Gene SFK1b (Sea Urchin)
SFK1b
Sequence
Protein domains of SFK1b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | SFK1b.AA | Src-Echino1 | 61-255 | 79 | 1.4e-131 | 443.41 | In-house | 1-198 (252) | Show / Hide |
Range on Protein: 61-255 Range on HMM: 1-198/252 Sequence Identity: 79% (160 aa) LRLTKQIGKGHCAEVWK-VY-GNTPVAVKTLKVGSNMSQADFLAEANVMKKVRHKGILQIFAVCSDS--VSIVTKLMSNGNLQAYLKRGKGK-VKLTTLI ||..|.||||||.|||| |. |||||||||||... ||.||||||||||||.||.||.||.|||||. ..|||.||||||||.||||||.| ||.|||| LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKT-MSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLI DMGAHIASGMDYLGSKNVVHRDLTAKNVLVGEGNVVKIADFGLARLMKKDVYVGKISSGAKLPIRWTAPEAALYGSFTIKSDVWSFGILLTEMVT-GGYP |||||||||||||||||||||||.|.|||||.|||.|||||||||.|.||||.||. ||||||.||||||||||.|||||||||||||.||||| |.|| DMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQ--GAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYP Y | Y |
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| Kinase | SFK1b.AA | Src | 61-255 | 57 | 2.2e-122 | 412.89 | In-house | 1-201 (255) | Show / Hide |
Range on Protein: 61-255 Range on HMM: 1-201/255 Sequence Identity: 57% (117 aa) LRLTKQIGKGHCAEVWK-VY-GNTPVAVKTLKVGSNMSQADFLAEANVMKKVRHKGILQIFAVCSDS--VSIVTKLMSNGNLQAYLK-RGKGK-VKLTTL ..| ...|.|.. |||. .. |||.||||||| |. ||...||.||..|||.||. ..|..||||. . ||| .||.|.|..||| .|.|. ..|..| IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQL IDMGAHIASGMDYLGSKNVVHRDLTAKNVLVGEGNVVKIADFGLARLMK--KDVYVGKISSGAKLPIRWTAPEAALYGSFTIKSDVWSFGILLTEMVT-G |||.|..|.||.||.|.|..|||| |.||||||.||.|.||||||||.| .|.|. . |||.||.||||||..||.||||||||||||||||.|| | IDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH--GAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYG GYPY .|| RVPY |
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| Kinase | SFK1b.AA | SFK-Src | 61-252 | 50 | 4.2e-93 | 276.22 | In-house | 1-196 (259) | Show / Hide |
Range on Protein: 61-252 Range on HMM: 1-196/259 Sequence Identity: 50% (100 aa) LRLTKQIGKGHCAEVWKVYGN--TPVAVKTLKVGSNMSQADFLAEANVMKKVRHKGILQIFAVCSDS--VSIVTKLMSNGNLQAYLKRGKGK-VKLTTLI || |. | | .||| | | ||||||| |. ||. ||.|| |||| || | .||| | . |.| || .| | ||. .|. .. .|. IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGA-MSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLV DMGAHIASGMDYLGSKNVVHRDLTAKNVLVGEGNVVKIADFGLARLMKKDVYVGKISSGAKLPIRWTAPEAALYGSFTIKSDVWSFGILLTEMVTGG ||.| .|.|| || .| ||||| | |||||. ||.|..|||..| . .| ||| ||.||||||... | |||||||||||..|.|| | DMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYG |
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| Kinase | SFK1b.AA | Pkinase_Tyr | 61-252 | 42 | 4.5e-82 | 278.57 | Pfam | 1-211 (270) | Show / Hide |
Range on Protein: 61-252
Range on HMM: 1-211/270
Sequence Identity: 42% (91 aa)
LRLTKQIGKGHCAEVWKVYGN-------TPVAVKTLKVGSNMSQ---ADFLAEANVMKKV-RHKGILQIFAVCS---DS--VSIVTKLMSNGNLQAYLKR
... |..|.|. ||.| . . .|||||.|| |. .| .||..||..||. .|. |.. .||. .. . ||. .| .|.| ||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK
G---KGKVKLTTLIDMGAHIASGMDYLGSKNVVHRDLTAKNVLVGEGNVVKIADFGLARLM-KKDVYVGKISSGAKLPIRWTAPEAALYGSFTIKSDVWS
|..... .|..| . ||.||.|| ||| .|||| |.|.||.|.|||||.||||||.. ..| | . ..|.||||.|.|||. || ||.||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS
FGILLTEMVTGG
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FGVLMWEIFTYG
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| Kinase | SFK1b.AA | SrcA | 61-252 | 54 | 1.1e-80 | 254.6 | In-house | 1-193 (250) | Show / Hide |
Range on Protein: 61-252 Range on HMM: 1-193/250 Sequence Identity: 54% (107 aa) LRLTKQIGKGHCAEVW--KVYGNTPVAVKTLKVGSNMSQADFLAEANVMKKVRHKGILQIFAVCSDS-VSIVTKLMSNGNLQAYLKRGKGK-VKLTTLID .|| ...|.| ||| |.| ||.|||| | || || || .|||.|| . |..|| |. . ||| |. | | .|| ..|| .|| |.| IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGT-MSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVD MGAHIASGMDYLGSKNVVHRDLTAKNVLVGEGNVVKIADFGLARLMKKDVYVGKISSGAKLPIRWTAPEAALYGSFTIKSDVWSFGILLTEMVTGG | | .|.|| |. | .|||| | |.|||| . ||||||||||.. . | . ||| ||.|||||||||| ||||||||||||||||.|| | MAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQ--GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKG |
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| Kinase | SFK1b.AA | Frk | 61-255 | 53 | 8.6e-80 | 271.4 | In-house | 1-203 (260) | Show / Hide |
Range on Protein: 61-255 Range on HMM: 1-203/260 Sequence Identity: 53% (110 aa) LRLTKQIGKGHCAEVWKVYGN--TPVAVKTLKVGSNMSQADFLAEANVMKKVRHKGILQIFAVCS--DSVSIVTKLMSNGNLQAYLK--RGKG-KVKLTT ..| ...| | ||| | ||||||||| |. | |||.|| .|||.|| ..|..||| . . |.| || .| || ||. .|| ...... IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGT-MDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQ LIDMGAHIASGMDYLGSKNVVHRDLTAKNVLVGEGNVVKIADFGLAR-LMKKDVYVGKISSGAKLPIRWTAPEAALYGSFTIKSDVWSFGILLTEMVT-G |.|| | .|.|| || |.| .|||| |.||||||.|..||||||||| ||| . . ||..||.||||||| | .||||||||||||||||..| | LVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYG GYPY || RMPY |
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| Kinase | SFK1b.AA | TK | 61-255 | 25 | 6.2e-79 | 264.1 | In-house | 1-395 (486) | Show / Hide |
Range on Protein: 61-255
Range on HMM: 1-395/486
Sequence Identity: 25% (102 aa)
LRLTKQIGKGHCA---EVWKV----------------------------YGNTPVAVKTLKVGSNMSQADFLA--------------EANVMKKVR----
..| |..|.|. ||.| |.||||||.|| |..|||..|.. ||..||. .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
-HKGILQIFAVCSDS--------------VSIVTKLMSNGN----LQAYLK--RGKGK------------------------------------------
|. |.....||... . ||. .|..|. |. ||. |.|..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------VKLTTLIDMGAHIASGMDYLGSK------NVVHRDLTAKNVLVGEGNV-----------VKIADFG---
. . .|. | . ||.|| || || |.||||| | |.||||.|| .||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----LARLMKKDVYVGKIS-----------------------SGAKLPIRWTAPEAAL---------YGSFTIKSDVWSFGILLTEMVTGG-YPY
||| . .| . . | ||.||||||.|||. . || ||.||||||||.|. |..| | ||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPY
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| Kinase | SFK1b.AA | Src-Unclassified | 61-252 | 41 | 5.6e-78 | 265.38 | In-house | 1-224 (284) | Show / Hide |
Range on Protein: 61-252 Range on HMM: 1-224/284 Sequence Identity: 41% (93 aa) LRLTKQIGKGHCAEVWK-VYGN-TPVAVKTLKVG--SNMSQADFL--------AEANVMKKVRHKGILQIFAVCSDS--VSIVTKLMSNGNLQAYLKRGK ..| . .| | |||. . . |||||.. | || . || .||..||| || . . .||||. |.| .|.|| | ..|. | VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG GKV-KLTTL------------IDMGAHIASGMDYLGSKNVVHRDLTAKNVLVGEGN-----VVKIADFGLA--RLMKKDVYVGKISSGAKLPIRWTAPEA |. . . .|. | .||||.|| || ||||| | |||.|. | |||..||||| .|| | |. . ||..|. |.|||. GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMR--TGAMFPWKWMAPEC ALYGSFTIKSDVWSFGILLTEMVTGG ..|| |.|||||||.|||| |. | | FIYGNFSIKSDVWSYGILLWEIMTKG |
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| Kinase | SFK1b.AA | SRM | 61-252 | 47 | 1.3e-73 | 245.52 | In-house | 1-195 (253) | Show / Hide |
Range on Protein: 61-252 Range on HMM: 1-195/253 Sequence Identity: 47% (93 aa) LRLTKQIGKGHCAEVWKV--YGNTPVAVKTLKVGSNMSQADFLAEANVMKKVRHKGILQIFAVCS--DSVSIVTKLMSNGNLQAYLKRGKGKV-KLTTLI | . |.| ||| | .||.| | | |... .| ||| ||| |. .|||| | | |.| || ||||.||. .|. .. |. FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL DMGAHIASGMDYLGSKNVVHRDLTAKNVLVGEGNVVKIADFGLARLMKKDVYVGKISSGAKLPIRWTAPEAALYGSFTIKSDVWSFGILLTEMVTGG |. .| || || ..|..|||| | |||||..|. |..|||||||.| |.| |.. . |..||||||| |. . .||||||||||| || | | DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYS--PSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYG |
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| Kinase | SFK1b.AA | SrcB | 61-252 | 51 | 1.4e-70 | 238.0 | In-house | 1-193 (251) | Show / Hide |
Range on Protein: 61-252 Range on HMM: 1-193/251 Sequence Identity: 51% (100 aa) LRLTKQIGKGHCAEVWKVY--GNTPVAVKTLKVGSNMSQADFLAEANVMKKVRHKGILQIFAVCS-DSVSIVTKLMSNGNLQAYLKRGKG-KVKLTTLID |.| |..| | ||| | ... |||||.| |. || |||||||||.. |. . ...|| . . . |.| | .| | .|| .| |..| ||| LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGT-MSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID MGAHIASGMDYLGSKNVVHRDLTAKNVLVGEGNVVKIADFGLARLMKKDVYVGKISSGAKLPIRWTAPEAALYGSFTIKSDVWSFGILLTEMVTGG | | || || |. .| .|||| | |.|| | . |||||||||.. . | . ||| ||.|||||| .|.||||||||||||||.|.|| | MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAR--EGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYG |
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| Kinase | SFK1b.AA | Abl | 61-252 | 44 | 1.5e-64 | 214.13 | In-house | 1-195 (252) | Show / Hide |
Range on Protein: 61-252 Range on HMM: 1-195/252 Sequence Identity: 44% (89 aa) LRLTKQIGKGHCAEV----WKVYGNTPVAVKTLKVGSNMSQADFLAEANVMKKVRHKGILQIFAVCSDSVS--IVTKLMSNGNLQAYLKR-GKGKVKLTT . . ...| | || || ...| ||||||| .| .||.|| .||...|. . |. || |.| |..||| ||.. .. ... . IMMKHKLGGGQYGEVYEGVWKRHDCT-VAVKTLKE-DTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVV LIDMGAHIASGMDYLGSKNVVHRDLTAKNVLVGEGNVVKIADFGLARLMKKDVYVGKISSGAKLPIRWTAPEAALYGSFTIKSDVWSFGILLTEMVTGG |. | . |||||.|| ... .|||| |.| |||| ..||.|||||||.||.|.| . ||| ||.|||||. | | .||||| ||.|| |. | | LLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHA--GAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYG |
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| Kinase | SFK1b.AA | TyrKc | 61-255 | 31 | 4.3e-51 | 176.97 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 61-255 Range on HMM: 1-280/280 Sequence Identity: 31% (89 aa) LRLTKQIGKGHCAEVWK-VYGNTPVAVKTLKVGSNMSQADFLAEANVMKKV--RHKGILQIFAVCS---------DSVSIVTKLMSNGNLQAYLKRGKGK ..| |..| |. ||.| .. ..||||.|| .. ..||. ||..|.|. .|. |.....||. . . ||. .|..|.|. ||.. ..| ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK VKLTTLIDMGAHIASGMDYLGSKNVVHRDLTAKNVLVGEGNVVKIADFGLARLMKKD--------VYVGKISSGAK--LPIRWTAPEAALYGSFTIKSDV ... .|... ||.||.|| |||..|||| | |.||||...|||.||||.| . | .|. | ..|.| |||||.|||. || ||.|||| LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV WSFGILLTEMVTGG---YP----------------------------------------------------------------Y ||||... |. | | || WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | SFK1b.AA | Pkinase | 61-255 | 24 | 1.4e-30 | 109.22 | Pfam | 1-212 (293) | Show / Hide |
Range on Protein: 61-255 Range on HMM: 1-212/293 Sequence Identity: 24% (53 aa) LRLTKQIGKGHCAEVWKVYGNTP---VAVKTLKVGSNMS---QADFL-AEANVMKKVRHKGILQIFAVC--SDSVSIVTKLMSNG----NLQAYLK-RGK ... ..||.| ..|.| . ||||..|. .. | |.... .|. .||...|. |.... .. .|.. .|. .. .| | .|.. . . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GKV--KLTTLIDMGAHIASGMDYLGSKNVVHRDLTAKNVLVGEGNVV----KIADFGLARLMKKDVYVGKISSGAKLPIRWTAPEAAL-YGSFTIKSDVW |.. ..... |..|..|. |....|||| |.|. . ... ||.|||||.... . .. ... ||| . . . |.|.| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW SFGILLTEMVTGGYPY |.|..| ||..| |. SCGCILYEMLCGRPPF |
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| Kinase | SFK1b.AA | S_TKc | 61-255 | 21 | 9.7e-16 | 53.9 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 61-255 Range on HMM: 1-231/231 Sequence Identity: 21% (54 aa) LRLTKQIGKGHCAEVWKVYGNT---PVAVKTLKVGSNMSQADFLAEANVMKKVRHKGILQIFAVCS-DSVSIVTKLMSN--GNLQAYLKRGKGK-----V .. ..|||| ..|.|.. . ||.| .| ... | ...|| .|. | ... |. |.. .|. .... |.| |.|. ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF KLTTLIDMGAHIASGMDYLGSKNVVHRDLTAKNVLVGEGNVVKIADFGLARLMKKDVYVGKISSGAKLPIRWTAPEAALYGSFTI-KSDVWSFGILLTEM . . . |.....|. |....|||| |.|. | ..||.||||||.. . . ||| ... |.|.||.|..| || PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM VTGGYP-------------------------------------------------Y .. ||| LC-GYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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