  |. . . ..  |....|.|| .|| ||.|  ...|||||.|||....|....||.|||.|||.|  |.| .| ||  .||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMSPEAIM--FGRF-TVESDIWSFGVVLWEIYSYGLQPFYGYNNNEVIEMIRTRHILPSPSGC-PQYIYALMTECWSEIPARRPPFKVISTRL
|||.||..    | . | .||.|||||..||| ..| .|..|. . ...|.||  ...| |..| .. .| || .||.. |  || |  |  ||
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ROR.AA UTK 712-985 32 1.2e-88 300.76 In-house 1-296 (296) Show / Hide 
Range on Protein: 712-985
Range on HMM: 1-296/296
Sequence Identity: 32% (100 aa)

IKFSEALGDGTFGKVWRGELMGLNNQYSCTSIVIKTLDKEAS-PALQQ---DYRNETS---VMASLN-HPNIITLLGVCTKEKPNCMLFEFLPHGDLHEF
..... || | || | ....   ...       .|.....|. .  .    | ..|.    .|. .. |||.. |.||||.|.| ... |. . |||  .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LVRHSPNSDVGFGSGDDDTQSSLDASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMVGEHH-------QIKITDFG---LARDIY---------SGDY
| ||.|. .        . . .|.  . |  | .| .|| ||.|..||||||||||| |..|.       ..|| |||   ..|...         . .|
LRRHRPTPP--------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYY

YRMPSQAVLPIRWMSPEAIMFG-RFTVESDIWSFGVVLWEIYSYGLQPFYGYNNNEVIEMIRTR--HILPSPSGCPQYIYALMTECWSEIPARRPPFKVI
|.. .|  .|||||.|||.  . |||  ||.||||||.|||...| .|. |..| .|.. .. .  . .|.| .||  .| ||..||   |..|| |. .
YMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDL

STRL
  ..
VQQM
Kinase ROR.AA InsR 712-987 38 5.6e-87 292.18 In-house 1-278 (278) Show / Hide 
Range on Protein: 712-987
Range on HMM: 1-278/278
Sequence Identity: 38% (107 aa)

IKFSEALGDGTFGKVWRGELMGLNNQYSCT--SIVIKTLDKEASPALQQDYRNETSVMASLNHPNIITLLGVCTKEKPNCMLFEFLPHGDLHEFLVRHSP
|     .| | ||.|  | . |.      .   . |||.  .||     .. || |||   |. ... |||||..  |     |.  .|||  .|  . |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

NSDVGFGSGDDD-TQSSLDASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMVGEHHQIKITDFGLARDIYSGDYYRMPSQAVLPIRWMSPEAIMFGRF
  ...|  ..    |.    ..... |..| .|| || .. |||||||.||||| .   .|| |||..||||  ||||      ||.|||.|| .  | |
--EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVF

TVESDIWSFGVVLWEIYSYGLQPFYGYNNNEVIEMI-RTRHILPSPSGCPQYIYALMTECWSEIPARRPPFKVISTRLRA
|  ||.|||||||||. . | ||  |  | .| . | . . .|  | .||.| ..||  ||   |  || |. |   |. 
TTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase ROR.AA DDR 712-985 34 5.8e-85 288.57 In-house 1-306 (306) Show / Hide 
Range on Protein: 712-985
Range on HMM: 1-306/306
Sequence Identity: 34% (106 aa)

IKFSEALGDGTFGKVWRGELMGLNN---QYSCTS--------IVIKTLDKEASPALQQDYRNETSVMASLN-HPNIITLLGVCTKEKPNCMLFEFLPH-G
  | |..| | || |   |. |..    . .  .        .  |.| ..|. .. .| . |  .|...  ||||. |.|||| ..| ||. |.    |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLHEFLVRHSPN---SDVGFGSGDDDTQSSLDASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMVGEHHQIKITDFG--LARDIYSGDYYRMPS----
||  |. .| .    .    . .. . ..... .  . |. || ||| ||.|  |||||||.|||.||.   ||| |||  ..|  ||.||||       
DLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTGR

-QAVLPIRWMSPEAIMFGRFTVESDIWSFGVVLWEIYSYG-LQPFYGYNNNEVIEMI-------RTRHILPSPSGCPQYIY-ALMTECWSEIPARRPPFK
  ...|||||..|.|. | ||  ||.|.||| .||. .    ||.    .  ||| .        .  .|| |  ||. ||  ||..||.  . .||.|.
QRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSFE

VISTRL
 | . |
EIHKFL
Kinase ROR.AA Src 712-985 36 1.9e-84 286.78 In-house 1-255 (255) Show / Hide 
Range on Protein: 712-985
Range on HMM: 1-255/255
Sequence Identity: 36% (100 aa)

IKFSEALGDGTFGKVWRGELMGLNNQYSC-TSIVIKTLDKEASPALQQDYRNETSVMASLNHPNIITLLGVCTKEKPNCMLFEFLPHGDLHEFLVRHSPN
||. . ||.| || || |        .   |   .||| |...   ....  |  .| .| |.... |. ||..|.|     |.  || | ..| .    
IKLCRKLGQGQFGEVWMG-------YWNGNTKVAVKTL-KPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----

SDVGFGSGDDDTQSSLDASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMVGEHHQIKITDFGLARDIYSG-DYYRMPSQAVLPIRWMSPEAIMFGRFT
         |.. ..|   . . .| |. .||.||.|. ..||||||||  |||.   |. |||||| |  . | | . . | .||.|. |||| .||||
---------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFT

VESDIWSFGVVLWEIYSYGLQPFYGYNNNEVIEMIRTRHILPSPSGCPQYIYA-LMTECWSEIPARRPPFKVISTRL
. || ||||. |.|| .||  |  | .| ||....     .| |..||...|  .|..|| . | .|| |. .   |
IKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ROR.AA ALK 712-987 36 2.6e-83 283.11 In-house 1-273 (273) Show / Hide 
Range on Protein: 712-987
Range on HMM: 1-273/273
Sequence Identity: 36% (102 aa)

IKFSEALGDGTFGKVWRGELMGLNNQYSCTSIVIKTLDKEASPALQQDYRNETSVMASLNHPNIITLLGVCTKEKPNCMLFEFLPHGDLHEFLVRHSPNS
|.   ||| | || |  |.  .. .  .   . .|||   .|.. . |. .|  .|.  ||.|.. ..|.| ...|   . |..  ||.  || |.. . 
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFL-RECRPH

DVGFGSGDDDTQSSLDASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMV---GEHHQIKITDFGLARDI-YSGDYYRMPSQAVLPIRWMSPEAIMFGR
 . .        |.|  .| | ..  .  |  || ..||.||| |||||     |     || ||| |||| |  ||||   .| .|. || ||| | | 
PESL------QPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGI

FTVESDIWSFGVVLWEIYSYGLQPFYGYNNNEVIEMIRTRHILPSPSGCPQYIYALMTECWSEIPARRPPFKVISTRLRA
||  .|.||||| .|||.| |  |. |  | ||.|.. .   . .| .||| .| .||.||  .|. ||.|  |  .. .
FTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase ROR.AA Pkinase 712-976 20 9.1e-44 155.84 Pfam 1-282 (293) Show / Hide 
Range on Protein: 712-976
Range on HMM: 1-282/293
Sequence Identity: 20% (63 aa)

IKFSEALGDGTFGKVWRGELMGLNNQYSCTSIVIKTLDKEASPALQQDYRN----ETSVMASLNHPNIITLLGVCTKEKPNCMLFEFLPHG----DLHEF
... . .| |.||.|...   | .        ..|...|. .   ..|...    | ..|..||||||..|..... ..  .| .|....|    ||...
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LVRHSPNSDVGFGSGDDDTQSSL--DASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMVGEHHQI----KITDFGLARDIYSGDYYRMPSQAVLPIRW
. .              . . ..  .  .  ... ||..|..|. |. ..||||   |... .. .|    ||.|||||. ..    .. ..  .  ...
IST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWY

MSPEAIM-FGRFTVESDIWSFGVVLWEIYSYGLQPFYGY------NNNEVIEMIRT-RHILPSPSGCP-------------------QYIYALMTECWSE
|.|| |.     . ..|.||.|..|.| .. |  ||.|       . ...|..|.  .   ..|  |.                   .    ... |.  
MAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

IPARRP
 |..||
DPKKRP
Kinase ROR.AA S_TKc 712-988 19 7e-40 139.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 712-988
Range on HMM: 1-231/231
Sequence Identity: 19% (57 aa)

IKFSEALGDGTFGKVWRGELMGLNNQYSCTSIVIKTLDKEASPALQQDYRNETSVMASLNHPNIITLLGVCTKEKPNCMLFEFLPH--GDLHEFLVRHSP
 .. . .| |.||||...   .     .     || ..        .. |.| ... . .||||..|..|.   .  .| .|....  |||....... .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

NSDVGFGSGDDDTQSSLDASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMVGEHHQIKITDFGLARDIYSGDYYRMPSQAVLPIRWMSPEAIMFGRFT
.           ... ..  .   .. ||.....|. |....||||   | .. |  .|||.|||||| .         .  .    .|.|| .    ..
H----------GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYG

V-ESDIWSFGVVLWEIYSYGLQPFYGYNNNEVIEMIRTRHILPSPSGCPQYIYALMTECWSEIPARRPPFKVIST------RLRAL
  ..|.||.|..|.| .. |  ||.  . ......|.           ..    ..  |.   |..||    . .          .
KCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF